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Protein

Forkhead box protein D4-like 1

Gene

FOXD4L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi107 – 201Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 1
Short name:
FOXD4-like 1
Gene namesi
Name:FOXD4L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000184492.6
HGNCiHGNC:18521 FOXD4L1
MIMi611084 gene
neXtProtiNX_Q9NU39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184492
PharmGKBiPA134928763

Polymorphism and mutation databases

BioMutaiFOXD4L1
DMDMi27923782

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918241 – 408Forkhead box protein D4-like 1Add BLAST408

Proteomic databases

EPDiQ9NU39
PaxDbiQ9NU39
PeptideAtlasiQ9NU39
PRIDEiQ9NU39

PTM databases

iPTMnetiQ9NU39
PhosphoSitePlusiQ9NU39

Expressioni

Gene expression databases

BgeeiENSG00000184492
CleanExiHS_FOXD4L1
GenevisibleiQ9NU39 HS

Organism-specific databases

HPAiHPA012836

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi128321, 1 interactor
IntActiQ9NU39, 21 interactors
MINTiQ9NU39
STRINGi9606.ENSP00000302756

Structurei

3D structure databases

ProteinModelPortaliQ9NU39
SMRiQ9NU39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi210 – 317Pro-richAdd BLAST108

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231285
HOVERGENiHBG051641
InParanoidiQ9NU39
KOiK09397
OMAiCAISCAP
OrthoDBiEOG091G0HW9
PhylomeDBiQ9NU39
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NU39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEASQKF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGPS DPSEFGTEFR APPRSAAASE
110 120 130 140 150
DARQPAKPPY SYIALITMAI LQSPHKRLTL SGICAFISGR FPYYRRKFPA
160 170 180 190 200
WQNSIRHNLS LNDCFVKIPR EPGHPGKGTY WSLDPASQDM FDNGSFLRRR
210 220 230 240 250
KRFKRHQLTP GAHLPHPFPL PAAHAALHNP RPGPLLGAPA LPQPVPGAYP
260 270 280 290 300
NTAPGRRPYA LLHPHPPRYL LLSAPAYAGA PKKAEGADLA TPGTLPVLQP
310 320 330 340 350
SLGPQPWEEG KGLASPPGGG CISFSIESIM QGVRGAGTGA AQSLSPTAWS
360 370 380 390 400
YCPLLQRPSS LSDNFAATAA ASGGGLRQRL RSHQGRGAGR APVGRVGAAA

VSGGGRGL
Length:408
Mass (Da):43,610
Last modified:October 1, 2000 - v1
Checksum:i9FD4B5688B0CE758
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05929929V → I. Corresponds to variant dbSNP:rs9308683Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452723 mRNA Translation: AAN64908.1
AY344639 mRNA Translation: AAQ76877.1
AK125398 mRNA Translation: BAG54193.1
AL078621 Genomic DNA No translation available.
BC136428 mRNA Translation: AAI36429.1
CCDSiCCDS2117.1
RefSeqiNP_036316.1, NM_012184.4
UniGeneiHs.591554

Genome annotation databases

EnsembliENST00000306507; ENSP00000302756; ENSG00000184492
GeneIDi200350
KEGGihsa:200350
UCSCiuc002tjw.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFX4L1_HUMAN
AccessioniPrimary (citable) accession number: Q9NU39
Secondary accession number(s): B3KWN1, B9EGF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health