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Q9NUP9

- LIN7C_HUMAN

UniProt

Q9NUP9 - LIN7C_HUMAN

Protein

Protein lin-7 homolog C

Gene

LIN7C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

    GO - Molecular functioni

    1. cytoskeletal protein binding Source: UniProtKB
    2. L27 domain binding Source: UniProt
    3. protein domain specific binding Source: BHF-UCL

    GO - Biological processi

    1. exocytosis Source: UniProtKB-KW
    2. morphogenesis of an epithelial sheet Source: UniProt
    3. neurotransmitter secretion Source: Ensembl
    4. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lin-7 homolog C
    Short name:
    Lin-7C
    Alternative name(s):
    Mammalian lin-seven protein 3
    Short name:
    MALS-3
    Vertebrate lin-7 homolog 3
    Short name:
    Veli-3
    Gene namesi
    Name:LIN7C
    Synonyms:MALS3, VELI3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:17789. LIN7C.

    Subcellular locationi

    Cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Basolateral cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Cell junction By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity; Peripheral membrane protein By similarity. Cell junctiontight junction By similarity. Cell junctionsynapsesynaptosome By similarity
    Note: Enriched in synaptosomes and at epithelial cell-cell junctions By similarity. Mainly basolateral in renal epithelial cells.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. cell-cell junction Source: UniProt
    3. cytoplasm Source: UniProt
    4. extracellular vesicular exosome Source: UniProt
    5. MPP7-DLG1-LIN7 complex Source: UniProt
    6. neuron projection Source: UniProtKB-SubCell
    7. plasma membrane Source: UniProt
    8. postsynaptic density Source: UniProtKB-SubCell
    9. postsynaptic membrane Source: UniProtKB-KW
    10. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891786.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 197196Protein lin-7 homolog CPRO_0000189629Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9NUP9.
    PaxDbiQ9NUP9.
    PeptideAtlasiQ9NUP9.
    PRIDEiQ9NUP9.

    PTM databases

    PhosphoSiteiQ9NUP9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NUP9.
    BgeeiQ9NUP9.
    CleanExiHS_LIN7C.
    GenevestigatoriQ9NUP9.

    Organism-specific databases

    HPAiHPA051118.

    Interactioni

    Subunit structurei

    Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 By similarity. Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4 By similarity. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with MAPK12 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi120608. 17 interactions.
    IntActiQ9NUP9. 9 interactions.
    MINTiMINT-5002028.
    STRINGi9606.ENSP00000278193.

    Structurei

    Secondary structure

    1
    197
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 2620
    Helixi33 – 4311
    Helixi45 – 6016

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LRAX-ray2.95A3-64[»]
    ProteinModelPortaliQ9NUP9.
    SMRiQ9NUP9. Positions 3-64, 93-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NUP9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 6556L27PROSITE-ProRule annotationAdd
    BLAST
    Domaini93 – 17583PDZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi2 – 1312Kinase interacting siteBy similarityAdd
    BLAST

    Domaini

    The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.By similarity
    The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.By similarity
    The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.By similarity

    Sequence similaritiesi

    Belongs to the lin-7 family.Curated
    Contains 1 L27 domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG320117.
    HOGENOMiHOG000285929.
    HOVERGENiHBG052329.
    InParanoidiQ9NUP9.
    OMAiVDINSSP.
    OrthoDBiEOG75MVXG.
    PhylomeDBiQ9NUP9.
    TreeFamiTF316850.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR004172. L27.
    IPR014775. L27_C.
    IPR017365. Lin-7_homologue.
    IPR001478. PDZ.
    [Graphical view]
    PfamiPF02828. L27. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038039. Lin-7_homologue. 1 hit.
    SMARTiSM00569. L27. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS51022. L27. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NUP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALGEPVRL ERDICRAIEL LEKLQRSGEV PPQKLQALQR VLQSEFCNAV    50
    REVYEHVYET VDISSSPEVR ANATAKATVA AFAASEGHSH PRVVELPKTE 100
    EGLGFNIMGG KEQNSPIYIS RIIPGGIADR HGGLKRGDQL LSVNGVSVEG 150
    EHHEKAVELL KAAQGKVKLV VRYTPKVLEE MESRFEKMRS AKRRQQT 197
    Length:197
    Mass (Da):21,834
    Last modified:October 1, 2000 - v1
    Checksum:i7410FBFA3BD24F45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002077 mRNA. Translation: BAA92072.1.
    BC053907 mRNA. Translation: AAH53907.1.
    CCDSiCCDS7864.1.
    RefSeqiNP_060832.1. NM_018362.3.
    UniGeneiHs.91393.

