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Q9NUJ7

- PLCX1_HUMAN

UniProt

Q9NUJ7 - PLCX1_HUMAN

Protein

PI-PLC X domain-containing protein 1

Gene

PLCXD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. lipid metabolic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PI-PLC X domain-containing protein 1
    Gene namesi
    Name:PLCXD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:23148. PLCXD1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134878642.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323PI-PLC X domain-containing protein 1PRO_0000304804Add
    BLAST

    Proteomic databases

    MaxQBiQ9NUJ7.
    PaxDbiQ9NUJ7.
    PRIDEiQ9NUJ7.

    PTM databases

    PhosphoSiteiQ9NUJ7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NUJ7.
    BgeeiQ9NUJ7.
    CleanExiHS_PLCXD1.
    GenevestigatoriQ9NUJ7.

    Organism-specific databases

    HPAiHPA007721.

    Interactioni

    Protein-protein interaction databases

    BioGridi120625. 2 interactions.
    STRINGi9606.ENSP00000371073.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NUJ7.
    SMRiQ9NUJ7. Positions 21-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 206177PI-PLC X-boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG311948.
    HOGENOMiHOG000007180.
    HOVERGENiHBG099748.
    InParanoidiQ9NUJ7.
    OMAiLRIAHRP.
    OrthoDBiEOG776SQ6.
    PhylomeDBiQ9NUJ7.
    TreeFamiTF314457.

    Family and domain databases

    Gene3Di3.20.20.190. 1 hit.
    InterProiIPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    [Graphical view]
    PfamiPF00388. PI-PLC-X. 1 hit.
    [Graphical view]
    SUPFAMiSSF51695. SSF51695. 1 hit.
    PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NUJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGQVSASNS FSRLHCRNAN EDWMSALCPR LWDVPLHHLS IPGSHDTMTY    50
    CLNKKSPISH EESRLLQLLN KALPCITRPV VLKWSVTQAL DVTEQLDAGV 100
    RYLDLRIAHM LEGSEKNLHF VHMVYTTALV EDTLTEISEW LERHPREVVI 150
    LACRNFEGLS EDLHEYLVAC IKNIFGDMLC PRGEVPTLRQ LWSRGQQVIV 200
    SYEDESSLRR HHELWPGVPY WWGNRVKTEA LIRYLETMKS CGRPGGLFVA 250
    GINLTENLQY VLAHPSESLE KMTLPNLPRL SAWVREQCPG PGSRCTNIIA 300
    GDFIGADGFV SDVIALNQKL LWC 323
    Length:323
    Mass (Da):36,668
    Last modified:October 1, 2000 - v1
    Checksum:iD37D9FB182EC57DC
    GO

    Sequence cautioni

    The sequence CAM28359.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAM28360.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002185 mRNA. Translation: BAA92127.1.
    BX537334 Genomic DNA. Translation: CAM28359.1. Sequence problems.
    BX537334 Genomic DNA. Translation: CAM28360.1. Sequence problems.
    BX537334 Genomic DNA. Translation: CAI43217.1.
    CH471225 Genomic DNA. Translation: EAW66822.1.
    BC005028 mRNA. Translation: AAH05028.1.
    CCDSiCCDS14103.1.
    RefSeqiNP_060860.1. NM_018390.3.
    XP_006724507.1. XM_006724444.1.
    XP_006724508.1. XM_006724445.1.
    XP_006724509.1. XM_006724446.1.
    XP_006724928.1. XM_006724865.1.
    XP_006724929.1. XM_006724866.1.
    XP_006724930.1. XM_006724867.1.
    UniGeneiHs.522568.

    Genome annotation databases

    EnsembliENST00000381657; ENSP00000371073; ENSG00000182378.
    ENST00000381663; ENSP00000371079; ENSG00000182378.
    ENST00000399012; ENSP00000381976; ENSG00000182378.
    GeneIDi55344.
    KEGGihsa:55344.
    UCSCiuc004cpc.3. human.

    Polymorphism databases

    DMDMi74752980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002185 mRNA. Translation: BAA92127.1 .
    BX537334 Genomic DNA. Translation: CAM28359.1 . Sequence problems.
    BX537334 Genomic DNA. Translation: CAM28360.1 . Sequence problems.
    BX537334 Genomic DNA. Translation: CAI43217.1 .
    CH471225 Genomic DNA. Translation: EAW66822.1 .
    BC005028 mRNA. Translation: AAH05028.1 .
    CCDSi CCDS14103.1.
    RefSeqi NP_060860.1. NM_018390.3.
    XP_006724507.1. XM_006724444.1.
    XP_006724508.1. XM_006724445.1.
    XP_006724509.1. XM_006724446.1.
    XP_006724928.1. XM_006724865.1.
    XP_006724929.1. XM_006724866.1.
    XP_006724930.1. XM_006724867.1.
    UniGenei Hs.522568.

    3D structure databases

    ProteinModelPortali Q9NUJ7.
    SMRi Q9NUJ7. Positions 21-201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120625. 2 interactions.
    STRINGi 9606.ENSP00000371073.

    PTM databases

    PhosphoSitei Q9NUJ7.

    Polymorphism databases

    DMDMi 74752980.

    Proteomic databases

    MaxQBi Q9NUJ7.
    PaxDbi Q9NUJ7.
    PRIDEi Q9NUJ7.

    Protocols and materials databases

    DNASUi 55344.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381657 ; ENSP00000371073 ; ENSG00000182378 .
    ENST00000381663 ; ENSP00000371079 ; ENSG00000182378 .
    ENST00000399012 ; ENSP00000381976 ; ENSG00000182378 .
    GeneIDi 55344.
    KEGGi hsa:55344.
    UCSCi uc004cpc.3. human.

    Organism-specific databases

    CTDi 55344.
    GeneCardsi GC0XP000192.
    HGNCi HGNC:23148. PLCXD1.
    HPAi HPA007721.
    neXtProti NX_Q9NUJ7.
    PharmGKBi PA134878642.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311948.
    HOGENOMi HOG000007180.
    HOVERGENi HBG099748.
    InParanoidi Q9NUJ7.
    OMAi LRIAHRP.
    OrthoDBi EOG776SQ6.
    PhylomeDBi Q9NUJ7.
    TreeFami TF314457.

    Miscellaneous databases

    GeneWikii PLCXD1.
    GenomeRNAii 55344.
    NextBioi 59675.
    PROi Q9NUJ7.

    Gene expression databases

    ArrayExpressi Q9NUJ7.
    Bgeei Q9NUJ7.
    CleanExi HS_PLCXD1.
    Genevestigatori Q9NUJ7.

    Family and domain databases

    Gene3Di 3.20.20.190. 1 hit.
    InterProi IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    [Graphical view ]
    Pfami PF00388. PI-PLC-X. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51695. SSF51695. 1 hit.
    PROSITEi PS50007. PIPLC_X_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.

    Entry informationi

    Entry nameiPLCX1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NUJ7
    Secondary accession number(s): A2BH51, A2BH52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3