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Q9NU22 (MDN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Midasin
Alternative name(s):
MIDAS-containing protein
Gene names
Name:MDN1
Synonyms:KIAA0301
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length5596 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits By similarity.

Subcellular location

Nucleus By similarity. Nucleusnucleolus Ref.14.

Sequence similarities

Belongs to the midasin family.

Contains 1 VWFA domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PELP1Q8IZL83EBI-1050480,EBI-716449

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 55965596Midasin
PRO_0000096336

Regions

Domain5384 – 5583200VWFA
Nucleotide binding329 – 3368ATP Potential
Nucleotide binding677 – 6848ATP Potential
Nucleotide binding1084 – 10918ATP Potential
Nucleotide binding1390 – 13978ATP Potential
Nucleotide binding1753 – 17608ATP Potential
Nucleotide binding2066 – 20738ATP Potential
Compositional bias3566 – 35738Poly-Glu
Compositional bias4784 – 47918Poly-Glu
Compositional bias5008 – 50136Poly-Glu
Compositional bias5182 – 51876Poly-Glu

Amino acid modifications

Modified residue11N-acetylmethionine Ref.7
Modified residue11771Phosphothreonine Ref.13
Modified residue16831N6-acetyllysine Ref.10
Modified residue45381Phosphoserine Ref.5 Ref.6 Ref.8 Ref.9 Ref.11 Ref.13
Modified residue47521Phosphoserine Ref.9 Ref.13
Modified residue47541Phosphoserine Ref.9 Ref.13
Modified residue48891Phosphoserine Ref.13
Modified residue48981Phosphothreonine Ref.4 Ref.5 Ref.6 Ref.11 Ref.13
Modified residue49371Phosphoserine Ref.13
Modified residue49461Phosphoserine Ref.13
Modified residue50151Phosphoserine Ref.13

Natural variations

Natural variant4401F → V.
Corresponds to variant rs4707569 [ dbSNP | Ensembl ].
VAR_024234
Natural variant6601I → V.
Corresponds to variant rs12110451 [ dbSNP | Ensembl ].
VAR_051171
Natural variant10441A → V.
Corresponds to variant rs34764513 [ dbSNP | Ensembl ].
VAR_051172
Natural variant15591S → N.
Corresponds to variant rs4140446 [ dbSNP | Ensembl ].
VAR_024235
Natural variant19291H → D.
Corresponds to variant rs16882099 [ dbSNP | Ensembl ].
VAR_051173
Natural variant29721H → P.
Corresponds to variant rs34208137 [ dbSNP | Ensembl ].
VAR_051174
Natural variant30041E → K.
Corresponds to variant rs12530146 [ dbSNP | Ensembl ].
VAR_051175
Natural variant34231H → Y.
Corresponds to variant rs9294445 [ dbSNP | Ensembl ].
VAR_051176
Natural variant37941A → G.
Corresponds to variant rs34766278 [ dbSNP | Ensembl ].
VAR_051177
Natural variant39861R → L.
Corresponds to variant rs17293121 [ dbSNP | Ensembl ].
VAR_051178
Natural variant40441A → S.
Corresponds to variant rs9353689 [ dbSNP | Ensembl ].
VAR_024236
Natural variant41671A → T.
Corresponds to variant rs35509794 [ dbSNP | Ensembl ].
VAR_051179
Natural variant47201I → T.
Corresponds to variant rs16882046 [ dbSNP | Ensembl ].
VAR_051180
Natural variant47831D → E.
Corresponds to variant rs36040566 [ dbSNP | Ensembl ].
VAR_051181
Natural variant52511N → K.
Corresponds to variant rs4707557 [ dbSNP | Ensembl ].
VAR_051182

Sequences

Sequence LengthMass (Da)Tools
Q9NU22 [UniParc].

Last modified October 19, 2002. Version 2.
Checksum: 586C62616A1F96D4

FASTA5,596632,820
        10         20         30         40         50         60 
MEHFLLEVAA APLRLIAAKN EKSRSELGRF LAKQVWTPQD RQCVLSTLAQ LLLDKDCTVL 

        70         80         90        100        110        120 
VGRQLRPLLL DLLERNAEAI KAGGQINHDL HERLCVSMSK LIGNHPDVLP FALRYFKDTS 

       130        140        150        160        170        180 
PVFQRLFLES SDANPVRYGR RRMKLRDLME AAFKFLQQEQ SVFRELWDWS VCVPLLRSHD 

       190        200        210        220        230        240 
TLVRWYTANC LALVTCMNEE HKLSFLKKIF NSDELIHFRL RLLEEAQLQD LEKALVLANP 

       250        260        270        280        290        300 
EVSLWRKQKE LQYLQGHLVS SDLSPRVTAV CGVVLPGQLP APGELGGNRS SSREQELALR 

       310        320        330        340        350        360 
SYVLVESVCK SLQTLAMAVA SQNAVLLEGP IGCGKTSLVE YLAAVTGRTK PPQLLKVQLG 

       370        380        390        400        410        420 
DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATMGHWILL EDIDYAPLDV VSVLIPLLEN 

       430        440        450        460        470        480 
GELLIPGRGD CLKVAPGFQF FATRRLLSCG GNWYRPLNSH ATLLDKYWTK IHLDNLDKRE 

       490        500        510        520        530        540 
LNEVLQSRYP SLLAVVDHLL DIYIQLTGEK HHSWSDSSVG CEQAPEEVSE ARRENKRPTL 

       550        560        570        580        590        600 
EGRELSLRDL LNWCNRIAHS FDSSSLSASL NIFQEALDCF TAMLSEHTSK LKMAEVIGSK 

       610        620        630        640        650        660 
LNISRKKAEF FCQLYKPEIV INELDLQVGR VRLLRKQSEA VHLQREKFTF AATRPSSVLI 

       670        680        690        700        710        720 
EQLAVCVSKG EPVLLVGETG TGKTSTIQYL AHITGHRLRV VNMNQQSDTA DLLGGYKPVD 

       730        740        750        760        770        780 
HKLIWLPLRE AFEELFAQTF SKKQNFTFLG HIQTCYRQKR WHDLLRLMQH VHKSAVNKDG 

       790        800        810        820        830        840 
KDSETGLLIK EKWEAFGLRL NHAQQQMKMT ENTLLFAFVE GTLAQAVKKG EWILLDEINL 

       850        860        870        880        890        900 
AAPEILECLS GLLEGSSGSL VLLDRGDTEP LVRHPDFRLF ACMNPATDVG KRNLPPGIRN 

       910        920        930        940        950        960 
RFTELYVEEL ESKEDLQVLI VDYLKGLSVN KNTVQGIINF YTALRKESGT KLVDGTGHRP 

       970        980        990       1000       1010       1020 
HYSLRTLCRA LRFAASNPCG NIQRSLYEGF CLGFLTQLDR ASHPIVQKLI CQHIVPGNVK 

      1030       1040       1050       1060       1070       1080 
SLLKQPIPEP KGGRLIQVEG YWIAVGDKEP TIDETYILTS SVKLNLRDIV RVVSAGTYPV 

      1090       1100       1110       1120       1130       1140 
LIQGETSVGK TSLIQWLAAA TGNHCVRINN HEHTDIQEYI GCYTSDSSGK LVFKEGVLID 

      1150       1160       1170       1180       1190       1200 
AMRKGYWIIL DELNLAPTDV LEALNRLLDD NRELLVTETQ EVVKAHPRFM LFATQNPPGL 

      1210       1220       1230       1240       1250       1260 
YGGRKVLSRA FRNRFVELHF DELPSSELET ILHKRCSLPP SYCSKLVKVM LDLQSYRRSS 

      1270       1280       1290       1300       1310       1320 
SVFAGKQGFI TLRDLFRWAE RYRLAEPTEK EYDWLQHLAN DGYMLLAGRV RKQEEIDVIQ 

      1330       1340       1350       1360       1370       1380 
EVLEKHFKKK LCPQSLFSKE NVLKLLGKLS TQISTLECNF GHIVWTEGMR RLAMLVGRAL 

      1390       1400       1410       1420       1430       1440 
EFGEPVLLVG DTGCGKTTIC QVFAALANQK LYSVSCHLHM ETSDFLGGLR PVRQKPNDKE 

      1450       1460       1470       1480       1490       1500 
EIDTSRLFEW HDGPLVQAMK EDGFFLLDEI SLADDSVLER LNSVLEVEKS LVLAEKGSPE 

