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Protein

PI-PLC X domain-containing protein 1

Gene

PLCXD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PI-PLC X domain-containing protein 1
Gene namesi
Name:PLCXD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:23148. PLCXD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878642.

Polymorphism and mutation databases

BioMutaiPLCXD1.
DMDMi74752980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323PI-PLC X domain-containing protein 1PRO_0000304804Add
BLAST

Proteomic databases

MaxQBiQ9NUJ7.
PaxDbiQ9NUJ7.
PRIDEiQ9NUJ7.

PTM databases

PhosphoSiteiQ9NUJ7.

Expressioni

Gene expression databases

BgeeiQ9NUJ7.
CleanExiHS_PLCXD1.
ExpressionAtlasiQ9NUJ7. baseline and differential.
GenevisibleiQ9NUJ7. HS.

Organism-specific databases

HPAiHPA007721.

Interactioni

Protein-protein interaction databases

BioGridi120625. 3 interactions.
STRINGi9606.ENSP00000371073.

Structurei

3D structure databases

ProteinModelPortaliQ9NUJ7.
SMRiQ9NUJ7. Positions 21-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 206177PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG311948.
GeneTreeiENSGT00530000063361.
HOGENOMiHOG000007180.
HOVERGENiHBG099748.
InParanoidiQ9NUJ7.
OMAiLRIAHRP.
OrthoDBiEOG776SQ6.
PhylomeDBiQ9NUJ7.
TreeFamiTF314457.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
[Graphical view]
PfamiPF00388. PI-PLC-X. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NUJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGQVSASNS FSRLHCRNAN EDWMSALCPR LWDVPLHHLS IPGSHDTMTY
60 70 80 90 100
CLNKKSPISH EESRLLQLLN KALPCITRPV VLKWSVTQAL DVTEQLDAGV
110 120 130 140 150
RYLDLRIAHM LEGSEKNLHF VHMVYTTALV EDTLTEISEW LERHPREVVI
160 170 180 190 200
LACRNFEGLS EDLHEYLVAC IKNIFGDMLC PRGEVPTLRQ LWSRGQQVIV
210 220 230 240 250
SYEDESSLRR HHELWPGVPY WWGNRVKTEA LIRYLETMKS CGRPGGLFVA
260 270 280 290 300
GINLTENLQY VLAHPSESLE KMTLPNLPRL SAWVREQCPG PGSRCTNIIA
310 320
GDFIGADGFV SDVIALNQKL LWC
Length:323
Mass (Da):36,668
Last modified:October 1, 2000 - v1
Checksum:iD37D9FB182EC57DC
GO

Sequence cautioni

The sequence CAM28359.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAM28360.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002185 mRNA. Translation: BAA92127.1.
BX537334 Genomic DNA. Translation: CAM28359.1. Sequence problems.
BX537334 Genomic DNA. Translation: CAM28360.1. Sequence problems.
BX537334 Genomic DNA. Translation: CAI43217.1.
CH471225 Genomic DNA. Translation: EAW66822.1.
BC005028 mRNA. Translation: AAH05028.1.
CCDSiCCDS14103.1.
RefSeqiNP_060860.1. NM_018390.3.
XP_006724507.1. XM_006724444.1.
XP_006724508.1. XM_006724445.1.
XP_006724509.1. XM_006724446.1.
XP_006724928.1. XM_006724865.1.
XP_006724929.1. XM_006724866.1.
XP_006724930.1. XM_006724867.1.
UniGeneiHs.522568.

Genome annotation databases

EnsembliENST00000381657; ENSP00000371073; ENSG00000182378.
ENST00000381663; ENSP00000371079; ENSG00000182378.
ENST00000399012; ENSP00000381976; ENSG00000182378.
GeneIDi55344.
KEGGihsa:55344.
UCSCiuc004cpc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002185 mRNA. Translation: BAA92127.1.
BX537334 Genomic DNA. Translation: CAM28359.1. Sequence problems.
BX537334 Genomic DNA. Translation: CAM28360.1. Sequence problems.
BX537334 Genomic DNA. Translation: CAI43217.1.
CH471225 Genomic DNA. Translation: EAW66822.1.
BC005028 mRNA. Translation: AAH05028.1.
CCDSiCCDS14103.1.
RefSeqiNP_060860.1. NM_018390.3.
XP_006724507.1. XM_006724444.1.
XP_006724508.1. XM_006724445.1.
XP_006724509.1. XM_006724446.1.
XP_006724928.1. XM_006724865.1.
XP_006724929.1. XM_006724866.1.
XP_006724930.1. XM_006724867.1.
UniGeneiHs.522568.

3D structure databases

ProteinModelPortaliQ9NUJ7.
SMRiQ9NUJ7. Positions 21-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120625. 3 interactions.
STRINGi9606.ENSP00000371073.

PTM databases

PhosphoSiteiQ9NUJ7.

Polymorphism and mutation databases

BioMutaiPLCXD1.
DMDMi74752980.

Proteomic databases

MaxQBiQ9NUJ7.
PaxDbiQ9NUJ7.
PRIDEiQ9NUJ7.

Protocols and materials databases

DNASUi55344.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381657; ENSP00000371073; ENSG00000182378.
ENST00000381663; ENSP00000371079; ENSG00000182378.
ENST00000399012; ENSP00000381976; ENSG00000182378.
GeneIDi55344.
KEGGihsa:55344.
UCSCiuc004cpc.3. human.

Organism-specific databases

CTDi55344.
GeneCardsiGC0XP000192.
HGNCiHGNC:23148. PLCXD1.
HPAiHPA007721.
neXtProtiNX_Q9NUJ7.
PharmGKBiPA134878642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG311948.
GeneTreeiENSGT00530000063361.
HOGENOMiHOG000007180.
HOVERGENiHBG099748.
InParanoidiQ9NUJ7.
OMAiLRIAHRP.
OrthoDBiEOG776SQ6.
PhylomeDBiQ9NUJ7.
TreeFamiTF314457.

Miscellaneous databases

GeneWikiiPLCXD1.
GenomeRNAii55344.
NextBioi59675.
PROiQ9NUJ7.

Gene expression databases

BgeeiQ9NUJ7.
CleanExiHS_PLCXD1.
ExpressionAtlasiQ9NUJ7. baseline and differential.
GenevisibleiQ9NUJ7. HS.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
[Graphical view]
PfamiPF00388. PI-PLC-X. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiPLCX1_HUMAN
AccessioniPrimary (citable) accession number: Q9NUJ7
Secondary accession number(s): A2BH51, A2BH52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.