ID   Q9NUF9_HUMAN            Unreviewed;       153 AA.
AC   Q9NUF9;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   24-JAN-2024, entry version 103.
DE   RecName: Full=Nucleoside diphosphate kinase {ECO:0000256|RuleBase:RU004013};
DE            EC=2.7.4.6 {ECO:0000256|RuleBase:RU004013};
DE   Flags: Fragment;
GN   Name=c371H6.2 {ECO:0000313|EMBL:CAB72319.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAB72319.1};
RN   [1] {ECO:0000313|EMBL:CAB72319.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Bagguley C.;
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-
CC         deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316,
CC         ChEBI:CHEBI:456216; EC=2.7.4.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000082,
CC         ECO:0000256|RuleBase:RU004013};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-
CC         triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000937};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the NDK family. {ECO:0000256|ARBA:ARBA00008142,
CC       ECO:0000256|RuleBase:RU004011}.
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DR   EMBL; AL031718; CAB72319.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9NUF9; -.
DR   IntAct; Q9NUF9; 1.
DR   PeptideAtlas; Q9NUF9; -.
DR   ChiTaRS; NME3; human.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR   CDD; cd04413; NDPk_I; 1.
DR   Gene3D; 3.30.70.141; Nucleoside diphosphate kinase-like domain; 1.
DR   HAMAP; MF_00451; NDP_kinase; 1.
DR   InterPro; IPR034907; NDK-like_dom.
DR   InterPro; IPR036850; NDK-like_dom_sf.
DR   InterPro; IPR001564; Nucleoside_diP_kinase.
DR   InterPro; IPR023005; Nucleoside_diP_kinase_AS.
DR   PANTHER; PTHR11349; NUCLEOSIDE DIPHOSPHATE KINASE; 1.
DR   PANTHER; PTHR11349:SF54; NUCLEOSIDE DIPHOSPHATE KINASE 3; 1.
DR   Pfam; PF00334; NDK; 1.
DR   PRINTS; PR01243; NUCDPKINASE.
DR   SMART; SM00562; NDK; 1.
DR   SUPFAM; SSF54919; Nucleoside diphosphate kinase, NDK; 1.
DR   PROSITE; PS00469; NDP_KINASES; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004013};
KW   Kinase {ECO:0000256|RuleBase:RU004013, ECO:0000313|EMBL:CAB72319.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004013};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004013}.
FT   DOMAIN          5..142
FT                   /note="Nucleoside diphosphate kinase-like"
FT                   /evidence="ECO:0000259|SMART:SM00562"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAB72319.1"
SQ   SEQUENCE   153 AA;  17296 MW;  0A2D7059E1CC18EA CRC64;
     CTGAHERTFL AVKPDGVQRR LVGEIVRRFE RKGFKLVALK LVQASEELLR EHYAELRERP
     FYGRLVKYMA SGPVVAMVWQ GLDVVRTSRA LIGATNPADA PPGTIRGDFC IEVGKNLIHG
     SDSVESARRE IALWFRADEL LCWEDSAGHW LYE
//