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Q9NUJ1 (ABHDA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mycophenolic acid acyl-glucuronide esterase, mitochondrial

EC=3.1.1.93
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 10
Short name=Abhydrolase domain-containing protein 10
Gene names
Name:ABHD10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Ref.6

Catalytic activity

Mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate. Ref.6

Subcellular location

Mitochondrion Potential.

Sequence similarities

Belongs to the AB hydrolase superfamily.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityPolymorphism
   DomainTransit peptide
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglucuronoside catabolic process

Inferred from direct assay Ref.6. Source: BHF-UCL

   Cellular_componentcytosol

Inferred from direct assay Ref.6. Source: BHF-UCL

mitochondrion

Inferred from direct assay. Source: LIFEdb

   Molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds

Inferred from direct assay Ref.6. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5252Mitochondrion Potential
Chain53 – 306254Mycophenolic acid acyl-glucuronide esterase, mitochondrial
PRO_0000280733

Sites

Active site1521Charge relay system By similarity
Active site2491Charge relay system By similarity
Active site2791Charge relay system By similarity

Natural variations

Natural variant2511I → V.
Corresponds to variant rs17429033 [ dbSNP | Ensembl ].
VAR_031194

Sequences

Sequence LengthMass (Da)Tools
Q9NUJ1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: E41139D5C22A83FE

FASTA30633,933
        10         20         30         40         50         60 
MAVARLAAVA AWVPCRSWGW AAVPFGPHRG LSVLLARIPQ RAPRWLPACR QKTSLSFLNR 

        70         80         90        100        110        120 
PDLPNLAYKK LKGKSPGIIF IPGYLSYMNG TKALAIEEFC KSLGHACIRF DYSGVGSSDG 

       130        140        150        160        170        180 
NSEESTLGKW RKDVLSIIDD LADGPQILVG SSLGGWLMLH AAIARPEKVV ALIGVATAAD 

       190        200        210        220        230        240 
TLVTKFNQLP VELKKEVEMK GVWSMPSKYS EEGVYNVQYS FIKEAEHHCL LHSPIPVNCP 

       250        260        270        280        290        300 
IRLLHGMKDD IVPWHTSMQV ADRVLSTDVD VILRKHSDHR MREKADIQLL VYTIDDLIDK 


LSTIVN 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-306.
Tissue: Melanoma.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver."
Iwamura A., Fukami T., Higuchi R., Nakajima M., Yokoi T.
J. Biol. Chem. 287:9240-9249(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK002204 mRNA. Translation: BAA92133.1.
CH471052 Genomic DNA. Translation: EAW79688.1.
CH471052 Genomic DNA. Translation: EAW79689.1.
BC014516 mRNA. Translation: AAH14516.1.
AL713726 mRNA. Translation: CAD28516.2.
CCDSCCDS2963.1.
RefSeqNP_001258998.1. NM_001272069.1.
NP_060864.1. NM_018394.3.
UniGeneHs.477115.

3D structure databases

ProteinModelPortalQ9NUJ1.
SMRQ9NUJ1. Positions 76-299.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120628. 5 interactions.
IntActQ9NUJ1. 2 interactions.

Protein family/group databases

MEROPSS09.062.

PTM databases

PhosphoSiteQ9NUJ1.

Polymorphism databases

DMDM74734347.

Proteomic databases

MaxQBQ9NUJ1.
PaxDbQ9NUJ1.
PeptideAtlasQ9NUJ1.
PRIDEQ9NUJ1.

Protocols and materials databases

DNASU55347.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273359; ENSP00000273359; ENSG00000144827.
GeneID55347.
KEGGhsa:55347.
UCSCuc003dyk.5. human.

Organism-specific databases

CTD55347.
GeneCardsGC03P111697.
HGNCHGNC:25656. ABHD10.
HPAHPA036991.
HPA036992.
neXtProtNX_Q9NUJ1.
PharmGKBPA134978569.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0596.
HOGENOMHOG000139902.
HOVERGENHBG080562.
InParanoidQ9NUJ1.
KOK13702.
OMAIEDGRNH.
PhylomeDBQ9NUJ1.
TreeFamTF329757.

Enzyme and pathway databases

BioCycMetaCyc:ENSG00000144827-MONOMER.

Gene expression databases

ArrayExpressQ9NUJ1.
BgeeQ9NUJ1.
CleanExHS_ABHD10.
GenevestigatorQ9NUJ1.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi55347.
NextBio59687.
PROQ9NUJ1.

Entry information

Entry nameABHDA_HUMAN
AccessionPrimary (citable) accession number: Q9NUJ1
Secondary accession number(s): D3DN63, Q8TCF9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM