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Q9NUM4 (T106B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 106B
Gene names
Name:TMEM106B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching. Ref.14 Ref.19

Subunit structure

Interacts with MAP6. Ref.19

Subcellular location

Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein Ref.12 Ref.14 Ref.15 Ref.19.

Tissue specificity

Expressed in frontal cortex.

Involvement in disease

Ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]: Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.
Note: The gene represented in this entry acts as a disease modifier. Risk alleles confer genetic susceptibility by increasing gene expression (Ref.9, Ref.11). Increased expression may be the result of down-regulation of microRNA miR-132 and miR-212, that repress TMEM106B expression (Ref.13). Thr-185 is a risk allele associated with lower GRN protein levels and early age at onset in GRN UP-FTD mutation carriers: it presents slower protein degradation that leads to higher steady-state TMEM106B levels, leading to alterations in the intracellular versus extracellular partitioning of GRN (Ref.15). Ref.9 Ref.11 Ref.13 Ref.15

Frontotemporal dementia and/or amyotrophic lateral sclerosis (FTDALS) [MIM:105550]: An autosomal dominant neurodegenerative disorder characterized by adult onset of frontotemporal dementia and/or amyotrophic lateral sclerosis in an affected individual. There is high intrafamilial variation. Frontotemporal dementia is characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Amyotrophic lateral sclerosis is characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis.
Note: The gene represented in this entry acts as a disease modifier. Ref.16 Ref.17 Ref.18

Sequence similarities

Belongs to the TMEM106 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Transmembrane protein 106B
PRO_0000242650

Regions

Topological domain1 – 9696Cytoplasmic Potential
Transmembrane97 – 11721Helical; Potential
Topological domain118 – 274157Lumenal Potential

Amino acid modifications

Modified residue331Phosphoserine Ref.7 Ref.10
Glycosylation1451N-linked (GlcNAc...) Ref.12
Glycosylation1511N-linked (GlcNAc...) Ref.12
Glycosylation1641N-linked (GlcNAc...) Ref.12
Glycosylation1831N-linked (GlcNAc...) Ref.8 Ref.12 Ref.15
Glycosylation2561N-linked (GlcNAc...) Ref.12

Natural variations

Natural variant1851T → S. Ref.1 Ref.15
Corresponds to variant rs3173615 [ dbSNP | Ensembl ].
VAR_026849

Experimental info

Sequence conflict501Y → C in BAD96983. Ref.2
Sequence conflict1061L → P in BAD96983. Ref.2
Sequence conflict1971Y → N in BAD96983. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9NUM4 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: 906C923986DC04E6

FASTA27431,127
        10         20         30         40         50         60 
MGKSLSHLPL HSSKEDAYDG VTSENMRNGL VNSEVHNEDG RNGDVSQFPY VEFTGRDSVT 

        70         80         90        100        110        120 
CPTCQGTGRI PRGQENQLVA LIPYSDQRLR PRRTKLYVMA SVFVCLLLSG LAVFFLFPRS 

       130        140        150        160        170        180 
IDVKYIGVKS AYVSYDVQKR TIYLNITNTL NITNNNYYSV EVENITAQVQ FSKTVIGKAR 

       190        200        210        220        230        240 
LNNITIIGPL DMKQIDYTVP TVIAEEMSYM YDFCTLISIK VHNIVLMMQV TVTTTYFGHS 

       250        260        270 
EQISQERYQY VDCGRNTTYQ LGQSEYLNVL QPQQ 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-185.
Tissue: Placenta.
[2]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastric mucosa.
[3]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Skin.
[7]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-183.
Tissue: Liver.
[9]"Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions."
Van Deerlin V.M., Sleiman P.M., Martinez-Lage M., Chen-Plotkin A., Wang L.S., Graff-Radford N.R., Dickson D.W., Rademakers R., Boeve B.F., Grossman M., Arnold S.E., Mann D.M., Pickering-Brown S.M., Seelaar H., Heutink P., van Swieten J.C., Murrell J.R., Ghetti B. expand/collapse author list , Spina S., Grafman J., Hodges J., Spillantini M.G., Gilman S., Lieberman A.P., Kaye J.A., Woltjer R.L., Bigio E.H., Mesulam M., Al-Sarraj S., Troakes C., Rosenberg R.N., White C.L. III, Ferrer I., Llado A., Neumann M., Kretzschmar H.A., Hulette C.M., Welsh-Bohmer K.A., Miller B.L., Alzualde A., de Munain A.L., McKee A.C., Gearing M., Levey A.I., Lah J.J., Hardy J., Rohrer J.D., Lashley T., Mackenzie I.R., Feldman H.H., Hamilton R.L., Dekosky S.T., van der Zee J., Kumar-Singh S., Van Broeckhoven C., Mayeux R., Vonsattel J.P., Troncoso J.C., Kril J.J., Kwok J.B., Halliday G.M., Bird T.D., Ince P.G., Shaw P.J., Cairns N.J., Morris J.C., McLean C.A., DeCarli C., Ellis W.G., Freeman S.H., Frosch M.P., Growdon J.H., Perl D.P., Sano M., Bennett D.A., Schneider J.A., Beach T.G., Reiman E.M., Woodruff B.K., Cummings J., Vinters H.V., Miller C.A., Chui H.C., Alafuzoff I., Hartikainen P., Seilhean D., Galasko D., Masliah E., Cotman C.W., Tunon M.T., Martinez M.C., Munoz D.G., Carroll S.L., Marson D., Riederer P.F., Bogdanovic N., Schellenberg G.D., Hakonarson H., Trojanowski J.Q., Lee V.M.
Nat. Genet. 42:234-239(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN UP-FTD.
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers."
Finch N., Carrasquillo M.M., Baker M., Rutherford N.J., Coppola G., Dejesus-Hernandez M., Crook R., Hunter T., Ghidoni R., Benussi L., Crook J., Finger E., Hantanpaa K.J., Karydas A.M., Sengdy P., Gonzalez J., Seeley W.W., Johnson N. expand/collapse author list , Beach T.G., Mesulam M., Forloni G., Kertesz A., Knopman D.S., Uitti R., White C.L. III, Caselli R., Lippa C., Bigio E.H., Wszolek Z.K., Binetti G., Mackenzie I.R., Miller B.L., Boeve B.F., Younkin S.G., Dickson D.W., Petersen R.C., Graff-Radford N.R., Geschwind D.H., Rademakers R.
Neurology 76:467-474(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN UP-FTD.
[12]"Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration."
Lang C.M., Fellerer K., Schwenk B.M., Kuhn P.H., Kremmer E., Edbauer D., Capell A., Haass C.
J. Biol. Chem. 287:19355-19365(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION AT ASN-145; ASN-151; ASN-164; ASN-183 AND ASN-256.
[13]"TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways."
Chen-Plotkin A.S., Unger T.L., Gallagher M.D., Bill E., Kwong L.K., Volpicelli-Daley L., Busch J.I., Akle S., Grossman M., Van Deerlin V., Trojanowski J.Q., Lee V.M.
J. Neurosci. 32:11213-11227(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN UP-FTD.
[14]"The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function."
Brady O.A., Zheng Y., Murphy K., Huang M., Hu F.
Hum. Mol. Genet. 22:685-695(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[15]"TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia."
Nicholson A.M., Finch N.A., Wojtas A., Baker M.C., Perkerson R.B., Castanedes-Casey M., Rousseau L., Benussi L., Binetti G., Ghidoni R., Hsiung G.Y., Mackenzie I.R., Finger E., Boeve B.F., Ertekin-Taner N., Graff-Radford N.R., Dickson D.W., Rademakers R.
J. Neurochem. 126:781-791(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN UP-FTD, VARIANT SER-185, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-183.
[16]"TMEM106B: a strong FTLD disease modifier."
Deming Y., Cruchaga C.
Acta Neuropathol. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN FTDALS.
[17]"TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions."
Gallagher M.D., Suh E., Grossman M., Elman L., McCluskey L., Van Swieten J.C., Al-Sarraj S., Neumann M., Gelpi E., Ghetti B., Rohrer J.D., Halliday G., Van Broeckhoven C., Seilhean D., Shaw P.J., Frosch M.P., Alafuzoff I., Antonell A. expand/collapse author list , Bogdanovic N., Brooks W., Cairns N.J., Cooper-Knock J., Cotman C., Cras P., Cruts M., De Deyn P.P., Decarli C., Dobson-Stone C., Engelborghs S., Fox N., Galasko D., Gearing M., Gijselinck I., Grafman J., Hartikainen P., Hatanpaa K.J., Highley J.R., Hodges J., Hulette C., Ince P.G., Jin L.W., Kirby J., Kofler J., Kril J., Kwok J.B., Levey A., Lieberman A., Llado A., Martin J.J., Masliah E., McDermott C.J., McKee A., McLean C., Mead S., Miller C.A., Miller J., Munoz D.G., Murrell J., Paulson H., Piguet O., Rossor M., Sanchez-Valle R., Sano M., Schneider J., Silbert L.C., Spina S., van der Zee J., Van Langenhove T., Warren J., Wharton S.B., White Iii C.L., Woltjer R.L., Trojanowski J.Q., Lee V.M., Van Deerlin V., Chen-Plotkin A.S.
Acta Neuropathol. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN FTDALS.
[18]"TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia."
van Blitterswijk M., Mullen B., Nicholson A.M., Bieniek K.F., Heckman M.G., Baker M.C., Dejesus-Hernandez M., Finch N.A., Brown P.H., Murray M.E., Hsiung G.Y., Stewart H., Karydas A.M., Finger E., Kertesz A., Bigio E.H., Weintraub S., Mesulam M. expand/collapse author list , Hatanpaa K.J., White Iii C.L., Strong M.J., Beach T.G., Wszolek Z.K., Lippa C., Caselli R., Petrucelli L., Josephs K.A., Parisi J.E., Knopman D.S., Petersen R.C., Mackenzie I.R., Seeley W.W., Grinberg L.T., Miller B.L., Boylan K.B., Graff-Radford N.R., Boeve B.F., Dickson D.W., Rademakers R.
Acta Neuropathol. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN FTDALS.
[19]"The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes."
Schwenk B.M., Lang C.M., Hogl S., Tahirovic S., Orozco D., Rentzsch K., Lichtenthaler S.F., Hoogenraad C.C., Capell A., Haass C., Edbauer D.
EMBO J. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MAP6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK002135 mRNA. Translation: BAA92099.1.
AK223263 mRNA. Translation: BAD96983.1.
AC007321 Genomic DNA. Translation: AAQ96840.1.
CH236948 Genomic DNA. Translation: EAL24296.1.
CH471073 Genomic DNA. Translation: EAW93638.1.
BC033901 mRNA. Translation: AAH33901.1.
BC039741 mRNA. Translation: AAH39741.1.
RefSeqNP_001127704.1. NM_001134232.1.
NP_060844.2. NM_018374.3.
XP_005249846.1. XM_005249789.1.
UniGeneHs.396358.

