TMEM14B

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 14B
Gene namesⁱ	Name:TMEM14B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137210.13.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21384. TMEM14B.

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	8 – 28	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	34 – 54	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	60 – 80	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	83 – 103	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000137210.
PharmGKBⁱ	PA134964501.

Polymorphism and mutation databases

DMDMⁱ	27734593.

DMDMⁱ

27734593.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000221172	1 – 114	Transmembrane protein 14BAdd BLAST		114

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NUH8.
PaxDbⁱ	Q9NUH8.
PeptideAtlas More...PeptideAtlasⁱ	Q9NUH8.
PRIDEⁱ	Q9NUH8.
TopDownProteomicsⁱ	Q9NUH8-1. [Q9NUH8-1]

PTM databases

iPTMnetⁱ	Q9NUH8.
PhosphoSitePlusⁱ	Q9NUH8.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000137210.
CleanExⁱ	HS_TMEM14B.
ExpressionAtlasⁱ	Q9NUH8. baseline and differential.
Genevisibleⁱ	Q9NUH8. HS.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	123603. 15 interactors.
IntActⁱ	Q9NUH8. 9 interactors.
STRINGⁱ	9606.ENSP00000368858.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NUH8.
SMRⁱ	Q9NUH8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TMEM14 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4267. Eukaryota. ENOG4112205. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013475.
HOGENOMⁱ	HOG000211932.
HOVERGENⁱ	HBG054211.
InParanoidⁱ	Q9NUH8.
OMAⁱ	MEKGPFP.
TreeFamⁱ	TF323345.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005349. TMEM14.
PANTHERⁱ	PTHR12668. PTHR12668. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03647. Tmemb_14. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9NUH8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGSVPSLA AGLLFGSLAG 
        60         70         80         90        100
LGAYQLYQDP RNVWGFLAAT SVTFVGVMGM RSYYYGKFMP VGLIAGASLL 
       110 
MAAKVGVRML MTSD

Length:114

Mass (Da):12,078

Last modified:October 1, 2000 - v1

Checksum:ⁱAA2251A59C53BCB7

GO

Isoform 2 (identifier: Q9NUH8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
34-67: Missing.

« Hide

        10         20         30         40         50
MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTAATSVTF VGVMGMRSYY 
        60         70         80
YGKFMPVGLI AGASLLMAAK VGVRMLMTSD

Note: Gene prediction based on EST data.

Show »

Length:80

Mass (Da):8,557

Checksum:ⁱB28BCFD1A57908D3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	37	P → S in AAH07080 (PubMed:15489334).Curated	1
Sequence conflictⁱ	42	G → W in AAH01033 (PubMed:15489334).Curated	1
Sequence conflictⁱ	83	Y → C in AAH07080 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046899	34 – 67	Missing in isoform 2. CuratedAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL024498 Genomic DNA. Translation: CAB75822.1. AL357497 Genomic DNA. No translation available. CH471087 Genomic DNA. Translation: EAW55279.1. CH471087 Genomic DNA. Translation: EAW55281.1. BC001033 mRNA. Translation: AAH01033.1. BC007080 mRNA. Translation: AAH07080.1. BC013913 mRNA. Translation: AAH13913.1. BC071660 mRNA. Translation: AAH71660.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4515.1. [Q9NUH8-1] CCDS47372.1. [Q9NUH8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001121183.1. NM_001127711.2. [Q9NUH8-2] NP_001273413.1. NM_001286484.1. NP_112231.3. NM_030969.4. [Q9NUH8-1]
UniGeneⁱ	Hs.667371. Hs.95600.

Genome annotation databases

Ensemblⁱ	ENST00000379530; ENSP00000368845; ENSG00000137210. [Q9NUH8-2] ENST00000379542; ENSP00000368858; ENSG00000137210. [Q9NUH8-1]
GeneIDⁱ	81853.
KEGGⁱ	hsa:81853.
UCSC genome browser More...UCSCⁱ	uc003mzk.5. human. [Q9NUH8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9NUH8	A0A024QZV7	Homo sapiens (Human)	114	UniRef100_Q9NUH8	Cluster: Transmembrane protein 14B	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9NUH8	A0A024QZV7 A8MWL7 A8K768 G3QED1 H2QSA7 UPI00020ABD08 UPI000274649C UPI00029D964F G3R2L8	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pan paniscus (Pygmy chimpanzee) (Bonobo)	114	UniRef90_Q9NUH8	Cluster: Transmembrane protein 14B	10
Q9NUH8-2	F7B640 UPI0005F3C398 UPI0005F4B60F UPI00083C83F4	Macaca mulatta (Rhesus macaque) Colobus angolensis palliatus (Peters' Angolan colobus) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)	80	UniRef90_Q9NUH8-2	Cluster: Isoform 2 of Transmembrane protein 14B	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9NUH8	Q3ZCI1 W5Q2W7 L8HZB7 A0A212D4G9 UPI000576BCBF UPI0003AF4699 UPI00042CD977 UPI0003C1A0EE UPI0002BCEE6F F1RV94 +136	Bos taurus (Bovine) Ovis aries (Sheep) Bos mutus (wild yak) Cervus elaphus hippelaphus (European red deer) Bison bison bison Capra hircus (Goat) Bubalus bubalis (Domestic water buffalo) Pantholops hodgsonii (Chiru) (Tibetan antelope) Orcinus orca (Killer whale) Sus scrofa (Pig) And more	114	UniRef50_Q3ZCI1	Cluster: Transmembrane protein 14C	147
Q9NUH8-2	UPI0005F4B60F F7B640 UPI00083C83F4 UPI0005F3C398 UPI0000E20D7B UPI0004F1E2F2 G7N7Q7 G7PIJ4 G7NKV6 UPI0005F58151	Mandrillus leucophaeus (Drill) (Papio leucophaeus) Macaca mulatta (Rhesus macaque) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Colobus angolensis palliatus (Peters' Angolan colobus) Pan paniscus (Pygmy chimpanzee) (Bonobo) Papio anubis (Olive baboon) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	80	UniRef50_Q9NUH8-2	Cluster: Isoform 2 of Transmembrane protein 14B	11

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL024498 Genomic DNA. Translation: CAB75822.1. AL357497 Genomic DNA. No translation available. CH471087 Genomic DNA. Translation: EAW55279.1. CH471087 Genomic DNA. Translation: EAW55281.1. BC001033 mRNA. Translation: AAH01033.1. BC007080 mRNA. Translation: AAH07080.1. BC013913 mRNA. Translation: AAH13913.1. BC071660 mRNA. Translation: AAH71660.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4515.1. [Q9NUH8-1] CCDS47372.1. [Q9NUH8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001121183.1. NM_001127711.2. [Q9NUH8-2] NP_001273413.1. NM_001286484.1. NP_112231.3. NM_030969.4. [Q9NUH8-1]
UniGeneⁱ	Hs.667371. Hs.95600.

3D structure databases

ProteinModelPortalⁱ	Q9NUH8.
SMRⁱ	Q9NUH8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123603. 15 interactors.
IntActⁱ	Q9NUH8. 9 interactors.
STRINGⁱ	9606.ENSP00000368858.

PTM databases

iPTMnetⁱ	Q9NUH8.
PhosphoSitePlusⁱ	Q9NUH8.

Polymorphism and mutation databases

DMDMⁱ	27734593.

DMDMⁱ

27734593.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NUH8.
PaxDbⁱ	Q9NUH8.
PeptideAtlas More...PeptideAtlasⁱ	Q9NUH8.
PRIDEⁱ	Q9NUH8.
TopDownProteomicsⁱ	Q9NUH8-1. [Q9NUH8-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	81853.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000379530; ENSP00000368845; ENSG00000137210. [Q9NUH8-2] ENST00000379542; ENSP00000368858; ENSG00000137210. [Q9NUH8-1]
GeneIDⁱ	81853.
KEGGⁱ	hsa:81853.
UCSC genome browser More...UCSCⁱ	uc003mzk.5. human. [Q9NUH8-1]

Organism-specific databases

CTDⁱ	81853.
EuPathDBⁱ	HostDB:ENSG00000137210.13.
GeneCardsⁱ	TMEM14B.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21384. TMEM14B.
neXtProtⁱ	NX_Q9NUH8.
Open Targets More...OpenTargetsⁱ	ENSG00000137210.
PharmGKBⁱ	PA134964501.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4267. Eukaryota. ENOG4112205. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013475.
HOGENOMⁱ	HOG000211932.
HOVERGENⁱ	HBG054211.
InParanoidⁱ	Q9NUH8.
OMAⁱ	MEKGPFP.
TreeFamⁱ	TF323345.

Miscellaneous databases

ChiTaRSⁱ	TMEM14B. human.
GenomeRNAiⁱ	81853.
Protein Ontology More...PROⁱ	PR:Q9NUH8.

Gene expression databases

Bgeeⁱ	ENSG00000137210.
CleanExⁱ	HS_TMEM14B.
ExpressionAtlasⁱ	Q9NUH8. baseline and differential.
Genevisibleⁱ	Q9NUH8. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005349. TMEM14.
PANTHERⁱ	PTHR12668. PTHR12668. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03647. Tmemb_14. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM14B_HUMAN
Accessionⁱ	Q9NUH8Primary (citable) accession number: Q9NUH8 Secondary accession number(s): Q5THN7 , Q5THN8, Q96IX7, Q9BVN8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
	Last sequence update:	October 1, 2000
	Last modified:	September 27, 2017
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NUH8 (TM14B_HUMAN)

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Transmembrane protein 14B

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