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Protein

T-complex protein 11-like protein 1

Gene

TCP11L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 11-like protein 1
Gene namesi
Name:TCP11L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176148.15
HGNCiHGNC:25655 TCP11L1
neXtProtiNX_Q9NUJ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55346
OpenTargetsiENSG00000176148
PharmGKBiPA142670824

Polymorphism and mutation databases

BioMutaiTCP11L1
DMDMi74734348

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137471 – 509T-complex protein 11-like protein 1Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NUJ3
MaxQBiQ9NUJ3
PaxDbiQ9NUJ3
PeptideAtlasiQ9NUJ3
PRIDEiQ9NUJ3

PTM databases

iPTMnetiQ9NUJ3
PhosphoSitePlusiQ9NUJ3

Expressioni

Gene expression databases

BgeeiENSG00000176148
CleanExiHS_TCP11L1
ExpressionAtlasiQ9NUJ3 baseline and differential
GenevisibleiQ9NUJ3 HS

Organism-specific databases

HPAiHPA005769

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TBX6O959474EBI-2555179,EBI-2824328

Protein-protein interaction databases

BioGridi120627, 19 interactors
IntActiQ9NUJ3, 33 interactors
MINTiQ9NUJ3
STRINGi9606.ENSP00000335595

Structurei

3D structure databases

ProteinModelPortaliQ9NUJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP11 family.Curated

Phylogenomic databases

eggNOGiKOG1981 Eukaryota
ENOG410ZDEH LUCA
GeneTreeiENSGT00390000008958
HOGENOMiHOG000231350
HOVERGENiHBG008348
InParanoidiQ9NUJ3
OrthoDBiEOG091G07AC
PhylomeDBiQ9NUJ3
TreeFamiTF313385

Family and domain databases

InterProiView protein in InterPro
IPR008862 Tcp11
PANTHERiPTHR12832 PTHR12832, 1 hit
PfamiView protein in Pfam
PF05794 Tcp11, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NUJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENLDKSNV NEAGKSKSND SEEGLEDAVE GADEALQKAI KSDSSSPQRV
60 70 80 90 100
QRPHSSPPRF VTVEELLETA RGVTNMALAH EIVVNGDFQI KPVELPENSL
110 120 130 140 150
KKRVKEIVHK AFWDCLSVQL SEDPPAYDHA IKLVGEIKET LLSFLLPGHT
160 170 180 190 200
RLRNQITEVL DLDLIKQEAE NGALDISKLA EFIIGMMGTL CAPARDEEVK
210 220 230 240 250
KLKDIKEIVP LFREIFSVLD LMKVDMANFA ISSIRPHLMQ QSVEYERKKF
260 270 280 290 300
QEILERQPNS LDFVTQWLEE ASEDLMTQKY KHALPVGGMA AGSGDMPRLS
310 320 330 340 350
PVAVQNYAYL KLLKWDHLQR PFPETVLMDQ SRFHELQLQL EQLTILGAVL
360 370 380 390 400
LVTFSMAAPG ISSQADFAEK LKMIVKILLT DMHLPSFHLK DVLTTIGEKV
410 420 430 440 450
CLEVSSCLSL CGSSPFTTDK ETVLKGQIQA VASPDDPIRR IMESRILTFL
460 470 480 490 500
ETYLASGHQK PLPTVPGGLS PVQRELEEVA IKFARLVNYN KMVFCPYYDA

ILSKILVRS
Length:509
Mass (Da):57,035
Last modified:October 1, 2000 - v1
Checksum:i101F53A05F1B3C30
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037726109H → Q. Corresponds to variant dbSNP:rs16923785Ensembl.1
Natural variantiVAR_037727178K → R1 PublicationCorresponds to variant dbSNP:rs2273549Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002198 mRNA Translation: BAA92131.1
AL121926 Genomic DNA Translation: CAC48254.1
CH471064 Genomic DNA Translation: EAW68206.1
CH471064 Genomic DNA Translation: EAW68207.1
CH471064 Genomic DNA Translation: EAW68208.1
CH471064 Genomic DNA Translation: EAW68209.1
BC041696 mRNA Translation: AAH41696.1
CCDSiCCDS7882.1
RefSeqiNP_001139013.1, NM_001145541.1
NP_060863.3, NM_018393.3
XP_011518509.1, XM_011520207.2
XP_016873479.1, XM_017017990.1
UniGeneiHs.655341

Genome annotation databases

EnsembliENST00000334274; ENSP00000335595; ENSG00000176148
ENST00000432887; ENSP00000395070; ENSG00000176148
ENST00000531632; ENSP00000433067; ENSG00000176148
GeneIDi55346
KEGGihsa:55346
UCSCiuc001mud.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiT11L1_HUMAN
AccessioniPrimary (citable) accession number: Q9NUJ3
Secondary accession number(s): D3DR01, Q8IVX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health