Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TBC1 domain family member 22B

Gene

TBC1D22B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).By similarity

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • GTPase activator activity Source: GO_Central
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000065491-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 22B
Gene namesi
Name:TBC1D22B
Synonyms:C6orf197
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21602. TBC1D22B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi58S → E: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi88 – 90LNS → AAA: No effect on ACBD3-binding. 1 Publication3
Mutagenesisi91 – 92KV → AA: No effect on ACBD3-binding. 1 Publication2
Mutagenesisi94 – 96LAT → AAA: No effect on ACBD3-binding. 1 Publication3
Mutagenesisi99Q → A: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi100 – 101VL → AA: Almost complete loss of ACBD3-binding. 1 Publication2
Mutagenesisi102 – 104ENH → AAA: No effect on ACBD3-binding. 1 Publication3
Mutagenesisi114S → E: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi116 – 119STTS → EEEE: No effect on ACBD3-binding. 1 Publication4
Mutagenesisi140 – 141SS → EE: No effect on ACBD3-binding. 1 Publication2
Mutagenesisi143T → E: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi168S → E: No effect on ACBD3-binding. 1 Publication1

Organism-specific databases

DisGeNETi55633.
OpenTargetsiENSG00000065491.
PharmGKBiPA134867087.

Polymorphism and mutation databases

BioMutaiTBC1D22B.
DMDMi47117913.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002080542 – 505TBC1 domain family member 22BAdd BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei58PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei154PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NU19.
MaxQBiQ9NU19.
PaxDbiQ9NU19.
PeptideAtlasiQ9NU19.
PRIDEiQ9NU19.

PTM databases

iPTMnetiQ9NU19.
PhosphoSitePlusiQ9NU19.

Expressioni

Gene expression databases

BgeeiENSG00000065491.
CleanExiHS_TBC1D22B.
GenevisibleiQ9NU19. HS.

Organism-specific databases

HPAiHPA027908.
HPA027909.
HPA027910.

Interactioni

Subunit structurei

Interacts with ACBD3 and ARFGEF1. Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-8787464,EBI-739580
CCDC57Q2TAC23EBI-8787464,EBI-2808286
CCDC67E9PJR53EBI-8787464,EBI-10177066
CDR2Q018503EBI-8787464,EBI-1181367
FXR2P511163EBI-8787464,EBI-740459
GOLGA2A0A0C4DGS54EBI-8787464,EBI-11522202
HSD17B14Q9BPX15EBI-8787464,EBI-742664
IKZF3Q9UKT95EBI-8787464,EBI-747204
KRT40Q6A1623EBI-8787464,EBI-10171697
PNMA5Q96PV43EBI-8787464,EBI-10171633
RBM10P981753EBI-8787464,EBI-721525
SIAH1Q8IUQ43EBI-8787464,EBI-747107
SORBS3O605043EBI-8787464,EBI-741237
TACC3Q9Y6A55EBI-8787464,EBI-2554984
TEX11Q8IYF33EBI-8787464,EBI-742397
TP53BP2Q13625-33EBI-8787464,EBI-10175039
TRIM23P364065EBI-8787464,EBI-740098
TRIM27P143733EBI-8787464,EBI-719493
TRIM54Q9BYV23EBI-8787464,EBI-2130429
VPS52Q8N1B45EBI-8787464,EBI-2799833

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • Rab GTPase binding Source: GO_Central

Protein-protein interaction databases

BioGridi120772. 102 interactors.
IntActiQ9NU19. 43 interactors.
STRINGi9606.ENSP00000362590.

Structurei

Secondary structure

1505
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi185 – 193Combined sources9
Beta strandi195 – 197Combined sources3
Helixi200 – 207Combined sources8
Helixi213 – 215Combined sources3
Helixi216 – 223Combined sources8
Helixi238 – 252Combined sources15
Helixi285 – 300Combined sources16
Helixi313 – 315Combined sources3
Helixi316 – 326Combined sources11
Helixi331 – 333Combined sources3
Helixi336 – 338Combined sources3
Helixi341 – 360Combined sources20
Helixi361 – 365Combined sources5
Helixi371 – 387Combined sources17
Helixi389 – 397Combined sources9
Helixi403 – 411Combined sources9
Turni412 – 414Combined sources3
Helixi415 – 417Combined sources3
Helixi420 – 432Combined sources13
Helixi439 – 451Combined sources13
Helixi453 – 457Combined sources5
Helixi462 – 470Combined sources9
Helixi479 – 496Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DZXX-ray2.30A178-505[»]
ProteinModelPortaliQ9NU19.
SMRiQ9NU19.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NU19.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 434Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1092. Eukaryota.
ENOG410XQ68. LUCA.
GeneTreeiENSGT00860000133753.
HOVERGENiHBG057030.
InParanoidiQ9NU19.
KOiK20360.
OMAiIREIPFN.
OrthoDBiEOG091G055X.
PhylomeDBiQ9NU19.
TreeFamiTF314211.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NU19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAENSKQFW KRSAKLPGSI QPVYGAQHPP LDPRLTKNFI KERSKVNTVP
60 70 80 90 100
LKNKKASSFH EFARNTSDAW DIGDDEEEDF SSPSFQTLNS KVALATAAQV
110 120 130 140 150
LENHSKLRVK PERSQSTTSD VPANYKVIKS SSDAQLSRNS SDTCLRNPLH
160 170 180 190 200
KQQSLPLRPI IPLVARISDQ NASGAPPMTV REKTRLEKFR QLLSSQNTDL
210 220 230 240 250
DELRKCSWPG VPREVRPITW RLLSGYLPAN TERRKLTLQR KREEYFGFIE
260 270 280 290 300
QYYDSRNEEH HQDTYRQIHI DIPRTNPLIP LFQQPLVQEI FERILFIWAI
310 320 330 340 350
RHPASGYVQG INDLVTPFFV VFLSEYVEED VENFDVTNLS QDMLRSIEAD
360 370 380 390 400
SFWCMSKLLD GIQDNYTFAQ PGIQKKVKAL EELVSRIDEQ VHNHFRRYEV
410 420 430 440 450
EYLQFAFRWM NNLLMRELPL RCTIRLWDTY QSEPEGFSHF HLYVCAAFLI
460 470 480 490 500
KWRKEILDEE DFQGLLMLLQ NLPTIHWGNE EIGLLLAEAY RLKYMFADAP

NHYRR
Length:505
Mass (Da):59,081
Last modified:May 10, 2004 - v3
Checksum:iC0093770BE04AA4D
GO

Sequence cautioni

The sequence BAA91099 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti376 – 378KVK → HEE in AAH00291 (PubMed:15489334).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449909 mRNA. Translation: BAH16652.1.
AY313781 mRNA. Translation: AAQ72548.1.
AK000344 mRNA. Translation: BAA91099.1. Different initiation.
AK292893 mRNA. Translation: BAF85582.1.
AL096712, AL353579, AL589667 Genomic DNA. Translation: CAI22620.1.
AL353579, AL096712, AL589667 Genomic DNA. Translation: CAI20318.1.
AL589667, AL096712, AL353579 Genomic DNA. Translation: CAH71194.1.
CH471081 Genomic DNA. Translation: EAX03939.1.
BC000291 mRNA. Translation: AAH00291.2.
BC000743 mRNA. Translation: AAH00743.2.
BC001927 mRNA. Translation: AAH01927.1.
BC002720 mRNA. Translation: AAH02720.2.
BC063523 mRNA. Translation: AAH63523.1.
BC109026 mRNA. Translation: AAI09027.1.
BC109027 mRNA. Translation: AAI09028.1.
CCDSiCCDS4832.1.
RefSeqiNP_060242.2. NM_017772.3.
UniGeneiHs.731702.

Genome annotation databases

EnsembliENST00000373491; ENSP00000362590; ENSG00000065491.
GeneIDi55633.
KEGGihsa:55633.
UCSCiuc003onn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449909 mRNA. Translation: BAH16652.1.
AY313781 mRNA. Translation: AAQ72548.1.
AK000344 mRNA. Translation: BAA91099.1. Different initiation.
AK292893 mRNA. Translation: BAF85582.1.
AL096712, AL353579, AL589667 Genomic DNA. Translation: CAI22620.1.
AL353579, AL096712, AL589667 Genomic DNA. Translation: CAI20318.1.
AL589667, AL096712, AL353579 Genomic DNA. Translation: CAH71194.1.
CH471081 Genomic DNA. Translation: EAX03939.1.
BC000291 mRNA. Translation: AAH00291.2.
BC000743 mRNA. Translation: AAH00743.2.
BC001927 mRNA. Translation: AAH01927.1.
BC002720 mRNA. Translation: AAH02720.2.
BC063523 mRNA. Translation: AAH63523.1.
BC109026 mRNA. Translation: AAI09027.1.
BC109027 mRNA. Translation: AAI09028.1.
CCDSiCCDS4832.1.
RefSeqiNP_060242.2. NM_017772.3.
UniGeneiHs.731702.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DZXX-ray2.30A178-505[»]
ProteinModelPortaliQ9NU19.
SMRiQ9NU19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120772. 102 interactors.
IntActiQ9NU19. 43 interactors.
STRINGi9606.ENSP00000362590.

PTM databases

iPTMnetiQ9NU19.
PhosphoSitePlusiQ9NU19.

Polymorphism and mutation databases

BioMutaiTBC1D22B.
DMDMi47117913.

Proteomic databases

EPDiQ9NU19.
MaxQBiQ9NU19.
PaxDbiQ9NU19.
PeptideAtlasiQ9NU19.
PRIDEiQ9NU19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373491; ENSP00000362590; ENSG00000065491.
GeneIDi55633.
KEGGihsa:55633.
UCSCiuc003onn.3. human.

Organism-specific databases

CTDi55633.
DisGeNETi55633.
GeneCardsiTBC1D22B.
HGNCiHGNC:21602. TBC1D22B.
HPAiHPA027908.
HPA027909.
HPA027910.
MIMi616880. gene.
neXtProtiNX_Q9NU19.
OpenTargetsiENSG00000065491.
PharmGKBiPA134867087.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1092. Eukaryota.
ENOG410XQ68. LUCA.
GeneTreeiENSGT00860000133753.
HOVERGENiHBG057030.
InParanoidiQ9NU19.
KOiK20360.
OMAiIREIPFN.
OrthoDBiEOG091G055X.
PhylomeDBiQ9NU19.
TreeFamiTF314211.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000065491-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9NU19.
GenomeRNAii55633.
PROiQ9NU19.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065491.
CleanExiHS_TBC1D22B.
GenevisibleiQ9NU19. HS.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTB22B_HUMAN
AccessioniPrimary (citable) accession number: Q9NU19
Secondary accession number(s): A8KA28
, Q32MQ8, Q5VUK9, Q6P4C3, Q7Z6P7, Q9BPV6, Q9BUT5, Q9NXB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 10, 2004
Last modified: November 30, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.