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Q9NUD9

- PIGV_HUMAN

UniProt

Q9NUD9 - PIGV_HUMAN

Protein

GPI mannosyltransferase 2

Gene

PIGV

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.2 Publications

    Pathwayi

    GO - Molecular functioni

    1. mannosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. C-terminal protein lipidation Source: Reactome
    3. GPI anchor biosynthetic process Source: UniProtKB
    4. mannosylation Source: GOC
    5. post-translational protein modification Source: Reactome
    6. preassembly of GPI anchor in ER membrane Source: Reactome

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_952. Synthesis of glycosylphosphatidylinositol (GPI).
    UniPathwayiUPA00196.

    Protein family/group databases

    CAZyiGT76. Glycosyltransferase Family 76.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GPI mannosyltransferase 2 (EC:2.4.1.-)
    Alternative name(s):
    GPI mannosyltransferase II
    Short name:
    GPI-MT-II
    Phosphatidylinositol-glycan biosynthesis class V protein
    Short name:
    PIG-V
    Gene namesi
    Name:PIGV
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26031. PIGV.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Hyperphosphatasia with mental retardation syndrome 1 (HPMRS1) [MIM:239300]: A severe syndrome characterized by elevated serum alkaline phosphatase, severe mental retardation, seizures, hypotonia, facial dysmorphism, and hypoplastic terminal phalanges.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti256 – 2561Q → K in HPMRS1. 1 Publication
    VAR_064190
    Natural varianti341 – 3411A → E in HPMRS1. 1 Publication
    VAR_064191
    Natural varianti341 – 3411A → V in HPMRS1. 1 Publication
    VAR_064192
    Natural varianti385 – 3851H → P in HPMRS1. 1 Publication
    VAR_064193

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi66 – 661W → L: Loss of function. 1 Publication
    Mutagenesisi67 – 671D → A: Loss of function. 1 Publication
    Mutagenesisi293 – 2942PP → TA: N-glycosylated due to the creation of an acceptor site for N-glycosylation.
    Mutagenesisi308 – 3081Q → A: Induces a reduces enzyme activity. 1 Publication
    Mutagenesisi312 – 3121W → L: Loss of function. 1 Publication

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi239300. phenotype.
    Orphaneti247262. Hyperphosphatasia-intellectual disability syndrome.
    PharmGKBiPA134952230.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493GPI mannosyltransferase 2PRO_0000246234Add
    BLAST

    Post-translational modificationi

    Not N-glycosylated.

    Proteomic databases

    PaxDbiQ9NUD9.
    PRIDEiQ9NUD9.

    PTM databases

    PhosphoSiteiQ9NUD9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NUD9.
    BgeeiQ9NUD9.
    CleanExiHS_PIGV.
    GenevestigatoriQ9NUD9.

    Interactioni

    Protein-protein interaction databases

    BioGridi120782. 2 interactions.
    STRINGi9606.ENSP00000078527.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NUD9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 7743LumenalSequence AnalysisAdd
    BLAST
    Topological domaini99 – 11315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini135 – 1362LumenalSequence Analysis
    Topological domaini158 – 1614CytoplasmicSequence Analysis
    Topological domaini183 – 19210LumenalSequence Analysis
    Topological domaini214 – 23421CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 32772LumenalSequence AnalysisAdd
    BLAST
    Topological domaini349 – 37830CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini400 – 46970LumenalSequence AnalysisAdd
    BLAST
    Topological domaini491 – 4933CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei470 – 49021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PIGV family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5542.
    HOGENOMiHOG000232162.
    HOVERGENiHBG080592.
    InParanoidiQ9NUD9.
    KOiK07542.
    OMAiFLKYYEL.
    OrthoDBiEOG7VDXPB.
    PhylomeDBiQ9NUD9.
    TreeFamiTF314515.

    Family and domain databases

    InterProiIPR007315. GPI_Mannosyltransferase_2.
    [Graphical view]
    PANTHERiPTHR12468. PTHR12468. 1 hit.
    PfamiPF04188. Mannosyl_trans2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NUD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWPQDPSRKE VLRFAVSCRI LTLMLQALFN AIIPDHHAEA FSPPRLAPSG    50
    FVDQLVEGLL GGLSHWDAEH FLFIAEHGYL YEHNFAFFPG FPLALLVGTE 100
    LLRPLRGLLS LRSCLLISVA SLNFLFFMLA AVALHDLGCL VLHCPHQSFY 150
    AALLFCLSPA NVFLAAGYSE ALFALLTFSA MGQLERGRVW TSVLLFAFAT 200
    GVRSNGLVSV GFLMHSQCQG FFSSLTMLNP LRQLFKLMAS LFLSVFTLGL 250
    PFALFQYYAY TQFCLPGSAR PIPEPLVQLA VDKGYRIAEG NEPPWCFWDV 300
    PLIYSYIQDV YWNVGFLKYY ELKQVPNFLL AAPVAILVAW ATWTYVTTHP 350
    WLCLTLGLQR SKNNKTLEKP DLGFLSPQVF VYVVHAAVLL LFGGLCMHVQ 400
    VLTRFLGSST PIMYWFPAHL LQDQEPLLRS LKTVPWKPLA EDSPPGQKVP 450
    RNPIMGLLYH WKTCSPVTRY ILGYFLTYWL LGLLLHCNFL PWT 493
    Length:493
    Mass (Da):55,713
    Last modified:October 1, 2000 - v1
    Checksum:i087AE31E51BDD519
    GO

    Sequence cautioni

    The sequence CAI21625.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI21626.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI21627.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331I → T in BAA91196. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti256 – 2561Q → K in HPMRS1. 1 Publication
    VAR_064190
    Natural varianti341 – 3411A → E in HPMRS1. 1 Publication
    VAR_064191
    Natural varianti341 – 3411A → V in HPMRS1. 1 Publication
    VAR_064192
    Natural varianti385 – 3851H → P in HPMRS1. 1 Publication
    VAR_064193

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000484 mRNA. Translation: BAA91196.1.
    AL034380 Genomic DNA. Translation: CAB92120.1.
    AL034380 Genomic DNA. Translation: CAI21625.1. Sequence problems.
    AL034380 Genomic DNA. Translation: CAI21626.1. Sequence problems.
    AL034380 Genomic DNA. Translation: CAI21627.1. Sequence problems.
    CH471059 Genomic DNA. Translation: EAX07790.1.
    CH471059 Genomic DNA. Translation: EAX07791.1.
    CH471059 Genomic DNA. Translation: EAX07792.1.
    BC013568 mRNA. Translation: AAH13568.1.
    CCDSiCCDS287.1.
    RefSeqiNP_001189483.1. NM_001202554.1.
    NP_060307.2. NM_017837.3.
    UniGeneiHs.259605.
    Hs.732254.

    Genome annotation databases

    EnsembliENST00000078527; ENSP00000078527; ENSG00000060642.
    ENST00000374145; ENSP00000363260; ENSG00000060642.
    GeneIDi55650.
    KEGGihsa:55650.
    UCSCiuc001bmz.3. human.

    Polymorphism databases

    DMDMi74752975.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000484 mRNA. Translation: BAA91196.1 .
    AL034380 Genomic DNA. Translation: CAB92120.1 .
    AL034380 Genomic DNA. Translation: CAI21625.1 . Sequence problems.
    AL034380 Genomic DNA. Translation: CAI21626.1 . Sequence problems.
    AL034380 Genomic DNA. Translation: CAI21627.1 . Sequence problems.
    CH471059 Genomic DNA. Translation: EAX07790.1 .
    CH471059 Genomic DNA. Translation: EAX07791.1 .
    CH471059 Genomic DNA. Translation: EAX07792.1 .
    BC013568 mRNA. Translation: AAH13568.1 .
    CCDSi CCDS287.1.
    RefSeqi NP_001189483.1. NM_001202554.1.
    NP_060307.2. NM_017837.3.
    UniGenei Hs.259605.
    Hs.732254.

    3D structure databases

    ProteinModelPortali Q9NUD9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120782. 2 interactions.
    STRINGi 9606.ENSP00000078527.

    Protein family/group databases

    CAZyi GT76. Glycosyltransferase Family 76.

    PTM databases

    PhosphoSitei Q9NUD9.

    Polymorphism databases

    DMDMi 74752975.

    Proteomic databases

    PaxDbi Q9NUD9.
    PRIDEi Q9NUD9.

    Protocols and materials databases

    DNASUi 55650.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000078527 ; ENSP00000078527 ; ENSG00000060642 .
    ENST00000374145 ; ENSP00000363260 ; ENSG00000060642 .
    GeneIDi 55650.
    KEGGi hsa:55650.
    UCSCi uc001bmz.3. human.

    Organism-specific databases

    CTDi 55650.
    GeneCardsi GC01P027113.
    H-InvDB HIX0159960.
    HGNCi HGNC:26031. PIGV.
    MIMi 239300. phenotype.
    610274. gene.
    neXtProti NX_Q9NUD9.
    Orphaneti 247262. Hyperphosphatasia-intellectual disability syndrome.
    PharmGKBi PA134952230.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5542.
    HOGENOMi HOG000232162.
    HOVERGENi HBG080592.
    InParanoidi Q9NUD9.
    KOi K07542.
    OMAi FLKYYEL.
    OrthoDBi EOG7VDXPB.
    PhylomeDBi Q9NUD9.
    TreeFami TF314515.

    Enzyme and pathway databases

    UniPathwayi UPA00196 .
    Reactomei REACT_952. Synthesis of glycosylphosphatidylinositol (GPI).

    Miscellaneous databases

    GeneWikii PIGV.
    GenomeRNAii 55650.
    NextBioi 60346.
    PROi Q9NUD9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NUD9.
    Bgeei Q9NUD9.
    CleanExi HS_PIGV.
    Genevestigatori Q9NUD9.

    Family and domain databases

    InterProi IPR007315. GPI_Mannosyltransferase_2.
    [Graphical view ]
    PANTHERi PTHR12468. PTHR12468. 1 hit.
    Pfami PF04188. Mannosyl_trans2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "Familial hyperphosphatase with mental retardation, seizures, and neurologic deficits."
      Mabry C.C., Bautista A., Kirk R.F., Dubilier L.D., Braunstein H., Koepke J.A.
      J. Pediatr. 77:74-85(1970) [PubMed] [Europe PMC] [Abstract]
      Cited for: DESCRIPTION OF HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME.
    6. "Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly."
      Fabre A.-L., Orlean P., Taron C.H.
      FEBS J. 272:1160-1168(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol."
      Kang J.Y., Hong Y., Ashida H., Shishioh N., Murakami Y., Morita Y.S., Maeda Y., Kinoshita T.
      J. Biol. Chem. 280:9489-9497(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, LACK OF GLYCOSYLATION, MUTAGENESIS OF TRP-66; ASP-67; 293-PRO-PRO-294; GLN-308 AND TRP-312.
    8. "Hyperphosphatasia with seizures, neurologic deficit, and characteristic facial features: Five new patients with Mabry syndrome."
      Thompson M.D., Nezarati M.M., Gillessen-Kaesbach G., Meinecke P., Mendoza R., Mornet E., Brun-Heath I., Squarcioni C.P., Legeai-Mallet L., Munnich A., Cole D.E.
      Am. J. Med. Genet. A 152:1661-1669(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: DESCRIPTION OF HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME.
    9. Cited for: VARIANTS HPMRS1 LYS-256; VAL-341; GLU-341 AND PRO-385.

    Entry informationi

    Entry nameiPIGV_HUMAN
    AccessioniPrimary (citable) accession number: Q9NUD9
    Secondary accession number(s): D3DPL2
    , Q5JYG7, Q5JYG8, Q5JYG9, Q9NX26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3