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Protein

Zinc transporter ZIP9

Gene

SLC39A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a zinc-influx transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.5.6.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP9
Alternative name(s):
Solute carrier family 39 member 9
Zrt- and Irt-like protein 9
Short name:
ZIP-9
Gene namesi
Name:SLC39A9
Synonyms:ZIP9
ORF Names:UNQ714/PRO1377
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20182. SLC39A9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889179.

Polymorphism and mutation databases

BioMutaiSLC39A9.
DMDMi156633628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Zinc transporter ZIP9PRO_0000297597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NUM3.
MaxQBiQ9NUM3.
PaxDbiQ9NUM3.
PRIDEiQ9NUM3.
TopDownProteomicsiQ9NUM3-2. [Q9NUM3-2]

PTM databases

PhosphoSiteiQ9NUM3.

Expressioni

Gene expression databases

BgeeiQ9NUM3.
CleanExiHS_SLC39A9.
ExpressionAtlasiQ9NUM3. baseline and differential.
GenevisibleiQ9NUM3. HS.

Organism-specific databases

HPAiHPA007921.

Interactioni

Protein-protein interaction databases

BioGridi120615. 44 interactions.
IntActiQ9NUM3. 1 interaction.
STRINGi9606.ENSP00000336887.

Structurei

3D structure databases

ProteinModelPortaliQ9NUM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3907. Eukaryota.
ENOG410XQG5. LUCA.
GeneTreeiENSGT00390000010094.
HOGENOMiHOG000164405.
HOVERGENiHBG055074.
InParanoidiQ9NUM3.
KOiK14715.
OMAiMESEKVA.
OrthoDBiEOG7G4QGM.
PhylomeDBiQ9NUM3.
TreeFamiTF315051.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDFISISLL SLAMLVGCYV AGIIPLAVNF SEERLKLVTV LGAGLLCGTA
60 70 80 90 100
LAVIVPEGVH ALYEDILEGK HHQASETHNV IASDKAAEKS VVHEHEHSHD
110 120 130 140 150
HTQLHAYIGV SLVLGFVFML LVDQIGNSHV HSTDDPEAAR SSNSKITTTL
160 170 180 190 200
GLVVHAAADG VALGAAASTS QTSVQLIVFV AIMLHKAPAA FGLVSFLMHA
210 220 230 240 250
GLERNRIRKH LLVFALAAPV MSMVTYLGLS KSSKEALSEV NATGVAMLFS
260 270 280 290 300
AGTFLYVATV HVLPEVGGIG HSHKPDATGG RGLSRLEVAA LVLGCLIPLI

LSVGHQH
Length:307
Mass (Da):32,251
Last modified:August 21, 2007 - v2
Checksum:i3F2CB0ED7B193183
GO
Isoform 2 (identifier: Q9NUM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-157: Missing.

Show »
Length:284
Mass (Da):29,931
Checksum:i7A73F28242B69CF3
GO
Isoform 3 (identifier: Q9NUM3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-232: S → D
     233-307: Missing.

Show »
Length:232
Mass (Da):24,626
Checksum:iB3A9CE397D40D590
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221V → M in BAD96267 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641E → D.
Corresponds to variant rs2296723 [ dbSNP | Ensembl ].
VAR_034648
Natural varianti221 – 2211M → T.1 Publication
Corresponds to variant rs2232059 [ dbSNP | Ensembl ].
VAR_034649
Natural varianti285 – 2851R → C.1 Publication
Corresponds to variant rs17855898 [ dbSNP | Ensembl ].
VAR_034650

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei135 – 15723Missing in isoform 2. 1 PublicationVSP_027302Add
BLAST
Alternative sequencei232 – 2321S → D in isoform 3. 1 PublicationVSP_054057
Alternative sequencei233 – 30775Missing in isoform 3. 1 PublicationVSP_054058Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358687 mRNA. Translation: AAQ89050.1.
AK002136 mRNA. Translation: BAA92100.1.
AK222547 mRNA. Translation: BAD96267.1.
AY780789 mRNA. Translation: AAV98359.1.
AL157996 Genomic DNA. No translation available.
BC047682 mRNA. Translation: AAH47682.1.
BC064383 mRNA. Translation: AAH64383.1.
CCDSiCCDS58327.1. [Q9NUM3-3]
CCDS58328.1. [Q9NUM3-2]
CCDS9795.1. [Q9NUM3-1]
RefSeqiNP_001239077.1. NM_001252148.1. [Q9NUM3-2]
NP_001239079.1. NM_001252150.1. [Q9NUM3-3]
NP_001239080.1. NM_001252151.1.
NP_001239081.1. NM_001252152.1.
NP_060845.2. NM_018375.4. [Q9NUM3-1]
UniGeneiHs.432690.

Genome annotation databases

EnsembliENST00000336643; ENSP00000336887; ENSG00000029364. [Q9NUM3-1]
ENST00000555840; ENSP00000450639; ENSG00000029364. [Q9NUM3-1]
ENST00000556605; ENSP00000452385; ENSG00000029364. [Q9NUM3-3]
ENST00000557046; ENSP00000451833; ENSG00000029364. [Q9NUM3-2]
GeneIDi55334.
KEGGihsa:55334.
UCSCiuc001xle.5. human. [Q9NUM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358687 mRNA. Translation: AAQ89050.1.
AK002136 mRNA. Translation: BAA92100.1.
AK222547 mRNA. Translation: BAD96267.1.
AY780789 mRNA. Translation: AAV98359.1.
AL157996 Genomic DNA. No translation available.
BC047682 mRNA. Translation: AAH47682.1.
BC064383 mRNA. Translation: AAH64383.1.
CCDSiCCDS58327.1. [Q9NUM3-3]
CCDS58328.1. [Q9NUM3-2]
CCDS9795.1. [Q9NUM3-1]
RefSeqiNP_001239077.1. NM_001252148.1. [Q9NUM3-2]
NP_001239079.1. NM_001252150.1. [Q9NUM3-3]
NP_001239080.1. NM_001252151.1.
NP_001239081.1. NM_001252152.1.
NP_060845.2. NM_018375.4. [Q9NUM3-1]
UniGeneiHs.432690.

3D structure databases

ProteinModelPortaliQ9NUM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120615. 44 interactions.
IntActiQ9NUM3. 1 interaction.
STRINGi9606.ENSP00000336887.

Protein family/group databases

TCDBi2.A.5.6.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

PhosphoSiteiQ9NUM3.

Polymorphism and mutation databases

BioMutaiSLC39A9.
DMDMi156633628.

Proteomic databases

EPDiQ9NUM3.
MaxQBiQ9NUM3.
PaxDbiQ9NUM3.
PRIDEiQ9NUM3.
TopDownProteomicsiQ9NUM3-2. [Q9NUM3-2]

Protocols and materials databases

DNASUi55334.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336643; ENSP00000336887; ENSG00000029364. [Q9NUM3-1]
ENST00000555840; ENSP00000450639; ENSG00000029364. [Q9NUM3-1]
ENST00000556605; ENSP00000452385; ENSG00000029364. [Q9NUM3-3]
ENST00000557046; ENSP00000451833; ENSG00000029364. [Q9NUM3-2]
GeneIDi55334.
KEGGihsa:55334.
UCSCiuc001xle.5. human. [Q9NUM3-1]

Organism-specific databases

CTDi55334.
GeneCardsiSLC39A9.
H-InvDBHIX0011767.
HGNCiHGNC:20182. SLC39A9.
HPAiHPA007921.
neXtProtiNX_Q9NUM3.
PharmGKBiPA134889179.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3907. Eukaryota.
ENOG410XQG5. LUCA.
GeneTreeiENSGT00390000010094.
HOGENOMiHOG000164405.
HOVERGENiHBG055074.
InParanoidiQ9NUM3.
KOiK14715.
OMAiMESEKVA.
OrthoDBiEOG7G4QGM.
PhylomeDBiQ9NUM3.
TreeFamiTF315051.

Miscellaneous databases

ChiTaRSiSLC39A9. human.
GenomeRNAii55334.
PROiQ9NUM3.

Gene expression databases

BgeeiQ9NUM3.
CleanExiHS_SLC39A9.
ExpressionAtlasiQ9NUM3. baseline and differential.
GenevisibleiQ9NUM3. HS.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. Lin L., Zhong G., Ke R., Li H., Shen C., Nong W., Zhou G., Yang S.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-221.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 3).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-285.
    Tissue: Duodenum and Skin.

Entry informationi

Entry nameiS39A9_HUMAN
AccessioniPrimary (citable) accession number: Q9NUM3
Secondary accession number(s): G3V5J8
, Q53HN3, Q5MJQ0, Q6P2Q1, Q86WY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.