      1510       1520       1530       1540       1550       1560 
DKDSEIELLT AGKKFRILAT MNPGGDFGKK ELSPALRNRF TEIWCPQSTS REDLIQIISH 

      1570       1580       1590       1600       1610       1620 
NLRPGLCLGR IDPKGSDIPE VMLDFIDWLT HQEFGRKCVV SIRDILSWVN FMNKMGEEAA 

      1630       1640       1650       1660       1670       1680 
LKRPEIISTV TSFVHAACLV YIDGIGSGVT SSGFGTALLA RKECLKFLIK RLAKIVRLTE 

      1690       1700       1710       1720       1730       1740 
YQKNELKIYD RMKAKEFTGI DNLWGIHPFF IPRGPVLHRN NIADYALSAG TTAMNAQRLL 

      1750       1760       1770       1780       1790       1800 
RATKLKKPIL LEGSPGVGKT SLVGALAKAS GNTLVRINLS EQTDITDLFG ADLPVEGGKG 

      1810       1820       1830       1840       1850       1860 
GEFAWRDGPL LAALKAGHWV VLDELNLASQ SVLEGLNACF DHRGEIYVPE LGMSFQVQHE 

      1870       1880       1890       1900       1910       1920 
KTKIFGCQNP FRQGGGRKGL PRSFLNRFTQ VFVDPLTVID MEFIASTLFP AIEKNIVKKM 

      1930       1940       1950       1960       1970       1980 
VAFNNQIDHE VTVEKKWGQK GGPWEFNLRD LFRWCQLMLV DQSPGCYDPG QHVFLVYGER 

      1990       2000       2010       2020       2030       2040 
MRTEEDKKKV IAVFKDVFGS NSNPYMGTRL FRITPYDVQL GYSVLSRGSC VPHPSRHPLL 

      2050       2060       2070       2080       2090       2100 
LLHQSFQPLE SIMKCVQMSW MVILVGPASV GKTSLVQLLA HLTGHTLKIM AMNSAMDTTE 

      2110       2120       2130       2140       2150       2160 
LLGGFEQVDL IRPWRRLLEK VEGTVRALLR DSLLISADDA EVVLRAWSHF LLTYKPKCLG 

      2170       2180       2190       2200       2210       2220 
EGGKAITMEI VNKLEAVLLL MQRLNNKINS YCKAEFAKLV EEFRSFGVKL TQLASGHSHG 

      2230       2240       2250       2260       2270       2280 
TFEWVDSMLV QALKSGDWLL MDNVNFCNPS VLDRLNALLE PGGVLTISER GMIDGSTPTI 

      2290       2300       2310       2320       2330       2340 
TPNPNFRLFL SMDPVHGDIS RAMRNRGLEI YISGEGDAST PDNLDLKVLL HSLGLVGNSV 

      2350       2360       2370       2380       2390       2400 
CDILLALHTE TRSTVVGSPT SSVSTLIQTA ILIVQYLQRG LSLDRAFSEA CWEVYVCSQH 

      2410       2420       2430       2440       2450       2460 
SPANRKLVQA LLEKHVSSLR AHETWGDSIL GMGLWPDSVP SALFATEDSH LSTVRRDGQI 

      2470       2480       2490       2500       2510       2520 
LVYCLNRMSM KTSSWTRSQP FTLQDLEKIM QSPSPENLKF NAVEVNTYWI DEPDVLVMAV 

      2530       2540       2550       2560       2570       2580 
KLLIERATNQ DWMLRVKWLY HLAKNIPQGL ESIQIHLEAS AASLRNFYSH SLSGAVSNVF 

      2590       2600       2610       2620       2630       2640 
KILQPNTTDE FVIPLDPRWN MQALDMIRNL MDFDPQTDQP DQLFALLESA ANKTIIYLDR 

      2650       2660       2670       2680       2690       2700 
EKRVFTEANL VSVGSKKLRE SVLRMSFEFH QDPESYHTLP HEIVVNLAAF FELCDALVLL 

      2710       2720       2730       2740       2750       2760 
WVQSSQGMVS DASANEILGS LRWRDRFWTV ADTVKVDAPG LALLALHWHW VLKHLVHQIP 

      2770       2780       2790       2800       2810       2820 
RLLMNYEDKY YKEVQTVSEH IQNCLGSQTG GFAGIKKLQK FLGRPFPFKD KLVVECFSQL 

      2830       2840       2850       2860       2870       2880 
KVLNKVLAIR EQMSALGESG WQEDINRLQV VASQWTLKKS LLQAWGLILR ANILEDVSLD 

      2890       2900       2910       2920       2930       2940 
ELKNFVHAQC LELKAKGLSL GFLEKKHDEA SSLSHPDLTS VIHLTRSVQL WPAMEYLAML 

      2950       2960       2970       2980       2990       3000 
WRYKVTADFM AQACLRRCSK NQQPQINEEI SHLISFCLYH TPVTPQELRD LWSLLHHQKV 

      3010       3020       3030       3040       3050       3060 
SPEEITSLWS ELFNSMFMSF WSSTVTTNPE YWLMWNPLPG MQQREAPKSV LDSTLKGPGN 

      3070       3080       3090       3100       3110       3120 
LNRPIFSKCC FEVLTSSWRA SPWDVSGLPI LSSSHVTLGE WVERTQQLQD ISSMLWTNMA 

      3130       3140       3150       3160       3170       3180 
ISSVAEFRRT DSQLQGQVLF RHLAGLAELL PESRRQEYMQ NCEQLLLGSS QAFQHVGQTL 

      3190       3200       3210       3220       3230       3240 
GDMAGQEVLP KELLCQLLTS LHHFVGEGES KRSLPEPAQR GSLWVSLGLL QIQTWLPQAR 

      3250       3260       3270       3280       3290       3300 
FDPAVKREYK LNYVKEELHQ LQCEWKTRNL SSQLQTGRDL EDEVVVSYSH PHVRLLRQRM 

      3310       3320       3330       3340       3350       3360 
DRLDNLTCHL LKKQAFRPQL PAYESLVQEI HHYVTSIAKA PAVQDLLTRL LQALHIDGPR 

      3370       3380       3390       3400       3410       3420 
SAQVAQSLLK EEASWQQSHH QFRKRLSEEY TFYPDAVSPL QASILQLQHG MRLVASELHT 

      3430       3440       3450       3460       3470       3480 
SLHSSMVGAD RLGTLATALL AFPSVGPTFP TYYAHADTLC SVKSEEVLRG LGKLILKRSG 

      3490       3500       3510       3520       3530       3540 
GKELEGKGQK ACPTREQLLM NALLYLRSHV LCKGELDQRA LQLFRHVCQE IISEWDEQER 

      3550       3560       3570       3580       3590       3600 
IAQEKAEQES GLYRYRSRNS RTALSEEEEE EREFRKQFPL HEKDFADILV QPTLEENKGT 

      3610       3620       3630       3640       3650       3660 
SDGQEEEAGT NPALLSQNSM QAVMLIHQQL CLNFARSLWY QQTLPPHEAK HYLSLFLSCY 

      3670       3680       3690       3700       3710       3720 
QTGASLVTHF YPLMGVELND RLLGSQLLAC TLSHNTLFGE APSDLMVKPD GPYDFYQHPN 

      3730       3740       3750       3760       3770       3780 
VPEARQCQPV LQGFSEAVSH LLQDWPEHPA LEQLLVVMDR IRSFPLSSPI SKFLNGLEIL 

      3790       3800       3810       3820       3830       3840 
LAKAQDWEEN ASRALSLRKH LDLISQMIIR WRKLELNCWS MSLDNTMKRH TEKSTKHWFS 

      3850       3860       3870       3880       3890       3900 
IYQMLEKHMQ EQTEEQEDDK QMTLMLLVST LQAFIEGSSL GEFHVRLQML LVFHCHVLLM 

      3910       3920       3930       3940       3950       3960 
PQVEGKDSLC SVLWNLYHYY KQFFDRVQAK IVELRSPLEK ELKEFVKISK WNDVSFWSIK 

      3970       3980       3990       4000       4010       4020 
QSVEKTHRTL FKFMKKFEAV LSEPCRSSLV ESDKEEQPDF LPRPTDGAAS ELSSIQNLNR 

      4030       4040       4050       4060       4070       4080 
ALRETLLAQP AAGQATIPEW CQGAAPSGLE GELLRRLPKL RKRMRKMCLT FMKESPLPRL 

      4090       4100       4110       4120       4130       4140 
VEGLDQFTGE VISSVSELQS LKVEPSAEKE KQRSEAKHIL MQKQRALSDL FKHLAKIGLS 

      4150       4160       4170       4180       4190       4200 
YRKGLAWARS KNPQEMLHLH PLDLQSALSI VSSTQEADSR LLTEISSSWD GCQKYFYRSL 

      4210       4220       4230       4240       4250       4260 
ARHARLNAAL ATPAKEMGMG NVERCRGFSA HLMKMLVRQR RSLTTLSEQW IILRNLLSCV 

      4270       4280       4290       4300       4310       4320 
QEIHSRLMGP QAYPVAFPPQ DGVQQWTERL QHLAMQCQIL LEQLSWLLQC CPSVGPAPGH 

      4330       4340       4350       4360       4370       4380 
GNVQVLGQPP GPCLEGPELS KGQLCGVVLD LIPSNLSYPS PIPGSQLPSG CRMRKQDHLW 

      4390       4400       4410       4420       4430       4440 
QQSTTRLTEM LKTIKTVKAD VDKIRQQSCE TLFHSWKDFE VCSSALSCLS QVSVHLQGLE 

      4450       4460       4470       4480       4490       4500 
SLFILPGMEV EQRDSQMALV ESLEYVRGEI SKAMADFTTW KTHLLTSDSQ GGNQMLDEGF 

      4510       4520       4530       4540       4550       4560 
VEDFSEQMEI AIRAILCAIQ NLEERKNEKA EENTDQASPQ EDYAGFERLQ SGHLTKLLED 

      4570       4580       4590       4600       4610       4620 
DFWADVSTLH VQKIISAISE LLERLKSYGE DGTAAKHLFF SQSCSLLVRL VPVLSSYSDL 

      4630       4640       4650       4660       4670       4680 
VLFFLTMSLA THRSTAKLLS VLAQVFTELA QKGFCLPKEF MEDSAGEGAT EFHDYEGGGI 

      4690       4700       4710       4720       4730       4740 
GEGEGMKDVS DQIGNEEQVE DTFQKGQEKD KEDPDSKSDI KGEDNAIEMS EDFDGKMHDG 

      4750       4760       4770       4780       4790       4800 
ELEEQEEDDE KSDSEGGDLD KHMGDLNGEE ADKLDERLWG DDDEEEDEEE EDNKTEETGP 

      4810       4820       4830       4840       4850       4860 
GMDEEDSELV AKDDNLDSGN SNKDKSQQDK KEEKEEAEAD DGGQGEDKIN EQIDERDYDE 

      4870       4880       4890       4900       4910       4920 
NEVDPYHGNQ EKVPEPEALD LPDDLNLDSE DKNGGEDTDN EEGEEENPLE IKEKPEEAGH 

      4930       4940       4950       4960       4970       4980 
EAEERGETET DQNESQSPQE PEEGPSEDDK AEGEEEMDTG ADDQDGDAAQ HPEEHSEEQQ 

      4990       5000       5010       5020       5030       5040 
QSVEEKDKEA DEEGGENGPA DQGFQPQEEE EREDSDTEEQ VPEALERKEH ASCGQTGVEN 

      5050       5060       5070       5080       5090       5100 
MQNTQAMELA GAAPEKEQGK EEHGSGAADA NQAEGHESNF IAQLASQKHT RKNTQSFKRK 

      5110       5120       5130       5140       5150       5160 
PGQADNERSM GDHNERVHKR LRTVDTDSHA EQGPAQQPQA QVEDADAFEH IKQGSDAYDA 

      5170       5180       5190       5200       5210       5220 
QTYDVASKEQ QQSAKDSGKD QEEEEIEDTL MDTEEQEEFK AADVEQLKPE EIKSGTTAPL 

      5230       5240       5250       5260       5270       5280 
GFDEMEVEIQ TVKTEEDQDP RTDKAHKETE NEKPERSRES TIHTAHQFLM DTIFQPFLKD 

      5290       5300       5310       5320       5330       5340 
VNELRQELER QLEMWQPRES GNPEEEKVAA EMWQSYLILT APLSQRLCEE LRLILEPTQA 

      5350       5360       5370       5380       5390       5400 
AKLKGDYRTG KRLNIRKVIP YIASQFRKDK IWLRRTKPSK RQYQICLAID DSSSMVDNHT 

      5410       5420       5430       5440       5450       5460 
KQLAFESLAV IGNALTLLEV GQIAVCSFGE SVKLLHPFHE QFSDYSGSQI LRLCKFQQKK 

      5470       5480       5490       5500       5510       5520 
TKIAQFLESV ANMFAAAQQL SQNISSETAQ LLLVVSDGRG LFLEGKERVL AAVQAARNAN 

      5530       5540       5550       5560       5570       5580 
IFVIFVVLDN PSSRDSILDI KVPIFKGPGE MPEIRSYMEE FPFPYYIILR DVNALPETLS 

      5590 
DALRQWFELV TASDHP 

« Hide

References

« Hide 'large scale' references
[1]"Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein."
Garbarino J.E., Gibbons I.R.
BMC Genomics 3:18-18(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2387-5596.
Tissue: Brain.
[4]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538 AND THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538 AND THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538; SER-4752 AND SER-4754, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[10]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1683, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538 AND THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1177; SER-4538; SER-4752; SER-4754; SER-4889; THR-4898; SER-4937; SER-4946 AND SER-5015, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization."
Ahmad Y., Boisvert F.M., Lundberg E., Uhlen M., Lamond A.I.
Mol. Cell. Proteomics 11:M111.013680.01-M111.013680.15(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF503925 mRNA. Translation: AAM77722.1.
AL096678, AL158813, AL353692 Genomic DNA. Translation: CAI42279.1.
AL158813, AL096678, AL353692 Genomic DNA. Translation: CAI13203.1.
AL353692, AL096678, AL158813 Genomic DNA. Translation: CAI16236.1.
AB002299 mRNA. Translation: BAA20761.2.
RefSeqNP_055426.1. NM_014611.1.
UniGeneHs.529948.

3D structure databases

ProteinModelPortalQ9NU22.
SMRQ9NU22. Positions 309-486, 672-697, 816-915, 1080-1234, 1386-1562, 1739-1906, 2062-2087, 2232-2307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116804. 17 interactions.
IntActQ9NU22. 10 interactions.
MINTMINT-2819308.
STRING9606.ENSP00000358400.

PTM databases

PhosphoSiteQ9NU22.

Polymorphism databases

DMDM24212017.

Proteomic databases

PaxDbQ9NU22.
PeptideAtlasQ9NU22.
PRIDEQ9NU22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369393; ENSP00000358400; ENSG00000112159.
ENST00000428876; ENSP00000413970; ENSG00000112159.
GeneID23195.
KEGGhsa:23195.
UCSCuc003pnn.1. human.

Organism-specific databases

CTD23195.
GeneCardsGC06M090352.
H-InvDBHIX0033355.
HGNCHGNC:18302. MDN1.
HPAHPA029666.
HPA029667.
HPA029668.
HPA029669.
neXtProtNX_Q9NU22.
PharmGKBPA30720.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5271.
HOGENOMHOG000231719.
HOVERGENHBG031706.
InParanoidQ9NU22.
KOK14572.
OMAWQPHESG.
OrthoDBEOG7S4X6J.
PhylomeDBQ9NU22.
TreeFamTF300488.

Gene expression databases

ArrayExpressQ9NU22.
BgeeQ9NU22.
CleanExHS_MDN1.
GenevestigatorQ9NU22.

Family and domain databases

Gene3D3.40.50.300. 8 hits.
3.40.50.410. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR012099. Midasin.
IPR027417. P-loop_NTPase.
IPR002035. VWF_A.
[Graphical view]
PfamPF07728. AAA_5. 8 hits.
[Graphical view]
PIRSFPIRSF010340. Midasin. 1 hit.
SMARTSM00382. AAA. 6 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 8 hits.
SSF53300. SSF53300. 1 hit.
PROSITEPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMDN1.
GenomeRNAi23195.
NextBio44695.
PROQ9NU22.

Entry information

Entry nameMDN1_HUMAN
AccessionPrimary (citable) accession number: Q9NU22
Secondary accession number(s): O15019, Q5T794
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM