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Q9NUJ3

- T11L1_HUMAN

UniProt

Q9NUJ3 - T11L1_HUMAN

Protein

T-complex protein 11-like protein 1

Gene

TCP11L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-complex protein 11-like protein 1
    Gene namesi
    Name:TCP11L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:25655. TCP11L1.

    Subcellular locationi

    GO - Cellular componenti

    1. microtubule Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670824.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509T-complex protein 11-like protein 1PRO_0000313747Add
    BLAST

    Proteomic databases

    MaxQBiQ9NUJ3.
    PaxDbiQ9NUJ3.
    PRIDEiQ9NUJ3.

    PTM databases

    PhosphoSiteiQ9NUJ3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NUJ3.
    BgeeiQ9NUJ3.
    CleanExiHS_TCP11L1.
    GenevestigatoriQ9NUJ3.

    Organism-specific databases

    HPAiHPA005769.

    Interactioni

    Protein-protein interaction databases

    BioGridi120627. 5 interactions.
    IntActiQ9NUJ3. 3 interactions.
    STRINGi9606.ENSP00000335595.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NUJ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TCP11 family.Curated

    Phylogenomic databases

    eggNOGiNOG257003.
    HOGENOMiHOG000231350.
    HOVERGENiHBG008348.
    InParanoidiQ9NUJ3.
    PhylomeDBiQ9NUJ3.
    TreeFamiTF313385.

    Family and domain databases

    InterProiIPR008862. Tcp11.
    [Graphical view]
    PANTHERiPTHR12832. PTHR12832. 1 hit.
    PfamiPF05794. Tcp11. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NUJ3-1 [UniParc]FASTAAdd to Basket

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    MSENLDKSNV NEAGKSKSND SEEGLEDAVE GADEALQKAI KSDSSSPQRV    50
    QRPHSSPPRF VTVEELLETA RGVTNMALAH EIVVNGDFQI KPVELPENSL 100
    KKRVKEIVHK AFWDCLSVQL SEDPPAYDHA IKLVGEIKET LLSFLLPGHT 150
    RLRNQITEVL DLDLIKQEAE NGALDISKLA EFIIGMMGTL CAPARDEEVK 200
    KLKDIKEIVP LFREIFSVLD LMKVDMANFA ISSIRPHLMQ QSVEYERKKF 250
    QEILERQPNS LDFVTQWLEE ASEDLMTQKY KHALPVGGMA AGSGDMPRLS 300
    PVAVQNYAYL KLLKWDHLQR PFPETVLMDQ SRFHELQLQL EQLTILGAVL 350
    LVTFSMAAPG ISSQADFAEK LKMIVKILLT DMHLPSFHLK DVLTTIGEKV 400
    CLEVSSCLSL CGSSPFTTDK ETVLKGQIQA VASPDDPIRR IMESRILTFL 450
    ETYLASGHQK PLPTVPGGLS PVQRELEEVA IKFARLVNYN KMVFCPYYDA 500
    ILSKILVRS 509
    Length:509
    Mass (Da):57,035
    Last modified:October 1, 2000 - v1
    Checksum:i101F53A05F1B3C30
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091H → Q.
    Corresponds to variant rs16923785 [ dbSNP | Ensembl ].
    VAR_037726
    Natural varianti178 – 1781K → R.1 Publication
    Corresponds to variant rs2273549 [ dbSNP | Ensembl ].
    VAR_037727

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002198 mRNA. Translation: BAA92131.1.
    AL121926 Genomic DNA. Translation: CAC48254.1.
    CH471064 Genomic DNA. Translation: EAW68206.1.
    CH471064 Genomic DNA. Translation: EAW68207.1.
    CH471064 Genomic DNA. Translation: EAW68208.1.
    CH471064 Genomic DNA. Translation: EAW68209.1.
    BC041696 mRNA. Translation: AAH41696.1.
    CCDSiCCDS7882.1.
    RefSeqiNP_001139013.1. NM_001145541.1.
    NP_060863.3. NM_018393.3.
    XP_006718319.1. XM_006718256.1.
    UniGeneiHs.655341.

    Genome annotation databases

    EnsembliENST00000334274; ENSP00000335595; ENSG00000176148.
    ENST00000432887; ENSP00000395070; ENSG00000176148.
    ENST00000531632; ENSP00000433067; ENSG00000176148.
    GeneIDi55346.
    KEGGihsa:55346.
    UCSCiuc001mud.3. human.

    Polymorphism databases

    DMDMi74734348.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002198 mRNA. Translation: BAA92131.1 .
    AL121926 Genomic DNA. Translation: CAC48254.1 .
    CH471064 Genomic DNA. Translation: EAW68206.1 .
    CH471064 Genomic DNA. Translation: EAW68207.1 .
    CH471064 Genomic DNA. Translation: EAW68208.1 .
    CH471064 Genomic DNA. Translation: EAW68209.1 .
    BC041696 mRNA. Translation: AAH41696.1 .
    CCDSi CCDS7882.1.
    RefSeqi NP_001139013.1. NM_001145541.1.
    NP_060863.3. NM_018393.3.
    XP_006718319.1. XM_006718256.1.
    UniGenei Hs.655341.

    3D structure databases

    ProteinModelPortali Q9NUJ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120627. 5 interactions.
    IntActi Q9NUJ3. 3 interactions.
    STRINGi 9606.ENSP00000335595.

    PTM databases

    PhosphoSitei Q9NUJ3.

    Polymorphism databases

    DMDMi 74734348.

    Proteomic databases

    MaxQBi Q9NUJ3.
    PaxDbi Q9NUJ3.
    PRIDEi Q9NUJ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334274 ; ENSP00000335595 ; ENSG00000176148 .
    ENST00000432887 ; ENSP00000395070 ; ENSG00000176148 .
    ENST00000531632 ; ENSP00000433067 ; ENSG00000176148 .
    GeneIDi 55346.
    KEGGi hsa:55346.
    UCSCi uc001mud.3. human.

    Organism-specific databases

    CTDi 55346.
    GeneCardsi GC11P033018.
    H-InvDB HIX0009536.
    HGNCi HGNC:25655. TCP11L1.
    HPAi HPA005769.
    neXtProti NX_Q9NUJ3.
    PharmGKBi PA142670824.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257003.
    HOGENOMi HOG000231350.
    HOVERGENi HBG008348.
    InParanoidi Q9NUJ3.
    PhylomeDBi Q9NUJ3.
    TreeFami TF313385.

    Miscellaneous databases

    ChiTaRSi TCP11L1. human.
    GenomeRNAii 55346.
    NextBioi 59683.
    PROi Q9NUJ3.

    Gene expression databases

    ArrayExpressi Q9NUJ3.
    Bgeei Q9NUJ3.
    CleanExi HS_TCP11L1.
    Genevestigatori Q9NUJ3.

    Family and domain databases

    InterProi IPR008862. Tcp11.
    [Graphical view ]
    PANTHERi PTHR12832. PTHR12832. 1 hit.
    Pfami PF05794. Tcp11. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-178.
      Tissue: Blood.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiT11L1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NUJ3
    Secondary accession number(s): D3DR01, Q8IVX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3