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Protein

T-complex protein 11-like protein 1

Gene

TCP11L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 11-like protein 1
Gene namesi
Name:TCP11L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25655. TCP11L1.

Subcellular locationi

GO - Cellular componenti

  • microtubule Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670824.

Polymorphism and mutation databases

BioMutaiTCP11L1.
DMDMi74734348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509T-complex protein 11-like protein 1PRO_0000313747Add
BLAST

Proteomic databases

MaxQBiQ9NUJ3.
PaxDbiQ9NUJ3.
PRIDEiQ9NUJ3.

PTM databases

PhosphoSiteiQ9NUJ3.

Expressioni

Gene expression databases

BgeeiQ9NUJ3.
CleanExiHS_TCP11L1.
ExpressionAtlasiQ9NUJ3. baseline and differential.
GenevisibleiQ9NUJ3. HS.

Organism-specific databases

HPAiHPA005769.

Interactioni

Protein-protein interaction databases

BioGridi120627. 6 interactions.
IntActiQ9NUJ3. 3 interactions.
STRINGi9606.ENSP00000335595.

Structurei

3D structure databases

ProteinModelPortaliQ9NUJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP11 family.Curated

Phylogenomic databases

eggNOGiNOG257003.
GeneTreeiENSGT00390000008958.
HOGENOMiHOG000231350.
HOVERGENiHBG008348.
InParanoidiQ9NUJ3.
PhylomeDBiQ9NUJ3.
TreeFamiTF313385.

Family and domain databases

InterProiIPR008862. Tcp11.
[Graphical view]
PANTHERiPTHR12832. PTHR12832. 1 hit.
PfamiPF05794. Tcp11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NUJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENLDKSNV NEAGKSKSND SEEGLEDAVE GADEALQKAI KSDSSSPQRV
60 70 80 90 100
QRPHSSPPRF VTVEELLETA RGVTNMALAH EIVVNGDFQI KPVELPENSL
110 120 130 140 150
KKRVKEIVHK AFWDCLSVQL SEDPPAYDHA IKLVGEIKET LLSFLLPGHT
160 170 180 190 200
RLRNQITEVL DLDLIKQEAE NGALDISKLA EFIIGMMGTL CAPARDEEVK
210 220 230 240 250
KLKDIKEIVP LFREIFSVLD LMKVDMANFA ISSIRPHLMQ QSVEYERKKF
260 270 280 290 300
QEILERQPNS LDFVTQWLEE ASEDLMTQKY KHALPVGGMA AGSGDMPRLS
310 320 330 340 350
PVAVQNYAYL KLLKWDHLQR PFPETVLMDQ SRFHELQLQL EQLTILGAVL
360 370 380 390 400
LVTFSMAAPG ISSQADFAEK LKMIVKILLT DMHLPSFHLK DVLTTIGEKV
410 420 430 440 450
CLEVSSCLSL CGSSPFTTDK ETVLKGQIQA VASPDDPIRR IMESRILTFL
460 470 480 490 500
ETYLASGHQK PLPTVPGGLS PVQRELEEVA IKFARLVNYN KMVFCPYYDA

ILSKILVRS
Length:509
Mass (Da):57,035
Last modified:October 1, 2000 - v1
Checksum:i101F53A05F1B3C30
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091H → Q.
Corresponds to variant rs16923785 [ dbSNP | Ensembl ].
VAR_037726
Natural varianti178 – 1781K → R.1 Publication
Corresponds to variant rs2273549 [ dbSNP | Ensembl ].
VAR_037727

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002198 mRNA. Translation: BAA92131.1.
AL121926 Genomic DNA. Translation: CAC48254.1.
CH471064 Genomic DNA. Translation: EAW68206.1.
CH471064 Genomic DNA. Translation: EAW68207.1.
CH471064 Genomic DNA. Translation: EAW68208.1.
CH471064 Genomic DNA. Translation: EAW68209.1.
BC041696 mRNA. Translation: AAH41696.1.
CCDSiCCDS7882.1.
RefSeqiNP_001139013.1. NM_001145541.1.
NP_060863.3. NM_018393.3.
UniGeneiHs.655341.

Genome annotation databases

EnsembliENST00000334274; ENSP00000335595; ENSG00000176148.
ENST00000432887; ENSP00000395070; ENSG00000176148.
ENST00000531632; ENSP00000433067; ENSG00000176148.
GeneIDi55346.
KEGGihsa:55346.
UCSCiuc001mud.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002198 mRNA. Translation: BAA92131.1.
AL121926 Genomic DNA. Translation: CAC48254.1.
CH471064 Genomic DNA. Translation: EAW68206.1.
CH471064 Genomic DNA. Translation: EAW68207.1.
CH471064 Genomic DNA. Translation: EAW68208.1.
CH471064 Genomic DNA. Translation: EAW68209.1.
BC041696 mRNA. Translation: AAH41696.1.
CCDSiCCDS7882.1.
RefSeqiNP_001139013.1. NM_001145541.1.
NP_060863.3. NM_018393.3.
UniGeneiHs.655341.

3D structure databases

ProteinModelPortaliQ9NUJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120627. 6 interactions.
IntActiQ9NUJ3. 3 interactions.
STRINGi9606.ENSP00000335595.

PTM databases

PhosphoSiteiQ9NUJ3.

Polymorphism and mutation databases

BioMutaiTCP11L1.
DMDMi74734348.

Proteomic databases

MaxQBiQ9NUJ3.
PaxDbiQ9NUJ3.
PRIDEiQ9NUJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334274; ENSP00000335595; ENSG00000176148.
ENST00000432887; ENSP00000395070; ENSG00000176148.
ENST00000531632; ENSP00000433067; ENSG00000176148.
GeneIDi55346.
KEGGihsa:55346.
UCSCiuc001mud.3. human.

Organism-specific databases

CTDi55346.
GeneCardsiGC11P033018.
H-InvDBHIX0009536.
HGNCiHGNC:25655. TCP11L1.
HPAiHPA005769.
neXtProtiNX_Q9NUJ3.
PharmGKBiPA142670824.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG257003.
GeneTreeiENSGT00390000008958.
HOGENOMiHOG000231350.
HOVERGENiHBG008348.
InParanoidiQ9NUJ3.
PhylomeDBiQ9NUJ3.
TreeFamiTF313385.

Miscellaneous databases

ChiTaRSiTCP11L1. human.
GenomeRNAii55346.
NextBioi59683.
PROiQ9NUJ3.

Gene expression databases

BgeeiQ9NUJ3.
CleanExiHS_TCP11L1.
ExpressionAtlasiQ9NUJ3. baseline and differential.
GenevisibleiQ9NUJ3. HS.

Family and domain databases

InterProiIPR008862. Tcp11.
[Graphical view]
PANTHERiPTHR12832. PTHR12832. 1 hit.
PfamiPF05794. Tcp11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-178.
    Tissue: Blood.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiT11L1_HUMAN
AccessioniPrimary (citable) accession number: Q9NUJ3
Secondary accession number(s): D3DR01, Q8IVX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.