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Protein

SERTA domain-containing protein 4

Gene

SERTAD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 4
Gene namesi
Name:SERTAD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25236. SERTAD4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134897438.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356SERTA domain-containing protein 4PRO_0000314139Add
BLAST

Proteomic databases

PaxDbiQ9NUC0.
PRIDEiQ9NUC0.

Expressioni

Gene expression databases

BgeeiQ9NUC0.
CleanExiHS_SERTAD4.
GenevestigatoriQ9NUC0.

Organism-specific databases

HPAiHPA027344.
HPA028514.

Interactioni

Protein-protein interaction databases

BioGridi121121. 13 interactions.
IntActiQ9NUC0. 3 interactions.
STRINGi9606.ENSP00000355979.

Structurei

3D structure databases

ProteinModelPortaliQ9NUC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 14747SERTAPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi212 – 24130Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 SERTA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG25597.
GeneTreeiENSGT00530000063876.
HOGENOMiHOG000154425.
HOVERGENiHBG108514.
InParanoidiQ9NUC0.
OMAiIHGEIIM.
OrthoDBiEOG77Q4X1.
PhylomeDBiQ9NUC0.
TreeFamiTF336235.

Family and domain databases

InterProiIPR009263. SERTA_dom.
IPR029708. SERTAD4.
[Graphical view]
PANTHERiPTHR14272:SF3. PTHR14272:SF3. 1 hit.
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NUC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLVLSMNRF CEPIVSEGAA EIAGYQTLWE ADSYGGPSPP GPAQAPLQGD
60 70 80 90 100
RGAGPPLAGS HYRGISNPIT TSKITYFKRK YVEEEDFHPP LSSCSHKTIS
110 120 130 140 150
IFEERAHILY MSLEKLKFID DPEVYLRRSV LINNLMKRIH GEIIMQNNWC
160 170 180 190 200
FPACSFNGTS AQEWFMAQDC PYRKRPRMAK EECEKFHACC FYQECGGHYL
210 220 230 240 250
NLPLSVNANV GSASTAASSP SASSSSSSSS SSPPLPLPSC SRQVDFDVGS
260 270 280 290 300
ASIYKSDGQI PANEIFVTNV RSLGVQEKAK LNDEKANDDT NRDGGPLSHE
310 320 330 340 350
PVGNDLAFEC KGQFYDYFET GYNERNNVNE SWKKSLRKKE ASPPSNKLCC

SKGSKI
Length:356
Mass (Da):39,348
Last modified:October 1, 2000 - v1
Checksum:iAC08F5241EFECE74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315386 mRNA. Translation: BAG37779.1.
AL035414 Genomic DNA. Translation: CAB81635.1.
CH471100 Genomic DNA. Translation: EAW93433.1.
BC012083 mRNA. Translation: AAH12083.1.
CCDSiCCDS1494.1.
RefSeqiNP_062551.1. NM_019605.3.
UniGeneiHs.600545.

Genome annotation databases

EnsembliENST00000367012; ENSP00000355979; ENSG00000082497.
GeneIDi56256.
KEGGihsa:56256.
UCSCiuc001hhy.3. human.

Polymorphism databases

DMDMi74752974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315386 mRNA. Translation: BAG37779.1.
AL035414 Genomic DNA. Translation: CAB81635.1.
CH471100 Genomic DNA. Translation: EAW93433.1.
BC012083 mRNA. Translation: AAH12083.1.
CCDSiCCDS1494.1.
RefSeqiNP_062551.1. NM_019605.3.
UniGeneiHs.600545.

3D structure databases

ProteinModelPortaliQ9NUC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121121. 13 interactions.
IntActiQ9NUC0. 3 interactions.
STRINGi9606.ENSP00000355979.

Polymorphism databases

DMDMi74752974.

Proteomic databases

PaxDbiQ9NUC0.
PRIDEiQ9NUC0.

Protocols and materials databases

DNASUi56256.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367012; ENSP00000355979; ENSG00000082497.
GeneIDi56256.
KEGGihsa:56256.
UCSCiuc001hhy.3. human.

Organism-specific databases

CTDi56256.
GeneCardsiGC01P210406.
HGNCiHGNC:25236. SERTAD4.
HPAiHPA027344.
HPA028514.
neXtProtiNX_Q9NUC0.
PharmGKBiPA134897438.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25597.
GeneTreeiENSGT00530000063876.
HOGENOMiHOG000154425.
HOVERGENiHBG108514.
InParanoidiQ9NUC0.
OMAiIHGEIIM.
OrthoDBiEOG77Q4X1.
PhylomeDBiQ9NUC0.
TreeFamiTF336235.

Miscellaneous databases

GenomeRNAii56256.
NextBioi61901.
PROiQ9NUC0.

Gene expression databases

BgeeiQ9NUC0.
CleanExiHS_SERTAD4.
GenevestigatoriQ9NUC0.

Family and domain databases

InterProiIPR009263. SERTA_dom.
IPR029708. SERTAD4.
[Graphical view]
PANTHERiPTHR14272:SF3. PTHR14272:SF3. 1 hit.
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Corpus callosum.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiSRTD4_HUMAN
AccessioniPrimary (citable) accession number: Q9NUC0
Secondary accession number(s): B2RD32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.