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Protein

LYR motif-containing protein 2

Gene

LYRM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083099-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
LYR motif-containing protein 2
Gene namesi
Name:LYRM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:25229. LYRM2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000083099.
PharmGKBiPA162394751.

Polymorphism and mutation databases

BioMutaiLYRM2.
DMDMi74734344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002511751 – 88LYR motif-containing protein 2Add BLAST88

Proteomic databases

EPDiQ9NU23.
MaxQBiQ9NU23.
PaxDbiQ9NU23.
PeptideAtlasiQ9NU23.
PRIDEiQ9NU23.
TopDownProteomicsiQ9NU23.

PTM databases

iPTMnetiQ9NU23.
PhosphoSitePlusiQ9NU23.

Expressioni

Gene expression databases

BgeeiENSG00000083099.
CleanExiHS_LYRM2.
ExpressionAtlasiQ9NU23. baseline and differential.
GenevisibleiQ9NU23. HS.

Organism-specific databases

HPAiHPA063932.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-10313813,EBI-10175124

Protein-protein interaction databases

BioGridi121461. 11 interactors.
IntActiQ9NU23. 1 interactor.
STRINGi9606.ENSP00000430025.

Structurei

3D structure databases

ProteinModelPortaliQ9NU23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiENOG410J39U. Eukaryota.
ENOG411277T. LUCA.
GeneTreeiENSGT00390000002957.
HOVERGENiHBG056773.
InParanoidiQ9NU23.
OMAiQDAIRMM.
PhylomeDBiQ9NU23.
TreeFamiTF323797.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR026868. Lyrm2.
[Graphical view]
PANTHERiPTHR13675. PTHR13675. 1 hit.
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NU23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASRLPPAT LTLKQFVRRQ QVLLLYRRIL QTIRQVPNDS DRKYLKDWAR
60 70 80
EEFRRNKSAT EEDTIRMMIT QGNMQLKELE KTLALAKS
Length:88
Mass (Da):10,449
Last modified:October 1, 2000 - v1
Checksum:i33F3189D286A95A0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05041734R → W.Corresponds to variant rs11553069dbSNPEnsembl.1
Natural variantiVAR_03409946K → E.1 PublicationCorresponds to variant rs34012596dbSNPEnsembl.1
Natural variantiVAR_05041860T → P.Corresponds to variant rs1055889dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311948 mRNA. Translation: BAG34889.1.
CH471051 Genomic DNA. Translation: EAW48547.1.
CH471051 Genomic DNA. Translation: EAW48549.1.
BC009782 mRNA. Translation: AAH09782.1.
BC104668 mRNA. Translation: AAI04669.1.
CCDSiCCDS5023.1.
RefSeqiNP_065199.1. NM_020466.4.
UniGeneiHs.177275.

Genome annotation databases

EnsembliENST00000523377; ENSP00000430025; ENSG00000083099.
GeneIDi57226.
KEGGihsa:57226.
UCSCiuc003pnm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311948 mRNA. Translation: BAG34889.1.
CH471051 Genomic DNA. Translation: EAW48547.1.
CH471051 Genomic DNA. Translation: EAW48549.1.
BC009782 mRNA. Translation: AAH09782.1.
BC104668 mRNA. Translation: AAI04669.1.
CCDSiCCDS5023.1.
RefSeqiNP_065199.1. NM_020466.4.
UniGeneiHs.177275.

3D structure databases

ProteinModelPortaliQ9NU23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121461. 11 interactors.
IntActiQ9NU23. 1 interactor.
STRINGi9606.ENSP00000430025.

PTM databases

iPTMnetiQ9NU23.
PhosphoSitePlusiQ9NU23.

Polymorphism and mutation databases

BioMutaiLYRM2.
DMDMi74734344.

Proteomic databases

EPDiQ9NU23.
MaxQBiQ9NU23.
PaxDbiQ9NU23.
PeptideAtlasiQ9NU23.
PRIDEiQ9NU23.
TopDownProteomicsiQ9NU23.

Protocols and materials databases

DNASUi57226.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000523377; ENSP00000430025; ENSG00000083099.
GeneIDi57226.
KEGGihsa:57226.
UCSCiuc003pnm.4. human.

Organism-specific databases

CTDi57226.
GeneCardsiLYRM2.
HGNCiHGNC:25229. LYRM2.
HPAiHPA063932.
neXtProtiNX_Q9NU23.
OpenTargetsiENSG00000083099.
PharmGKBiPA162394751.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J39U. Eukaryota.
ENOG411277T. LUCA.
GeneTreeiENSGT00390000002957.
HOVERGENiHBG056773.
InParanoidiQ9NU23.
OMAiQDAIRMM.
PhylomeDBiQ9NU23.
TreeFamiTF323797.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083099-MONOMER.

Miscellaneous databases

ChiTaRSiLYRM2. human.
GenomeRNAii57226.
PROiQ9NU23.

Gene expression databases

BgeeiENSG00000083099.
CleanExiHS_LYRM2.
ExpressionAtlasiQ9NU23. baseline and differential.
GenevisibleiQ9NU23. HS.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR026868. Lyrm2.
[Graphical view]
PANTHERiPTHR13675. PTHR13675. 1 hit.
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYRM2_HUMAN
AccessioniPrimary (citable) accession number: Q9NU23
Secondary accession number(s): B2R4U2, E1P517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.