Reviewed,
UniProtKB/Swiss-Prot Q9NUJ1 (ABHDA_HUMAN)
Last modified
November 24, 2009.
Version 65.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Abhydrolase domain-containing protein 10, mitochondrial EC=3.4.-.- | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 306 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subcellular location | Mitochondrion Potential. |
| Sequence similarities | Belongs to the AB hydrolase superfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Coding sequence diversity | Polymorphism |
| Domain | Transit peptide |
| Molecular function | Hydrolase Protease Serine protease |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | mitochondrion Inferred from direct assay. Source: LIFEdb |
| Molecular function | serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 52 | 52 | Mitochondrion Potential | ||||||
| Chain | 53 – 306 | 254 | Abhydrolase domain-containing protein 10, mitochondrial | PRO_0000280733 | |||||
Sites | |||||||||
| Active site | 152 | 1 | Charge relay system By similarity | ||||||
| Active site | 249 | 1 | Charge relay system By similarity | ||||||
| Active site | 279 | 1 | Charge relay system By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 251 | 1 | I → V: dbSNP rs17429033. | VAR_031194 | |||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.  Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary. |
| [3] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-306. Tissue: Melanoma. |
| [4] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AK002204 mRNA. Translation: BAA92133.1. BC014516 mRNA. Translation: AAH14516.1. AL713726 mRNA. Translation: CAD28516.2. | |
| IPI | IPI00020075. |
| RefSeq | NP_060864.1. |
| UniGene | Hs.708240 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q9NUJ1. |
Proteomic databases | |
| PeptideAtlas | Q9NUJ1. |
| PRIDE | Q9NUJ1. |
Genome annotation databases | |
| Ensembl | ENST00000273359; ENSP00000273359; ENSG00000144827; Homo sapiens. [Genome view] |
| GeneID | 55347. |
| KEGG | hsa:55347. |
| UCSC | uc003dyk.2. human. |
Organism-specific databases | |
| CTD | 55347. |
| GeneCards | GC03P113181. |
| HGNC | HGNC:25656. ABHD10. |
| PharmGKB | PA134978569. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9NUJ1. |
| OMA | FDYSGHG |
| OrthoDB | EOG9GXJ6W |
Gene expression databases | |
| ArrayExpress | Q9NUJ1. |
| Bgee | Q9NUJ1. |
| CleanEx | HS_ABHD10. |
| Genevestigator | Q9NUJ1. |
Family and domain databases | |
| InterPro | IPR000073. AB_hydrolase_1. [Graphical view] |
| Pfam | PF00561. Abhydrolase_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 59687. |
Entry information
| Entry name | ABHDA_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NUJ1 Secondary accession number(s): Q8TCF9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |
