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Protein

Transmembrane protein 74B

Gene

TMEM74B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125895-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 74B
Gene namesi
Name:TMEM74B
Synonyms:C20orf46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15893. TMEM74B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55321.
OpenTargetsiENSG00000125895.
PharmGKBiPA25759.

Polymorphism and mutation databases

BioMutaiTMEM74B.
DMDMi27734260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794311 – 256Transmembrane protein 74BAdd BLAST256

Proteomic databases

PaxDbiQ9NUR3.
PeptideAtlasiQ9NUR3.
PRIDEiQ9NUR3.

PTM databases

iPTMnetiQ9NUR3.
PhosphoSitePlusiQ9NUR3.

Expressioni

Gene expression databases

BgeeiENSG00000125895.
CleanExiHS_C20orf46.
ExpressionAtlasiQ9NUR3. baseline and differential.
GenevisibleiQ9NUR3. HS.

Organism-specific databases

HPAiHPA045213.

Interactioni

Protein-protein interaction databases

IntActiQ9NUR3. 1 interactor.
STRINGi9606.ENSP00000371318.

Structurei

3D structure databases

ProteinModelPortaliQ9NUR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM74 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW2S. Eukaryota.
ENOG4111X0T. LUCA.
GeneTreeiENSGT00530000063880.
HOGENOMiHOG000112021.
HOVERGENiHBG051165.
InParanoidiQ9NUR3.
OMAiVENACFS.
OrthoDBiEOG091G0NPC.
PhylomeDBiQ9NUR3.
TreeFamiTF335735.

Family and domain databases

InterProiIPR029695. TMEM74-like.
[Graphical view]
PANTHERiPTHR16125. PTHR16125. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NUR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAQGYEFA AAKGPRDELG PSFPMASPPG LELKTLSNGP QAPRRSAPLG
60 70 80 90 100
PVAPTREGVE NACFSSEEHE THFQNPGNTR LGSSPSPPGG VSSLPRSQRD
110 120 130 140 150
DLSLHSEEGP ALEPVSRPVD YGFVSALVFL VSGILLVVTA YAIPREARVN
160 170 180 190 200
PDTVTAREME RLEMYYARLG SHLDRCIIAG LGLLTVGGML LSVLLMVSLC
210 220 230 240 250
KGELYRRRTF VPGKGSRKTY GSINLRMRQL NGDGGQALVE NEVVQVSETS

HTLQRS
Length:256
Mass (Da):27,551
Last modified:October 1, 2000 - v1
Checksum:i0824103831C4668A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03375733L → M.Corresponds to variant rs35393697dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002052 mRNA. Translation: BAA92058.1.
AL031665 Genomic DNA. Translation: CAC16505.1.
CH471133 Genomic DNA. Translation: EAX10647.1.
CH471133 Genomic DNA. Translation: EAX10648.1.
CCDSiCCDS13011.1.
RefSeqiNP_001291677.1. NM_001304748.1.
NP_001291678.1. NM_001304749.1.
NP_060824.1. NM_018354.2.
XP_011527584.1. XM_011529282.2.
XP_011527585.1. XM_011529283.2.
XP_011527586.1. XM_011529284.2.
XP_016883413.1. XM_017027924.1.
UniGeneiHs.516834.
Hs.744640.

Genome annotation databases

EnsembliENST00000381894; ENSP00000371318; ENSG00000125895.
GeneIDi55321.
KEGGihsa:55321.
UCSCiuc002weq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002052 mRNA. Translation: BAA92058.1.
AL031665 Genomic DNA. Translation: CAC16505.1.
CH471133 Genomic DNA. Translation: EAX10647.1.
CH471133 Genomic DNA. Translation: EAX10648.1.
CCDSiCCDS13011.1.
RefSeqiNP_001291677.1. NM_001304748.1.
NP_001291678.1. NM_001304749.1.
NP_060824.1. NM_018354.2.
XP_011527584.1. XM_011529282.2.
XP_011527585.1. XM_011529283.2.
XP_011527586.1. XM_011529284.2.
XP_016883413.1. XM_017027924.1.
UniGeneiHs.516834.
Hs.744640.

3D structure databases

ProteinModelPortaliQ9NUR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NUR3. 1 interactor.
STRINGi9606.ENSP00000371318.

PTM databases

iPTMnetiQ9NUR3.
PhosphoSitePlusiQ9NUR3.

Polymorphism and mutation databases

BioMutaiTMEM74B.
DMDMi27734260.

Proteomic databases

PaxDbiQ9NUR3.
PeptideAtlasiQ9NUR3.
PRIDEiQ9NUR3.

Protocols and materials databases

DNASUi55321.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381894; ENSP00000371318; ENSG00000125895.
GeneIDi55321.
KEGGihsa:55321.
UCSCiuc002weq.2. human.

Organism-specific databases

CTDi55321.
DisGeNETi55321.
GeneCardsiTMEM74B.
HGNCiHGNC:15893. TMEM74B.
HPAiHPA045213.
neXtProtiNX_Q9NUR3.
OpenTargetsiENSG00000125895.
PharmGKBiPA25759.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW2S. Eukaryota.
ENOG4111X0T. LUCA.
GeneTreeiENSGT00530000063880.
HOGENOMiHOG000112021.
HOVERGENiHBG051165.
InParanoidiQ9NUR3.
OMAiVENACFS.
OrthoDBiEOG091G0NPC.
PhylomeDBiQ9NUR3.
TreeFamiTF335735.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125895-MONOMER.

Miscellaneous databases

GenomeRNAii55321.
PROiQ9NUR3.

Gene expression databases

BgeeiENSG00000125895.
CleanExiHS_C20orf46.
ExpressionAtlasiQ9NUR3. baseline and differential.
GenevisibleiQ9NUR3. HS.

Family and domain databases

InterProiIPR029695. TMEM74-like.
[Graphical view]
PANTHERiPTHR16125. PTHR16125. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTM74B_HUMAN
AccessioniPrimary (citable) accession number: Q9NUR3
Secondary accession number(s): D3DVW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.