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Protein

Gamma-taxilin

Gene

TXLNG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.2 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000086712-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-taxilin
Alternative name(s):
Environmental lipopolysaccharide-responding gene protein
Factor inhibiting ATF4-mediated transcription
Short name:
FIAT
Lipopolysaccharide-specific response protein 5
Gene namesi
Name:TXLNG
Synonyms:CXorf15, ELRG, LSR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18578. TXLNG.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • nuclear membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55787.
OpenTargetsiENSG00000086712.
PharmGKBiPA38588.

Polymorphism and mutation databases

BioMutaiTXLNG.
DMDMi212276476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894261 – 528Gamma-taxilinAdd BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12Omega-N-methylarginineCombined sources1
Modified residuei24Omega-N-methylarginineCombined sources1
Modified residuei79PhosphoserineBy similarity1
Modified residuei86PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei283PhosphotyrosineCombined sources1
Modified residuei517PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NUQ3.
MaxQBiQ9NUQ3.
PaxDbiQ9NUQ3.
PeptideAtlasiQ9NUQ3.
PRIDEiQ9NUQ3.

PTM databases

iPTMnetiQ9NUQ3.
PhosphoSitePlusiQ9NUQ3.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.1 Publication

Inductioni

By bacterial lipopolysaccharides (LPS) in Hep-G2 cells.1 Publication

Gene expression databases

BgeeiENSG00000086712.
CleanExiHS_CXorf15.
GenevisibleiQ9NUQ3. HS.

Organism-specific databases

HPAiHPA000297.
HPA000841.

Interactioni

Subunit structurei

Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Forms a heterodimer with ATF4 in osteoblasts.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi120901. 46 interactors.
IntActiQ9NUQ3. 17 interactors.
STRINGi9606.ENSP00000369465.

Structurei

3D structure databases

ProteinModelPortaliQ9NUQ3.
SMRiQ9NUQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 464Sequence analysisAdd BLAST312

Sequence similaritiesi

Belongs to the taxilin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1850. Eukaryota.
ENOG410XQH1. LUCA.
GeneTreeiENSGT00390000001482.
HOGENOMiHOG000231384.
HOVERGENiHBG104385.
InParanoidiQ9NUQ3.
OMAiEPKSQRS.
OrthoDBiEOG091G0GVB.
PhylomeDBiQ9NUQ3.
TreeFamiTF318595.

Family and domain databases

InterProiIPR026183. Taxilin_fam.
[Graphical view]
PANTHERiPTHR16127. PTHR16127. 1 hit.
PfamiPF09728. Taxilin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRVEEAAR GRGGGAEEAT EAGRGGRRRS PRQKFEIGTM EEAGICGLGV
60 70 80 90 100
KADMLCNSQS NDILQHQGSN CGGTSNKHSL EEDEGSDFIT ENRNLVSPAY
110 120 130 140 150
CTQESREEIP GGEARTDPPD GQQDSECNRN KEKTLGKEVL LLMQALNTLS
160 170 180 190 200
TPEEKLAALC KKYADLLEES RSVQKQMKIL QKKQAQIVKE KVHLQSEHSK
210 220 230 240 250
AILARSKLES LCRELQRHNK TLKEENMQQA REEEERRKEA TAHFQITLNE
260 270 280 290 300
IQAQLEQHDI HNAKLRQENI ELGEKLKKLI EQYALREEHI DKVFKHKELQ
310 320 330 340 350
QQLVDAKLQQ TTQLIKEADE KHQREREFLL KEATESRHKY EQMKQQEVQL
360 370 380 390 400
KQQLSLYMDK FEEFQTTMAK SNELFTTFRQ EMEKMTKKIK KLEKETIIWR
410 420 430 440 450
TKWENNNKAL LQMAEEKTVR DKEYKALQIK LERLEKLCRA LQTERNELNE
460 470 480 490 500
KVEVLKEQVS IKAAIKAANR DLATPVMQPC TALDSHKELN TSSKRALGAH
510 520
LEAEPKSQRS AVQKPPSTGS APAIESVD
Length:528
Mass (Da):60,586
Last modified:November 4, 2008 - v2
Checksum:i4EAC314330CE4490
GO
Isoform 2 (identifier: Q9NUQ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-166: Missing.

