Q9NUQ8 (ABCF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-binding cassette sub-family F member 3

Gene names

Name:

ABCF3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	709 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. Contains 2 ABC transporter domains.
Caution	Lacks transmembrane domains and is probably not involved in transport.
Sequence caution	The sequence BAB14989.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NUQ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NUQ8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     69-74: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 709	709	ATP-binding cassette sub-family F member 3		PRO_0000248042
Regions
	Domain	178 – 424	247	ABC transporter 1
	Domain	492 – 707	216	ABC transporter 2
	Nucleotide binding	210 – 217	8	ATP 1 Potential
	Nucleotide binding	525 – 532	8	ATP 2 Potential
Amino acid modifications
	Modified residue	283	1	Phosphoserine Ref.3
Natural variations
	Alternative sequence	69 – 74	6	Missing in isoform 2.		VSP_020142
	Natural variant	503	1	P → L. Ref.1 Corresponds to variant rs11706273 [ dbSNP | Ensembl ].		VAR_027247
	Natural variant	510	1	R → H. Corresponds to variant rs9811715 [ dbSNP | Ensembl ].		VAR_027248
Experimental info
	Sequence conflict	231	1	P → S in BAC03881. Ref.1
	Sequence conflict	289	1	A → G in BAB14989. Ref.1
	Sequence conflict	468	1	K → R in BAA92063. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: E7E0FDB6426F3F60	FASTA	709	79,745
	10 20 30 40 50 60 MATCAEILRS EFPEIDGQVF DYVTGVLHSG SADFESVDDL VEAVGELLQE VSGDSKDDAG 70 80 90 100 110 120 IRAVCQRMYN TLRLAEPQSQ GNSQVLLDAP IQLSKITENY DCGTKLPGLL KREQSSTVNA 130 140 150 160 170 180 KKLEKAEARL KAKQEKRSEK DTLKTSNPLV LEEASASQAG SRKESRLESS GKNKSYDVRI 190 200 210 220 230 240 ENFDVSFGDR VLLAGADVNL AWGRRYGLVG RNGLGKTTLL KMLATRSLRV PAHISLLHVE 250 260 270 280 290 300 QEVAGDDTPA LQSVLESDSV REDLLRRERE LTAQIAAGRA EGSEAAELAE IYAKLEEIEA 310 320 330 340 350 360 DKAPARASVI LAGLGFTPKM QQQPTREFSG GWRMRLALAR ALFARPDLLL LDEPTNMLDV 370 380 390 400 410 420 RAILWLENYL QTWPSTILVV SHDRNFLNAI ATDIIHLHSQ RLDGYRGDFE TFIKSKQERL 430 440 450 460 470 480 LNQQREYEAQ QQYRQHIQVF IDRFRYNANR ASQVQSKLKM LEKLPELKPV DKESEVVMKF 490 500 510 520 530 540 PDGFEKFSPP ILQLDEVDFY YDPKHVIFSR LSVSADLESR ICVVGENGAG KSTMLKLLLG 550 560 570 580 590 600 DLAPVRGIRH AHRNLKIGYF SQHHVEQLDL NVSAVELLAR KFPGRPEEEY RHQLGRYGIS 610 620 630 640 650 660 GELAMRPLAS LSGGQKSRVA FAQMTMPCPN FYILDEPTNH LDMETIEALG RALNNFRGGV 670 680 690 700 ILVSHDERFI RLVCRELWVC EGGGVTRVEG GFDQYRALLQ EQFRREGFL
	Isoform 2 [UniParc]. Checksum: F952B10FD525CEB7	FASTA	703	78,984
	10 20 30 40 50 60 MATCAEILRS EFPEIDGQVF DYVTGVLHSG SADFESVDDL VEAVGELLQE VSGDSKDDAG 70 80 90 100 110 120 IRAVCQRMAE PQSQGNSQVL LDAPIQLSKI TENYDCGTKL PGLLKREQSS TVNAKKLEKA 130 140 150 160 170 180 EARLKAKQEK RSEKDTLKTS NPLVLEEASA SQAGSRKESR LESSGKNKSY DVRIENFDVS 190 200 210 220 230 240 FGDRVLLAGA DVNLAWGRRY GLVGRNGLGK TTLLKMLATR SLRVPAHISL LHVEQEVAGD 250 260 270 280 290 300 DTPALQSVLE SDSVREDLLR RERELTAQIA AGRAEGSEAA ELAEIYAKLE EIEADKAPAR 310 320 330 340 350 360 ASVILAGLGF TPKMQQQPTR EFSGGWRMRL ALARALFARP DLLLLDEPTN MLDVRAILWL 370 380 390 400 410 420 ENYLQTWPST ILVVSHDRNF LNAIATDIIH LHSQRLDGYR GDFETFIKSK QERLLNQQRE 430 440 450 460 470 480 YEAQQQYRQH IQVFIDRFRY NANRASQVQS KLKMLEKLPE LKPVDKESEV VMKFPDGFEK 490 500 510 520 530 540 FSPPILQLDE VDFYYDPKHV IFSRLSVSAD LESRICVVGE NGAGKSTMLK LLLGDLAPVR 550 560 570 580 590 600 GIRHAHRNLK IGYFSQHHVE QLDLNVSAVE LLARKFPGRP EEEYRHQLGR YGISGELAMR 610 620 630 640 650 660 PLASLSGGQK SRVAFAQMTM PCPNFYILDE PTNHLDMETI EALGRALNNF RGGVILVSHD 670 680 690 700 ERFIRLVCRE LWVCEGGGVT RVEGGFDQYR ALLQEQFRRE GFL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-503. Tissue: Placenta, Subthalamic nucleus and Vascular smooth muscle.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cervix, Muscle and Skin.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK002060 mRNA. Translation: BAA92063.1. AK024758 mRNA. Translation: BAB14989.1. Different initiation. AK092415 mRNA. Translation: BAC03881.1. AK290106 mRNA. Translation: BAF82795.1. BC009253 mRNA. Translation: AAH09253.1. BC051754 mRNA. Translation: AAH51754.1. BC051884 mRNA. Translation: AAH51884.2.
IPI	IPI00465160. IPI00784776.
RefSeq	NP_060828.2. NM_018358.2.
UniGene	Hs.361323.
3D structure databases
HSSP	HSSP built from PDB template 1F2T based on UniProtKB P58301.
ProteinModelPortal	Q9NUQ8.
SMR	Q9NUQ8. Positions 177-695.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NUQ8. 11 interactions.
MINT	MINT-1372042.
STRING	Q9NUQ8.
Polymorphism databases
DMDM	114149223.
Proteomic databases
PRIDE	Q9NUQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000429586; ENSP00000411471; ENSG00000161204.
GeneID	55324.
KEGG	hsa:55324.
UCSC	uc003fmz.2. human. uc003fna.2. human.
Organism-specific databases
CTD	55324.
GeneCards	GC03P183903.
H-InvDB	HIX0003918.
HGNC	HGNC:72. ABCF3.
HPA	HPA036332.
neXtProt	NX_Q9NUQ8.
PharmGKB	PA24407.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10305.
GeneTree	ENSGT00550000074722.
HOGENOM	HBG758042.
HOVERGEN	HBG050440.
InParanoid	Q9NUQ8.
OMA	LVCKELW.
OrthoDB	EOG4PNXGK.
PhylomeDB	Q9NUQ8.
Gene expression databases
ArrayExpress	Q9NUQ8.
Bgee	Q9NUQ8.
CleanEx	HS_ABCF3.
Genevestigator	Q9NUQ8.
GermOnline	ENSG00000161204. Homo sapiens.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K06158.
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	59592.

Entry information

Entry name

ABCF3_HUMAN

Accession

Primary (citable) accession number: Q9NUQ8
Secondary accession number(s): A8K241 , Q86UA2, Q8NAN1, Q96GS8, Q9H7A8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.