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Protein

p53 and DNA damage-regulated protein 1

Gene

PDRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in chaperone-mediated protein folding.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088356-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
p53 and DNA damage-regulated protein 1
Gene namesi
Name:PDRG1
Synonyms:C20orf126, PDRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16119. PDRG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi81572.
OpenTargetsiENSG00000088356.
PharmGKBiPA25667.

Polymorphism and mutation databases

BioMutaiPDRG1.
DMDMi24211602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582771 – 133p53 and DNA damage-regulated protein 1Add BLAST133

Proteomic databases

EPDiQ9NUG6.
MaxQBiQ9NUG6.
PaxDbiQ9NUG6.
PeptideAtlasiQ9NUG6.
PRIDEiQ9NUG6.
TopDownProteomicsiQ9NUG6.

PTM databases

iPTMnetiQ9NUG6.
PhosphoSitePlusiQ9NUG6.

Expressioni

Tissue specificityi

Predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs.1 Publication

Inductioni

By UV irradiation and repressed by p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000088356.
CleanExiHS_PDRG1.
GenevisibleiQ9NUG6. HS.

Organism-specific databases

HPAiHPA047084.
HPA063542.

Interactioni

Protein-protein interaction databases

BioGridi123533. 37 interactors.
DIPiDIP-27568N.
IntActiQ9NUG6. 21 interactors.
MINTiMINT-1140540.
STRINGi9606.ENSP00000202017.

Structurei

3D structure databases

ProteinModelPortaliQ9NUG6.
SMRiQ9NUG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiENOG410IYXP. Eukaryota.
ENOG41127ER. LUCA.
GeneTreeiENSGT00390000013253.
HOGENOMiHOG000007729.
HOVERGENiHBG053553.
InParanoidiQ9NUG6.
OMAiGNMFIRM.
OrthoDBiEOG091G0USB.
PhylomeDBiQ9NUG6.
TreeFamiTF329240.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR030482. PDRG1.
IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR21162:SF0. PTHR21162:SF0. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NUG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPEAERVL RYLVEVEELA EEVLADKRQI VDLDTKRNQN REGLRALQKD
60 70 80 90 100
LSLSEDVMVC FGNMFIKMPH PETKEMIEKD QDHLDKEIEK LRKQLKVKVN
110 120 130
RLFEAQGKPE LKGFNLNPLN QDELKALKVI LKG
Length:133
Mass (Da):15,511
Last modified:October 19, 2002 - v2
Checksum:i13D3293D9724B46A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286301 mRNA. Translation: AAP45329.1.
AK312021 mRNA. Translation: BAG34958.1.
AL031658 Genomic DNA. Translation: CAB88101.2.
CH471077 Genomic DNA. Translation: EAW76399.1.
BC001856 mRNA. Translation: AAH01856.2.
BC009334 mRNA. Translation: AAH09334.1.
CCDSiCCDS13194.1.
RefSeqiNP_110442.1. NM_030815.2.
UniGeneiHs.435755.

Genome annotation databases

EnsembliENST00000202017; ENSP00000202017; ENSG00000088356.
GeneIDi81572.
KEGGihsa:81572.
UCSCiuc002wxd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286301 mRNA. Translation: AAP45329.1.
AK312021 mRNA. Translation: BAG34958.1.
AL031658 Genomic DNA. Translation: CAB88101.2.
CH471077 Genomic DNA. Translation: EAW76399.1.
BC001856 mRNA. Translation: AAH01856.2.
BC009334 mRNA. Translation: AAH09334.1.
CCDSiCCDS13194.1.
RefSeqiNP_110442.1. NM_030815.2.
UniGeneiHs.435755.

3D structure databases

ProteinModelPortaliQ9NUG6.
SMRiQ9NUG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123533. 37 interactors.
DIPiDIP-27568N.
IntActiQ9NUG6. 21 interactors.
MINTiMINT-1140540.
STRINGi9606.ENSP00000202017.

PTM databases

iPTMnetiQ9NUG6.
PhosphoSitePlusiQ9NUG6.

Polymorphism and mutation databases

BioMutaiPDRG1.
DMDMi24211602.

Proteomic databases

EPDiQ9NUG6.
MaxQBiQ9NUG6.
PaxDbiQ9NUG6.
PeptideAtlasiQ9NUG6.
PRIDEiQ9NUG6.
TopDownProteomicsiQ9NUG6.

Protocols and materials databases

DNASUi81572.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000202017; ENSP00000202017; ENSG00000088356.
GeneIDi81572.
KEGGihsa:81572.
UCSCiuc002wxd.4. human.

Organism-specific databases

CTDi81572.
DisGeNETi81572.
GeneCardsiPDRG1.
HGNCiHGNC:16119. PDRG1.
HPAiHPA047084.
HPA063542.
MIMi610789. gene.
neXtProtiNX_Q9NUG6.
OpenTargetsiENSG00000088356.
PharmGKBiPA25667.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYXP. Eukaryota.
ENOG41127ER. LUCA.
GeneTreeiENSGT00390000013253.
HOGENOMiHOG000007729.
HOVERGENiHBG053553.
InParanoidiQ9NUG6.
OMAiGNMFIRM.
OrthoDBiEOG091G0USB.
PhylomeDBiQ9NUG6.
TreeFamiTF329240.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088356-MONOMER.

Miscellaneous databases

GenomeRNAii81572.
PROiQ9NUG6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088356.
CleanExiHS_PDRG1.
GenevisibleiQ9NUG6. HS.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR030482. PDRG1.
IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR21162:SF0. PTHR21162:SF0. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDRG1_HUMAN
AccessioniPrimary (citable) accession number: Q9NUG6
Secondary accession number(s): B2R511, Q96GP3, Q9BUW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.