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Reviewed, UniProtKB/Swiss-Prot Q9NTU7 (CBLN4_HUMAN)

Last modified January 19, 2010. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cerebellin-4
Alternative name(s):
    Cerebellin-like glycoprotein 1
Gene names
Name: CBLN4
Synonyms: CBLNL1
ORF Names: UNQ718/PRO1382
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May be involved in synaptic functions in the CNS. Can enable ER export and secretion of CBLN3 By similarity.

Subunit structure

Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers. May interact with CBLN1, CBLN2 and CBLN3 By similarity.

Subcellular location

Secreted By similarity. Cell junction › synapse By similarity.

Sequence similarities

Contains 1 C1q domain.

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Ontologies

Keywords
   Cellular componentCell junction
Secreted
Synapse
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Cellular componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

synapse

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Ref.4
Chain28 – 201174Cerebellin-4
PRO_0000003556

Regions

Domain66 – 201136C1q

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation881N-linked (GlcNAc...) Potential
Disulfide bond40Interchain By similarity
Disulfide bond44Interchain By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9NTU7-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 2CC9B6C25A1929B7

FASTA20121,808
        10         20         30         40         50         60 
MGSGRRALSA VPAVLLVLTL PGLPVWAQND TEPIVLEGKC LVVCDSNPAT DSKGSSSSPL 

        70         80         90        100        110        120 
GISVRAANSK VAFSAVRSTN HEPSEMSNKT RIIYFDQILV NVGNFFTLES VFVAPRKGIY 

       130        140        150        160        170        180 
SFSFHVIKVY QSQTIQVNLM LNGKPVISAF AGDKDVTREA ATNGVLLYLD KEDKVYLKLE 

       190        200 
KGNLVGGWQY STFSGFLVFP L

« Hide

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References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 28-42.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY358527 mRNA. Translation: AAQ88891.1.
AL117383 Genomic DNA. Translation: CAB90173.1.
BC050026 mRNA. Translation: AAH50026.1.
BC069402 mRNA. Translation: AAH69402.1.
BC069488 mRNA. Translation: AAH69488.1.
BC069516 mRNA. Translation: AAH69516.1.
IPIIPI00018396.
RefSeqNP_542184.1.
UniGeneHs.126141

3D structure databases

SMRQ9NTU7. Positions 69-201.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9NTU7.

Proteomic databases

PeptideAtlasQ9NTU7.
PRIDEQ9NTU7.

Genome annotation databases

EnsemblENST00000064571; ENSP00000064571; ENSG00000054803; Homo sapiens. [Genome view]
GeneID140689.
KEGGhsa:140689.
UCSCuc002xxa.1. human.

Organism-specific databases

CTD140689.
GeneCardsGC20M054005.
H-InvDBHIX0040557.
HGNCHGNC:16231. CBLN4.
PharmGKBPA26120.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG07652.
HOGENOMHBG444750.
HOVERGENQ9NTU7.
InParanoidQ9NTU7.
OMALESVFVS.
OrthoDBEOG9MGVSJ.
PhylomeDBQ9NTU7.

Gene expression databases

ArrayExpressQ9NTU7.
BgeeQ9NTU7.
CleanExHS_CBLN4.
GenevestigatorQ9NTU7.
GermOnlineENSG00000054803. Homo sapiens.

Family and domain databases

InterProIPR001073. C1q.
IPR008983. Tumour_necrosis_fac-like.
[Graphical view]
Gene3DG3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
PfamPF00386. C1q. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio84235.

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Entry information

Entry nameCBLN4_HUMAN
AccessionPrimary (citable) accession number: Q9NTU7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: January 19, 2010
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents