Q9NU23 (LYRM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LYR motif-containing protein 2

Gene names

Name:

LYRM2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	88 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the complex I LYR family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 88	88	LYR motif-containing protein 2		PRO_0000251175
Natural variations
	Natural variant	34	1	R → W. Corresponds to variant rs11553069 [ dbSNP | Ensembl ].		VAR_050417
	Natural variant	46	1	K → E. Ref.1 Corresponds to variant rs34012596 [ dbSNP | Ensembl ].		VAR_034099
	Natural variant	60	1	T → P. Corresponds to variant rs1055889 [ dbSNP | Ensembl ].		VAR_050418

Sequences

	Sequence		Length	Mass (Da)
	Q9NU23 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 33F3189D286A95A0	FASTA	88	10,449
	10 20 30 40 50 60 MAASRLPPAT LTLKQFVRRQ QVLLLYRRIL QTIRQVPNDS DRKYLKDWAR EEFRRNKSAT 70 80 EEDTIRMMIT QGNMQLKELE KTLALAKS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-46. Tissue: Testis.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Gall bladder.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK311948 mRNA. Translation: BAG34889.1. CH471051 Genomic DNA. Translation: EAW48547.1. CH471051 Genomic DNA. Translation: EAW48549.1. BC009782 mRNA. Translation: AAH09782.1. BC104668 mRNA. Translation: AAI04669.1.
IPI	IPI00007148.
RefSeq	NP_065199.1. NM_020466.4.
UniGene	Hs.177275.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9NU23.
Polymorphism databases
DMDM	74734344.
Proteomic databases
PaxDb	Q9NU23.
PRIDE	Q9NU23.
Protocols and materials databases
DNASU	57226.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000523377; ENSP00000430025; ENSG00000083099.
GeneID	57226.
KEGG	hsa:57226.
UCSC	uc003pnm.3. human.
Organism-specific databases
CTD	57226.
GeneCards	GC06M090311.
HGNC	HGNC:25229. LYRM2.
neXtProt	NX_Q9NU23.
PharmGKB	PA162394751.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG77547.
HOVERGEN	HBG056773.
InParanoid	Q9NU23.
OMA	AIRMMIT.
OrthoDB	EOG4W9J5M.
PhylomeDB	Q9NU23.
Gene expression databases
ArrayExpress	Q9NU23.
Bgee	Q9NU23.
CleanEx	HS_LYRM2.
Genevestigator	Q9NU23.
GermOnline	ENSG00000083099. Homo sapiens.
Family and domain databases
InterPro	IPR008011. Complex1_LYR. IPR026868. Lyrm2. [Graphical view]
PANTHER	PTHR13675. PTHR13675. 1 hit.
Pfam	PF05347. Complex1_LYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LYRM2. human.
GenomeRNAi	57226.
NextBio	63365.

Entry information

Entry name

LYRM2_HUMAN

Accession

Primary (citable) accession number: Q9NU23
Secondary accession number(s): B2R4U2, E1P517

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.