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Q9NU22

- MDN1_HUMAN

UniProt

Q9NU22 - MDN1_HUMAN

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Protein

Midasin

Gene

MDN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi329 – 3368ATPSequence Analysis
Nucleotide bindingi677 – 6848ATPSequence Analysis
Nucleotide bindingi1084 – 10918ATPSequence Analysis
Nucleotide bindingi1390 – 13978ATPSequence Analysis
Nucleotide bindingi1753 – 17608ATPSequence Analysis
Nucleotide bindingi2066 – 20738ATPSequence Analysis

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. unfolded protein binding Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. protein complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Midasin
Alternative name(s):
MIDAS-containing protein
Gene namesi
Name:MDN1
Synonyms:KIAA0301
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:18302. MDN1.

Subcellular locationi

Nucleus By similarity. Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. intermediate filament cytoskeleton Source: HPA
  3. membrane Source: UniProtKB
  4. nucleolus Source: HPA
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 55965596MidasinPRO_0000096336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei1177 – 11771Phosphothreonine1 Publication
Modified residuei1683 – 16831N6-acetyllysine1 Publication
Modified residuei4538 – 45381Phosphoserine6 Publications
Modified residuei4752 – 47521Phosphoserine2 Publications
Modified residuei4754 – 47541Phosphoserine2 Publications
Modified residuei4889 – 48891Phosphoserine1 Publication
Modified residuei4898 – 48981Phosphothreonine5 Publications
Modified residuei4937 – 49371Phosphoserine1 Publication
Modified residuei4946 – 49461Phosphoserine1 Publication
Modified residuei5015 – 50151Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NU22.
PaxDbiQ9NU22.
PeptideAtlasiQ9NU22.
PRIDEiQ9NU22.

PTM databases

PhosphoSiteiQ9NU22.

Expressioni

Gene expression databases

BgeeiQ9NU22.
CleanExiHS_MDN1.
ExpressionAtlasiQ9NU22. baseline and differential.
GenevestigatoriQ9NU22.

Organism-specific databases

HPAiHPA029666.
HPA029667.
HPA029668.
HPA029669.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PELP1Q8IZL83EBI-1050480,EBI-716449

Protein-protein interaction databases

BioGridi116804. 25 interactions.
IntActiQ9NU22. 10 interactions.
MINTiMINT-2819308.
STRINGi9606.ENSP00000358400.

Structurei

3D structure databases

ProteinModelPortaliQ9NU22.
SMRiQ9NU22. Positions 322-347, 673-701, 1080-1233, 1385-1411, 1513-1558, 1746-1844, 2062-2087, 2227-2266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5384 – 5583200VWFAPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3566 – 35738Poly-Glu
Compositional biasi4784 – 47918Poly-Glu
Compositional biasi5008 – 50136Poly-Glu
Compositional biasi5182 – 51876Poly-Glu

Sequence similaritiesi

Belongs to the midasin family.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5271.
GeneTreeiENSGT00550000074802.
HOGENOMiHOG000231719.
HOVERGENiHBG031706.
InParanoidiQ9NU22.
KOiK14572.
OMAiRIFLTMD.
OrthoDBiEOG7S4X6J.
PhylomeDBiQ9NU22.
TreeFamiTF300488.

Family and domain databases

Gene3Di3.40.50.300. 8 hits.
3.40.50.410. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR012099. Midasin.
IPR027417. P-loop_NTPase.
IPR002035. VWF_A.
[Graphical view]
PfamiPF07728. AAA_5. 8 hits.
[Graphical view]
PIRSFiPIRSF010340. Midasin. 1 hit.
SMARTiSM00382. AAA. 6 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 8 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NU22-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MEHFLLEVAA APLRLIAAKN EKSRSELGRF LAKQVWTPQD RQCVLSTLAQ
60 70 80 90 100
LLLDKDCTVL VGRQLRPLLL DLLERNAEAI KAGGQINHDL HERLCVSMSK
110 120 130 140 150
LIGNHPDVLP FALRYFKDTS PVFQRLFLES SDANPVRYGR RRMKLRDLME
160 170 180 190 200
AAFKFLQQEQ SVFRELWDWS VCVPLLRSHD TLVRWYTANC LALVTCMNEE
210 220 230 240 250
HKLSFLKKIF NSDELIHFRL RLLEEAQLQD LEKALVLANP EVSLWRKQKE
260 270 280 290 300
LQYLQGHLVS SDLSPRVTAV CGVVLPGQLP APGELGGNRS SSREQELALR
310 320 330 340 350
SYVLVESVCK SLQTLAMAVA SQNAVLLEGP IGCGKTSLVE YLAAVTGRTK
360 370 380 390 400
PPQLLKVQLG DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATMGHWILL
410 420 430 440 450
EDIDYAPLDV VSVLIPLLEN GELLIPGRGD CLKVAPGFQF FATRRLLSCG
460 470 480 490 500
GNWYRPLNSH ATLLDKYWTK IHLDNLDKRE LNEVLQSRYP SLLAVVDHLL
510 520 530 540 550
DIYIQLTGEK HHSWSDSSVG CEQAPEEVSE ARRENKRPTL EGRELSLRDL
560 570 580 590 600
LNWCNRIAHS FDSSSLSASL NIFQEALDCF TAMLSEHTSK LKMAEVIGSK
610 620 630 640 650
LNISRKKAEF FCQLYKPEIV INELDLQVGR VRLLRKQSEA VHLQREKFTF
660 670 680 690 700
AATRPSSVLI EQLAVCVSKG EPVLLVGETG TGKTSTIQYL AHITGHRLRV
710 720 730 740 750
VNMNQQSDTA DLLGGYKPVD HKLIWLPLRE AFEELFAQTF SKKQNFTFLG
760 770 780 790 800
HIQTCYRQKR WHDLLRLMQH VHKSAVNKDG KDSETGLLIK EKWEAFGLRL
810 820 830 840 850
NHAQQQMKMT ENTLLFAFVE GTLAQAVKKG EWILLDEINL AAPEILECLS
860 870 880 890 900
GLLEGSSGSL VLLDRGDTEP LVRHPDFRLF ACMNPATDVG KRNLPPGIRN
910 920 930 940 950
RFTELYVEEL ESKEDLQVLI VDYLKGLSVN KNTVQGIINF YTALRKESGT
960 970 980 990 1000
KLVDGTGHRP HYSLRTLCRA LRFAASNPCG NIQRSLYEGF CLGFLTQLDR
1010 1020 1030 1040 1050
ASHPIVQKLI CQHIVPGNVK SLLKQPIPEP KGGRLIQVEG YWIAVGDKEP
1060 1070 1080 1090 1100
TIDETYILTS SVKLNLRDIV RVVSAGTYPV LIQGETSVGK TSLIQWLAAA
1110 1120 1130 1140 1150
TGNHCVRINN HEHTDIQEYI GCYTSDSSGK LVFKEGVLID AMRKGYWIIL
1160 1170 1180 1190 1200
DELNLAPTDV LEALNRLLDD NRELLVTETQ EVVKAHPRFM LFATQNPPGL
1210 1220 1230 1240 1250
YGGRKVLSRA FRNRFVELHF DELPSSELET ILHKRCSLPP SYCSKLVKVM
1260 1270 1280 1290 1300
LDLQSYRRSS SVFAGKQGFI TLRDLFRWAE RYRLAEPTEK EYDWLQHLAN
1310 1320 1330 1340 1350
DGYMLLAGRV RKQEEIDVIQ EVLEKHFKKK LCPQSLFSKE NVLKLLGKLS
1360 1370 1380 1390 1400
TQISTLECNF GHIVWTEGMR RLAMLVGRAL EFGEPVLLVG DTGCGKTTIC
1410 1420 1430 1440 1450
QVFAALANQK LYSVSCHLHM ETSDFLGGLR PVRQKPNDKE EIDTSRLFEW
1460 1470 1480 1490 1500
HDGPLVQAMK EDGFFLLDEI SLADDSVLER LNSVLEVEKS LVLAEKGSPE
1510 1520 1530 1540 1550
DKDSEIELLT AGKKFRILAT MNPGGDFGKK ELSPALRNRF TEIWCPQSTS
1560 1570 1580 1590 1600
REDLIQIISH NLRPGLCLGR IDPKGSDIPE VMLDFIDWLT HQEFGRKCVV
1610 1620 1630 1640 1650
SIRDILSWVN FMNKMGEEAA LKRPEIISTV TSFVHAACLV YIDGIGSGVT
1660 1670 1680 1690 1700
SSGFGTALLA RKECLKFLIK RLAKIVRLTE YQKNELKIYD RMKAKEFTGI
1710 1720 1730 1740 1750
DNLWGIHPFF IPRGPVLHRN NIADYALSAG TTAMNAQRLL RATKLKKPIL
1760 1770 1780 1790 1800
LEGSPGVGKT SLVGALAKAS GNTLVRINLS EQTDITDLFG ADLPVEGGKG
1810 1820 1830 1840 1850
GEFAWRDGPL LAALKAGHWV VLDELNLASQ SVLEGLNACF DHRGEIYVPE
1860 1870 1880 1890 1900
LGMSFQVQHE KTKIFGCQNP FRQGGGRKGL PRSFLNRFTQ VFVDPLTVID
1910 1920 1930 1940 1950
MEFIASTLFP AIEKNIVKKM VAFNNQIDHE VTVEKKWGQK GGPWEFNLRD
1960 1970 1980 1990 2000
LFRWCQLMLV DQSPGCYDPG QHVFLVYGER MRTEEDKKKV IAVFKDVFGS
2010 2020 2030 2040 2050
NSNPYMGTRL FRITPYDVQL GYSVLSRGSC VPHPSRHPLL LLHQSFQPLE
2060 2070 2080 2090 2100
SIMKCVQMSW MVILVGPASV GKTSLVQLLA HLTGHTLKIM AMNSAMDTTE
2110 2120 2130 2140 2150
LLGGFEQVDL IRPWRRLLEK VEGTVRALLR DSLLISADDA EVVLRAWSHF
2160 2170 2180 2190 2200
LLTYKPKCLG EGGKAITMEI VNKLEAVLLL MQRLNNKINS YCKAEFAKLV
2210 2220 2230 2240 2250
EEFRSFGVKL TQLASGHSHG TFEWVDSMLV QALKSGDWLL MDNVNFCNPS
2260 2270 2280 2290 2300
VLDRLNALLE PGGVLTISER GMIDGSTPTI TPNPNFRLFL SMDPVHGDIS
2310 2320 2330 2340 2350
RAMRNRGLEI YISGEGDAST PDNLDLKVLL HSLGLVGNSV CDILLALHTE
2360 2370 2380 2390 2400
TRSTVVGSPT SSVSTLIQTA ILIVQYLQRG LSLDRAFSEA CWEVYVCSQH
2410 2420 2430 2440 2450
SPANRKLVQA LLEKHVSSLR AHETWGDSIL GMGLWPDSVP SALFATEDSH
2460 2470 2480 2490 2500
LSTVRRDGQI LVYCLNRMSM KTSSWTRSQP FTLQDLEKIM QSPSPENLKF
2510 2520 2530 2540 2550
NAVEVNTYWI DEPDVLVMAV KLLIERATNQ DWMLRVKWLY HLAKNIPQGL
2560 2570 2580 2590 2600
ESIQIHLEAS AASLRNFYSH SLSGAVSNVF KILQPNTTDE FVIPLDPRWN
2610 2620 2630 2640 2650
MQALDMIRNL MDFDPQTDQP DQLFALLESA ANKTIIYLDR EKRVFTEANL
2660 2670 2680 2690 2700
VSVGSKKLRE SVLRMSFEFH QDPESYHTLP HEIVVNLAAF FELCDALVLL
2710 2720 2730 2740 2750
WVQSSQGMVS DASANEILGS LRWRDRFWTV ADTVKVDAPG LALLALHWHW
2760 2770 2780 2790 2800
VLKHLVHQIP RLLMNYEDKY YKEVQTVSEH IQNCLGSQTG GFAGIKKLQK
2810 2820 2830 2840 2850
FLGRPFPFKD KLVVECFSQL KVLNKVLAIR EQMSALGESG WQEDINRLQV
2860 2870 2880 2890 2900
VASQWTLKKS LLQAWGLILR ANILEDVSLD ELKNFVHAQC LELKAKGLSL
2910 2920 2930 2940 2950
GFLEKKHDEA SSLSHPDLTS VIHLTRSVQL WPAMEYLAML WRYKVTADFM
2960 2970 2980 2990 3000
AQACLRRCSK NQQPQINEEI SHLISFCLYH TPVTPQELRD LWSLLHHQKV
3010 3020 3030 3040 3050
SPEEITSLWS ELFNSMFMSF WSSTVTTNPE YWLMWNPLPG MQQREAPKSV
3060 3070 3080 3090 3100
LDSTLKGPGN LNRPIFSKCC FEVLTSSWRA SPWDVSGLPI LSSSHVTLGE
3110 3120 3130 3140 3150
WVERTQQLQD ISSMLWTNMA ISSVAEFRRT DSQLQGQVLF RHLAGLAELL
3160 3170 3180 3190 3200
PESRRQEYMQ NCEQLLLGSS QAFQHVGQTL GDMAGQEVLP KELLCQLLTS
3210 3220 3230 3240 3250
LHHFVGEGES KRSLPEPAQR GSLWVSLGLL QIQTWLPQAR FDPAVKREYK
3260 3270 3280 3290 3300
LNYVKEELHQ LQCEWKTRNL SSQLQTGRDL EDEVVVSYSH PHVRLLRQRM
3310 3320 3330 3340 3350
DRLDNLTCHL LKKQAFRPQL PAYESLVQEI HHYVTSIAKA PAVQDLLTRL
3360 3370 3380 3390 3400
LQALHIDGPR SAQVAQSLLK EEASWQQSHH QFRKRLSEEY TFYPDAVSPL
3410 3420 3430 3440 3450
QASILQLQHG MRLVASELHT SLHSSMVGAD RLGTLATALL AFPSVGPTFP
3460 3470 3480 3490 3500
TYYAHADTLC SVKSEEVLRG LGKLILKRSG GKELEGKGQK ACPTREQLLM
3510 3520 3530 3540 3550
NALLYLRSHV LCKGELDQRA LQLFRHVCQE IISEWDEQER IAQEKAEQES
3560 3570 3580 3590 3600
GLYRYRSRNS RTALSEEEEE EREFRKQFPL HEKDFADILV QPTLEENKGT
3610 3620 3630 3640 3650
SDGQEEEAGT NPALLSQNSM QAVMLIHQQL CLNFARSLWY QQTLPPHEAK
3660 3670 3680 3690 3700
HYLSLFLSCY QTGASLVTHF YPLMGVELND RLLGSQLLAC TLSHNTLFGE
3710 3720 3730 3740 3750
APSDLMVKPD GPYDFYQHPN VPEARQCQPV LQGFSEAVSH LLQDWPEHPA
3760 3770 3780 3790 3800
LEQLLVVMDR IRSFPLSSPI SKFLNGLEIL LAKAQDWEEN ASRALSLRKH
3810 3820 3830 3840 3850
LDLISQMIIR WRKLELNCWS MSLDNTMKRH TEKSTKHWFS IYQMLEKHMQ
3860 3870 3880 3890 3900
EQTEEQEDDK QMTLMLLVST LQAFIEGSSL GEFHVRLQML LVFHCHVLLM
3910 3920 3930 3940 3950
PQVEGKDSLC SVLWNLYHYY KQFFDRVQAK IVELRSPLEK ELKEFVKISK
3960 3970 3980 3990 4000
WNDVSFWSIK QSVEKTHRTL FKFMKKFEAV LSEPCRSSLV ESDKEEQPDF
4010 4020 4030 4040 4050
LPRPTDGAAS ELSSIQNLNR ALRETLLAQP AAGQATIPEW CQGAAPSGLE
4060 4070 4080 4090 4100
GELLRRLPKL RKRMRKMCLT FMKESPLPRL VEGLDQFTGE VISSVSELQS
4110 4120 4130 4140 4150
LKVEPSAEKE KQRSEAKHIL MQKQRALSDL FKHLAKIGLS YRKGLAWARS
4160 4170 4180 4190 4200
KNPQEMLHLH PLDLQSALSI VSSTQEADSR LLTEISSSWD GCQKYFYRSL
4210 4220 4230 4240 4250
ARHARLNAAL ATPAKEMGMG NVERCRGFSA HLMKMLVRQR RSLTTLSEQW
4260 4270 4280 4290 4300
IILRNLLSCV QEIHSRLMGP QAYPVAFPPQ DGVQQWTERL QHLAMQCQIL
4310 4320 4330 4340 4350
LEQLSWLLQC CPSVGPAPGH GNVQVLGQPP GPCLEGPELS KGQLCGVVLD
4360 4370 4380 4390 4400
LIPSNLSYPS PIPGSQLPSG CRMRKQDHLW QQSTTRLTEM LKTIKTVKAD
4410 4420 4430 4440 4450
VDKIRQQSCE TLFHSWKDFE VCSSALSCLS QVSVHLQGLE SLFILPGMEV
4460 4470 4480 4490 4500
EQRDSQMALV ESLEYVRGEI SKAMADFTTW KTHLLTSDSQ GGNQMLDEGF
4510 4520 4530 4540 4550
VEDFSEQMEI AIRAILCAIQ NLEERKNEKA EENTDQASPQ EDYAGFERLQ
4560 4570 4580 4590 4600
SGHLTKLLED DFWADVSTLH VQKIISAISE LLERLKSYGE DGTAAKHLFF
4610 4620 4630 4640 4650
SQSCSLLVRL VPVLSSYSDL VLFFLTMSLA THRSTAKLLS VLAQVFTELA
4660 4670 4680 4690 4700
QKGFCLPKEF MEDSAGEGAT EFHDYEGGGI GEGEGMKDVS DQIGNEEQVE
4710 4720 4730 4740 4750
DTFQKGQEKD KEDPDSKSDI KGEDNAIEMS EDFDGKMHDG ELEEQEEDDE
4760 4770 4780 4790 4800
KSDSEGGDLD KHMGDLNGEE ADKLDERLWG DDDEEEDEEE EDNKTEETGP
4810 4820 4830 4840 4850
GMDEEDSELV AKDDNLDSGN SNKDKSQQDK KEEKEEAEAD DGGQGEDKIN
4860 4870 4880 4890 4900
EQIDERDYDE NEVDPYHGNQ EKVPEPEALD LPDDLNLDSE DKNGGEDTDN
4910 4920 4930 4940 4950
EEGEEENPLE IKEKPEEAGH EAEERGETET DQNESQSPQE PEEGPSEDDK
4960 4970 4980 4990 5000
AEGEEEMDTG ADDQDGDAAQ HPEEHSEEQQ QSVEEKDKEA DEEGGENGPA
5010 5020 5030 5040 5050
DQGFQPQEEE EREDSDTEEQ VPEALERKEH ASCGQTGVEN MQNTQAMELA
5060 5070 5080 5090 5100
GAAPEKEQGK EEHGSGAADA NQAEGHESNF IAQLASQKHT RKNTQSFKRK
5110 5120 5130 5140 5150
PGQADNERSM GDHNERVHKR LRTVDTDSHA EQGPAQQPQA QVEDADAFEH
5160 5170 5180 5190 5200
IKQGSDAYDA QTYDVASKEQ QQSAKDSGKD QEEEEIEDTL MDTEEQEEFK
5210 5220 5230 5240 5250
AADVEQLKPE EIKSGTTAPL GFDEMEVEIQ TVKTEEDQDP RTDKAHKETE
5260 5270 5280 5290 5300
NEKPERSRES TIHTAHQFLM DTIFQPFLKD VNELRQELER QLEMWQPRES
5310 5320 5330 5340 5350
GNPEEEKVAA EMWQSYLILT APLSQRLCEE LRLILEPTQA AKLKGDYRTG
5360 5370 5380 5390 5400
KRLNIRKVIP YIASQFRKDK IWLRRTKPSK RQYQICLAID DSSSMVDNHT
5410 5420 5430 5440 5450
KQLAFESLAV IGNALTLLEV GQIAVCSFGE SVKLLHPFHE QFSDYSGSQI
5460 5470 5480 5490 5500
LRLCKFQQKK TKIAQFLESV ANMFAAAQQL SQNISSETAQ LLLVVSDGRG
5510 5520 5530 5540 5550
LFLEGKERVL AAVQAARNAN IFVIFVVLDN PSSRDSILDI KVPIFKGPGE
5560 5570 5580 5590
MPEIRSYMEE FPFPYYIILR DVNALPETLS DALRQWFELV TASDHP
Length:5,596
Mass (Da):632,820
Last modified:October 19, 2002 - v2
Checksum:i586C62616A1F96D4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti440 – 4401F → V.
Corresponds to variant rs4707569 [ dbSNP | Ensembl ].
VAR_024234
Natural varianti660 – 6601I → V.
Corresponds to variant rs12110451 [ dbSNP | Ensembl ].
VAR_051171
Natural varianti1044 – 10441A → V.
Corresponds to variant rs34764513 [ dbSNP | Ensembl ].
VAR_051172
Natural varianti1559 – 15591S → N.
Corresponds to variant rs4140446 [ dbSNP | Ensembl ].
VAR_024235
Natural varianti1929 – 19291H → D.
Corresponds to variant rs16882099 [ dbSNP | Ensembl ].
VAR_051173
Natural varianti2972 – 29721H → P.
Corresponds to variant rs34208137 [ dbSNP | Ensembl ].
VAR_051174
Natural varianti3004 – 30041E → K.
Corresponds to variant rs12530146 [ dbSNP | Ensembl ].
VAR_051175
Natural varianti3423 – 34231H → Y.
Corresponds to variant rs9294445 [ dbSNP | Ensembl ].
VAR_051176
Natural varianti3794 – 37941A → G.
Corresponds to variant rs34766278 [ dbSNP | Ensembl ].
VAR_051177
Natural varianti3986 – 39861R → L.
Corresponds to variant rs17293121 [ dbSNP | Ensembl ].
VAR_051178
Natural varianti4044 – 40441A → S.
Corresponds to variant rs9353689 [ dbSNP | Ensembl ].
VAR_024236
Natural varianti4167 – 41671A → T.
Corresponds to variant rs35509794 [ dbSNP | Ensembl ].
VAR_051179
Natural varianti4720 – 47201I → T.
Corresponds to variant rs16882046 [ dbSNP | Ensembl ].
VAR_051180
Natural varianti4783 – 47831D → E.
Corresponds to variant rs36040566 [ dbSNP | Ensembl ].
VAR_051181
Natural varianti5251 – 52511N → K.
Corresponds to variant rs4707557 [ dbSNP | Ensembl ].
VAR_051182

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503925 mRNA. Translation: AAM77722.1.
AL096678, AL158813, AL353692 Genomic DNA. Translation: CAI42279.1.
AL158813, AL096678, AL353692 Genomic DNA. Translation: CAI13203.1.
AL353692, AL096678, AL158813 Genomic DNA. Translation: CAI16236.1.
AB002299 mRNA. Translation: BAA20761.2.
CCDSiCCDS5024.1.
RefSeqiNP_055426.1. NM_014611.2.
UniGeneiHs.529948.

Genome annotation databases

EnsembliENST00000369393; ENSP00000358400; ENSG00000112159.
GeneIDi23195.
KEGGihsa:23195.
UCSCiuc003pnn.1. human.

Polymorphism databases

DMDMi24212017.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503925 mRNA. Translation: AAM77722.1 .
AL096678 , AL158813 , AL353692 Genomic DNA. Translation: CAI42279.1 .
AL158813 , AL096678 , AL353692 Genomic DNA. Translation: CAI13203.1 .
AL353692 , AL096678 , AL158813 Genomic DNA. Translation: CAI16236.1 .
AB002299 mRNA. Translation: BAA20761.2 .
CCDSi CCDS5024.1.
RefSeqi NP_055426.1. NM_014611.2.
UniGenei Hs.529948.

3D structure databases

ProteinModelPortali Q9NU22.
SMRi Q9NU22. Positions 322-347, 673-701, 1080-1233, 1385-1411, 1513-1558, 1746-1844, 2062-2087, 2227-2266.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116804. 25 interactions.
IntActi Q9NU22. 10 interactions.
MINTi MINT-2819308.
STRINGi 9606.ENSP00000358400.

PTM databases

PhosphoSitei Q9NU22.

Polymorphism databases

DMDMi 24212017.

Proteomic databases

MaxQBi Q9NU22.
PaxDbi Q9NU22.
PeptideAtlasi Q9NU22.
PRIDEi Q9NU22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369393 ; ENSP00000358400 ; ENSG00000112159 .
GeneIDi 23195.
KEGGi hsa:23195.
UCSCi uc003pnn.1. human.

Organism-specific databases

CTDi 23195.
GeneCardsi GC06M090352.
H-InvDB HIX0033355.
HGNCi HGNC:18302. MDN1.
HPAi HPA029666.
HPA029667.
HPA029668.
HPA029669.
neXtProti NX_Q9NU22.
PharmGKBi PA30720.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5271.
GeneTreei ENSGT00550000074802.
HOGENOMi HOG000231719.
HOVERGENi HBG031706.
InParanoidi Q9NU22.
KOi K14572.
OMAi RIFLTMD.
OrthoDBi EOG7S4X6J.
PhylomeDBi Q9NU22.
TreeFami TF300488.

Miscellaneous databases

GeneWikii MDN1.
GenomeRNAii 23195.
NextBioi 44695.
PROi Q9NU22.

Gene expression databases

Bgeei Q9NU22.
CleanExi HS_MDN1.
ExpressionAtlasi Q9NU22. baseline and differential.
Genevestigatori Q9NU22.

Family and domain databases

Gene3Di 3.40.50.300. 8 hits.
3.40.50.410. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR012099. Midasin.
IPR027417. P-loop_NTPase.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF07728. AAA_5. 8 hits.
[Graphical view ]
PIRSFi PIRSF010340. Midasin. 1 hit.
SMARTi SM00382. AAA. 6 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 8 hits.
SSF53300. SSF53300. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein."
    Garbarino J.E., Gibbons I.R.
    BMC Genomics 3:18-18(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2387-5596.
    Tissue: Brain.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538 AND THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538 AND THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538; SER-4752 AND SER-4754, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1683, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4538 AND THR-4898, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1177; SER-4538; SER-4752; SER-4754; SER-4889; THR-4898; SER-4937; SER-4946 AND SER-5015, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization."
    Ahmad Y., Boisvert F.M., Lundberg E., Uhlen M., Lamond A.I.
    Mol. Cell. Proteomics 11:M111.013680.01-M111.013680.15(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMDN1_HUMAN
AccessioniPrimary (citable) accession number: Q9NU22
Secondary accession number(s): O15019, Q5T794
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3