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Q9NU22

- MDN1_HUMAN

UniProt

Q9NU22 - MDN1_HUMAN

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Protein

Midasin

Gene
MDN1, KIAA0301
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi329 – 3368ATP Reviewed prediction
Nucleotide bindingi677 – 6848ATP Reviewed prediction
Nucleotide bindingi1084 – 10918ATP Reviewed prediction
Nucleotide bindingi1390 – 13978ATP Reviewed prediction
Nucleotide bindingi1753 – 17608ATP Reviewed prediction
Nucleotide bindingi2066 – 20738ATP Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
  4. unfolded protein binding Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. protein complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Midasin
Alternative name(s):
MIDAS-containing protein
Gene namesi
Name:MDN1
Synonyms:KIAA0301
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:18302. MDN1.

Subcellular locationi

Nucleus By similarity. Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. intermediate filament cytoskeleton Source: HPA
  3. nucleolus Source: HPA
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 55965596MidasinPRO_0000096336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei1177 – 11771Phosphothreonine1 Publication
Modified residuei1683 – 16831N6-acetyllysine1 Publication
Modified residuei4538 – 45381Phosphoserine6 Publications
Modified residuei4752 – 47521Phosphoserine2 Publications
Modified residuei4754 – 47541Phosphoserine2 Publications
Modified residuei4889 – 48891Phosphoserine1 Publication
Modified residuei4898 – 48981Phosphothreonine5 Publications
Modified residuei4937 – 49371Phosphoserine1 Publication
Modified residuei4946 – 49461Phosphoserine1 Publication
Modified residuei5015 – 50151Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NU22.
PaxDbiQ9NU22.
PeptideAtlasiQ9NU22.
PRIDEiQ9NU22.

PTM databases

PhosphoSiteiQ9NU22.

Expressioni

Gene expression databases

ArrayExpressiQ9NU22.
BgeeiQ9NU22.
CleanExiHS_MDN1.
GenevestigatoriQ9NU22.

Organism-specific databases

HPAiHPA029666.
HPA029667.
HPA029668.
HPA029669.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PELP1Q8IZL83EBI-1050480,EBI-716449

Protein-protein interaction databases

BioGridi116804. 18 interactions.
IntActiQ9NU22. 10 interactions.
MINTiMINT-2819308.
STRINGi9606.ENSP00000358400.

Structurei

3D structure databases

ProteinModelPortaliQ9NU22.
SMRiQ9NU22. Positions 322-347, 673-703, 1080-1154, 1386-1416, 1746-1909, 2060-2092.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5384 – 5583200VWFAAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3566 – 35738Poly-Glu
Compositional biasi4784 – 47918Poly-Glu
Compositional biasi5008 – 50136Poly-Glu
Compositional biasi5182 – 51876Poly-Glu

Sequence similaritiesi

Belongs to the midasin family.
Contains 1 VWFA domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5271.
HOGENOMiHOG000231719.
HOVERGENiHBG031706.
InParanoidiQ9NU22.
KOiK14572.
OMAiRIFLTMD.
OrthoDBiEOG7S4X6J.
PhylomeDBiQ9NU22.
TreeFamiTF300488.

Family and domain databases

Gene3Di3.40.50.300. 8 hits.
3.40.50.410. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR012099. Midasin.
IPR027417. P-loop_NTPase.
IPR002035. VWF_A.
[Graphical view]
PfamiPF07728. AAA_5. 8 hits.
[Graphical view]
PIRSFiPIRSF010340. Midasin. 1 hit.
SMARTiSM00382. AAA. 6 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 8 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NU22-1 [UniParc]FASTAAdd to Basket

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MEHFLLEVAA APLRLIAAKN EKSRSELGRF LAKQVWTPQD RQCVLSTLAQ     50
LLLDKDCTVL VGRQLRPLLL DLLERNAEAI KAGGQINHDL HERLCVSMSK 100
LIGNHPDVLP FALRYFKDTS PVFQRLFLES SDANPVRYGR RRMKLRDLME 150
AAFKFLQQEQ SVFRELWDWS VCVPLLRSHD TLVRWYTANC LALVTCMNEE 200
HKLSFLKKIF NSDELIHFRL RLLEEAQLQD LEKALVLANP EVSLWRKQKE 250
LQYLQGHLVS SDLSPRVTAV CGVVLPGQLP APGELGGNRS SSREQELALR 300
SYVLVESVCK SLQTLAMAVA SQNAVLLEGP IGCGKTSLVE YLAAVTGRTK 350
PPQLLKVQLG DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATMGHWILL 400
EDIDYAPLDV VSVLIPLLEN GELLIPGRGD CLKVAPGFQF FATRRLLSCG 450
GNWYRPLNSH ATLLDKYWTK IHLDNLDKRE LNEVLQSRYP SLLAVVDHLL 500
DIYIQLTGEK HHSWSDSSVG CEQAPEEVSE ARRENKRPTL EGRELSLRDL 550
LNWCNRIAHS FDSSSLSASL NIFQEALDCF TAMLSEHTSK LKMAEVIGSK 600
LNISRKKAEF FCQLYKPEIV INELDLQVGR VRLLRKQSEA VHLQREKFTF 650
AATRPSSVLI EQLAVCVSKG EPVLLVGETG TGKTSTIQYL AHITGHRLRV 700
VNMNQQSDTA DLLGGYKPVD HKLIWLPLRE AFEELFAQTF SKKQNFTFLG 750
HIQTCYRQKR WHDLLRLMQH VHKSAVNKDG KDSETGLLIK EKWEAFGLRL 800
NHAQQQMKMT ENTLLFAFVE GTLAQAVKKG EWILLDEINL AAPEILECLS 850
GLLEGSSGSL VLLDRGDTEP LVRHPDFRLF ACMNPATDVG KRNLPPGIRN 900
RFTELYVEEL ESKEDLQVLI VDYLKGLSVN KNTVQGIINF YTALRKESGT 950
KLVDGTGHRP HYSLRTLCRA LRFAASNPCG NIQRSLYEGF CLGFLTQLDR 1000
ASHPIVQKLI CQHIVPGNVK SLLKQPIPEP KGGRLIQVEG YWIAVGDKEP 1050
TIDETYILTS SVKLNLRDIV RVVSAGTYPV LIQGETSVGK TSLIQWLAAA 1100
TGNHCVRINN HEHTDIQEYI GCYTSDSSGK LVFKEGVLID AMRKGYWIIL 1150
DELNLAPTDV LEALNRLLDD NRELLVTETQ EVVKAHPRFM LFATQNPPGL 1200
YGGRKVLSRA FRNRFVELHF DELPSSELET ILHKRCSLPP SYCSKLVKVM 1250
LDLQSYRRSS SVFAGKQGFI TLRDLFRWAE RYRLAEPTEK EYDWLQHLAN 1300
DGYMLLAGRV RKQEEIDVIQ EVLEKHFKKK LCPQSLFSKE NVLKLLGKLS 1350
TQISTLECNF GHIVWTEGMR RLAMLVGRAL EFGEPVLLVG DTGCGKTTIC 1400
QVFAALANQK LYSVSCHLHM ETSDFLGGLR PVRQKPNDKE EIDTSRLFEW 1450
HDGPLVQAMK EDGFFLLDEI SLADDSVLER LNSVLEVEKS LVLAEKGSPE 1500
DKDSEIELLT AGKKFRILAT MNPGGDFGKK ELSPALRNRF TEIWCPQSTS 1550
REDLIQIISH NLRPGLCLGR IDPKGSDIPE VMLDFIDWLT HQEFGRKCVV 1600
SIRDILSWVN FMNKMGEEAA LKRPEIISTV TSFVHAACLV YIDGIGSGVT 1650
SSGFGTALLA RKECLKFLIK RLAKIVRLTE YQKNELKIYD RMKAKEFTGI 1700
DNLWGIHPFF IPRGPVLHRN NIADYALSAG TTAMNAQRLL RATKLKKPIL 1750
LEGSPGVGKT SLVGALAKAS GNTLVRINLS EQTDITDLFG ADLPVEGGKG 1800
GEFAWRDGPL LAALKAGHWV VLDELNLASQ SVLEGLNACF DHRGEIYVPE 1850
LGMSFQVQHE KTKIFGCQNP FRQGGGRKGL PRSFLNRFTQ VFVDPLTVID 1900
MEFIASTLFP AIEKNIVKKM VAFNNQIDHE VTVEKKWGQK GGPWEFNLRD 1950
LFRWCQLMLV DQSPGCYDPG QHVFLVYGER MRTEEDKKKV IAVFKDVFGS 2000
NSNPYMGTRL FRITPYDVQL GYSVLSRGSC VPHPSRHPLL LLHQSFQPLE 2050
SIMKCVQMSW MVILVGPASV GKTSLVQLLA HLTGHTLKIM AMNSAMDTTE 2100
LLGGFEQVDL IRPWRRLLEK VEGTVRALLR DSLLISADDA EVVLRAWSHF 2150
LLTYKPKCLG EGGKAITMEI VNKLEAVLLL MQRLNNKINS YCKAEFAKLV 2200
EEFRSFGVKL TQLASGHSHG TFEWVDSMLV QALKSGDWLL MDNVNFCNPS 2250
VLDRLNALLE PGGVLTISER GMIDGSTPTI TPNPNFRLFL SMDPVHGDIS 2300
RAMRNRGLEI YISGEGDAST PDNLDLKVLL HSLGLVGNSV CDILLALHTE 2350
TRSTVVGSPT SSVSTLIQTA ILIVQYLQRG LSLDRAFSEA CWEVYVCSQH 2400
SPANRKLVQA LLEKHVSSLR AHETWGDSIL GMGLWPDSVP SALFATEDSH 2450
LSTVRRDGQI LVYCLNRMSM KTSSWTRSQP FTLQDLEKIM QSPSPENLKF 2500
NAVEVNTYWI DEPDVLVMAV KLLIERATNQ DWMLRVKWLY HLAKNIPQGL 2550
ESIQIHLEAS AASLRNFYSH SLSGAVSNVF KILQPNTTDE FVIPLDPRWN 2600
MQALDMIRNL MDFDPQTDQP DQLFALLESA ANKTIIYLDR EKRVFTEANL 2650
VSVGSKKLRE SVLRMSFEFH QDPESYHTLP HEIVVNLAAF FELCDALVLL 2700
WVQSSQGMVS DASANEILGS LRWRDRFWTV ADTVKVDAPG LALLALHWHW 2750
VLKHLVHQIP RLLMNYEDKY YKEVQTVSEH IQNCLGSQTG GFAGIKKLQK 2800
FLGRPFPFKD KLVVECFSQL KVLNKVLAIR EQMSALGESG WQEDINRLQV 2850
VASQWTLKKS LLQAWGLILR ANILEDVSLD ELKNFVHAQC LELKAKGLSL 2900
GFLEKKHDEA SSLSHPDLTS VIHLTRSVQL WPAMEYLAML WRYKVTADFM 2950
AQACLRRCSK NQQPQINEEI SHLISFCLYH TPVTPQELRD LWSLLHHQKV 3000
SPEEITSLWS ELFNSMFMSF WSSTVTTNPE YWLMWNPLPG MQQREAPKSV 3050
LDSTLKGPGN LNRPIFSKCC FEVLTSSWRA SPWDVSGLPI LSSSHVTLGE 3100
WVERTQQLQD ISSMLWTNMA ISSVAEFRRT DSQLQGQVLF RHLAGLAELL 3150
PESRRQEYMQ NCEQLLLGSS QAFQHVGQTL GDMAGQEVLP KELLCQLLTS 3200
LHHFVGEGES KRSLPEPAQR GSLWVSLGLL QIQTWLPQAR FDPAVKREYK 3250
LNYVKEELHQ LQCEWKTRNL SSQLQTGRDL EDEVVVSYSH PHVRLLRQRM 3300
DRLDNLTCHL LKKQAFRPQL PAYESLVQEI HHYVTSIAKA PAVQDLLTRL 3350
LQALHIDGPR SAQVAQSLLK EEASWQQSHH QFRKRLSEEY TFYPDAVSPL 3400
QASILQLQHG MRLVASELHT SLHSSMVGAD RLGTLATALL AFPSVGPTFP 3450
TYYAHADTLC SVKSEEVLRG LGKLILKRSG GKELEGKGQK ACPTREQLLM 3500
NALLYLRSHV LCKGELDQRA LQLFRHVCQE IISEWDEQER IAQEKAEQES 3550
GLYRYRSRNS RTALSEEEEE EREFRKQFPL HEKDFADILV QPTLEENKGT 3600
SDGQEEEAGT NPALLSQNSM QAVMLIHQQL CLNFARSLWY QQTLPPHEAK 3650
HYLSLFLSCY QTGASLVTHF YPLMGVELND RLLGSQLLAC TLSHNTLFGE 3700
APSDLMVKPD GPYDFYQHPN VPEARQCQPV LQGFSEAVSH LLQDWPEHPA 3750
LEQLLVVMDR IRSFPLSSPI SKFLNGLEIL LAKAQDWEEN ASRALSLRKH 3800
LDLISQMIIR WRKLELNCWS MSLDNTMKRH TEKSTKHWFS IYQMLEKHMQ 3850
EQTEEQEDDK QMTLMLLVST LQAFIEGSSL GEFHVRLQML LVFHCHVLLM 3900
PQVEGKDSLC SVLWNLYHYY KQFFDRVQAK IVELRSPLEK ELKEFVKISK 3950
WNDVSFWSIK QSVEKTHRTL FKFMKKFEAV LSEPCRSSLV ESDKEEQPDF 4000
LPRPTDGAAS ELSSIQNLNR ALRETLLAQP AAGQATIPEW CQGAAPSGLE 4050
GELLRRLPKL RKRMRKMCLT FMKESPLPRL VEGLDQFTGE VISSVSELQS 4100
LKVEPSAEKE KQRSEAKHIL MQKQRALSDL FKHLAKIGLS YRKGLAWARS 4150
KNPQEMLHLH PLDLQSALSI VSSTQEADSR LLTEISSSWD GCQKYFYRSL 4200
ARHARLNAAL ATPAKEMGMG NVERCRGFSA HLMKMLVRQR RSLTTLSEQW 4250
IILRNLLSCV QEIHSRLMGP QAYPVAFPPQ DGVQQWTERL QHLAMQCQIL 4300
LEQLSWLLQC CPSVGPAPGH GNVQVLGQPP GPCLEGPELS KGQLCGVVLD 4350
LIPSNLSYPS PIPGSQLPSG CRMRKQDHLW QQSTTRLTEM LKTIKTVKAD 4400
VDKIRQQSCE TLFHSWKDFE VCSSALSCLS QVSVHLQGLE SLFILPGMEV 4450
EQRDSQMALV ESLEYVRGEI SKAMADFTTW KTHLLTSDSQ GGNQMLDEGF 4500
VEDFSEQMEI AIRAILCAIQ NLEERKNEKA EENTDQASPQ EDYAGFERLQ 4550
SGHLTKLLED DFWADVSTLH VQKIISAISE LLERLKSYGE DGTAAKHLFF 4600
SQSCSLLVRL VPVLSSYSDL VLFFLTMSLA THRSTAKLLS VLAQVFTELA 4650
QKGFCLPKEF MEDSAGEGAT EFHDYEGGGI GEGEGMKDVS DQIGNEEQVE 4700
DTFQKGQEKD KEDPDSKSDI KGEDNAIEMS EDFDGKMHDG ELEEQEEDDE 4750
KSDSEGGDLD KHMGDLNGEE ADKLDERLWG DDDEEEDEEE EDNKTEETGP 4800
GMDEEDSELV AKDDNLDSGN SNKDKSQQDK KEEKEEAEAD DGGQGEDKIN 4850
EQIDERDYDE NEVDPYHGNQ EKVPEPEALD LPDDLNLDSE DKNGGEDTDN 4900
EEGEEENPLE IKEKPEEAGH EAEERGETET DQNESQSPQE PEEGPSEDDK 4950
AEGEEEMDTG ADDQDGDAAQ HPEEHSEEQQ QSVEEKDKEA DEEGGENGPA 5000
DQGFQPQEEE EREDSDTEEQ VPEALERKEH ASCGQTGVEN MQNTQAMELA 5050
GAAPEKEQGK EEHGSGAADA NQAEGHESNF IAQLASQKHT RKNTQSFKRK 5100
PGQADNERSM GDHNERVHKR LRTVDTDSHA EQGPAQQPQA QVEDADAFEH 5150
IKQGSDAYDA QTYDVASKEQ QQSAKDSGKD QEEEEIEDTL MDTEEQEEFK 5200
