Q9NTW7 (ZF64B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 64 homolog, isoforms 3 and 4
Short name=Zfp-64

Alternative name(s):
Zinc finger protein 338

Gene names

Name:	ZFP64
Synonyms:	ZNF338

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	645 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 13 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q9NTW7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 4 (identifier: Q9NTW7-2)

Also known as: ZNF338;

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.
     220-254: KHLRIHSDERPFKCQICPYASRNSSQLTVHLRSHT → MSRRKQAKPQHLNSEEPRPARRECAEVAPQVAGEP

Isoform 1 (identifier: Q9NPA5-1)

The sequence of this isoform can be found in the external entry Q9NPA5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 2 (identifier: Q9NPA5-2)

The sequence of this isoform can be found in the external entry Q9NPA5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 5 (identifier: Q9NTW7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     411-415: DTPFQ → CCYVA
     416-645: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 645	645	Zinc finger protein 64 homolog, isoforms 3 and 4		PRO_0000047308
Regions
	Zinc finger	175 – 197	23	C2H2-type 1
	Zinc finger	203 – 225	23	C2H2-type 2
	Zinc finger	231 – 253	23	C2H2-type 3
	Zinc finger	299 – 324	26	C2H2-type 4; atypical
	Zinc finger	330 – 352	23	C2H2-type 5
	Zinc finger	358 – 380	23	C2H2-type 6
	Zinc finger	386 – 408	23	C2H2-type 7
	Zinc finger	414 – 436	23	C2H2-type 8
	Zinc finger	442 – 465	24	C2H2-type 9
	Zinc finger	467 – 489	23	C2H2-type 10
	Zinc finger	495 – 517	23	C2H2-type 11
	Zinc finger	523 – 546	24	C2H2-type 12
	Zinc finger	580 – 602	23	C2H2-type 13
Sites
	Metal binding	497	1	Zinc 1 By similarity
	Metal binding	500	1	Zinc 1 By similarity
	Metal binding	513	1	Zinc 1 By similarity
	Metal binding	517	1	Zinc 1 By similarity
	Metal binding	525	1	Zinc 2 By similarity
	Metal binding	528	1	Zinc 2 By similarity
	Metal binding	541	1	Zinc 2 By similarity
	Metal binding	546	1	Zinc 2 By similarity
Natural variations
	Alternative sequence	1 – 219	219	Missing in isoform 4.		VSP_007285
	Alternative sequence	220 – 254	35	KHLRI…LRSHT → MSRRKQAKPQHLNSEEPRPA RRECAEVAPQVAGEP in isoform 4.		VSP_007286
	Alternative sequence	411 – 415	5	DTPFQ → CCYVA in isoform 5.		VSP_038213
	Alternative sequence	416 – 645	230	Missing in isoform 5.		VSP_038214
	Natural variant	593	1	D → E in a breast cancer sample; somatic mutation. Ref.7		VAR_035564
	Natural variant	609	1	K → N in a breast cancer sample; somatic mutation. Ref.7		VAR_035565
Experimental info
	Sequence conflict	240	1	S → G in BAD96432. Ref.3
	Sequence conflict	521	1	R → C in AAP88762. Ref.2
	Sequence conflict	521	1	R → C in BC021087. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified April 30, 2003. Version 3. Checksum: D7D336A59C128CC0	FASTA	645	72,217
	10 20 30 40 50 60 MNASSEGESF AGSVQIPGGT TVLVELTPDI HICGICKQQF NNLDAFVAHK QSGCQLTGTS 70 80 90 100 110 120 AAAPSTVQFV SEETVPATQT QTTTRTITSE TQTITVSAPE FVFEHGYQTY LPTESNENQT 130 140 150 160 170 180 ATVISLPAKS RTKKPTTPPA QKRLNCCYPG CQFKTAYGMK DMERHLKIHT GDKPHKCEVC 190 200 210 220 230 240 GKCFSRKDKL KTHMRCHTGV KPYKCKTCDY AAADSSSLNK HLRIHSDERP FKCQICPYAS 250 260 270 280 290 300 RNSSQLTVHL RSHTASELDD DVPKANCLST ESTDTPKAPV ITLPSEAREQ MATLGERTFN 310 320 330 340 350 360 CCYPGCHFKT VHGMKDLDRH LRIHTGDKPH KCEFCDKCFS RKDNLTMHMR CHTSVKPHKC 370 380 390 400 410 420 HLCDYAAVDS SSLKKHLRIH SDERPYKCQL CPYASRNSSQ LTVHLRSHTG DTPFQCWLCS 430 440 450 460 470 480 AKFKISSDLK RHMIVHSGEK PFKCEFCDVR CTMKANLKSH IRIKHTFKCL HCAFQGRDRA 490 500 510 520 530 540 DLLEHSRLHQ ADHPEKCPEC SYSCSSAAAL RVHSRVHCKD RPFKCDFCSF DTKRPSSLAK 550 560 570 580 590 600 HVDKVHRDEA KTENRAPLGK EGLREGSSQH VAKIVTQRAF RCETCGASFV RDDSLRCHKK 610 620 630 640 QHSDQSENKN SDLVTFPPES GASGQLSTLV SVGQLEAPLE PSQDL
	Isoform 4 (ZNF338) [UniParc]. Checksum: 1058B24E5147E9C7	FASTA	426	48,165
	10 20 30 40 50 60 MSRRKQAKPQ HLNSEEPRPA RRECAEVAPQ VAGEPASELD DDVPKANCLS TESTDTPKAP 70 80 90 100 110 120 VITLPSEARE QMATLGERTF NCCYPGCHFK TVHGMKDLDR HLRIHTGDKP HKCEFCDKCF 130 140 150 160 170 180 SRKDNLTMHM RCHTSVKPHK CHLCDYAAVD SSSLKKHLRI HSDERPYKCQ LCPYASRNSS 190 200 210 220 230 240 QLTVHLRSHT GDTPFQCWLC SAKFKISSDL KRHMIVHSGE KPFKCEFCDV RCTMKANLKS 250 260 270 280 290 300 HIRIKHTFKC LHCAFQGRDR ADLLEHSRLH QADHPEKCPE CSYSCSSAAA LRVHSRVHCK 310 320 330 340 350 360 DRPFKCDFCS FDTKRPSSLA KHVDKVHRDE AKTENRAPLG KEGLREGSSQ HVAKIVTQRA 370 380 390 400 410 420 FRCETCGASF VRDDSLRCHK KQHSDQSENK NSDLVTFPPE SGASGQLSTL VSVGQLEAPL EPSQDL
	Isoform 1 [UniParc]. See Q9NPA5.		–	–
	Isoform 2 [UniParc]. See Q9NPA5.		–	–
	Isoform 5 [UniParc]. Checksum: FF37B0E6DE035CF7	FASTA	415	46,253
	10 20 30 40 50 60 MNASSEGESF AGSVQIPGGT TVLVELTPDI HICGICKQQF NNLDAFVAHK QSGCQLTGTS 70 80 90 100 110 120 AAAPSTVQFV SEETVPATQT QTTTRTITSE TQTITVSAPE FVFEHGYQTY LPTESNENQT 130 140 150 160 170 180 ATVISLPAKS RTKKPTTPPA QKRLNCCYPG CQFKTAYGMK DMERHLKIHT GDKPHKCEVC 190 200 210 220 230 240 GKCFSRKDKL KTHMRCHTGV KPYKCKTCDY AAADSSSLNK HLRIHSDERP FKCQICPYAS 250 260 270 280 290 300 RNSSQLTVHL RSHTASELDD DVPKANCLST ESTDTPKAPV ITLPSEAREQ MATLGERTFN 310 320 330 340 350 360 CCYPGCHFKT VHGMKDLDRH LRIHTGDKPH KCEFCDKCFS RKDNLTMHMR CHTSVKPHKC 370 380 390 400 410 HLCDYAAVDS SSLKKHLRIH SDERPYKCQL CPYASRNSSQ LTVHLRSHTG CCYVA

