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Protein

Transmembrane protein 14B

Gene

TMEM14B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.1 Publication

Miscellaneous

When expressed in embryonic mouse neocortex, induces intermediate progenitor cells and outer radial glia expansion, cortical thickening and induces gyrification (PubMed:29033352).1 Publication

GO - Biological processi

  • cerebral cortex development Source: UniProtKB
  • neural precursor cell proliferation Source: UniProtKB
  • regulation of G1/S transition of mitotic cell cycle Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14B
Gene namesi
Name:TMEM14B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137210.13
HGNCiHGNC:21384 TMEM14B
neXtProtiNX_Q9NUH8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137210
PharmGKBiPA134964501

Polymorphism and mutation databases

DMDMi27734593

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211721 – 114Transmembrane protein 14BAdd BLAST114

Proteomic databases

MaxQBiQ9NUH8
PaxDbiQ9NUH8
PeptideAtlasiQ9NUH8
PRIDEiQ9NUH8
TopDownProteomicsiQ9NUH8-1 [Q9NUH8-1]

PTM databases

iPTMnetiQ9NUH8
PhosphoSitePlusiQ9NUH8

Expressioni

Tissue specificityi

Mainly expressed in the outer subventricular zone (OSVZ) of the fetal brains.1 Publication

Gene expression databases

BgeeiENSG00000137210
CleanExiHS_TMEM14B
ExpressionAtlasiQ9NUH8 baseline and differential
GenevisibleiQ9NUH8 HS

Interactioni

Subunit structurei

Interacts with IQGAP1; this interaction promotes phosphorylation and nuclear translocation of IQGAP1.1 Publication

Protein-protein interaction databases

BioGridi123603, 17 interactors
IntActiQ9NUH8, 9 interactors
MINTiQ9NUH8
STRINGi9606.ENSP00000368858

Structurei

3D structure databases

ProteinModelPortaliQ9NUH8
SMRiQ9NUH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4267 Eukaryota
ENOG4112205 LUCA
GeneTreeiENSGT00390000013475
HOGENOMiHOG000211932
HOVERGENiHBG054211
InParanoidiQ9NUH8
OMAiMEKGPFP
TreeFamiTF323345

Family and domain databases

InterProiView protein in InterPro
IPR005349 TMEM14
PANTHERiPTHR12668 PTHR12668, 1 hit
PfamiView protein in Pfam
PF03647 Tmemb_14, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGSVPSLA AGLLFGSLAG
60 70 80 90 100
LGAYQLYQDP RNVWGFLAAT SVTFVGVMGM RSYYYGKFMP VGLIAGASLL
110
MAAKVGVRML MTSD
Length:114
Mass (Da):12,078
Last modified:October 1, 2000 - v1
Checksum:iAA2251A59C53BCB7
GO
Isoform 2 (identifier: Q9NUH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-67: Missing.

Note: Gene prediction based on EST data.
Show »
Length:80
Mass (Da):8,557
Checksum:iB28BCFD1A57908D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37P → S in AAH07080 (PubMed:15489334).Curated1
Sequence conflicti42G → W in AAH01033 (PubMed:15489334).Curated1
Sequence conflicti83Y → C in AAH07080 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04689934 – 67Missing in isoform 2. CuratedAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL024498 Genomic DNA No translation available.
AL357497 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55279.1
CH471087 Genomic DNA Translation: EAW55281.1
BC001033 mRNA Translation: AAH01033.1
BC007080 mRNA Translation: AAH07080.1
BC013913 mRNA Translation: AAH13913.1
BC071660 mRNA Translation: AAH71660.1
CCDSiCCDS4515.1 [Q9NUH8-1]
CCDS47372.1 [Q9NUH8-2]
RefSeqiNP_001121183.1, NM_001127711.2 [Q9NUH8-2]
NP_001273413.1, NM_001286484.1
NP_112231.3, NM_030969.4 [Q9NUH8-1]
UniGeneiHs.667371
Hs.95600

Genome annotation databases

EnsembliENST00000379530; ENSP00000368845; ENSG00000137210 [Q9NUH8-2]
ENST00000379542; ENSP00000368858; ENSG00000137210 [Q9NUH8-1]
GeneIDi81853
KEGGihsa:81853
UCSCiuc003mzk.5 human [Q9NUH8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTM14B_HUMAN
AccessioniPrimary (citable) accession number: Q9NUH8
Secondary accession number(s): Q5THN7
, Q5THN8, Q96IX7, Q9BVN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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