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Q9NUJ1

- ABHDA_HUMAN

UniProt

Q9NUJ1 - ABHDA_HUMAN

Protein

Mycophenolic acid acyl-glucuronide esterase, mitochondrial

Gene

ABHD10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.1 Publication

    Catalytic activityi

    Mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei152 – 1521Charge relay systemBy similarity
    Active sitei249 – 2491Charge relay systemBy similarity
    Active sitei279 – 2791Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: BHF-UCL

    GO - Biological processi

    1. glucuronoside catabolic process Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000144827-MONOMER.

    Protein family/group databases

    MEROPSiS09.062.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mycophenolic acid acyl-glucuronide esterase, mitochondrial (EC:3.1.1.93)
    Alternative name(s):
    Alpha/beta hydrolase domain-containing protein 10
    Short name:
    Abhydrolase domain-containing protein 10
    Gene namesi
    Name:ABHD10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:25656. ABHD10.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: BHF-UCL
    2. mitochondrion Source: LIFEdb

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134978569.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5252MitochondrionSequence AnalysisAdd
    BLAST
    Chaini53 – 306254Mycophenolic acid acyl-glucuronide esterase, mitochondrialPRO_0000280733Add
    BLAST

    Proteomic databases

    MaxQBiQ9NUJ1.
    PaxDbiQ9NUJ1.
    PeptideAtlasiQ9NUJ1.
    PRIDEiQ9NUJ1.

    PTM databases

    PhosphoSiteiQ9NUJ1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NUJ1.
    BgeeiQ9NUJ1.
    CleanExiHS_ABHD10.
    GenevestigatoriQ9NUJ1.

    Organism-specific databases

    HPAiHPA036991.
    HPA036992.

    Interactioni

    Protein-protein interaction databases

    BioGridi120628. 5 interactions.
    IntActiQ9NUJ1. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NUJ1.
    SMRiQ9NUJ1. Positions 76-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000139902.
    HOVERGENiHBG080562.
    InParanoidiQ9NUJ1.
    KOiK13702.
    OMAiIEDGRNH.
    PhylomeDBiQ9NUJ1.
    TreeFamiTF329757.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NUJ1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVARLAAVA AWVPCRSWGW AAVPFGPHRG LSVLLARIPQ RAPRWLPACR    50
    QKTSLSFLNR PDLPNLAYKK LKGKSPGIIF IPGYLSYMNG TKALAIEEFC 100
    KSLGHACIRF DYSGVGSSDG NSEESTLGKW RKDVLSIIDD LADGPQILVG 150
    SSLGGWLMLH AAIARPEKVV ALIGVATAAD TLVTKFNQLP VELKKEVEMK 200
    GVWSMPSKYS EEGVYNVQYS FIKEAEHHCL LHSPIPVNCP IRLLHGMKDD 250
    IVPWHTSMQV ADRVLSTDVD VILRKHSDHR MREKADIQLL VYTIDDLIDK 300
    LSTIVN 306
    Length:306
    Mass (Da):33,933
    Last modified:October 1, 2000 - v1
    Checksum:iE41139D5C22A83FE
    GO
    Isoform 2 (identifier: Q9NUJ1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-157: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:149
    Mass (Da):16,910
    Checksum:iBB6B75027A2FD486
    GO
    Isoform 3 (identifier: Q9NUJ1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         193-205: LKKEVEMKGVWSM → DSGRKNYISLHSA
         206-306: Missing.

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:205
    Mass (Da):22,141
    Checksum:i8EDC2A7F6446189B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti251 – 2511I → V.
    Corresponds to variant rs17429033 [ dbSNP | Ensembl ].
    VAR_031194

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 157157Missing in isoform 2. 1 PublicationVSP_056093Add
    BLAST
    Alternative sequencei193 – 20513LKKEV…GVWSM → DSGRKNYISLHSA in isoform 3. CuratedVSP_056742Add
    BLAST
    Alternative sequencei206 – 306101Missing in isoform 3. CuratedVSP_056743Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002204 mRNA. Translation: BAA92133.1.
    AK300018 mRNA. Translation: BAH13194.1.
    AC060225 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79688.1.
    CH471052 Genomic DNA. Translation: EAW79689.1.
    BC014516 mRNA. Translation: AAH14516.1.
    AL713726 mRNA. Translation: CAD28516.2.
    CCDSiCCDS2963.1.
    RefSeqiNP_001258998.1. NM_001272069.1.
    NP_060864.1. NM_018394.3.
    UniGeneiHs.477115.

    Genome annotation databases

    EnsembliENST00000273359; ENSP00000273359; ENSG00000144827.
    ENST00000494817; ENSP00000418973; ENSG00000144827.
    ENST00000534857; ENSP00000442932; ENSG00000144827.
    GeneIDi55347.
    KEGGihsa:55347.
    UCSCiuc003dyk.5. human.
    uc031saw.1. human.

    Polymorphism databases

    DMDMi74734347.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002204 mRNA. Translation: BAA92133.1 .
    AK300018 mRNA. Translation: BAH13194.1 .
    AC060225 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79688.1 .
    CH471052 Genomic DNA. Translation: EAW79689.1 .
    BC014516 mRNA. Translation: AAH14516.1 .
    AL713726 mRNA. Translation: CAD28516.2 .
    CCDSi CCDS2963.1.
    RefSeqi NP_001258998.1. NM_001272069.1.
    NP_060864.1. NM_018394.3.
    UniGenei Hs.477115.

    3D structure databases

    ProteinModelPortali Q9NUJ1.
    SMRi Q9NUJ1. Positions 76-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120628. 5 interactions.
    IntActi Q9NUJ1. 2 interactions.

    Protein family/group databases

    MEROPSi S09.062.

    PTM databases

    PhosphoSitei Q9NUJ1.

    Polymorphism databases

    DMDMi 74734347.

    Proteomic databases

    MaxQBi Q9NUJ1.
    PaxDbi Q9NUJ1.
    PeptideAtlasi Q9NUJ1.
    PRIDEi Q9NUJ1.

    Protocols and materials databases

    DNASUi 55347.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273359 ; ENSP00000273359 ; ENSG00000144827 .
    ENST00000494817 ; ENSP00000418973 ; ENSG00000144827 .
    ENST00000534857 ; ENSP00000442932 ; ENSG00000144827 .
    GeneIDi 55347.
    KEGGi hsa:55347.
    UCSCi uc003dyk.5. human.
    uc031saw.1. human.

    Organism-specific databases

    CTDi 55347.
    GeneCardsi GC03P111697.
    HGNCi HGNC:25656. ABHD10.
    HPAi HPA036991.
    HPA036992.
    neXtProti NX_Q9NUJ1.
    PharmGKBi PA134978569.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000139902.
    HOVERGENi HBG080562.
    InParanoidi Q9NUJ1.
    KOi K13702.
    OMAi IEDGRNH.
    PhylomeDBi Q9NUJ1.
    TreeFami TF329757.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000144827-MONOMER.

    Miscellaneous databases

    GenomeRNAii 55347.
    NextBioi 59687.
    PROi Q9NUJ1.

    Gene expression databases

    ArrayExpressi Q9NUJ1.
    Bgeei Q9NUJ1.
    CleanExi HS_ABHD10.
    Genevestigatori Q9NUJ1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Ovary.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-306 (ISOFORM 1).
      Tissue: Melanoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver."
      Iwamura A., Fukami T., Higuchi R., Nakajima M., Yokoi T.
      J. Biol. Chem. 287:9240-9249(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.
      Tissue: Liver.

    Entry informationi

    Entry nameiABHDA_HUMAN
    AccessioniPrimary (citable) accession number: Q9NUJ1
    Secondary accession number(s): B7Z6A8
    , C9IZX5, D3DN63, Q8TCF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3