Show »
Length:396
Mass (Da):46,252
Checksum:iE05B3ED888BEE3A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249N → D in BAA92068 (PubMed:14702039).Curated1
Sequence conflicti296H → R in BAA92068 (PubMed:14702039).Curated1
Sequence conflicti402K → I in AAF70546 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019809246I → V.Corresponds to variant rs5969783dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03939135 – 166Missing in isoform 2. 1 PublicationAdd BLAST132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY739713 mRNA. Translation: AAW65982.1.
AK002071 mRNA. Translation: BAA92068.1.
AL929302, BX004861 Genomic DNA. Translation: CAI41279.1.
BX004861, AL929302 Genomic DNA. Translation: CAI41713.1.
CH471074 Genomic DNA. Translation: EAW98918.1.
BC101572 mRNA. Translation: AAI01573.1.
BC101576 mRNA. Translation: AAI01577.1.
AF143740 mRNA. Translation: AAF70546.2.
CCDSiCCDS14178.1. [Q9NUQ3-1]
CCDS55373.1. [Q9NUQ3-2]
RefSeqiNP_001162154.1. NM_001168683.1. [Q9NUQ3-2]
NP_060830.2. NM_018360.2. [Q9NUQ3-1]
UniGeneiHs.555961.

Genome annotation databases

EnsembliENST00000380122; ENSP00000369465; ENSG00000086712. [Q9NUQ3-1]
ENST00000398155; ENSP00000381222; ENSG00000086712. [Q9NUQ3-2]
GeneIDi55787.
KEGGihsa:55787.
UCSCiuc004cxq.3. human. [Q9NUQ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY739713 mRNA. Translation: AAW65982.1.
AK002071 mRNA. Translation: BAA92068.1.
AL929302, BX004861 Genomic DNA. Translation: CAI41279.1.
BX004861, AL929302 Genomic DNA. Translation: CAI41713.1.
CH471074 Genomic DNA. Translation: EAW98918.1.
BC101572 mRNA. Translation: AAI01573.1.
BC101576 mRNA. Translation: AAI01577.1.
AF143740 mRNA. Translation: AAF70546.2.
CCDSiCCDS14178.1. [Q9NUQ3-1]
CCDS55373.1. [Q9NUQ3-2]
RefSeqiNP_001162154.1. NM_001168683.1. [Q9NUQ3-2]
NP_060830.2. NM_018360.2. [Q9NUQ3-1]
UniGeneiHs.555961.

3D structure databases

ProteinModelPortaliQ9NUQ3.
SMRiQ9NUQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120901. 46 interactors.
IntActiQ9NUQ3. 17 interactors.
STRINGi9606.ENSP00000369465.

PTM databases

iPTMnetiQ9NUQ3.
PhosphoSitePlusiQ9NUQ3.

Polymorphism and mutation databases

BioMutaiTXLNG.
DMDMi212276476.

Proteomic databases

EPDiQ9NUQ3.
MaxQBiQ9NUQ3.
PaxDbiQ9NUQ3.
PeptideAtlasiQ9NUQ3.
PRIDEiQ9NUQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380122; ENSP00000369465; ENSG00000086712. [Q9NUQ3-1]
ENST00000398155; ENSP00000381222; ENSG00000086712. [Q9NUQ3-2]
GeneIDi55787.
KEGGihsa:55787.
UCSCiuc004cxq.3. human. [Q9NUQ3-1]

Organism-specific databases

CTDi55787.
DisGeNETi55787.
GeneCardsiTXLNG.
H-InvDBHIX0020474.
HGNCiHGNC:18578. TXLNG.
HPAiHPA000297.
HPA000841.
MIMi300677. gene.
neXtProtiNX_Q9NUQ3.
OpenTargetsiENSG00000086712.
PharmGKBiPA38588.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1850. Eukaryota.
ENOG410XQH1. LUCA.
GeneTreeiENSGT00390000001482.
HOGENOMiHOG000231384.
HOVERGENiHBG104385.
InParanoidiQ9NUQ3.
OMAiEPKSQRS.
OrthoDBiEOG091G0GVB.
PhylomeDBiQ9NUQ3.
TreeFamiTF318595.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000086712-MONOMER.

Miscellaneous databases

ChiTaRSiTXLNG. human.
GenomeRNAii55787.
PROiQ9NUQ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000086712.
CleanExiHS_CXorf15.
GenevisibleiQ9NUQ3. HS.

Family and domain databases

InterProiIPR026183. Taxilin_fam.
[Graphical view]
PANTHERiPTHR16127. PTHR16127. 1 hit.
PfamiPF09728. Taxilin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXLNG_HUMAN
AccessioniPrimary (citable) accession number: Q9NUQ3
Secondary accession number(s): Q2KQ75, Q5JNZ7, Q9P0X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Depletion of TXLNG by siRNA decreases the percentage of Hep-G2 cells arrested in G1 phase.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.