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Protein

Double-stranded RNA-binding protein Staufen homolog 2

Gene

STAU2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).By similarity

GO - Molecular functioni

  • double-stranded RNA binding Source: MGI
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Double-stranded RNA-binding protein Staufen homolog 2
Gene namesi
Name:STAU2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:11371. STAU2.

Subcellular locationi

  • Cytoplasm
  • Nucleus
  • Nucleusnucleolus
  • Endoplasmic reticulum

  • Note: Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity).By similarity

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27067.
OpenTargetsiENSG00000040341.
PharmGKBiPA36189.

Polymorphism and mutation databases

BioMutaiSTAU2.
DMDMi73919458.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722461 – 570Double-stranded RNA-binding protein Staufen homolog 2Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei405PhosphothreonineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei426PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NUL3.
MaxQBiQ9NUL3.
PaxDbiQ9NUL3.
PeptideAtlasiQ9NUL3.
PRIDEiQ9NUL3.

PTM databases

iPTMnetiQ9NUL3.
PhosphoSitePlusiQ9NUL3.

Expressioni

Gene expression databases

BgeeiENSG00000040341.
CleanExiHS_STAU2.
ExpressionAtlasiQ9NUL3. baseline and differential.
GenevisibleiQ9NUL3. HS.

Organism-specific databases

HPAiCAB020836.
HPA019155.

Interactioni

Subunit structurei

Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules. Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DHX58Q96C102EBI-722938,EBI-744193
EIF2AK2P195252EBI-722938,EBI-640775

Protein-protein interaction databases

BioGridi117978. 47 interactors.
IntActiQ9NUL3. 17 interactors.
MINTiMINT-1426106.
STRINGi9606.ENSP00000428756.

Structurei

3D structure databases

ProteinModelPortaliQ9NUL3.
SMRiQ9NUL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 75DRBM 1PROSITE-ProRule annotationAdd BLAST68
Domaini95 – 181DRBM 2PROSITE-ProRule annotationAdd BLAST87
Domaini207 – 274DRBM 3PROSITE-ProRule annotationAdd BLAST68
Domaini307 – 375DRBM 4PROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni381 – 570Required for dendritic transportBy similarityAdd BLAST190

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi273 – 291Nuclear localization signal 1By similarityAdd BLAST19
Motifi373 – 412Nuclear localization signal 2By similarityAdd BLAST40

Domaini

The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity).By similarity

Sequence similaritiesi

Contains 4 DRBM (double-stranded RNA-binding) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3732. Eukaryota.
ENOG410XSCK. LUCA.
GeneTreeiENSGT00830000128290.
HOGENOMiHOG000231025.
HOVERGENiHBG005013.
InParanoidiQ9NUL3.
KOiK17597.
PhylomeDBiQ9NUL3.
TreeFamiTF350296.

Family and domain databases

Gene3Di3.30.160.20. 4 hits.
InterProiIPR014720. dsRBD_dom.
IPR032478. Staufen_C.
[Graphical view]
PfamiPF00035. dsrm. 4 hits.
PF16482. Staufen_C. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 4 hits.
[Graphical view]
PROSITEiPS50137. DS_RBD. 4 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUL3-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANPKEKTAM CLVNELARFN RVQPQYKLLN ERGPAHSKMF SVQLSLGEQT
60 70 80 90 100
WESEGSSIKK AQQAVANKAL TESTLPKPVQ KPPKSNVNNN PGSITPTVEL
110 120 130 140 150
NGLAMKRGEP AIYRPLDPKP FPNYRANYNF RGMYNQRYHC PVPKIFYVQL
160 170 180 190 200
TVGNNEFFGE GKTRQAARHN AAMKALQALQ NEPIPERSPQ NGESGKDMDD
210 220 230 240 250
DKDANKSEIS LVFEIALKRN MPVSFEVIKE SGPPHMKSFV TRVSVGEFSA
260 270 280 290 300
EGEGNSKKLS KKRAATTVLQ ELKKLPPLPV VEKPKLFFKK RPKTIVKAGP
310 320 330 340 350
EYGQGMNPIS RLAQIQQAKK EKEPDYVLLS ERGMPRRREF VMQVKVGNEV
360 370 380 390 400
ATGTGPNKKI AKKNAAEAML LQLGYKASTN LQDQLEKTGE NKGWSGPKPG
410 420 430 440 450
FPEPTNNTPK GILHLSPDVY QEMEASRHKV ISGTTLGYLS PKDMNQPSSS
460 470 480 490 500
FFSISPTSNS SATIARELLM NGTSSTAEAI GLKGSSPTPP CSPVQPSKQL
510 520 530 540 550
EYLARIQGFQ AALSALKQFS EQGLDPIDGA MNIEKGSLEK QAKHLREKAD
560 570
NNQAPPGSIA QDCKKSNSAV
Length:570
Mass (Da):62,641
Last modified:October 1, 2000 - v1
Checksum:i09B0BC7A96B1D2FA
GO
Isoform 2 (identifier: Q9NUL3-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MANPKEKTAMCLVNELARFNRVQPQYKLLNERGPAHSK → MLQINQ

