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Protein

Cerebellin-4

Gene

CBLN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebellin-4
Alternative name(s):
Cerebellin-like glycoprotein 1
Gene namesi
Name:CBLN4
Synonyms:CBLNL1
ORF Names:UNQ718/PRO1382
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16231. CBLN4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26120.

Polymorphism and mutation databases

DMDMi13626170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 201174Cerebellin-4PRO_0000003556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)By similarity
Disulfide bondi40 – 40InterchainBy similarity
Disulfide bondi44 – 44InterchainBy similarity
Glycosylationi88 – 881N-linked (GlcNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NTU7.
PeptideAtlasiQ9NTU7.
PRIDEiQ9NTU7.

PTM databases

PhosphoSiteiQ9NTU7.

Expressioni

Gene expression databases

BgeeiENSG00000054803.
CleanExiHS_CBLN4.
GenevisibleiQ9NTU7. HS.

Organism-specific databases

HPAiCAB013584.

Interactioni

Subunit structurei

Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers (By similarity). May form oligomers with CBLN1, CBLN2 and CBLN3 prior to secretion (By similarity). Strongly interacts with DCC in a NTN1-displaceable fashion (By similarity). Weakly binds to NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Interaction with NRXN3 short isoform is hardly detectable; no interaction at all with NRXN3 long isoform (By similarity).By similarity

Protein-protein interaction databases

BioGridi126652. 14 interactions.
IntActiQ9NTU7. 1 interaction.
STRINGi9606.ENSP00000064571.

Structurei

3D structure databases

ProteinModelPortaliQ9NTU7.
SMRiQ9NTU7. Positions 70-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 201136C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFXA. Eukaryota.
ENOG410Y16R. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085657.
HOVERGENiHBG108329.
InParanoidiQ9NTU7.
OMAiRSNNHEP.
OrthoDBiEOG091G0XK2.
PhylomeDBiQ9NTU7.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NTU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGRRALSA VPAVLLVLTL PGLPVWAQND TEPIVLEGKC LVVCDSNPAT
60 70 80 90 100
DSKGSSSSPL GISVRAANSK VAFSAVRSTN HEPSEMSNKT RIIYFDQILV
110 120 130 140 150
NVGNFFTLES VFVAPRKGIY SFSFHVIKVY QSQTIQVNLM LNGKPVISAF
160 170 180 190 200
AGDKDVTREA ATNGVLLYLD KEDKVYLKLE KGNLVGGWQY STFSGFLVFP

L
Length:201
Mass (Da):21,808
Last modified:October 1, 2000 - v1
Checksum:i2CC9B6C25A1929B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911S → P in BAF82329 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358527 mRNA. Translation: AAQ88891.1.
AK289640 mRNA. Translation: BAF82329.1.
AL117383 Genomic DNA. Translation: CAB90173.1.
BC050026 mRNA. Translation: AAH50026.1.
BC069402 mRNA. Translation: AAH69402.1.
BC069488 mRNA. Translation: AAH69488.1.
BC069516 mRNA. Translation: AAH69516.1.
CCDSiCCDS13448.1.
RefSeqiNP_542184.1. NM_080617.5.
UniGeneiHs.126141.
Hs.741877.

Genome annotation databases

EnsembliENST00000064571; ENSP00000064571; ENSG00000054803.
GeneIDi140689.
KEGGihsa:140689.
UCSCiuc002xxa.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358527 mRNA. Translation: AAQ88891.1.
AK289640 mRNA. Translation: BAF82329.1.
AL117383 Genomic DNA. Translation: CAB90173.1.
BC050026 mRNA. Translation: AAH50026.1.
BC069402 mRNA. Translation: AAH69402.1.
BC069488 mRNA. Translation: AAH69488.1.
BC069516 mRNA. Translation: AAH69516.1.
CCDSiCCDS13448.1.
RefSeqiNP_542184.1. NM_080617.5.
UniGeneiHs.126141.
Hs.741877.

3D structure databases

ProteinModelPortaliQ9NTU7.
SMRiQ9NTU7. Positions 70-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126652. 14 interactions.
IntActiQ9NTU7. 1 interaction.
STRINGi9606.ENSP00000064571.

PTM databases

PhosphoSiteiQ9NTU7.

Polymorphism and mutation databases

DMDMi13626170.

Proteomic databases

PaxDbiQ9NTU7.
PeptideAtlasiQ9NTU7.
PRIDEiQ9NTU7.

Protocols and materials databases

DNASUi140689.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000064571; ENSP00000064571; ENSG00000054803.
GeneIDi140689.
KEGGihsa:140689.
UCSCiuc002xxa.5. human.

Organism-specific databases

CTDi140689.
GeneCardsiCBLN4.
HGNCiHGNC:16231. CBLN4.
HPAiCAB013584.
MIMi615029. gene.
neXtProtiNX_Q9NTU7.
PharmGKBiPA26120.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFXA. Eukaryota.
ENOG410Y16R. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085657.
HOVERGENiHBG108329.
InParanoidiQ9NTU7.
OMAiRSNNHEP.
OrthoDBiEOG091G0XK2.
PhylomeDBiQ9NTU7.
TreeFamiTF329591.

Miscellaneous databases

GenomeRNAii140689.
PROiQ9NTU7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000054803.
CleanExiHS_CBLN4.
GenevisibleiQ9NTU7. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBLN4_HUMAN
AccessioniPrimary (citable) accession number: Q9NTU7
Secondary accession number(s): A8K0S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.