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Q9NUJ3 (T11L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-complex protein 11-like protein 1
Gene names
Name:TCP11L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the TCP11 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmicrotubule

Inferred from direct assay PubMed 21525035. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509T-complex protein 11-like protein 1
PRO_0000313747

Natural variations

Natural variant1091H → Q.
Corresponds to variant rs16923785 [ dbSNP | Ensembl ].
VAR_037726
Natural variant1781K → R. Ref.4
Corresponds to variant rs2273549 [ dbSNP | Ensembl ].
VAR_037727

Sequences

Sequence LengthMass (Da)Tools
Q9NUJ3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 101F53A05F1B3C30

FASTA50957,035
        10         20         30         40         50         60 
MSENLDKSNV NEAGKSKSND SEEGLEDAVE GADEALQKAI KSDSSSPQRV QRPHSSPPRF 

        70         80         90        100        110        120 
VTVEELLETA RGVTNMALAH EIVVNGDFQI KPVELPENSL KKRVKEIVHK AFWDCLSVQL 

       130        140        150        160        170        180 
SEDPPAYDHA IKLVGEIKET LLSFLLPGHT RLRNQITEVL DLDLIKQEAE NGALDISKLA 

       190        200        210        220        230        240 
EFIIGMMGTL CAPARDEEVK KLKDIKEIVP LFREIFSVLD LMKVDMANFA ISSIRPHLMQ 

       250        260        270        280        290        300 
QSVEYERKKF QEILERQPNS LDFVTQWLEE ASEDLMTQKY KHALPVGGMA AGSGDMPRLS 

       310        320        330        340        350        360 
PVAVQNYAYL KLLKWDHLQR PFPETVLMDQ SRFHELQLQL EQLTILGAVL LVTFSMAAPG 

       370        380        390        400        410        420 
ISSQADFAEK LKMIVKILLT DMHLPSFHLK DVLTTIGEKV CLEVSSCLSL CGSSPFTTDK 

       430        440        450        460        470        480 
ETVLKGQIQA VASPDDPIRR IMESRILTFL ETYLASGHQK PLPTVPGGLS PVQRELEEVA 

       490        500 
IKFARLVNYN KMVFCPYYDA ILSKILVRS 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-178.
Tissue: Blood.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK002198 mRNA. Translation: BAA92131.1.
AL121926 Genomic DNA. Translation: CAC48254.1.
CH471064 Genomic DNA. Translation: EAW68206.1.
CH471064 Genomic DNA. Translation: EAW68207.1.
CH471064 Genomic DNA. Translation: EAW68208.1.
CH471064 Genomic DNA. Translation: EAW68209.1.
BC041696 mRNA. Translation: AAH41696.1.
RefSeqNP_001139013.1. NM_001145541.1.
NP_060863.3. NM_018393.3.
UniGeneHs.655341.

3D structure databases

ProteinModelPortalQ9NUJ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120627. 5 interactions.
IntActQ9NUJ3. 3 interactions.
STRING9606.ENSP00000335595.

PTM databases

PhosphoSiteQ9NUJ3.

Polymorphism databases

DMDM74734348.

Proteomic databases

PaxDbQ9NUJ3.
PRIDEQ9NUJ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334274; ENSP00000335595; ENSG00000176148.
ENST00000432887; ENSP00000395070; ENSG00000176148.
ENST00000531632; ENSP00000433067; ENSG00000176148.
GeneID55346.
KEGGhsa:55346.
UCSCuc001mud.3. human.

Organism-specific databases

CTD55346.
GeneCardsGC11P033018.
H-InvDBHIX0009536.
HGNCHGNC:25655. TCP11L1.
HPAHPA005769.
neXtProtNX_Q9NUJ3.
PharmGKBPA142670824.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG257003.
HOGENOMHOG000231350.
HOVERGENHBG008348.
InParanoidQ9NUJ3.
PhylomeDBQ9NUJ3.
TreeFamTF313385.

Gene expression databases

ArrayExpressQ9NUJ3.
BgeeQ9NUJ3.
CleanExHS_TCP11L1.
GenevestigatorQ9NUJ3.

Family and domain databases

InterProIPR008862. Tcp11.
[Graphical view]
PANTHERPTHR12832. PTHR12832. 1 hit.
PfamPF05794. Tcp11. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTCP11L1. human.
GenomeRNAi55346.
NextBio59683.
PROQ9NUJ3.

Entry information

Entry nameT11L1_HUMAN
AccessionPrimary (citable) accession number: Q9NUJ3
Secondary accession number(s): D3DR01, Q8IVX4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM