ID   T11L1_HUMAN             Reviewed;         509 AA.
AC   Q9NUJ3; D3DR01; Q8IVX4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   24-JAN-2024, entry version 138.
DE   RecName: Full=T-complex protein 11-like protein 1;
GN   Name=TCP11L1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-178.
RC   TISSUE=Blood;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- INTERACTION:
CC       Q9NUJ3; Q9UIV1: CNOT7; NbExp=3; IntAct=EBI-2555179, EBI-2105113;
CC       Q9NUJ3; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-2555179, EBI-742054;
CC       Q9NUJ3; Q5T890: ERCC6L2; NbExp=3; IntAct=EBI-2555179, EBI-3951765;
CC       Q9NUJ3; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-2555179, EBI-740641;
CC       Q9NUJ3; Q8TEX9: IPO4; NbExp=3; IntAct=EBI-2555179, EBI-395967;
CC       Q9NUJ3; P50458: LHX2; NbExp=3; IntAct=EBI-2555179, EBI-12179869;
CC       Q9NUJ3; P43365: MAGEA12; NbExp=3; IntAct=EBI-2555179, EBI-749530;
CC       Q9NUJ3; P50221: MEOX1; NbExp=3; IntAct=EBI-2555179, EBI-2864512;
CC       Q9NUJ3; P26367: PAX6; NbExp=3; IntAct=EBI-2555179, EBI-747278;
CC       Q9NUJ3; Q5SXH7-1: PLEKHS1; NbExp=3; IntAct=EBI-2555179, EBI-26412802;
CC       Q9NUJ3; Q8TBF2: PRXL2B; NbExp=6; IntAct=EBI-2555179, EBI-7280826;
CC       Q9NUJ3; P55036: PSMD4; NbExp=5; IntAct=EBI-2555179, EBI-359318;
CC       Q9NUJ3; Q04864-2: REL; NbExp=3; IntAct=EBI-2555179, EBI-10829018;
CC       Q9NUJ3; Q9H190: SDCBP2; NbExp=3; IntAct=EBI-2555179, EBI-742426;
CC       Q9NUJ3; Q13573: SNW1; NbExp=3; IntAct=EBI-2555179, EBI-632715;
CC       Q9NUJ3; O95947: TBX6; NbExp=3; IntAct=EBI-2555179, EBI-2824328;
CC       Q9NUJ3; P19474: TRIM21; NbExp=3; IntAct=EBI-2555179, EBI-81290;
CC       Q9NUJ3; Q99598: TSNAX; NbExp=3; IntAct=EBI-2555179, EBI-742638;
CC       Q9NUJ3; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-2555179, EBI-2799833;
CC       Q9NUJ3; Q9GZV5: WWTR1; NbExp=3; IntAct=EBI-2555179, EBI-747743;
CC   -!- SIMILARITY: Belongs to the TCP11 family. {ECO:0000305}.
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DR   EMBL; AK002198; BAA92131.1; -; mRNA.
DR   EMBL; AL121926; CAC48254.1; -; Genomic_DNA.
DR   EMBL; CH471064; EAW68206.1; -; Genomic_DNA.
DR   EMBL; CH471064; EAW68207.1; -; Genomic_DNA.
DR   EMBL; CH471064; EAW68208.1; -; Genomic_DNA.
DR   EMBL; CH471064; EAW68209.1; -; Genomic_DNA.
DR   EMBL; BC041696; AAH41696.1; -; mRNA.
DR   CCDS; CCDS7882.1; -.
DR   RefSeq; NP_001139013.1; NM_001145541.1.
DR   RefSeq; NP_060863.3; NM_018393.3.
DR   RefSeq; XP_011518509.1; XM_011520207.2.
DR   RefSeq; XP_016873479.1; XM_017017990.1.
DR   AlphaFoldDB; Q9NUJ3; -.
DR   BioGRID; 120627; 121.
DR   IntAct; Q9NUJ3; 37.
DR   MINT; Q9NUJ3; -.
DR   STRING; 9606.ENSP00000335595; -.
DR   iPTMnet; Q9NUJ3; -.
DR   PhosphoSitePlus; Q9NUJ3; -.
DR   BioMuta; TCP11L1; -.
DR   DMDM; 74734348; -.
DR   EPD; Q9NUJ3; -.
DR   jPOST; Q9NUJ3; -.
DR   MassIVE; Q9NUJ3; -.
DR   MaxQB; Q9NUJ3; -.
DR   PaxDb; 9606-ENSP00000335595; -.
DR   PeptideAtlas; Q9NUJ3; -.
DR   ProteomicsDB; 82677; -.
DR   Pumba; Q9NUJ3; -.
DR   Antibodypedia; 1092; 21 antibodies from 11 providers.
DR   DNASU; 55346; -.
DR   Ensembl; ENST00000334274.9; ENSP00000335595.4; ENSG00000176148.16.
DR   Ensembl; ENST00000432887.5; ENSP00000395070.1; ENSG00000176148.16.
DR   Ensembl; ENST00000531632.6; ENSP00000433067.1; ENSG00000176148.16.
DR   GeneID; 55346; -.
DR   KEGG; hsa:55346; -.
DR   MANE-Select; ENST00000334274.9; ENSP00000335595.4; NM_018393.4; NP_060863.3.
DR   UCSC; uc001mud.3; human.
DR   AGR; HGNC:25655; -.
DR   CTD; 55346; -.
DR   DisGeNET; 55346; -.
DR   GeneCards; TCP11L1; -.
DR   HGNC; HGNC:25655; TCP11L1.
DR   HPA; ENSG00000176148; Low tissue specificity.
DR   neXtProt; NX_Q9NUJ3; -.
DR   OpenTargets; ENSG00000176148; -.
DR   PharmGKB; PA142670824; -.
DR   VEuPathDB; HostDB:ENSG00000176148; -.
DR   eggNOG; KOG1981; Eukaryota.
DR   GeneTree; ENSGT00940000157402; -.
DR   HOGENOM; CLU_026469_0_1_1; -.
DR   InParanoid; Q9NUJ3; -.
DR   OMA; CRDEDIN; -.
DR   OrthoDB; 5353227at2759; -.
DR   PhylomeDB; Q9NUJ3; -.
DR   TreeFam; TF313385; -.
DR   PathwayCommons; Q9NUJ3; -.
DR   SignaLink; Q9NUJ3; -.
DR   BioGRID-ORCS; 55346; 7 hits in 1151 CRISPR screens.
DR   ChiTaRS; TCP11L1; human.
DR   GenomeRNAi; 55346; -.
DR   Pharos; Q9NUJ3; Tdark.
DR   PRO; PR:Q9NUJ3; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9NUJ3; Protein.
DR   Bgee; ENSG00000176148; Expressed in primordial germ cell in gonad and 155 other cell types or tissues.
DR   ExpressionAtlas; Q9NUJ3; baseline and differential.
DR   GO; GO:0005874; C:microtubule; IDA:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR008862; Tcp11.
DR   PANTHER; PTHR12832:SF15; T-COMPLEX PROTEIN 11-LIKE PROTEIN 1; 1.
DR   PANTHER; PTHR12832; TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11; 1.
DR   Pfam; PF05794; Tcp11; 1.
DR   Genevisible; Q9NUJ3; HS.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..509
FT                   /note="T-complex protein 11-like protein 1"
FT                   /id="PRO_0000313747"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VARIANT         109
FT                   /note="H -> Q (in dbSNP:rs16923785)"
FT                   /id="VAR_037726"
FT   VARIANT         178
FT                   /note="K -> R (in dbSNP:rs2273549)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037727"
SQ   SEQUENCE   509 AA;  57035 MW;  101F53A05F1B3C30 CRC64;
     MSENLDKSNV NEAGKSKSND SEEGLEDAVE GADEALQKAI KSDSSSPQRV QRPHSSPPRF
     VTVEELLETA RGVTNMALAH EIVVNGDFQI KPVELPENSL KKRVKEIVHK AFWDCLSVQL
     SEDPPAYDHA IKLVGEIKET LLSFLLPGHT RLRNQITEVL DLDLIKQEAE NGALDISKLA
     EFIIGMMGTL CAPARDEEVK KLKDIKEIVP LFREIFSVLD LMKVDMANFA ISSIRPHLMQ
     QSVEYERKKF QEILERQPNS LDFVTQWLEE ASEDLMTQKY KHALPVGGMA AGSGDMPRLS
     PVAVQNYAYL KLLKWDHLQR PFPETVLMDQ SRFHELQLQL EQLTILGAVL LVTFSMAAPG
     ISSQADFAEK LKMIVKILLT DMHLPSFHLK DVLTTIGEKV CLEVSSCLSL CGSSPFTTDK
     ETVLKGQIQA VASPDDPIRR IMESRILTFL ETYLASGHQK PLPTVPGGLS PVQRELEEVA
     IKFARLVNYN KMVFCPYYDA ILSKILVRS
//