    Genome annotation databases

    EnsembliENST00000278193; ENSP00000278193; ENSG00000148943.
    GeneIDi55327.
    KEGGihsa:55327.
    UCSCiuc001mrl.3. human.

    Polymorphism databases

    DMDMi59798474.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002077 mRNA. Translation: BAA92072.1 .
    BC053907 mRNA. Translation: AAH53907.1 .
    CCDSi CCDS7864.1.
    RefSeqi NP_060832.1. NM_018362.3.
    UniGenei Hs.91393.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LRA X-ray 2.95 A 3-64 [» ]
    ProteinModelPortali Q9NUP9.
    SMRi Q9NUP9. Positions 3-64, 93-175.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120608. 17 interactions.
    IntActi Q9NUP9. 9 interactions.
    MINTi MINT-5002028.
    STRINGi 9606.ENSP00000278193.

    PTM databases

    PhosphoSitei Q9NUP9.

    Polymorphism databases

    DMDMi 59798474.

    Proteomic databases

    MaxQBi Q9NUP9.
    PaxDbi Q9NUP9.
    PeptideAtlasi Q9NUP9.
    PRIDEi Q9NUP9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278193 ; ENSP00000278193 ; ENSG00000148943 .
    GeneIDi 55327.
    KEGGi hsa:55327.
    UCSCi uc001mrl.3. human.

    Organism-specific databases

    CTDi 55327.
    GeneCardsi GC11M027472.
    HGNCi HGNC:17789. LIN7C.
    HPAi HPA051118.
    MIMi 612332. gene.
    neXtProti NX_Q9NUP9.
    PharmGKBi PA134891786.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320117.
    HOGENOMi HOG000285929.
    HOVERGENi HBG052329.
    InParanoidi Q9NUP9.
    OMAi VDINSSP.
    OrthoDBi EOG75MVXG.
    PhylomeDBi Q9NUP9.
    TreeFami TF316850.

    Miscellaneous databases

    EvolutionaryTracei Q9NUP9.
    GeneWikii LIN7C.
    GenomeRNAii 55327.
    NextBioi 59604.
    PROi Q9NUP9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NUP9.
    Bgeei Q9NUP9.
    CleanExi HS_LIN7C.
    Genevestigatori Q9NUP9.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR004172. L27.
    IPR014775. L27_C.
    IPR017365. Lin-7_homologue.
    IPR001478. PDZ.
    [Graphical view ]
    Pfami PF02828. L27. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038039. Lin-7_homologue. 1 hit.
    SMARTi SM00569. L27. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS51022. L27. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    3. Bienvenut W.V., Lao L., Ryan K.M.
      Submitted (JUN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-12; 17-23 AND 77-92, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Osteosarcoma.
    4. "Polar expression of ErbB-2/HER2 in epithelia. Bimodal regulation by Lin-7."
      Shelly M., Mosesson Y., Citri A., Lavi S., Zwang Y., Melamed-Book N., Aroeti B., Yarden Y.
      Dev. Cell 5:475-486(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH EGFR.
    5. "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions."
      Bohl J., Brimer N., Lyons C., Vande Pol S.B.
      J. Biol. Chem. 282:9392-9400(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DLG1 AND MPP7.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Structural basis for tandem L27 domain-mediated polymerization."
      Yang X., Xie X., Chen L., Zhou H., Wang Z., Zhao W., Tian R., Zhang R., Tian C., Long J., Shen Y.
      FASEB J. 24:4806-4815(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 3-64 IN COMPLEX WITH MPP7 AND DLG1, SUBUNIT.

    Entry informationi

    Entry nameiLIN7C_HUMAN
    AccessioniPrimary (citable) accession number: Q9NUP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3