Reviewed,
UniProtKB/Swiss-Prot Q9NUN7 (ACER3_HUMAN)
Last modified
November 24, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alkaline ceramidase 3 Short name=Alkaline CDase 3 Short name=AlkCDase 3 EC=3.5.1.- Alternative name(s): Alkaline phytoceramidase Short name=aPHC Alkaline dihydroceramidase SB89 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 267 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity. |
| Enzyme regulation | Activated by Ca2+ and inhibited by Zn2+. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. |
| Tissue specificity | Ubiquitously expressed. Highest expression in placenta. |
| Sequence similarities | Belongs to the alkaline ceramidase family. |
| Sequence caution | The sequence BAA92085.1 differs from that shown. Reason: Frameshift at several positions. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Golgi apparatus Membrane |
| Domain | Transmembrane |
| Molecular function | Hydrolase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ceramide metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | Golgi membrane Inferred from electronic annotation. Source: InterPro endoplasmic reticulum membrane Ref.1Inferred from Experiment. Source: Reactome integral to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | phytoceramidase activity Ref.1 Inferred from Experiment. Source: Reactome |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 267 | 267 | Alkaline ceramidase 3 | PRO_0000212463 | |||||
Regions | |||||||||
| Transmembrane | 29 – 51 | 23 | Potential | ||||||
| Transmembrane | 63 – 84 | 22 | Potential | ||||||
| Transmembrane | 94 – 111 | 18 | Potential | ||||||
| Transmembrane | 118 – 137 | 20 | Potential | ||||||
| Transmembrane | 147 – 169 | 23 | Potential | ||||||
| Transmembrane | 174 – 196 | 23 | Potential | ||||||
| Transmembrane | 216 – 238 | 23 | Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 24 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide." Mao C., Xu R., Szulc Z.M., Bielawska A., Galadari S.H., Obeid L.M. J. Biol. Chem. 276:26577-26588(2001) [PubMed: 11356846] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Kidney. |
| [2] | Li N., Zhang W., Wan T., Chen T., Cao X. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Thalamus. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye. |
Cross-references
Sequence databases | |
|---|---|
| AF214454 mRNA. Translation: AAK71923.1. AF327353 mRNA. Translation: AAL56013.1. AK002100 mRNA. Translation: BAA92085.1. Frameshift. AK315000 mRNA. Translation: BAG37496.1. CH471076 Genomic DNA. Translation: EAW75010.1. BC073853 mRNA. Translation: AAH73853.1. | |
| IPI | IPI00018961. |
| RefSeq | NP_060837.3. |
| UniGene | Hs.23862 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9NUN7. |
Proteomic databases | |
| PRIDE | Q9NUN7. |
Genome annotation databases | |
| Ensembl | ENST00000278544; ENSP00000278544; ENSG00000078124; Homo sapiens. [Genome view] |
| GeneID | 55331. |
| KEGG | hsa:55331. |
Organism-specific databases | |
| CTD | 55331. |
| GeneCards | GC11P076250. |
| H-InvDB | HIX0021493. |
| HGNC | HGNC:16066. ACER3. |
| PharmGKB | PA33256. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9NUN7. |
| HOVERGEN | Q9NUN7. |
Enzyme and pathway databases | |
| Reactome | REACT_602. Metabolism of lipids and lipoproteins. |
Gene expression databases | |
| ArrayExpress | Q9NUN7. |
| Bgee | Q9NUN7. |
| CleanEx | HS_ACER3. |
| Genevestigator | Q9NUN7. |
| GermOnline | ENSG00000078124. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008901. APHC. [Graphical view] |
| Pfam | PF05875. aPHC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 59622. |
Entry information
| Entry name | ACER3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NUN7 Secondary accession number(s): B2RC99 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


