ID   PDRG1_HUMAN             Reviewed;         133 AA.
AC   Q9NUG6; B2R511; Q96GP3; Q9BUW8;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2002, sequence version 2.
DT   18-APR-2012, entry version 80.
DE   RecName: Full=p53 and DNA damage-regulated protein 1;
GN   Name=PDRG1; Synonyms=C20orf126, PDRG;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RX   MEDLINE=22924027; PubMed=14562055; DOI=10.1038/sj.onc.1207010;
RA   Luo X., Huang Y., Sheikh M.S.;
RT   "Cloning and characterization of a novel gene PDRG that is
RT   differentially regulated by p53 and ultraviolet radiation.";
RL   Oncogene 22:7247-7257(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in chaperone-mediated protein folding
CC       (Potential).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in normal testis and
CC       exhibits reduced but detectable expression in other organs.
CC   -!- INDUCTION: By UV irradiation and repressed by p53/TP53.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
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DR   EMBL; AY286301; AAP45329.1; -; mRNA.
DR   EMBL; AK312021; BAG34958.1; -; mRNA.
DR   EMBL; AL031658; CAB88101.2; -; Genomic_DNA.
DR   EMBL; CH471077; EAW76399.1; -; Genomic_DNA.
DR   EMBL; BC001856; AAH01856.2; -; mRNA.
DR   EMBL; BC009334; AAH09334.1; -; mRNA.
DR   IPI; IPI00027887; -.
DR   RefSeq; NP_110442.1; NM_030815.2.
DR   UniGene; Hs.435755; -.
DR   ProteinModelPortal; Q9NUG6; -.
DR   DIP; DIP-27568N; -.
DR   IntAct; Q9NUG6; 2.
DR   MINT; MINT-1140540; -.
DR   STRING; Q9NUG6; -.
DR   PhosphoSite; Q9NUG6; -.
DR   DMDM; 24211602; -.
DR   PRIDE; Q9NUG6; -.
DR   DNASU; 81572; -.
DR   Ensembl; ENST00000202017; ENSP00000202017; ENSG00000088356.
DR   GeneID; 81572; -.
DR   KEGG; hsa:81572; -.
DR   UCSC; uc002wxd.3; human.
DR   CTD; 81572; -.
DR   GeneCards; GC20M030532; -.
DR   H-InvDB; HIX0015718; -.
DR   HGNC; HGNC:16119; PDRG1.
DR   MIM; 610789; gene.
DR   neXtProt; NX_Q9NUG6; -.
DR   PharmGKB; PA25667; -.
DR   eggNOG; NOG70550; -.
DR   GeneTree; ENSGT00390000013253; -.
DR   HOGENOM; HBG443699; -.
DR   HOVERGEN; HBG053553; -.
DR   InParanoid; Q9NUG6; -.
DR   OMA; KRNRNRE; -.
DR   OrthoDB; EOG4CZBHD; -.
DR   PhylomeDB; Q9NUG6; -.
DR   NextBio; 71876; -.
DR   ArrayExpress; Q9NUG6; -.
DR   Bgee; Q9NUG6; -.
DR   CleanEx; HS_PDRG1; -.
DR   Genevestigator; Q9NUG6; -.
DR   GermOnline; ENSG00000088356; Homo sapiens.
DR   GO; GO:0016272; C:prefoldin complex; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   InterPro; IPR002777; PFD_beta-like.
DR   Pfam; PF01920; Prefoldin_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Complete proteome; Cytoplasm; Reference proteome.
FT   CHAIN         1    133       p53 and DNA damage-regulated protein 1.
FT                                /FTId=PRO_0000058277.
SQ   SEQUENCE   133 AA;  15511 MW;  13D3293D9724B46A CRC64;
     MLSPEAERVL RYLVEVEELA EEVLADKRQI VDLDTKRNQN REGLRALQKD LSLSEDVMVC
     FGNMFIKMPH PETKEMIEKD QDHLDKEIEK LRKQLKVKVN RLFEAQGKPE LKGFNLNPLN
     QDELKALKVI LKG
//