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Protein

p53 and DNA damage-regulated protein 1

Gene

PDRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in chaperone-mediated protein folding.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
p53 and DNA damage-regulated protein 1
Gene namesi
Name:PDRG1
Synonyms:C20orf126, PDRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000088356.5
HGNCiHGNC:16119 PDRG1
MIMi610789 gene
neXtProtiNX_Q9NUG6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi81572
OpenTargetsiENSG00000088356
PharmGKBiPA25667

Polymorphism and mutation databases

BioMutaiPDRG1
DMDMi24211602

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582771 – 133p53 and DNA damage-regulated protein 1Add BLAST133

Proteomic databases

EPDiQ9NUG6
MaxQBiQ9NUG6
PaxDbiQ9NUG6
PeptideAtlasiQ9NUG6
PRIDEiQ9NUG6
TopDownProteomicsiQ9NUG6

PTM databases

iPTMnetiQ9NUG6
PhosphoSitePlusiQ9NUG6

Expressioni

Tissue specificityi

Predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs.1 Publication

Inductioni

By UV irradiation and repressed by p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000088356
CleanExiHS_PDRG1
GenevisibleiQ9NUG6 HS

Organism-specific databases

HPAiHPA047084
HPA063542

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123533, 41 interactors
CORUMiQ9NUG6
DIPiDIP-27568N
IntActiQ9NUG6, 22 interactors
STRINGi9606.ENSP00000202017

Structurei

3D structure databases

ProteinModelPortaliQ9NUG6
SMRiQ9NUG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiENOG410IYXP Eukaryota
ENOG41127ER LUCA
GeneTreeiENSGT00390000013253
HOGENOMiHOG000007729
HOVERGENiHBG053553
InParanoidiQ9NUG6
OMAiMPHPQTK
OrthoDBiEOG091G0USB
PhylomeDBiQ9NUG6
TreeFamiTF329240

Family and domain databases

InterProiView protein in InterPro
IPR030482 PDRG1
IPR002777 PFD_beta-like
PANTHERiPTHR21162 PTHR21162, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NUG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPEAERVL RYLVEVEELA EEVLADKRQI VDLDTKRNQN REGLRALQKD
60 70 80 90 100
LSLSEDVMVC FGNMFIKMPH PETKEMIEKD QDHLDKEIEK LRKQLKVKVN
110 120 130
RLFEAQGKPE LKGFNLNPLN QDELKALKVI LKG
Length:133
Mass (Da):15,511
Last modified:October 19, 2002 - v2
Checksum:i13D3293D9724B46A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286301 mRNA Translation: AAP45329.1
AK312021 mRNA Translation: BAG34958.1
AL031658 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76399.1
BC001856 mRNA Translation: AAH01856.2
BC009334 mRNA Translation: AAH09334.1
CCDSiCCDS13194.1
RefSeqiNP_110442.1, NM_030815.2
UniGeneiHs.435755

Genome annotation databases

EnsembliENST00000202017; ENSP00000202017; ENSG00000088356
GeneIDi81572
KEGGihsa:81572
UCSCiuc002wxd.4 human

Similar proteinsi

Entry informationi

Entry nameiPDRG1_HUMAN
AccessioniPrimary (citable) accession number: Q9NUG6
Secondary accession number(s): B2R511, Q96GP3, Q9BUW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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