Show »
Length:538
Mass (Da):59,002
Checksum:i25AC7A3A8A787A11
GO
Isoform 3 (identifier: Q9NUL3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MANPKEKTAMCLVNELARFNRVQPQYKLLNERGPAHSK → MLQINQ
     511-511: A → V
     512-570: Missing.

Show »
Length:479
Mass (Da):52,769
Checksum:iA799D1C30D1DF8B9
GO
Isoform 4 (identifier: Q9NUL3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-197: Missing.
     511-511: A → V
     512-570: Missing.

Note: No experimental confirmation available.
Show »
Length:314
Mass (Da):34,357
Checksum:i3693E8AC06717D95
GO
Isoform 5 (identifier: Q9NUL3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MANPKEKTAMCLVNELARFNRVQPQYKLLNERGPAHSK → MLQINQ
     138-570: Missing.

Show »
Length:105
Mass (Da):11,763
Checksum:i581E40C45AE59FDC
GO
Isoform 6 (identifier: Q9NUL3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.

Note: No experimental confirmation available.
Show »
Length:398
Mass (Da):43,310
Checksum:iD5EE6567A238F902
GO
Isoform 7 (identifier: Q9NUL3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     509-509: F → FQVHYCDRQSGKECVTCLTLAPVQMTFHAIGSSIEASHD

Note: No experimental confirmation available.
Show »
Length:504
Mass (Da):55,446
Checksum:iD705A2812D5F4CB6
GO
Isoform 8 (identifier: Q9NUL3-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     511-570: AALSALKQFSEQGLDPIDGAMNIEKGSLEKQAKHLREKADNNQAPPGSIAQDCKKSNSAV → V

Note: No experimental confirmation available.
Show »
Length:473
Mass (Da):52,041
Checksum:i75978FFF1EFE2B05
GO

Sequence cautioni

The sequence BAA91766 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14522 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345K → T in BAH11778 (PubMed:14702039).Curated1
Sequence conflicti433G → D in CAH10527 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023394198M → V.2 PublicationsCorresponds to variant rs949493dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0153731 – 197Missing in isoform 4. 1 PublicationAdd BLAST197
Alternative sequenceiVSP_0461381 – 172Missing in isoform 6. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_0461391 – 104Missing in isoform 7. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_0153741 – 38MANPK…PAHSK → MLQINQ in isoform 2, isoform 3 and isoform 5. 3 PublicationsAdd BLAST38
Alternative sequenceiVSP_0461401 – 38Missing in isoform 8. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_015375138 – 570Missing in isoform 5. 1 PublicationAdd BLAST433
Alternative sequenceiVSP_046141509F → FQVHYCDRQSGKECVTCLTL APVQMTFHAIGSSIEASHD in isoform 7. 1 Publication1
Alternative sequenceiVSP_046142511 – 570AALSA…SNSAV → V in isoform 8. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_015376511A → V in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_015377512 – 570Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19062 mRNA. Translation: CAB64341.1.
AF459097 mRNA. Translation: AAN37926.1.
AF459098 mRNA. Translation: AAN37927.1.
AK001576 mRNA. Translation: BAA91766.1. Different initiation.
AK002152 mRNA. Translation: BAA92111.1.
AK023314 mRNA. Translation: BAB14522.1. Different initiation.
AK293496 mRNA. Translation: BAH11522.1.
AK294466 mRNA. Translation: BAH11778.1.
AK303104 mRNA. Translation: BAH13900.1.
CR627442 mRNA. Translation: CAH10527.1.
AC018620 Genomic DNA. No translation available.
AC027018 Genomic DNA. No translation available.
AC100784 Genomic DNA. No translation available.
BC008369 mRNA. Translation: AAH08369.1.
BC008370 mRNA. Translation: AAH08370.1.
CCDSiCCDS55244.1. [Q9NUL3-6]
CCDS55245.1. [Q9NUL3-7]
CCDS55246.1. [Q9NUL3-8]
CCDS55247.1. [Q9NUL3-1]
CCDS55248.1. [Q9NUL3-2]
CCDS6214.1. [Q9NUL3-3]
RefSeqiNP_001157852.1. NM_001164380.1.
NP_001157853.1. NM_001164381.1.
NP_001157854.1. NM_001164382.1.
NP_001157855.1. NM_001164383.1.
NP_001157856.1. NM_001164384.1.
NP_001157857.1. NM_001164385.1.
NP_055208.2. NM_014393.2.
UniGeneiHs.561815.

Genome annotation databases

EnsembliENST00000524104; ENSP00000430611; ENSG00000040341. [Q9NUL3-5]
GeneIDi27067.
KEGGihsa:27067.
UCSCiuc003xzs.5. human. [Q9NUL3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19062 mRNA. Translation: CAB64341.1.
AF459097 mRNA. Translation: AAN37926.1.
AF459098 mRNA. Translation: AAN37927.1.
AK001576 mRNA. Translation: BAA91766.1. Different initiation.
AK002152 mRNA. Translation: BAA92111.1.
AK023314 mRNA. Translation: BAB14522.1. Different initiation.
AK293496 mRNA. Translation: BAH11522.1.
AK294466 mRNA. Translation: BAH11778.1.
AK303104 mRNA. Translation: BAH13900.1.
CR627442 mRNA. Translation: CAH10527.1.
AC018620 Genomic DNA. No translation available.
AC027018 Genomic DNA. No translation available.
AC100784 Genomic DNA. No translation available.
BC008369 mRNA. Translation: AAH08369.1.
BC008370 mRNA. Translation: AAH08370.1.
CCDSiCCDS55244.1. [Q9NUL3-6]
CCDS55245.1. [Q9NUL3-7]
CCDS55246.1. [Q9NUL3-8]
CCDS55247.1. [Q9NUL3-1]
CCDS55248.1. [Q9NUL3-2]
CCDS6214.1. [Q9NUL3-3]
RefSeqiNP_001157852.1. NM_001164380.1.
NP_001157853.1. NM_001164381.1.
NP_001157854.1. NM_001164382.1.
NP_001157855.1. NM_001164383.1.
NP_001157856.1. NM_001164384.1.
NP_001157857.1. NM_001164385.1.
NP_055208.2. NM_014393.2.
UniGeneiHs.561815.

3D structure databases

ProteinModelPortaliQ9NUL3.
SMRiQ9NUL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117978. 47 interactors.
IntActiQ9NUL3. 17 interactors.
MINTiMINT-1426106.
STRINGi9606.ENSP00000428756.

PTM databases

iPTMnetiQ9NUL3.
PhosphoSitePlusiQ9NUL3.

Polymorphism and mutation databases

BioMutaiSTAU2.
DMDMi73919458.

Proteomic databases

EPDiQ9NUL3.
MaxQBiQ9NUL3.
PaxDbiQ9NUL3.
PeptideAtlasiQ9NUL3.
PRIDEiQ9NUL3.

Protocols and materials databases

DNASUi27067.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000524104; ENSP00000430611; ENSG00000040341. [Q9NUL3-5]
GeneIDi27067.
KEGGihsa:27067.
UCSCiuc003xzs.5. human. [Q9NUL3-1]

Organism-specific databases

CTDi27067.
DisGeNETi27067.
GeneCardsiSTAU2.
H-InvDBHIX0007585.
HGNCiHGNC:11371. STAU2.
HPAiCAB020836.
HPA019155.
MIMi605920. gene.
neXtProtiNX_Q9NUL3.
OpenTargetsiENSG00000040341.
PharmGKBiPA36189.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3732. Eukaryota.
ENOG410XSCK. LUCA.
GeneTreeiENSGT00830000128290.
HOGENOMiHOG000231025.
HOVERGENiHBG005013.
InParanoidiQ9NUL3.
KOiK17597.
PhylomeDBiQ9NUL3.
TreeFamiTF350296.

Miscellaneous databases

ChiTaRSiSTAU2. human.
GeneWikiiSTAU2.
GenomeRNAii27067.
PROiQ9NUL3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000040341.
CleanExiHS_STAU2.
ExpressionAtlasiQ9NUL3. baseline and differential.
GenevisibleiQ9NUL3. HS.

Family and domain databases

Gene3Di3.30.160.20. 4 hits.
InterProiIPR014720. dsRBD_dom.
IPR032478. Staufen_C.
[Graphical view]
PfamiPF00035. dsrm. 4 hits.
PF16482. Staufen_C. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 4 hits.
[Graphical view]
PROSITEiPS50137. DS_RBD. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAU2_HUMAN
AccessioniPrimary (citable) accession number: Q9NUL3
Secondary accession number(s): B7Z1I6
, B7Z292, B7Z8B4, E7ER74, E9PEI3, E9PF26, E9PF50, Q6AHY7, Q96HM0, Q96HM1, Q9NVI5, Q9UGG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.