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Protein

Palmitoyltransferase ZDHHC18

Gene

ZDHHC18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has palmitoyltransferase activity towards HRAS and LCK.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei222S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular protein localization Source: Ensembl
  • protein palmitoylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC18 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 18
Short name:
DHHC-18
Gene namesi
Name:ZDHHC18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20712. ZDHHC18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204160.
PharmGKBiPA134968241.

Polymorphism and mutation databases

BioMutaiZDHHC18.
DMDMi34395910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129021 – 388Palmitoyltransferase ZDHHC18Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9NUE0.
PaxDbiQ9NUE0.
PeptideAtlasiQ9NUE0.
PRIDEiQ9NUE0.

PTM databases

iPTMnetiQ9NUE0.
PhosphoSitePlusiQ9NUE0.
SwissPalmiQ9NUE0.

Expressioni

Gene expression databases

BgeeiENSG00000204160.
CleanExiHS_ZDHHC18.
ExpressionAtlasiQ9NUE0. baseline and differential.
GenevisibleiQ9NUE0. HS.

Organism-specific databases

HPAiHPA040234.

Interactioni

Protein-protein interaction databases

BioGridi123972. 17 interactors.
STRINGi9606.ENSP00000363257.

Structurei

3D structure databases

ProteinModelPortaliQ9NUE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 242DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 46Pro-richAdd BLAST36

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiQ9NUE0.
KOiK16675.
OMAiPRATICE.
OrthoDBiEOG091G0BOW.
PhylomeDBiQ9NUE0.
TreeFamiTF312923.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDCEYQQIS PGAAPLPASP GARRPGPAAS PTPGPGPAPP AAPAPPRWSS
60 70 80 90 100
SGSGSGSGSG SLGRRPRRKW EVFPGRNRFY CGGRLMLAGH GGVFALTLLL
110 120 130 140 150
ILTTTGLFFV FDCPYLARKL TLAIPIIAAI LFFFVMSCLL QTSFTDPGIL
160 170 180 190 200
PRATVCEAAA LEKQIDNTGS STYRPPPRTR EVLINGQMVK LKYCFTCKMF
210 220 230 240 250
RPPRTSHCSV CDNCVERFDH HCPWVGNCVG RRNYRFFYAF ILSLSFLTAF
260 270 280 290 300
IFACVVTHLT LRAQGSNFLS TLKETPASVL ELVICFFSIW SILGLSGFHT
310 320 330 340 350
YLVASNLTTN EDIKGSWSSK RGGEASVNPY SHKSIITNCC AVLCGPLPPS
360 370 380
LIDRRGFVQS DTVLPSPIRS DEPACRAKPD ASMVGGHP
Length:388
Mass (Da):42,031
Last modified:August 29, 2003 - v2
Checksum:i446114704C461C6E
GO
Isoform 2 (identifier: Q9NUE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):27,940
Checksum:iF830CB10F25997D6
GO

Sequence cautioni

The sequence CAI21624 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560001 – 135Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298683 mRNA. Translation: BAG60846.1.
AL034380 Genomic DNA. Translation: CAI21624.1. Different initiation.
CH471059 Genomic DNA. Translation: EAX07788.1.
BC066776 mRNA. Translation: AAH66776.1.
AL512765 mRNA. Translation: CAC21682.1.
CCDSiCCDS30650.1. [Q9NUE0-1]
RefSeqiNP_115659.1. NM_032283.2. [Q9NUE0-1]
UniGeneiHs.523710.

Genome annotation databases

EnsembliENST00000374141; ENSP00000363256; ENSG00000204160. [Q9NUE0-2]
ENST00000374142; ENSP00000363257; ENSG00000204160. [Q9NUE0-1]
GeneIDi84243.
KEGGihsa:84243.
UCSCiuc001bnb.4. human. [Q9NUE0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298683 mRNA. Translation: BAG60846.1.
AL034380 Genomic DNA. Translation: CAI21624.1. Different initiation.
CH471059 Genomic DNA. Translation: EAX07788.1.
BC066776 mRNA. Translation: AAH66776.1.
AL512765 mRNA. Translation: CAC21682.1.
CCDSiCCDS30650.1. [Q9NUE0-1]
RefSeqiNP_115659.1. NM_032283.2. [Q9NUE0-1]
UniGeneiHs.523710.

3D structure databases

ProteinModelPortaliQ9NUE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123972. 17 interactors.
STRINGi9606.ENSP00000363257.

PTM databases

iPTMnetiQ9NUE0.
PhosphoSitePlusiQ9NUE0.
SwissPalmiQ9NUE0.

Polymorphism and mutation databases

BioMutaiZDHHC18.
DMDMi34395910.

Proteomic databases

EPDiQ9NUE0.
PaxDbiQ9NUE0.
PeptideAtlasiQ9NUE0.
PRIDEiQ9NUE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374141; ENSP00000363256; ENSG00000204160. [Q9NUE0-2]
ENST00000374142; ENSP00000363257; ENSG00000204160. [Q9NUE0-1]
GeneIDi84243.
KEGGihsa:84243.
UCSCiuc001bnb.4. human. [Q9NUE0-1]

Organism-specific databases

CTDi84243.
GeneCardsiZDHHC18.
H-InvDBHIX0199867.
HGNCiHGNC:20712. ZDHHC18.
HPAiHPA040234.
neXtProtiNX_Q9NUE0.
OpenTargetsiENSG00000204160.
PharmGKBiPA134968241.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiQ9NUE0.
KOiK16675.
OMAiPRATICE.
OrthoDBiEOG091G0BOW.
PhylomeDBiQ9NUE0.
TreeFamiTF312923.

Miscellaneous databases

GenomeRNAii84243.
PROiQ9NUE0.

Gene expression databases

BgeeiENSG00000204160.
CleanExiHS_ZDHHC18.
ExpressionAtlasiQ9NUE0. baseline and differential.
GenevisibleiQ9NUE0. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH18_HUMAN
AccessioniPrimary (citable) accession number: Q9NUE0
Secondary accession number(s): A6NHY9
, B4DQ84, Q5JYH0, Q9H020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.