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Protein

Zinc finger CCHC domain-containing protein 3

Gene

ZCCHC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri334 – 35118CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 36918CCHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 38818CCHC-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 3
Gene namesi
Name:ZCCHC3
Synonyms:C20orf99
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16230. ZCCHC3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25806.

Polymorphism and mutation databases

BioMutaiZCCHC3.
DMDMi23396534.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Zinc finger CCHC domain-containing protein 3PRO_0000150951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki45 – 45Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei202 – 2021PhosphotyrosineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NUD5.
MaxQBiQ9NUD5.
PaxDbiQ9NUD5.
PRIDEiQ9NUD5.

PTM databases

iPTMnetiQ9NUD5.
PhosphoSiteiQ9NUD5.

Expressioni

Gene expression databases

BgeeiQ9NUD5.
CleanExiHS_ZCCHC3.
GenevisibleiQ9NUD5. HS.

Organism-specific databases

HPAiHPA042972.

Interactioni

Protein-protein interaction databases

BioGridi124492. 23 interactions.
IntActiQ9NUD5. 8 interactions.
STRINGi9606.ENSP00000371789.

Structurei

3D structure databases

ProteinModelPortaliQ9NUD5.
SMRiQ9NUD5. Positions 353-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 715Poly-Gly
Compositional biasi126 – 1349Poly-Ala
Compositional biasi155 – 1595Poly-Ala

Sequence similaritiesi

Contains 3 CCHC-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri334 – 35118CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 36918CCHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 38818CCHC-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410KDWA. Eukaryota.
ENOG4112A5Z. LUCA.
HOGENOMiHOG000115679.
HOVERGENiHBG068441.
InParanoidiQ9NUD5.
OrthoDBiEOG73BVD3.
PhylomeDBiQ9NUD5.
TreeFamiTF334042.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 3 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATGGGAEEE RKRGRPQLLP PARPAARGEE ADGGREKMGW AQVVKNLAEK
60 70 80 90 100
KGEFREPRPP RREEESGGGG GSAGLGGPAG LAAPDLGDFP PAGRGDPKGR
110 120 130 140 150
RRDPAGEAVD PRKKKGAAEA GRRKKAEAAA AAMATPARPG EAEDAAERPL
160 170 180 190 200
QDEPAAAAAG PGKGRFLVRI CFQGDEGACP TRDFVVGALI LRSIGMDPSD
210 220 230 240 250
IYAVIQIPGS REFDVSFRSA EKLALFLRVY EEKREQEDCW ENFVVLGRSK
260 270 280 290 300
SSLKTLFILF RNETVDVEDI VTWLKRHCDV LAVPVKVTDR FGIWTGEYKC
310 320 330 340 350
EIELRQGEGG VRHLPGAFFL GAERGYSWYK GQPKTCFKCG SRTHMSGSCT
360 370 380 390 400
QDRCFRCGEE GHLSPYCRKG IVCNLCGKRG HAFAQCPKAV HNSVAAQLTG

VAGH
Length:404
Mass (Da):43,618
Last modified:October 1, 2000 - v1
Checksum:iC3B728090D2D7A4B
GO
Isoform 2 (identifier: Q9NUD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-213: Missing.

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):26,654
Checksum:iB7F8A73818DBE9B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 1551Missing in AAH69238 (PubMed:15489334).Curated
Sequence conflicti263 – 2631E → D in AAI07585 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei49 – 213165Missing in isoform 2. 1 PublicationVSP_055996Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034548 Genomic DNA. Translation: CAB81631.1.
BC069238 mRNA. Translation: AAH69238.1.
BC107584 mRNA. Translation: AAI07585.1.
RefSeqiNP_149080.2. NM_033089.6.
UniGeneiHs.28608.
Hs.603608.

Genome annotation databases

EnsembliENST00000500893; ENSP00000484056; ENSG00000247315.
GeneIDi85364.
KEGGihsa:85364.
UCSCiuc032oxz.2. human. [Q9NUD5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034548 Genomic DNA. Translation: CAB81631.1.
BC069238 mRNA. Translation: AAH69238.1.
BC107584 mRNA. Translation: AAI07585.1.
RefSeqiNP_149080.2. NM_033089.6.
UniGeneiHs.28608.
Hs.603608.

3D structure databases

ProteinModelPortaliQ9NUD5.
SMRiQ9NUD5. Positions 353-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124492. 23 interactions.
IntActiQ9NUD5. 8 interactions.
STRINGi9606.ENSP00000371789.

PTM databases

iPTMnetiQ9NUD5.
PhosphoSiteiQ9NUD5.

Polymorphism and mutation databases

BioMutaiZCCHC3.
DMDMi23396534.

Proteomic databases

EPDiQ9NUD5.
MaxQBiQ9NUD5.
PaxDbiQ9NUD5.
PRIDEiQ9NUD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000500893; ENSP00000484056; ENSG00000247315.
GeneIDi85364.
KEGGihsa:85364.
UCSCiuc032oxz.2. human. [Q9NUD5-1]

Organism-specific databases

CTDi85364.
GeneCardsiZCCHC3.
H-InvDBHIX0015550.
HIX0138064.
HGNCiHGNC:16230. ZCCHC3.
HPAiHPA042972.
neXtProtiNX_Q9NUD5.
PharmGKBiPA25806.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDWA. Eukaryota.
ENOG4112A5Z. LUCA.
HOGENOMiHOG000115679.
HOVERGENiHBG068441.
InParanoidiQ9NUD5.
OrthoDBiEOG73BVD3.
PhylomeDBiQ9NUD5.
TreeFamiTF334042.

Miscellaneous databases

GenomeRNAii85364.
NextBioi75891.
PROiQ9NUD5.

Gene expression databases

BgeeiQ9NUD5.
CleanExiHS_ZCCHC3.
GenevisibleiQ9NUD5. HS.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 3 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver.
  3. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-45.
    Tissue: Mammary cancer.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZCHC3_HUMAN
AccessioniPrimary (citable) accession number: Q9NUD5
Secondary accession number(s): Q3B7J3, Q6NT79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.