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Q9NUJ7

- PLCX1_HUMAN

UniProt

Q9NUJ7 - PLCX1_HUMAN

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Protein

PI-PLC X domain-containing protein 1

Gene

PLCXD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. phosphoric diester hydrolase activity Source: InterPro

GO - Biological processi

  1. lipid metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PI-PLC X domain-containing protein 1
Gene namesi
Name:PLCXD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:23148. PLCXD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323PI-PLC X domain-containing protein 1PRO_0000304804Add
BLAST

Proteomic databases

MaxQBiQ9NUJ7.
PaxDbiQ9NUJ7.
PRIDEiQ9NUJ7.

PTM databases

PhosphoSiteiQ9NUJ7.

Expressioni

Gene expression databases

BgeeiQ9NUJ7.
CleanExiHS_PLCXD1.
ExpressionAtlasiQ9NUJ7. baseline and differential.
GenevestigatoriQ9NUJ7.

Organism-specific databases

HPAiHPA007721.

Interactioni

Protein-protein interaction databases

BioGridi120625. 3 interactions.
STRINGi9606.ENSP00000371073.

Structurei

3D structure databases

ProteinModelPortaliQ9NUJ7.
SMRiQ9NUJ7. Positions 21-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 206177PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG311948.
GeneTreeiENSGT00530000063361.
HOGENOMiHOG000007180.
HOVERGENiHBG099748.
InParanoidiQ9NUJ7.
OMAiLRIAHRP.
OrthoDBiEOG776SQ6.
PhylomeDBiQ9NUJ7.
TreeFamiTF314457.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
[Graphical view]
PfamiPF00388. PI-PLC-X. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NUJ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGQVSASNS FSRLHCRNAN EDWMSALCPR LWDVPLHHLS IPGSHDTMTY
60 70 80 90 100
CLNKKSPISH EESRLLQLLN KALPCITRPV VLKWSVTQAL DVTEQLDAGV
110 120 130 140 150
RYLDLRIAHM LEGSEKNLHF VHMVYTTALV EDTLTEISEW LERHPREVVI
160 170 180 190 200
LACRNFEGLS EDLHEYLVAC IKNIFGDMLC PRGEVPTLRQ LWSRGQQVIV
210 220 230 240 250
SYEDESSLRR HHELWPGVPY WWGNRVKTEA LIRYLETMKS CGRPGGLFVA
260 270 280 290 300
GINLTENLQY VLAHPSESLE KMTLPNLPRL SAWVREQCPG PGSRCTNIIA
310 320
GDFIGADGFV SDVIALNQKL LWC
Length:323
Mass (Da):36,668
Last modified:October 1, 2000 - v1
Checksum:iD37D9FB182EC57DC
GO

Sequence cautioni

The sequence CAM28359.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAM28360.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002185 mRNA. Translation: BAA92127.1.
BX537334 Genomic DNA. Translation: CAM28359.1. Sequence problems.
BX537334 Genomic DNA. Translation: CAM28360.1. Sequence problems.
BX537334 Genomic DNA. Translation: CAI43217.1.
CH471225 Genomic DNA. Translation: EAW66822.1.
BC005028 mRNA. Translation: AAH05028.1.
CCDSiCCDS14103.1.
RefSeqiNP_060860.1. NM_018390.3.
XP_006724507.1. XM_006724444.1.
XP_006724508.1. XM_006724445.1.
XP_006724509.1. XM_006724446.1.
XP_006724928.1. XM_006724865.1.
XP_006724929.1. XM_006724866.1.
XP_006724930.1. XM_006724867.1.
UniGeneiHs.522568.

Genome annotation databases

EnsembliENST00000381657; ENSP00000371073; ENSG00000182378.
ENST00000381663; ENSP00000371079; ENSG00000182378.
ENST00000399012; ENSP00000381976; ENSG00000182378.
GeneIDi55344.
KEGGihsa:55344.
UCSCiuc004cpc.3. human.

Polymorphism databases

DMDMi74752980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002185 mRNA. Translation: BAA92127.1 .
BX537334 Genomic DNA. Translation: CAM28359.1 . Sequence problems.
BX537334 Genomic DNA. Translation: CAM28360.1 . Sequence problems.
BX537334 Genomic DNA. Translation: CAI43217.1 .
CH471225 Genomic DNA. Translation: EAW66822.1 .
BC005028 mRNA. Translation: AAH05028.1 .
CCDSi CCDS14103.1.
RefSeqi NP_060860.1. NM_018390.3.
XP_006724507.1. XM_006724444.1.
XP_006724508.1. XM_006724445.1.
XP_006724509.1. XM_006724446.1.
XP_006724928.1. XM_006724865.1.
XP_006724929.1. XM_006724866.1.
XP_006724930.1. XM_006724867.1.
UniGenei Hs.522568.

3D structure databases

ProteinModelPortali Q9NUJ7.
SMRi Q9NUJ7. Positions 21-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120625. 3 interactions.
STRINGi 9606.ENSP00000371073.

PTM databases

PhosphoSitei Q9NUJ7.

Polymorphism databases

DMDMi 74752980.

Proteomic databases

MaxQBi Q9NUJ7.
PaxDbi Q9NUJ7.
PRIDEi Q9NUJ7.

Protocols and materials databases

DNASUi 55344.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381657 ; ENSP00000371073 ; ENSG00000182378 .
ENST00000381663 ; ENSP00000371079 ; ENSG00000182378 .
ENST00000399012 ; ENSP00000381976 ; ENSG00000182378 .
GeneIDi 55344.
KEGGi hsa:55344.
UCSCi uc004cpc.3. human.

Organism-specific databases

CTDi 55344.
GeneCardsi GC0XP000192.
HGNCi HGNC:23148. PLCXD1.
HPAi HPA007721.
neXtProti NX_Q9NUJ7.
PharmGKBi PA134878642.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311948.
GeneTreei ENSGT00530000063361.
HOGENOMi HOG000007180.
HOVERGENi HBG099748.
InParanoidi Q9NUJ7.
OMAi LRIAHRP.
OrthoDBi EOG776SQ6.
PhylomeDBi Q9NUJ7.
TreeFami TF314457.

Miscellaneous databases

GeneWikii PLCXD1.
GenomeRNAii 55344.
NextBioi 59675.
PROi Q9NUJ7.

Gene expression databases

Bgeei Q9NUJ7.
CleanExi HS_PLCXD1.
ExpressionAtlasi Q9NUJ7. baseline and differential.
Genevestigatori Q9NUJ7.

Family and domain databases

Gene3Di 3.20.20.190. 1 hit.
InterProi IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
[Graphical view ]
Pfami PF00388. PI-PLC-X. 1 hit.
[Graphical view ]
SUPFAMi SSF51695. SSF51695. 1 hit.
PROSITEi PS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiPLCX1_HUMAN
AccessioniPrimary (citable) accession number: Q9NUJ7
Secondary accession number(s): A2BH51, A2BH52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3