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Protein

RNA-binding protein 12

Gene

RBM12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 12
Alternative name(s):
RNA-binding motif protein 12
SH3/WW domain anchor protein in the nucleus
Short name:
SWAN
Gene namesi
Name:RBM12
Synonyms:KIAA0765
ORF Names:HRIHFB2091
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9898. RBM12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10137.
OpenTargetsiENSG00000244462.
PharmGKBiPA34261.

Polymorphism and mutation databases

BioMutaiRBM12.
DMDMi30173387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817701 – 932RNA-binding protein 12Add BLAST932

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei352PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NTZ6.
MaxQBiQ9NTZ6.
PaxDbiQ9NTZ6.
PeptideAtlasiQ9NTZ6.
PRIDEiQ9NTZ6.

PTM databases

iPTMnetiQ9NTZ6.
PhosphoSitePlusiQ9NTZ6.

Expressioni

Gene expression databases

BgeeiENSG00000244462.
CleanExiHS_RBM12.
ExpressionAtlasiQ9NTZ6. baseline and differential.
GenevisibleiQ9NTZ6. HS.

Organism-specific databases

HPAiHPA043258.
HPA043621.

Interactioni

Protein-protein interaction databases

BioGridi115440. 39 interactors.
IntActiQ9NTZ6. 7 interactors.
MINTiMINT-1366084.
STRINGi9606.ENSP00000352668.

Structurei

Secondary structure

1932
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi301 – 304Combined sources4
Beta strandi305 – 309Combined sources5
Helixi317 – 323Combined sources7
Turni324 – 326Combined sources3
Beta strandi331 – 334Combined sources4
Beta strandi344 – 349Combined sources6
Helixi353 – 361Combined sources9
Turni362 – 364Combined sources3
Beta strandi373 – 376Combined sources4
Helixi379 – 386Combined sources8
Beta strandi431 – 435Combined sources5
Helixi443 – 449Combined sources7
Turni457 – 459Combined sources3
Beta strandi461 – 464Combined sources4
Beta strandi468 – 481Combined sources14
Helixi482 – 488Combined sources7
Beta strandi500 – 505Combined sources6
Helixi507 – 521Combined sources15
Beta strandi545 – 550Combined sources6
Helixi557 – 563Combined sources7
Turni564 – 566Combined sources3
Beta strandi574 – 576Combined sources3
Beta strandi588 – 591Combined sources4
Helixi595 – 601Combined sources7
Helixi602 – 604Combined sources3
Beta strandi606 – 609Combined sources4
Beta strandi612 – 619Combined sources8
Helixi621 – 629Combined sources9
Beta strandi856 – 861Combined sources6
Helixi869 – 875Combined sources7
Turni876 – 880Combined sources5
Beta strandi887 – 890Combined sources4
Beta strandi896 – 906Combined sources11
Helixi907 – 917Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WELNMR-A412-522[»]
2CPYNMR-A536-636[»]
2DNNNMR-A295-390[»]
2EK1X-ray2.00A/B/C/D/E/F/G/H848-929[»]
2EK6X-ray2.38A/B/C/D848-929[»]
ProteinModelPortaliQ9NTZ6.
SMRiQ9NTZ6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NTZ6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini304 – 379RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini430 – 507RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini856 – 932RRM 3PROSITE-ProRule annotationAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 301Pro-richAdd BLAST143
Compositional biasi186 – 194Poly-Pro9
Compositional biasi631 – 855Pro-richAdd BLAST225
Compositional biasi635 – 854Gly-richAdd BLAST220

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4307. Eukaryota.
ENOG4111WZ9. LUCA.
GeneTreeiENSGT00760000119102.
HOVERGENiHBG057691.
InParanoidiQ9NTZ6.
OMAiISCFIRC.
OrthoDBiEOG091G05IT.
PhylomeDBiQ9NTZ6.
TreeFamiTF331899.

Family and domain databases

Gene3Di3.30.70.330. 5 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 5 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NTZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVIRLQGL PIVAGTMDIR HFFSGLTIPD GGVHIVGGEL GEAFIVFATD
60 70 80 90 100
EDARLGMMRT GGTIKGSKVT LLLSSKTEMQ NMIELSRRRF ETANLDIPPA
110 120 130 140 150
NASRSGPPPS SGMSSRVNLP TTVSNFNNPS PSVVTATTSV HESNKNIQTF
160 170 180 190 200
STASVGTAPP NMGASFGSPT FSSTVPSTAS PMNTVPPPPI PPIPAMPSLP
210 220 230 240 250
PMPSIPPIPV PPPVPTLPPV PPVPPIPPVP SVPPMTPLPP MSGMPPLNPP
260 270 280 290 300
PVAPLPAGMN GSGAPMNLNN NLNPMFLGPL NPVNPIQMNS QSSVKPLPIN
310 320 330 340 350
PDDLYVSVHG MPFSAMENDV RDFFHGLRVD AVHLLKDHVG RNNGNGLVKF
360 370 380 390 400
LSPQDTFEAL KRNRMLMIQR YVEVSPATER QWVAAGGHIT FKQNMGPSGQ
410 420 430 440 450
THPPPQTLPR SKSPSGQKRS RSRSPHEAGF CVYLKGLPFE AENKHVIDFF
460 470 480 490 500
KKLDIVEDSI YIAYGPNGKA TGEGFVEFRN EADYKAALCR HKQYMGNRFI
510 520 530 540 550
QVHPITKKGM LEKIDMIRKR LQNFSYDQRE MILNPEGDVN SAKVCAHITN
560 570 580 590 600
IPFSITKMDV LQFLEGIPVD ENAVHVLVDN NGQGLGQALV QFKNEDDARK
610 620 630 640 650
SERLHRKKLN GREAFVHVVT LEDMREIEKN PPAQGKKGLK MPVPGNPAVP
660 670 680 690 700
GMPNAGLPGV GLPSAGLPGA GLPSTGLPGS AITSAGLPGA GMPSAGIPSA
710 720 730 740 750
GGEEHAFLTV GSKEANNGPP FNFPGNFGGS NAFGPPIPPP GLGGGAFGDA
760 770 780 790 800
RPGMPSVGNS GLPGLGLDVP GFGGGPNNLS GPSGFGGGPQ NFGNGPGSLG
810 820 830 840 850
GPPGFGSGPP GLGSAPGHLG GPPAFGPGPG PGPGPGPIHI GGPPGFASSS
860 870 880 890 900
GKPGPTVIKV QNMPFTVSID EILDFFYGYQ VIPGSVCLKY NEKGMPTGEA
910 920 930
MVAFESRDEA TAAVIDLNDR PIGSRKVKLV LG
Length:932
Mass (Da):97,395
Last modified:October 1, 2000 - v1
Checksum:i10623E1EBCC93FC5
GO

Sequence cautioni

The sequence BAA34485 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti601S → T in CAC20441 (PubMed:11435693).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052217572N → S.Corresponds to variant rs17092928dbSNPEnsembl.1
Natural variantiVAR_052218921P → L.Corresponds to variant rs6121012dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ289772 mRNA. Translation: CAC20441.1.
AF345332 mRNA. Translation: AAL83752.1.
AF345335 Genomic DNA. Translation: AAL83755.1.
AF393214 mRNA. Translation: AAM73682.1.
AB018308 mRNA. Translation: BAA34485.2. Different initiation.
AK092239 mRNA. Translation: BAG52504.1.
AL109827 Genomic DNA. Translation: CAB87611.1.
CH471077 Genomic DNA. Translation: EAW76182.1.
CH471077 Genomic DNA. Translation: EAW76184.1.
CH471077 Genomic DNA. Translation: EAW76188.1.
BC012787 mRNA. Translation: AAH12787.1.
BC013981 mRNA. Translation: AAH13981.1.
AL834472 mRNA. Translation: CAD39131.1.
AB015336 mRNA. Translation: BAA34794.1.
CCDSiCCDS13261.1.
RefSeqiNP_001185767.1. NM_001198838.1.
NP_001185769.1. NM_001198840.1.
NP_006038.2. NM_006047.5.
NP_690051.1. NM_152838.3.
UniGeneiHs.700188.

Genome annotation databases

EnsembliENST00000359646; ENSP00000352668; ENSG00000244462.
ENST00000374104; ENSP00000363217; ENSG00000244462.
ENST00000374114; ENSP00000363228; ENSG00000244462.
GeneIDi10137.
KEGGihsa:10137.
UCSCiuc002xdq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ289772 mRNA. Translation: CAC20441.1.
AF345332 mRNA. Translation: AAL83752.1.
AF345335 Genomic DNA. Translation: AAL83755.1.
AF393214 mRNA. Translation: AAM73682.1.
AB018308 mRNA. Translation: BAA34485.2. Different initiation.
AK092239 mRNA. Translation: BAG52504.1.
AL109827 Genomic DNA. Translation: CAB87611.1.
CH471077 Genomic DNA. Translation: EAW76182.1.
CH471077 Genomic DNA. Translation: EAW76184.1.
CH471077 Genomic DNA. Translation: EAW76188.1.
BC012787 mRNA. Translation: AAH12787.1.
BC013981 mRNA. Translation: AAH13981.1.
AL834472 mRNA. Translation: CAD39131.1.
AB015336 mRNA. Translation: BAA34794.1.
CCDSiCCDS13261.1.
RefSeqiNP_001185767.1. NM_001198838.1.
NP_001185769.1. NM_001198840.1.
NP_006038.2. NM_006047.5.
NP_690051.1. NM_152838.3.
UniGeneiHs.700188.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WELNMR-A412-522[»]
2CPYNMR-A536-636[»]
2DNNNMR-A295-390[»]
2EK1X-ray2.00A/B/C/D/E/F/G/H848-929[»]
2EK6X-ray2.38A/B/C/D848-929[»]
ProteinModelPortaliQ9NTZ6.
SMRiQ9NTZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115440. 39 interactors.
IntActiQ9NTZ6. 7 interactors.
MINTiMINT-1366084.
STRINGi9606.ENSP00000352668.

PTM databases

iPTMnetiQ9NTZ6.
PhosphoSitePlusiQ9NTZ6.

Polymorphism and mutation databases

BioMutaiRBM12.
DMDMi30173387.

Proteomic databases

EPDiQ9NTZ6.
MaxQBiQ9NTZ6.
PaxDbiQ9NTZ6.
PeptideAtlasiQ9NTZ6.
PRIDEiQ9NTZ6.

Protocols and materials databases

DNASUi10137.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359646; ENSP00000352668; ENSG00000244462.
ENST00000374104; ENSP00000363217; ENSG00000244462.
ENST00000374114; ENSP00000363228; ENSG00000244462.
GeneIDi10137.
KEGGihsa:10137.
UCSCiuc002xdq.4. human.

Organism-specific databases

CTDi10137.
DisGeNETi10137.
GeneCardsiRBM12.
HGNCiHGNC:9898. RBM12.
HPAiHPA043258.
HPA043621.
MIMi607179. gene.
neXtProtiNX_Q9NTZ6.
OpenTargetsiENSG00000244462.
PharmGKBiPA34261.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4307. Eukaryota.
ENOG4111WZ9. LUCA.
GeneTreeiENSGT00760000119102.
HOVERGENiHBG057691.
InParanoidiQ9NTZ6.
OMAiISCFIRC.
OrthoDBiEOG091G05IT.
PhylomeDBiQ9NTZ6.
TreeFamiTF331899.

Miscellaneous databases

EvolutionaryTraceiQ9NTZ6.
GeneWikiiRBM12.
GenomeRNAii10137.
PROiQ9NTZ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000244462.
CleanExiHS_RBM12.
ExpressionAtlasiQ9NTZ6. baseline and differential.
GenevisibleiQ9NTZ6. HS.

Family and domain databases

Gene3Di3.30.70.330. 5 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 5 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM12_HUMAN
AccessioniPrimary (citable) accession number: Q9NTZ6
Secondary accession number(s): B3KRU2
, E1P5R6, O94865, Q8N3B1, Q9H196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.