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Teratocarcinoma.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Colon.
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Lymph.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-593 AND ASN-609.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022690 mRNA. Translation: BAB14182.1. BT009760 mRNA. Translation: AAP88762.1. AK222712 mRNA. Translation: BAD96432.1. Different termination. AL109984 Genomic DNA. Translation: CAB86405.2. AL109984, AL121771 Genomic DNA. Translation: CAI43095.1. AL109984, AL121771 Genomic DNA. Translation: CAM28323.1. AL121771, AL109984 Genomic DNA. Translation: CAI21789.1. AL121771, AL109984 Genomic DNA. Translation: CAM28264.1. CH471077 Genomic DNA. Translation: EAW75591.1. BC021087 mRNA. No translation available.
IPI	IPI00005020. IPI00414782. IPI00796082.
RefSeq	NP_955459.2. NM_199427.2.
UniGene	Hs.473082.
3D structure databases
ProteinModelPortal	Q9NTW7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NTW7. 2 interactions.
Polymorphism databases
DMDM	30316391.
Proteomic databases
PRIDE	Q9NTW7.
Protocols and materials databases
DNASU	55734.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361387; ENSP00000355179; ENSG00000020256. ENST00000371518; ENSP00000360573; ENSG00000020256. ENST00000371523; ENSP00000360578; ENSG00000020256.
GeneID	55734.
KEGG	hsa:55734.
UCSC	uc002xwj.3. human. uc002xwk.3. human.
Organism-specific databases
CTD	55734.
GeneCards	GC20M050668.
HGNC	HGNC:15940. ZFP64.
neXtProt	NX_Q9NTW7.
PharmGKB	PA38060.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG056373.
OMA	KDGPRES.
OrthoDB	EOG4JT053.
Gene expression databases
ArrayExpress	Q9NTW7.
Bgee	Q9NTW7.
CleanEx	HS_ZFP64.
Genevestigator	Q9NTW7.
GermOnline	ENSG00000020256. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 12 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 15 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 6 hits. PS50157. ZINC_FINGER_C2H2_2. 13 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55734.
NextBio	60666.

Entry information

Entry name

ZF64B_HUMAN

Accession

Primary (citable) accession number: Q9NTW7
Secondary accession number(s): A2A2N4 , Q53H69, Q53XQ1, Q5JWM0, Q8WU98, Q9H9P1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	April 30, 2003
Last modified:	May 1, 2013
This is version 118 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.