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Protein

ATP-binding cassette sub-family F member 3

Gene

ABCF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 217ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi525 – 532ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 3
Gene namesi
Name:ABCF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:72. ABCF3.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161204.
PharmGKBiPA24407.

Polymorphism and mutation databases

BioMutaiABCF3.
DMDMi114149223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002480422 – 709ATP-binding cassette sub-family F member 3Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NUQ8.
MaxQBiQ9NUQ8.
PaxDbiQ9NUQ8.
PeptideAtlasiQ9NUQ8.
PRIDEiQ9NUQ8.

PTM databases

iPTMnetiQ9NUQ8.
PhosphoSitePlusiQ9NUQ8.

Expressioni

Gene expression databases

BgeeiENSG00000161204.
CleanExiHS_ABCF3.
ExpressionAtlasiQ9NUQ8. baseline and differential.
GenevisibleiQ9NUQ8. HS.

Organism-specific databases

HPAiHPA036332.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FCHSD2O948683EBI-717672,EBI-1215612
TRIM27P143734EBI-717672,EBI-719493

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi120605. 27 interactors.
IntActiQ9NUQ8. 20 interactors.
MINTiMINT-1372042.
STRINGi9606.ENSP00000411471.

Structurei

3D structure databases

ProteinModelPortaliQ9NUQ8.
SMRiQ9NUQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 424ABC transporter 1PROSITE-ProRule annotationAdd BLAST247
Domaini492 – 707ABC transporter 2PROSITE-ProRule annotationAdd BLAST216

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0927. Eukaryota.
COG0488. LUCA.
GeneTreeiENSGT00630000089843.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ9NUQ8.
KOiK06158.
OMAiFYLVHDK.
OrthoDBiEOG091G031N.
PhylomeDBiQ9NUQ8.
TreeFamiTF105209.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
PF12848. ABC_tran_Xtn. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATCAEILRS EFPEIDGQVF DYVTGVLHSG SADFESVDDL VEAVGELLQE
60 70 80 90 100
VSGDSKDDAG IRAVCQRMYN TLRLAEPQSQ GNSQVLLDAP IQLSKITENY
110 120 130 140 150
DCGTKLPGLL KREQSSTVNA KKLEKAEARL KAKQEKRSEK DTLKTSNPLV
160 170 180 190 200
LEEASASQAG SRKESRLESS GKNKSYDVRI ENFDVSFGDR VLLAGADVNL
210 220 230 240 250
AWGRRYGLVG RNGLGKTTLL KMLATRSLRV PAHISLLHVE QEVAGDDTPA
260 270 280 290 300
LQSVLESDSV REDLLRRERE LTAQIAAGRA EGSEAAELAE IYAKLEEIEA
310 320 330 340 350
DKAPARASVI LAGLGFTPKM QQQPTREFSG GWRMRLALAR ALFARPDLLL
360 370 380 390 400
LDEPTNMLDV RAILWLENYL QTWPSTILVV SHDRNFLNAI ATDIIHLHSQ
410 420 430 440 450
RLDGYRGDFE TFIKSKQERL LNQQREYEAQ QQYRQHIQVF IDRFRYNANR
460 470 480 490 500
ASQVQSKLKM LEKLPELKPV DKESEVVMKF PDGFEKFSPP ILQLDEVDFY
510 520 530 540 550
YDPKHVIFSR LSVSADLESR ICVVGENGAG KSTMLKLLLG DLAPVRGIRH
560 570 580 590 600
AHRNLKIGYF SQHHVEQLDL NVSAVELLAR KFPGRPEEEY RHQLGRYGIS
610 620 630 640 650
GELAMRPLAS LSGGQKSRVA FAQMTMPCPN FYILDEPTNH LDMETIEALG
660 670 680 690 700
RALNNFRGGV ILVSHDERFI RLVCRELWVC EGGGVTRVEG GFDQYRALLQ

EQFRREGFL
Length:709
Mass (Da):79,745
Last modified:September 5, 2006 - v2
Checksum:iE7E0FDB6426F3F60
GO
Isoform 2 (identifier: Q9NUQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-74: Missing.

Show »
Length:703
Mass (Da):78,984
Checksum:iF952B10FD525CEB7
GO

Sequence cautioni

The sequence BAB14989 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231P → S in BAC03881 (PubMed:14702039).Curated1
Sequence conflicti289A → G in BAB14989 (PubMed:14702039).Curated1
Sequence conflicti468K → R in BAA92063 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027247503P → L.1 PublicationCorresponds to variant rs11706273dbSNPEnsembl.1
Natural variantiVAR_027248510R → H.Corresponds to variant rs9811715dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02014269 – 74Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002060 mRNA. Translation: BAA92063.1.
AK024758 mRNA. Translation: BAB14989.1. Different initiation.
AK092415 mRNA. Translation: BAC03881.1.
AK290106 mRNA. Translation: BAF82795.1.
BC009253 mRNA. Translation: AAH09253.1.
BC051754 mRNA. Translation: AAH51754.1.
BC051884 mRNA. Translation: AAH51884.2.
CCDSiCCDS3254.1. [Q9NUQ8-1]
RefSeqiNP_060828.2. NM_018358.2. [Q9NUQ8-1]
UniGeneiHs.361323.

Genome annotation databases

EnsembliENST00000292808; ENSP00000292808; ENSG00000161204. [Q9NUQ8-2]
ENST00000429586; ENSP00000411471; ENSG00000161204. [Q9NUQ8-1]
GeneIDi55324.
KEGGihsa:55324.
UCSCiuc003fmz.3. human. [Q9NUQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002060 mRNA. Translation: BAA92063.1.
AK024758 mRNA. Translation: BAB14989.1. Different initiation.
AK092415 mRNA. Translation: BAC03881.1.
AK290106 mRNA. Translation: BAF82795.1.
BC009253 mRNA. Translation: AAH09253.1.
BC051754 mRNA. Translation: AAH51754.1.
BC051884 mRNA. Translation: AAH51884.2.
CCDSiCCDS3254.1. [Q9NUQ8-1]
RefSeqiNP_060828.2. NM_018358.2. [Q9NUQ8-1]
UniGeneiHs.361323.

3D structure databases

ProteinModelPortaliQ9NUQ8.
SMRiQ9NUQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120605. 27 interactors.
IntActiQ9NUQ8. 20 interactors.
MINTiMINT-1372042.
STRINGi9606.ENSP00000411471.

PTM databases

iPTMnetiQ9NUQ8.
PhosphoSitePlusiQ9NUQ8.

Polymorphism and mutation databases

BioMutaiABCF3.
DMDMi114149223.

Proteomic databases

EPDiQ9NUQ8.
MaxQBiQ9NUQ8.
PaxDbiQ9NUQ8.
PeptideAtlasiQ9NUQ8.
PRIDEiQ9NUQ8.

Protocols and materials databases

DNASUi55324.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292808; ENSP00000292808; ENSG00000161204. [Q9NUQ8-2]
ENST00000429586; ENSP00000411471; ENSG00000161204. [Q9NUQ8-1]
GeneIDi55324.
KEGGihsa:55324.
UCSCiuc003fmz.3. human. [Q9NUQ8-1]

Organism-specific databases

CTDi55324.
GeneCardsiABCF3.
HGNCiHGNC:72. ABCF3.
HPAiHPA036332.
neXtProtiNX_Q9NUQ8.
OpenTargetsiENSG00000161204.
PharmGKBiPA24407.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0927. Eukaryota.
COG0488. LUCA.
GeneTreeiENSGT00630000089843.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ9NUQ8.
KOiK06158.
OMAiFYLVHDK.
OrthoDBiEOG091G031N.
PhylomeDBiQ9NUQ8.
TreeFamiTF105209.

Miscellaneous databases

ChiTaRSiABCF3. human.
GenomeRNAii55324.
PROiQ9NUQ8.

Gene expression databases

BgeeiENSG00000161204.
CleanExiHS_ABCF3.
ExpressionAtlasiQ9NUQ8. baseline and differential.
GenevisibleiQ9NUQ8. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
PF12848. ABC_tran_Xtn. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCF3_HUMAN
AccessioniPrimary (citable) accession number: Q9NUQ8
Secondary accession number(s): A8K241
, Q86UA2, Q8NAN1, Q96GS8, Q9H7A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks transmembrane domains and is probably not involved in transport.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.