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Q9NUJ1

- ABHDA_HUMAN

UniProt

Q9NUJ1 - ABHDA_HUMAN

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Protein
Mycophenolic acid acyl-glucuronide esterase, mitochondrial
Gene
ABHD10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.1 Publication

Catalytic activityi

Mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Charge relay system By similarity
Active sitei249 – 2491Charge relay system By similarity
Active sitei279 – 2791Charge relay system By similarity

GO - Molecular functioni

  1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: BHF-UCL

GO - Biological processi

  1. glucuronoside catabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000144827-MONOMER.

Protein family/group databases

MEROPSiS09.062.

Names & Taxonomyi

Protein namesi
Recommended name:
Mycophenolic acid acyl-glucuronide esterase, mitochondrial (EC:3.1.1.93)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 10
Short name:
Abhydrolase domain-containing protein 10
Gene namesi
Name:ABHD10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:25656. ABHD10.

Subcellular locationi

Mitochondrion Reviewed prediction

GO - Cellular componenti

  1. cytosol Source: BHF-UCL
  2. mitochondrion Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5252Mitochondrion Reviewed prediction
Add
BLAST
Chaini53 – 306254Mycophenolic acid acyl-glucuronide esterase, mitochondrial
PRO_0000280733Add
BLAST

Proteomic databases

MaxQBiQ9NUJ1.
PaxDbiQ9NUJ1.
PeptideAtlasiQ9NUJ1.
PRIDEiQ9NUJ1.

PTM databases

PhosphoSiteiQ9NUJ1.

Expressioni

Gene expression databases

ArrayExpressiQ9NUJ1.
BgeeiQ9NUJ1.
CleanExiHS_ABHD10.
GenevestigatoriQ9NUJ1.

Organism-specific databases

HPAiHPA036991.
HPA036992.

Interactioni

Protein-protein interaction databases

BioGridi120628. 5 interactions.
IntActiQ9NUJ1. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9NUJ1.
SMRiQ9NUJ1. Positions 76-299.

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000139902.
HOVERGENiHBG080562.
InParanoidiQ9NUJ1.
KOiK13702.
OMAiIEDGRNH.
PhylomeDBiQ9NUJ1.
TreeFamiTF329757.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NUJ1-1 [UniParc]FASTAAdd to Basket

« Hide

MAVARLAAVA AWVPCRSWGW AAVPFGPHRG LSVLLARIPQ RAPRWLPACR    50
QKTSLSFLNR PDLPNLAYKK LKGKSPGIIF IPGYLSYMNG TKALAIEEFC 100
KSLGHACIRF DYSGVGSSDG NSEESTLGKW RKDVLSIIDD LADGPQILVG 150
SSLGGWLMLH AAIARPEKVV ALIGVATAAD TLVTKFNQLP VELKKEVEMK 200
GVWSMPSKYS EEGVYNVQYS FIKEAEHHCL LHSPIPVNCP IRLLHGMKDD 250
IVPWHTSMQV ADRVLSTDVD VILRKHSDHR MREKADIQLL VYTIDDLIDK 300
LSTIVN 306
Length:306
Mass (Da):33,933
Last modified:October 1, 2000 - v1
Checksum:iE41139D5C22A83FE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti251 – 2511I → V.
Corresponds to variant rs17429033 [ dbSNP | Ensembl ].
VAR_031194

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002204 mRNA. Translation: BAA92133.1.
CH471052 Genomic DNA. Translation: EAW79688.1.
CH471052 Genomic DNA. Translation: EAW79689.1.
BC014516 mRNA. Translation: AAH14516.1.
AL713726 mRNA. Translation: CAD28516.2.
CCDSiCCDS2963.1.
RefSeqiNP_001258998.1. NM_001272069.1.
NP_060864.1. NM_018394.3.
UniGeneiHs.477115.

Genome annotation databases

EnsembliENST00000273359; ENSP00000273359; ENSG00000144827.
GeneIDi55347.
KEGGihsa:55347.
UCSCiuc003dyk.5. human.

Polymorphism databases

DMDMi74734347.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002204 mRNA. Translation: BAA92133.1 .
CH471052 Genomic DNA. Translation: EAW79688.1 .
CH471052 Genomic DNA. Translation: EAW79689.1 .
BC014516 mRNA. Translation: AAH14516.1 .
AL713726 mRNA. Translation: CAD28516.2 .
CCDSi CCDS2963.1.
RefSeqi NP_001258998.1. NM_001272069.1.
NP_060864.1. NM_018394.3.
UniGenei Hs.477115.

3D structure databases

ProteinModelPortali Q9NUJ1.
SMRi Q9NUJ1. Positions 76-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120628. 5 interactions.
IntActi Q9NUJ1. 2 interactions.

Protein family/group databases

MEROPSi S09.062.

PTM databases

PhosphoSitei Q9NUJ1.

Polymorphism databases

DMDMi 74734347.

Proteomic databases

MaxQBi Q9NUJ1.
PaxDbi Q9NUJ1.
PeptideAtlasi Q9NUJ1.
PRIDEi Q9NUJ1.

Protocols and materials databases

DNASUi 55347.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273359 ; ENSP00000273359 ; ENSG00000144827 .
GeneIDi 55347.
KEGGi hsa:55347.
UCSCi uc003dyk.5. human.

Organism-specific databases

CTDi 55347.
GeneCardsi GC03P111697.
HGNCi HGNC:25656. ABHD10.
HPAi HPA036991.
HPA036992.
neXtProti NX_Q9NUJ1.
PharmGKBi PA134978569.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000139902.
HOVERGENi HBG080562.
InParanoidi Q9NUJ1.
KOi K13702.
OMAi IEDGRNH.
PhylomeDBi Q9NUJ1.
TreeFami TF329757.

Enzyme and pathway databases

BioCyci MetaCyc:ENSG00000144827-MONOMER.

Miscellaneous databases

GenomeRNAii 55347.
NextBioi 59687.
PROi Q9NUJ1.

Gene expression databases

ArrayExpressi Q9NUJ1.
Bgeei Q9NUJ1.
CleanExi HS_ABHD10.
Genevestigatori Q9NUJ1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-306.
    Tissue: Melanoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver."
    Iwamura A., Fukami T., Higuchi R., Nakajima M., Yokoi T.
    J. Biol. Chem. 287:9240-9249(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
    Tissue: Liver.

Entry informationi

Entry nameiABHDA_HUMAN
AccessioniPrimary (citable) accession number: Q9NUJ1
Secondary accession number(s): D3DN63, Q8TCF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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