3D structure databases

ProteinModelPortalQ9NUM4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120093. 2 interactions.
MINTMINT-4658429.
STRING9606.ENSP00000336673.

PTM databases

PhosphoSiteQ9NUM4.

Polymorphism databases

DMDM109895058.

Proteomic databases

PaxDbQ9NUM4.
PeptideAtlasQ9NUM4.
PRIDEQ9NUM4.

Protocols and materials databases

DNASU54664.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000396667; ENSP00000379901; ENSG00000106460.
ENST00000396668; ENSP00000379902; ENSG00000106460.
GeneID54664.
KEGGhsa:54664.
UCSCuc003ssh.3. human.

Organism-specific databases

CTD54664.
GeneCardsGC07P012217.
HGNCHGNC:22407. TMEM106B.
HPAHPA058342.
MIM105550. phenotype.
607485. phenotype.
613413. gene.
neXtProtNX_Q9NUM4.
PharmGKBPA142670756.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44552.
HOVERGENHBG055025.
InParanoidQ9NUM4.
OMAHSNKEDG.
OrthoDBEOG7D85X7.
PhylomeDBQ9NUM4.
TreeFamTF328907.

Gene expression databases

ArrayExpressQ9NUM4.
BgeeQ9NUM4.
CleanExHS_TMEM106B.
GenevestigatorQ9NUM4.

Family and domain databases

InterProIPR009790. DUF1356_TMEM106.
[Graphical view]
PfamPF07092. DUF1356. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTMEM106B.
GenomeRNAi54664.
NextBio57212.
PMAP-CutDBQ9NUM4.
PROQ9NUM4.
SOURCESearch...

Entry information

Entry nameT106B_HUMAN
AccessionPrimary (citable) accession number: Q9NUM4
Secondary accession number(s): A4D108, Q53FL9, Q8N4L0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM