Q9NUK0 (MBNL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Muscleblind-like protein 3

Alternative name(s):
Cys3His CCG1-required protein
Muscleblind-like X-linked protein
Protein HCHCR

Gene names

Name:	MBNL3
Synonyms:	CHCR, MBLX39, MBXL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. Ref.1 Ref.9
Subcellular location	Nucleus. Cytoplasm. Note: Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts. Ref.8
Tissue specificity	Highly expressed in the placenta. Ref.8
Sequence similarities	Belongs to the muscleblind family. Contains 4 C3H1-type zinc fingers.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of myoblast differentiation Inferred from electronic annotation. Source: Compara regulation of RNA splicing Inferred from direct assay Ref.9. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NUK0-1)

Also known as: HCHCR-G; G;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NUK0-2)

Also known as: HCHCR-R; R;

The sequence of this isoform differs from the canonical sequence as follows:
     258-292: Missing.
     352-354: LKF → IPQLSIDELNSSMFVSQM

Isoform 3 (identifier: Q9NUK0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.
     51-57: VVACFDS → MERASKN

Isoform 4 (identifier: Q9NUK0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.
     51-57: VVACFDS → MERASKN
     308-319: Missing.

Isoform 5 (identifier: Q9NUK0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Muscleblind-like protein 3		PRO_0000089180
Regions
	Zinc finger	14 – 42	29	C3H1-type 1
	Zinc finger	48 – 74	27	C3H1-type 2
	Zinc finger	174 – 202	29	C3H1-type 3
	Zinc finger	210 – 236	27	C3H1-type 4
	Compositional bias	118 – 169	52	Pro-rich
Natural variations
	Alternative sequence	1 – 96	96	Missing in isoform 5.		VSP_044309
	Alternative sequence	1 – 50	50	Missing in isoform 3 and isoform 4.		VSP_006431
	Alternative sequence	51 – 57	7	VVACFDS → MERASKN in isoform 3 and isoform 4.		VSP_006432
	Alternative sequence	258 – 292	35	Missing in isoform 2.		VSP_006433
	Alternative sequence	308 – 319	12	Missing in isoform 4.		VSP_015935
	Alternative sequence	352 – 354	3	LKF → IPQLSIDELNSSMFVSQM in isoform 2.		VSP_006434
Experimental info
	Sequence conflict	113	1	S → P in AAQ75759. Ref.3
	Sequence conflict	187	1	N → I in AAQ75759. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (HCHCR-G) (G) [UniParc]. Last modified December 6, 2002. Version 2. Checksum: 145E1AF8CB3BEE27	FASTA	354	38,532
	10 20 30 40 50 60 MTAVNVALIR DTKWLTLEVC REFQRGTCSR ADADCKFAHP PRVCHVENGR VVACFDSLKG 70 80 90 100 110 120 RCTRENCKYL HPPPHLKTQL EINGRNNLIQ QKTAAAMFAQ QMQLMLQNAQ MSSLGSFPMT 130 140 150 160 170 180 PSIPANPPMA FNPYIPHPGM GLVPAELVPN TPVLIPGNPP LAMPGAVGPK LMRSDKLEVC 190 200 210 220 230 240 REFQRGNCTR GENDCRYAHP TDASMIEASD NTVTICMDYI KGRCSREKCK YFHPPAHLQA 250 260 270 280 290 300 RLKAAHHQMN HSAASAMALQ PGTLQLIPKR SALEKPNGAT PVFNPTVFHC QQALTNLQLP 310 320 330 340 350 QPAFIPAGPI LCMAPASNIV PMMHGATPTT VSAATTPATS VPFAAPTTGN QLKF
	Isoform 2 (HCHCR-R) (R) [UniParc]. Checksum: 9FB835135F474DCE	FASTA	334	36,380
	10 20 30 40 50 60 MTAVNVALIR DTKWLTLEVC REFQRGTCSR ADADCKFAHP PRVCHVENGR VVACFDSLKG 70 80 90 100 110 120 RCTRENCKYL HPPPHLKTQL EINGRNNLIQ QKTAAAMFAQ QMQLMLQNAQ MSSLGSFPMT 130 140 150 160 170 180 PSIPANPPMA FNPYIPHPGM GLVPAELVPN TPVLIPGNPP LAMPGAVGPK LMRSDKLEVC 190 200 210 220 230 240 REFQRGNCTR GENDCRYAHP TDASMIEASD NTVTICMDYI KGRCSREKCK YFHPPAHLQA 250 260 270 280 290 300 RLKAAHHQMN HSAASAMALT NLQLPQPAFI PAGPILCMAP ASNIVPMMHG ATPTTVSAAT 310 320 330 TPATSVPFAA PTTGNQIPQL SIDELNSSMF VSQM
	Isoform 3 [UniParc]. Checksum: ACB92E93B3E5C097	FASTA	304	32,942
	10 20 30 40 50 60 MERASKNLKG RCTRENCKYL HPPPHLKTQL EINGRNNLIQ QKTAAAMFAQ QMQLMLQNAQ 70 80 90 100 110 120 MSSLGSFPMT PSIPANPPMA FNPYIPHPGM GLVPAELVPN TPVLIPGNPP LAMPGAVGPK 130 140 150 160 170 180 LMRSDKLEVC REFQRGNCTR GENDCRYAHP TDASMIEASD NTVTICMDYI KGRCSREKCK 190 200 210 220 230 240 YFHPPAHLQA RLKAAHHQMN HSAASAMALQ PGTLQLIPKR SALEKPNGAT PVFNPTVFHC 250 260 270 280 290 300 QQALTNLQLP QPAFIPAGPI LCMAPASNIV PMMHGATPTT VSAATTPATS VPFAAPTTGN QLKF
	Isoform 4 [UniParc]. Checksum: FB239634C3247296	FASTA	292	31,774
	10 20 30 40 50 60 MERASKNLKG RCTRENCKYL HPPPHLKTQL EINGRNNLIQ QKTAAAMFAQ QMQLMLQNAQ 70 80 90 100 110 120 MSSLGSFPMT PSIPANPPMA FNPYIPHPGM GLVPAELVPN TPVLIPGNPP LAMPGAVGPK 130 140 150 160 170 180 LMRSDKLEVC REFQRGNCTR GENDCRYAHP TDASMIEASD NTVTICMDYI KGRCSREKCK 190 200 210 220 230 240 YFHPPAHLQA RLKAAHHQMN HSAASAMALQ PGTLQLIPKR SALEKPNGAT PVFNPTVFHC 250 260 270 280 290 QQALTNLQLP QPAFIPAVPM MHGATPTTVS AATTPATSVP FAAPTTGNQL KF
	Isoform 5 [UniParc]. Checksum: 1DBE7A26DE8F5A4B	FASTA	258	27,687
	10 20 30 40 50 60 MFAQQMQLML QNAQMSSLGS FPMTPSIPAN PPMAFNPYIP HPGMGLVPAE LVPNTPVLIP 70 80 90 100 110 120 GNPPLAMPGA VGPKLMRSDK LEVCREFQRG NCTRGENDCR YAHPTDASMI EASDNTVTIC 130 140 150 160 170 180 MDYIKGRCSR EKCKYFHPPA HLQARLKAAH HQMNHSAASA MALQPGTLQL IPKRSALEKP 190 200 210 220 230 240 NGATPVFNPT VFHCQQALTN LQLPQPAFIP AGPILCMAPA SNIVPMMHGA TPTTVSAATT 250 PATSVPFAAP TTGNQLKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Inhibition of muscle differentiation by the novel muscleblind-related protein CHCR." Squillace R.M., Chenault D.M., Wang E.H. Dev. Biol. 250:218-230(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION. Tissue: Embryonic kidney.
[2]	"MBLX39 sequence." Urbinati C.R., Swanson M.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	Li H., Yu R., Zheng G., Ke R., Zhou G., Shen C., Li M., Xiao W., Lin L., Yang S. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5). Tissue: Placenta.
[5]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5). Tissue: Lung.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-354. Tissue: Testis.
[8]	"Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells." Fardaei M., Rogers M.T., Thorpe H.M., Larkin K., Hamshere M.G., Harper P.S., Brook J.D. Hum. Mol. Genet. 11:805-814(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
[9]	"Muscleblind proteins regulate alternative splicing." Ho T.H., Charlet-B N., Poulos M.G., Singh G., Swanson M.S., Cooper T.A. EMBO J. 23:3103-3112(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY072692 mRNA. Translation: AAL65661.1. AF467070 mRNA. Translation: AAL87670.1. AB077698 mRNA. Translation: BAB85648.1. AB077699 mRNA. Translation: BAB85649.1. AJ427918 mRNA. Translation: CAD20869.1. AJ427919 mRNA. Translation: CAD20870.1. AF491305 mRNA. Translation: AAM09533.1. AY372211 mRNA. Translation: AAQ75759.1. AK002178 mRNA. Translation: BAA92124.1. AK300248 mRNA. Translation: BAG62014.1. AL161442 Genomic DNA. No translation available. AL050310 Genomic DNA. Translation: CAI43102.1. AL050310 Genomic DNA. Translation: CAI43105.1. AL050310 Genomic DNA. Translation: CAI43106.1. AL050310 Genomic DNA. Translation: CAI43108.1. BC042090 mRNA. Translation: AAH42090.1. BC074775 mRNA. Translation: AAH74775.1. BC074776 mRNA. Translation: AAH74776.1. AL133625 mRNA. Translation: CAB63751.1.
IPI	IPI00020062. IPI00219790. IPI00219792. IPI00654643.
PIR	T43463.
RefSeq	NP_001164172.1. NM_001170701.1. NP_001164173.1. NM_001170702.1. NP_001164174.1. NM_001170703.1. NP_001164175.1. NM_001170704.1. NP_060858.2. NM_018388.3. NP_597846.1. NM_133486.2.
UniGene	Hs.105134. Hs.596347.
3D structure databases
ProteinModelPortal	Q9NUK0.
ModBase	Search...
PTM databases
PhosphoSite	Q9NUK0.
Polymorphism databases
DMDM	26396510.
Proteomic databases
PaxDb	Q9NUK0.
PRIDE	Q9NUK0.
Protocols and materials databases
DNASU	55796.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370839; ENSP00000359876; ENSG00000076770. ENST00000370844; ENSP00000359881; ENSG00000076770. ENST00000370849; ENSP00000359886; ENSG00000076770. ENST00000370853; ENSP00000359890; ENSG00000076770. ENST00000394311; ENSP00000377848; ENSG00000076770. ENST00000538204; ENSP00000439618; ENSG00000076770.
GeneID	55796.
KEGG	hsa:55796.
UCSC	uc004ewt.3. human. uc004ewu.4. human. uc004ewv.4. human. uc004ewx.2. human.
Organism-specific databases
CTD	55796.
GeneCards	GC0XM131506.
HGNC	HGNC:20564. MBNL3.
HPA	HPA001584.
MIM	300413. gene.
neXtProt	NX_Q9NUK0.
PharmGKB	PA134992936.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG241142.
HOVERGEN	HBG006999.
InParanoid	Q9NUK0.
KO	K14943.
OMA	KLRAAHH.
PhylomeDB	Q9NUK0.
Gene expression databases
ArrayExpress	Q9NUK0.
Bgee	Q9NUK0.
Genevestigator	Q9NUK0.
GermOnline	ENSG00000076770. Homo sapiens.
Family and domain databases
InterPro	IPR000571. Znf_CCCH. [Graphical view]
SMART	SM00356. ZnF_C3H1. 4 hits. [Graphical view]
PROSITE	PS50103. ZF_C3H1. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55796.
NextBio	60923.
SOURCE	Search...

Entry information

Entry name

MBNL3_HUMAN

Accession

Primary (citable) accession number: Q9NUK0
Secondary accession number(s): Q5JXN8 , Q5JXN9, Q5JXP4, Q6UDQ1, Q8IUR4, Q8TAD9, Q8TAF4, Q9H0Z7, Q9UF37

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	December 6, 2002
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.