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Protein

Transmembrane protein 14B

Gene

TMEM14B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14B
Gene namesi
Name:TMEM14B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21384. TMEM14B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134964501.

Polymorphism and mutation databases

DMDMi27734593.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114Transmembrane protein 14BPRO_0000221172Add
BLAST

Proteomic databases

MaxQBiQ9NUH8.
PaxDbiQ9NUH8.
PRIDEiQ9NUH8.
TopDownProteomicsiQ9NUH8-1. [Q9NUH8-1]

PTM databases

iPTMnetiQ9NUH8.
PhosphoSiteiQ9NUH8.

Expressioni

Gene expression databases

BgeeiQ9NUH8.
CleanExiHS_TMEM14B.
ExpressionAtlasiQ9NUH8. baseline and differential.
GenevisibleiQ9NUH8. HS.

Interactioni

Protein-protein interaction databases

BioGridi123603. 15 interactions.
IntActiQ9NUH8. 5 interactions.
STRINGi9606.ENSP00000368858.

Structurei

3D structure databases

ProteinModelPortaliQ9NUH8.
SMRiQ9NUH8. Positions 8-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4267. Eukaryota.
ENOG4112205. LUCA.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9NUH8.
OMAiMEKGPFP.
OrthoDBiEOG7NKKP0.
TreeFamiTF323345.

Family and domain databases

InterProiIPR005349. TMEM14.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGSVPSLA AGLLFGSLAG
60 70 80 90 100
LGAYQLYQDP RNVWGFLAAT SVTFVGVMGM RSYYYGKFMP VGLIAGASLL
110
MAAKVGVRML MTSD
Length:114
Mass (Da):12,078
Last modified:October 1, 2000 - v1
Checksum:iAA2251A59C53BCB7
GO
Isoform 2 (identifier: Q9NUH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-67: Missing.

Note: Gene prediction based on EST data.
Show »
Length:80
Mass (Da):8,557
Checksum:iB28BCFD1A57908D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371P → S in AAH07080 (PubMed:15489334).Curated
Sequence conflicti42 – 421G → W in AAH01033 (PubMed:15489334).Curated
Sequence conflicti83 – 831Y → C in AAH07080 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei34 – 6734Missing in isoform 2. CuratedVSP_046899Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL024498 Genomic DNA. Translation: CAB75822.1.
AL357497 Genomic DNA. No translation available.
CH471087 Genomic DNA. Translation: EAW55279.1.
CH471087 Genomic DNA. Translation: EAW55281.1.
BC001033 mRNA. Translation: AAH01033.1.
BC007080 mRNA. Translation: AAH07080.1.
BC013913 mRNA. Translation: AAH13913.1.
BC071660 mRNA. Translation: AAH71660.1.
CCDSiCCDS4515.1. [Q9NUH8-1]
CCDS47372.1. [Q9NUH8-2]
RefSeqiNP_001121183.1. NM_001127711.2. [Q9NUH8-2]
NP_001273413.1. NM_001286484.1.
NP_112231.3. NM_030969.4. [Q9NUH8-1]
UniGeneiHs.667371.
Hs.95600.

Genome annotation databases

EnsembliENST00000379530; ENSP00000368845; ENSG00000137210. [Q9NUH8-2]
ENST00000379542; ENSP00000368858; ENSG00000137210. [Q9NUH8-1]
GeneIDi81853.
KEGGihsa:81853.
UCSCiuc003mzk.5. human. [Q9NUH8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL024498 Genomic DNA. Translation: CAB75822.1.
AL357497 Genomic DNA. No translation available.
CH471087 Genomic DNA. Translation: EAW55279.1.
CH471087 Genomic DNA. Translation: EAW55281.1.
BC001033 mRNA. Translation: AAH01033.1.
BC007080 mRNA. Translation: AAH07080.1.
BC013913 mRNA. Translation: AAH13913.1.
BC071660 mRNA. Translation: AAH71660.1.
CCDSiCCDS4515.1. [Q9NUH8-1]
CCDS47372.1. [Q9NUH8-2]
RefSeqiNP_001121183.1. NM_001127711.2. [Q9NUH8-2]
NP_001273413.1. NM_001286484.1.
NP_112231.3. NM_030969.4. [Q9NUH8-1]
UniGeneiHs.667371.
Hs.95600.

3D structure databases

ProteinModelPortaliQ9NUH8.
SMRiQ9NUH8. Positions 8-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123603. 15 interactions.
IntActiQ9NUH8. 5 interactions.
STRINGi9606.ENSP00000368858.

PTM databases

iPTMnetiQ9NUH8.
PhosphoSiteiQ9NUH8.

Polymorphism and mutation databases

DMDMi27734593.

Proteomic databases

MaxQBiQ9NUH8.
PaxDbiQ9NUH8.
PRIDEiQ9NUH8.
TopDownProteomicsiQ9NUH8-1. [Q9NUH8-1]

Protocols and materials databases

DNASUi81853.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379530; ENSP00000368845; ENSG00000137210. [Q9NUH8-2]
ENST00000379542; ENSP00000368858; ENSG00000137210. [Q9NUH8-1]
GeneIDi81853.
KEGGihsa:81853.
UCSCiuc003mzk.5. human. [Q9NUH8-1]

Organism-specific databases

CTDi81853.
GeneCardsiTMEM14B.
HGNCiHGNC:21384. TMEM14B.
neXtProtiNX_Q9NUH8.
PharmGKBiPA134964501.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4267. Eukaryota.
ENOG4112205. LUCA.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9NUH8.
OMAiMEKGPFP.
OrthoDBiEOG7NKKP0.
TreeFamiTF323345.

Miscellaneous databases

ChiTaRSiTMEM14B. human.
GenomeRNAii81853.
NextBioi72170.
PROiQ9NUH8.

Gene expression databases

BgeeiQ9NUH8.
CleanExiHS_TMEM14B.
ExpressionAtlasiQ9NUH8. baseline and differential.
GenevisibleiQ9NUH8. HS.

Family and domain databases

InterProiIPR005349. TMEM14.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Liver, Placenta and Urinary bladder.

Entry informationi

Entry nameiTM14B_HUMAN
AccessioniPrimary (citable) accession number: Q9NUH8
Secondary accession number(s): Q5THN7
, Q5THN8, Q96IX7, Q9BVN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: April 13, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.