AADVEQLKPE EIKSGTTAPL GFDEMEVEIQ TVKTEEDQDP RTDKAHKETE 5250
NEKPERSRES TIHTAHQFLM DTIFQPFLKD VNELRQELER QLEMWQPRES 5300
GNPEEEKVAA EMWQSYLILT APLSQRLCEE LRLILEPTQA AKLKGDYRTG 5350
KRLNIRKVIP YIASQFRKDK IWLRRTKPSK RQYQICLAID DSSSMVDNHT 5400
KQLAFESLAV IGNALTLLEV GQIAVCSFGE SVKLLHPFHE QFSDYSGSQI 5450
LRLCKFQQKK TKIAQFLESV ANMFAAAQQL SQNISSETAQ LLLVVSDGRG 5500
LFLEGKERVL AAVQAARNAN IFVIFVVLDN PSSRDSILDI KVPIFKGPGE 5550
MPEIRSYMEE FPFPYYIILR DVNALPETLS DALRQWFELV TASDHP 5596
Length:5,596
Mass (Da):632,820
Last modified:October 19, 2002 - v2
Checksum:i586C62616A1F96D4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti440 – 4401F → V.
Corresponds to variant rs4707569 [ dbSNP | Ensembl ].
VAR_024234
Natural varianti660 – 6601I → V.
Corresponds to variant rs12110451 [ dbSNP | Ensembl ].
VAR_051171
Natural varianti1044 – 10441A → V.
Corresponds to variant rs34764513 [ dbSNP | Ensembl ].
VAR_051172
Natural varianti1559 – 15591S → N.
Corresponds to variant rs4140446 [ dbSNP | Ensembl ].
VAR_024235
Natural varianti1929 – 19291H → D.
Corresponds to variant rs16882099 [ dbSNP | Ensembl ].
VAR_051173
Natural varianti2972 – 29721H → P.
Corresponds to variant rs34208137 [ dbSNP | Ensembl ].
VAR_051174
Natural varianti3004 – 30041E → K.
Corresponds to variant rs12530146 [ dbSNP | Ensembl ].
VAR_051175
Natural varianti3423 – 34231H → Y.
Corresponds to variant rs9294445 [ dbSNP | Ensembl ].
VAR_051176
Natural varianti3794 – 37941A → G.
Corresponds to variant rs34766278 [ dbSNP | Ensembl ].
VAR_051177
Natural varianti3986 – 39861R → L.
Corresponds to variant rs17293121 [ dbSNP | Ensembl ].
VAR_051178
Natural varianti4044 – 40441A → S.
Corresponds to variant rs9353689 [ dbSNP | Ensembl ].
VAR_024236
Natural varianti4167 – 41671A → T.
Corresponds to variant rs35509794 [ dbSNP | Ensembl ].
VAR_051179
Natural varianti4720 – 47201I → T.
Corresponds to variant rs16882046 [ dbSNP | Ensembl ].
VAR_051180
Natural varianti4783 – 47831D → E.
Corresponds to variant rs36040566 [ dbSNP | Ensembl ].
VAR_051181
Natural varianti5251 – 52511N → K.
Corresponds to variant rs4707557 [ dbSNP | Ensembl ].
VAR_051182

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503925 mRNA. Translation: AAM77722.1.
AL096678, AL158813, AL353692 Genomic DNA. Translation: CAI42279.1.
AL158813, AL096678, AL353692 Genomic DNA. Translation: CAI13203.1.
AL353692, AL096678, AL158813 Genomic DNA. Translation: CAI16236.1.
AB002299 mRNA. Translation: BAA20761.2.
CCDSiCCDS5024.1.
RefSeqiNP_055426.1. NM_014611.2.
UniGeneiHs.529948.

Genome annotation databases

EnsembliENST00000369393; ENSP00000358400; ENSG00000112159.
ENST00000428876; ENSP00000413970; ENSG00000112159.
GeneIDi23195.
KEGGihsa:23195.
UCSCiuc003pnn.1. human.

Polymorphism databases

DMDMi24212017.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503925 mRNA. Translation: AAM77722.1 .
AL096678 , AL158813 , AL353692 Genomic DNA. Translation: CAI42279.1 .
AL158813 , AL096678 , AL353692 Genomic DNA. Translation: CAI13203.1 .
AL353692 , AL096678 , AL158813 Genomic DNA. Translation: CAI16236.1 .
AB002299 mRNA. Translation: BAA20761.2 .
CCDSi CCDS5024.1.
RefSeqi NP_055426.1. NM_014611.2.
UniGenei Hs.529948.

3D structure databases

ProteinModelPortali Q9NU22.
SMRi Q9NU22. Positions 322-347, 673-703, 1080-1154, 1386-1416, 1746-1909, 2060-2092.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116804. 18 interactions.
IntActi Q9NU22. 10 interactions.
MINTi MINT-2819308.
STRINGi 9606.ENSP00000358400.

PTM databases

PhosphoSitei Q9NU22.

Polymorphism databases

DMDMi 24212017.

Proteomic databases

MaxQBi Q9NU22.
PaxDbi Q9NU22.
PeptideAtlasi Q9NU22.
PRIDEi Q9NU22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369393 ; ENSP00000358400 ; ENSG00000112159 .
ENST00000428876 ; ENSP00000413970 ; ENSG00000112159 .
GeneIDi 23195.
KEGGi hsa:23195.
UCSCi uc003pnn.1. human.

Organism-specific databases

CTDi 23195.
GeneCardsi GC06M090352.
H-InvDB HIX0033355.
HGNCi HGNC:18302. MDN1.
HPAi HPA029666.
HPA029667.
HPA029668.
HPA029669.
neXtProti NX_Q9NU22.
PharmGKBi PA30720.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5271.
HOGENOMi HOG000231719.
HOVERGENi HBG031706.
InParanoidi Q9NU22.
KOi K14572.
OMAi RIFLTMD.
OrthoDBi EOG7S4X6J.
PhylomeDBi Q9NU22.
TreeFami TF300488.

Miscellaneous databases

GeneWikii MDN1.
GenomeRNAii 23195.
NextBioi 44695.
PROi Q9NU22.

Gene expression databases

ArrayExpressi Q9NU22.
Bgeei Q9NU22.
CleanExi HS_MDN1.
Genevestigatori Q9NU22.

Family and domain databases

Gene3Di 3.40.50.300. 8 hits.
3.40.50.410. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR012099. Midasin.
IPR027417. P-loop_NTPase.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF07728. AAA_5. 8 hits.
[Graphical view ]
PIRSFi PIRSF010340. Midasin. 1 hit.
SMARTi SM00382. AAA. 6 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 8 hits.
SSF53300. SSF53300. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein."
    Garbarino J.E., Gibbons I.R.
    BMC Genomics 3:18-18(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2387-5596.
    Tissue: Brain.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538 AND THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538 AND THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538; SER-4752 AND SER-4754, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1683, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538 AND THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1177; SER-4538; SER-4752; SER-4754; SER-4889; THR-4898; SER-4937; SER-4946 AND SER-5015, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization."
    Ahmad Y., Boisvert F.M., Lundberg E., Uhlen M., Lamond A.I.
    Mol. Cell. Proteomics 11:M111.013680.01-M111.013680.15(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMDN1_HUMAN
AccessioniPrimary (citable) accession number: Q9NU22
Secondary accession number(s): O15019, Q5T794
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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