UniProtKB - Q9NUH8 (TM14B_HUMAN)
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Protein
Transmembrane protein 14B
Gene
TMEM14B
Organism
Homo sapiens (Human)
Status
Functioni
Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.1 Publication
Miscellaneous
When expressed in embryonic mouse neocortex, induces intermediate progenitor cells and outer radial glia expansion, cortical thickening and induces gyrification (PubMed:29033352).1 Publication
GO - Biological processi
- cerebral cortex development Source: UniProtKB
- neural precursor cell proliferation Source: UniProtKB
- regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Neurogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 14B |
Gene namesi | Name:TMEM14B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137210.13. |
HGNCi | HGNC:21384. TMEM14B. |
neXtProti | NX_Q9NUH8. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000137210. |
PharmGKBi | PA134964501. |
Polymorphism and mutation databases
DMDMi | 27734593. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221172 | 1 – 114 | Transmembrane protein 14BAdd BLAST | 114 |
Proteomic databases
MaxQBi | Q9NUH8. |
PaxDbi | Q9NUH8. |
PeptideAtlasi | Q9NUH8. |
PRIDEi | Q9NUH8. |
TopDownProteomicsi | Q9NUH8-1. [Q9NUH8-1] |
PTM databases
iPTMneti | Q9NUH8. |
PhosphoSitePlusi | Q9NUH8. |
Expressioni
Tissue specificityi
Mainly expressed in the outer subventricular zone (OSVZ) of the fetal brains.1 Publication
Gene expression databases
Bgeei | ENSG00000137210. |
CleanExi | HS_TMEM14B. |
ExpressionAtlasi | Q9NUH8. baseline and differential. |
Genevisiblei | Q9NUH8. HS. |
Interactioni
Subunit structurei
Interacts with IQGAP1; this interaction promotes phosphorylation and nuclear translocation of IQGAP1.1 Publication
Protein-protein interaction databases
BioGridi | 123603. 16 interactors. |
IntActi | Q9NUH8. 9 interactors. |
MINTi | Q9NUH8. |
STRINGi | 9606.ENSP00000368858. |
Structurei
3D structure databases
ProteinModelPortali | Q9NUH8. |
SMRi | Q9NUH8. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM14 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4267. Eukaryota. ENOG4112205. LUCA. |
GeneTreei | ENSGT00390000013475. |
HOGENOMi | HOG000211932. |
HOVERGENi | HBG054211. |
InParanoidi | Q9NUH8. |
OMAi | MEKGPFP. |
TreeFami | TF323345. |
Family and domain databases
InterProi | View protein in InterPro IPR005349. TMEM14. |
PANTHERi | PTHR12668. PTHR12668. 1 hit. |
Pfami | View protein in Pfam PF03647. Tmemb_14. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NUH8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGSVPSLA AGLLFGSLAG
60 70 80 90 100
LGAYQLYQDP RNVWGFLAAT SVTFVGVMGM RSYYYGKFMP VGLIAGASLL
110
MAAKVGVRML MTSD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | P → S in AAH07080 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 42 | G → W in AAH01033 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 83 | Y → C in AAH07080 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046899 | 34 – 67 | Missing in isoform 2. CuratedAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL024498 Genomic DNA. No translation available. AL357497 Genomic DNA. No translation available. CH471087 Genomic DNA. Translation: EAW55279.1. CH471087 Genomic DNA. Translation: EAW55281.1. BC001033 mRNA. Translation: AAH01033.1. BC007080 mRNA. Translation: AAH07080.1. BC013913 mRNA. Translation: AAH13913.1. BC071660 mRNA. Translation: AAH71660.1. |
CCDSi | CCDS4515.1. [Q9NUH8-1] CCDS47372.1. [Q9NUH8-2] |
RefSeqi | NP_001121183.1. NM_001127711.2. [Q9NUH8-2] NP_001273413.1. NM_001286484.1. NP_112231.3. NM_030969.4. [Q9NUH8-1] |
UniGenei | Hs.667371. Hs.95600. |
Genome annotation databases
Ensembli | ENST00000379530; ENSP00000368845; ENSG00000137210. [Q9NUH8-2] ENST00000379542; ENSP00000368858; ENSG00000137210. [Q9NUH8-1] |
GeneIDi | 81853. |
KEGGi | hsa:81853. |
UCSCi | uc003mzk.5. human. [Q9NUH8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | TM14B_HUMAN | |
Accessioni | Q9NUH8Primary (citable) accession number: Q9NUH8 Secondary accession number(s): Q5THN7 Q9BVN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |