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Protein

SERTA domain-containing protein 4

Gene

SERTAD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000082497-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 4
Gene namesi
Name:SERTAD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25236. SERTAD4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000082497.
ENSG00000281230.
PharmGKBiPA134897438.

Polymorphism and mutation databases

BioMutaiSERTAD4.
DMDMi74752974.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141391 – 356SERTA domain-containing protein 4Add BLAST356

Proteomic databases

PaxDbiQ9NUC0.
PRIDEiQ9NUC0.

PTM databases

iPTMnetiQ9NUC0.
PhosphoSitePlusiQ9NUC0.

Expressioni

Gene expression databases

BgeeiENSG00000082497.
CleanExiHS_SERTAD4.
GenevisibleiQ9NUC0. HS.

Organism-specific databases

HPAiHPA027344.
HPA028514.

Interactioni

Protein-protein interaction databases

BioGridi121121. 13 interactors.
IntActiQ9NUC0. 3 interactors.
STRINGi9606.ENSP00000355979.

Structurei

3D structure databases

ProteinModelPortaliQ9NUC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 147SERTAPROSITE-ProRule annotationAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi212 – 241Ser-richAdd BLAST30

Sequence similaritiesi

Contains 1 SERTA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IE5V. Eukaryota.
ENOG4111FEG. LUCA.
GeneTreeiENSGT00530000063876.
HOGENOMiHOG000154425.
HOVERGENiHBG108514.
InParanoidiQ9NUC0.
OMAiIHGEIIM.
OrthoDBiEOG091G0BXM.
PhylomeDBiQ9NUC0.
TreeFamiTF336235.

Family and domain databases

InterProiIPR009263. SERTA_dom.
IPR029708. SERTAD4.
[Graphical view]
PANTHERiPTHR14272:SF4. PTHR14272:SF4. 1 hit.
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NUC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLVLSMNRF CEPIVSEGAA EIAGYQTLWE ADSYGGPSPP GPAQAPLQGD
60 70 80 90 100
RGAGPPLAGS HYRGISNPIT TSKITYFKRK YVEEEDFHPP LSSCSHKTIS
110 120 130 140 150
IFEERAHILY MSLEKLKFID DPEVYLRRSV LINNLMKRIH GEIIMQNNWC
160 170 180 190 200
FPACSFNGTS AQEWFMAQDC PYRKRPRMAK EECEKFHACC FYQECGGHYL
210 220 230 240 250
NLPLSVNANV GSASTAASSP SASSSSSSSS SSPPLPLPSC SRQVDFDVGS
260 270 280 290 300
ASIYKSDGQI PANEIFVTNV RSLGVQEKAK LNDEKANDDT NRDGGPLSHE
310 320 330 340 350
PVGNDLAFEC KGQFYDYFET GYNERNNVNE SWKKSLRKKE ASPPSNKLCC

SKGSKI
Length:356
Mass (Da):39,348
Last modified:October 1, 2000 - v1
Checksum:iAC08F5241EFECE74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315386 mRNA. Translation: BAG37779.1.
AL035414 Genomic DNA. Translation: CAB81635.1.
CH471100 Genomic DNA. Translation: EAW93433.1.
BC012083 mRNA. Translation: AAH12083.1.
CCDSiCCDS1494.1.
RefSeqiNP_062551.1. NM_019605.3.
UniGeneiHs.600545.

Genome annotation databases

EnsembliENST00000367012; ENSP00000355979; ENSG00000082497.
ENST00000630425; ENSP00000486369; ENSG00000281230.
GeneIDi56256.
KEGGihsa:56256.
UCSCiuc001hhy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315386 mRNA. Translation: BAG37779.1.
AL035414 Genomic DNA. Translation: CAB81635.1.
CH471100 Genomic DNA. Translation: EAW93433.1.
BC012083 mRNA. Translation: AAH12083.1.
CCDSiCCDS1494.1.
RefSeqiNP_062551.1. NM_019605.3.
UniGeneiHs.600545.

3D structure databases

ProteinModelPortaliQ9NUC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121121. 13 interactors.
IntActiQ9NUC0. 3 interactors.
STRINGi9606.ENSP00000355979.

PTM databases

iPTMnetiQ9NUC0.
PhosphoSitePlusiQ9NUC0.

Polymorphism and mutation databases

BioMutaiSERTAD4.
DMDMi74752974.

Proteomic databases

PaxDbiQ9NUC0.
PRIDEiQ9NUC0.

Protocols and materials databases

DNASUi56256.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367012; ENSP00000355979; ENSG00000082497.
ENST00000630425; ENSP00000486369; ENSG00000281230.
GeneIDi56256.
KEGGihsa:56256.
UCSCiuc001hhy.4. human.

Organism-specific databases

CTDi56256.
GeneCardsiSERTAD4.
HGNCiHGNC:25236. SERTAD4.
HPAiHPA027344.
HPA028514.
neXtProtiNX_Q9NUC0.
OpenTargetsiENSG00000082497.
ENSG00000281230.
PharmGKBiPA134897438.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5V. Eukaryota.
ENOG4111FEG. LUCA.
GeneTreeiENSGT00530000063876.
HOGENOMiHOG000154425.
HOVERGENiHBG108514.
InParanoidiQ9NUC0.
OMAiIHGEIIM.
OrthoDBiEOG091G0BXM.
PhylomeDBiQ9NUC0.
TreeFamiTF336235.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000082497-MONOMER.

Miscellaneous databases

GenomeRNAii56256.
PROiQ9NUC0.

Gene expression databases

BgeeiENSG00000082497.
CleanExiHS_SERTAD4.
GenevisibleiQ9NUC0. HS.

Family and domain databases

InterProiIPR009263. SERTA_dom.
IPR029708. SERTAD4.
[Graphical view]
PANTHERiPTHR14272:SF4. PTHR14272:SF4. 1 hit.
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRTD4_HUMAN
AccessioniPrimary (citable) accession number: Q9NUC0
Secondary accession number(s): B2RD32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.