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Protein

Semaphorin-4G

Gene

SEMA4G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4G
Gene namesi
Name:SEMA4G
Synonyms:KIAA1619
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:10735. SEMA4G.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 675658ExtracellularSequence AnalysisAdd
BLAST
Transmembranei676 – 69621HelicalSequence AnalysisAdd
BLAST
Topological domaini697 – 838142CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35657.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 838821Semaphorin-4GPRO_0000032333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 115By similarity
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi133 ↔ 142By similarity
Disulfide bondi270 ↔ 377By similarity
Disulfide bondi294 ↔ 337By similarity
Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi508 ↔ 525By similarity
Disulfide bondi517 ↔ 534By similarity
Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi584 ↔ 632By similarity
Glycosylationi598 – 5981N-linked (GlcNAc...)Sequence Analysis
Modified residuei837 – 8371PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NTN9.
PaxDbiQ9NTN9.
PRIDEiQ9NTN9.

PTM databases

PhosphoSiteiQ9NTN9.

Expressioni

Gene expression databases

BgeeiQ9NTN9.
CleanExiHS_SEMA4G.
ExpressionAtlasiQ9NTN9. baseline and differential.
GenevestigatoriQ9NTN9.

Organism-specific databases

HPAiHPA038362.

Interactioni

Subunit structurei

Interacts with PLXNB2.By similarity

Protein-protein interaction databases

BioGridi121738. 7 interactions.
IntActiQ9NTN9. 2 interactions.
MINTiMINT-1475595.
STRINGi9606.ENSP00000210633.

Structurei

3D structure databases

ProteinModelPortaliQ9NTN9.
SMRiQ9NTN9. Positions 34-636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 505471SemaPROSITE-ProRule annotationAdd
BLAST
Domaini507 – 55852PSIAdd
BLAST
Domaini567 – 64983Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi565 – 5684Poly-Pro
Compositional biasi763 – 77412Poly-ProAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG309161.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000116087.
HOVERGENiHBG061165.
InParanoidiQ9NTN9.
KOiK06521.
OMAiHMEAVYI.
OrthoDBiEOG7M6D6N.
PhylomeDBiQ9NTN9.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NTN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWGRLWPLLL SILTATAVPG PSLRRPSREL DATPRMTIPY EELSGTRHFK
60 70 80 90 100
GQAQNYSTLL LEEASARLLV GARGALFSLS ANDIGDGAHK EIHWEASPEM
110 120 130 140 150
QSKCHQKGKN NQTECFNHVR FLQRLNSTHL YACGTHAFQP LCAAIDAEAF
160 170 180 190 200
TLPTSFEEGK EKCPYDPARG FTGLIIDGGL YTATRYEFRS IPDIRRSRHP
210 220 230 240 250
HSLRTEETPM HWLNDAEFVF SVLVRESKAS AVGDDDKVYY FFTERATEEG
260 270 280 290 300
SGSFTQSRSS HRVARVARVC KGDLGGKKIL QKKWTSFLKA RLICHIPLYE
310 320 330 340 350
TLRGVCSLDA ETSSRTHFYA AFTLSTQWKT LEASAICRYD LAEIQAVFAG
360 370 380 390 400
PYMEYQDGSR RWGRYEGGVP EPRPGSCITD SLRSQGYNSS QDLPSLVLDF
410 420 430 440 450
VKLHPLMARP VVPTRGRPLL LKRNIRYTHL TGTPVTTPAG PTYDLLFLGT
460 470 480 490 500
ADGWIHKAVV LGSGMHIIEE TQVFRESQSV ENLVISLLQH SLYVGAPSGV
510 520 530 540 550
IQLPLSSCSR YRSCYDCILA RDPYCGWDPG THACAAATTI ANRTALIQDI
560 570 580 590 600
ERGNRGCESS RDTGPPPPLK TRSVLRGDDV LLPCDQPSNL ARALWLLNGS
610 620 630 640 650
MGLSDGQGGY RVGVDGLLVT DAQPEHSGNY GCYAEENGLR TLLASYSLTV
660 670 680 690 700
RPATPAPAPK APATPGAQLA PDVRLLYVLA IAALGGLCLI LASSLLYVAC
710 720 730 740 750
LREGRRGRRR KYSLGRASRA GGSAVQLQTV SGQCPGEEDE GDDEGAGGLE
760 770 780 790 800
GSCLQIIPGE GAPAPPPPPP PPPPAELTNG LVALPSRLRR MNGNSYVLLR
810 820 830
QSNNGVPAGP CSFAEELSRI LEKRKHTQLV EQLDESSV
Length:838
Mass (Da):91,497
Last modified:October 1, 2000 - v1
Checksum:i9B281AEE8681F245
GO
Isoform 2 (identifier: Q9NTN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-543: R → RSQGSR

Note: No experimental confirmation available.

Show »
Length:843
Mass (Da):92,012
Checksum:i6AEE7436BCEC60CD
GO
Isoform 3 (identifier: Q9NTN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-543: R → RSQGSR
     565-838: PPPPLKTRSV...LVEQLDESSV → RALQVHMGSM...PHSPWSFSRV

Note: No experimental confirmation available.

Show »
Length:702
Mass (Da):77,577
Checksum:iC1D05183AF6793CA
GO

Sequence cautioni

The sequence BAB13445.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei543 – 5431R → RSQGSR in isoform 2 and isoform 3. 1 PublicationVSP_035067
Alternative sequencei565 – 838274PPPPL…DESSV → RALQVHMGSMSPPSAWPCVL DGPETRQDLCQPPKPCVHSH AHMEECLSAGLQCPHPHLLL VHSCFIPASGLGVPSQLPHP IWSSSPAPCGDLFVKSLGTG QPGEVRLHHSPPLPSCVALV NQPPHSPWSFSRV in isoform 3. 1 PublicationVSP_043883Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046839 mRNA. Translation: BAB13445.1. Different initiation.
AL133215 Genomic DNA. No translation available.
BC051030 mRNA. Translation: AAH51030.1.
BC128579 mRNA. Translation: AAI28580.1.
CCDSiCCDS55724.1. [Q9NTN9-3]
CCDS7501.1. [Q9NTN9-2]
RefSeqiNP_001190173.1. NM_001203244.1. [Q9NTN9-3]
NP_060363.2. NM_017893.3. [Q9NTN9-2]
XP_005270065.1. XM_005270008.1. [Q9NTN9-2]
XP_005270066.1. XM_005270009.2. [Q9NTN9-2]
XP_005270067.1. XM_005270010.1. [Q9NTN9-1]
UniGeneiHs.591923.
Hs.735152.

Genome annotation databases

EnsembliENST00000210633; ENSP00000210633; ENSG00000095539. [Q9NTN9-2]
ENST00000370250; ENSP00000359270; ENSG00000095539. [Q9NTN9-1]
ENST00000517724; ENSP00000430175; ENSG00000095539. [Q9NTN9-3]
ENST00000521006; ENSP00000430881; ENSG00000095539. [Q9NTN9-1]
GeneIDi57715.
KEGGihsa:57715.
UCSCiuc001krw.2. human. [Q9NTN9-2]
uc001krx.3. human. [Q9NTN9-3]
uc010qpt.1. human. [Q9NTN9-1]

Polymorphism databases

DMDMi13633937.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046839 mRNA. Translation: BAB13445.1. Different initiation.
AL133215 Genomic DNA. No translation available.
BC051030 mRNA. Translation: AAH51030.1.
BC128579 mRNA. Translation: AAI28580.1.
CCDSiCCDS55724.1. [Q9NTN9-3]
CCDS7501.1. [Q9NTN9-2]
RefSeqiNP_001190173.1. NM_001203244.1. [Q9NTN9-3]
NP_060363.2. NM_017893.3. [Q9NTN9-2]
XP_005270065.1. XM_005270008.1. [Q9NTN9-2]
XP_005270066.1. XM_005270009.2. [Q9NTN9-2]
XP_005270067.1. XM_005270010.1. [Q9NTN9-1]
UniGeneiHs.591923.
Hs.735152.

3D structure databases

ProteinModelPortaliQ9NTN9.
SMRiQ9NTN9. Positions 34-636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121738. 7 interactions.
IntActiQ9NTN9. 2 interactions.
MINTiMINT-1475595.
STRINGi9606.ENSP00000210633.

PTM databases

PhosphoSiteiQ9NTN9.

Polymorphism databases

DMDMi13633937.

Proteomic databases

MaxQBiQ9NTN9.
PaxDbiQ9NTN9.
PRIDEiQ9NTN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000210633; ENSP00000210633; ENSG00000095539. [Q9NTN9-2]
ENST00000370250; ENSP00000359270; ENSG00000095539. [Q9NTN9-1]
ENST00000517724; ENSP00000430175; ENSG00000095539. [Q9NTN9-3]
ENST00000521006; ENSP00000430881; ENSG00000095539. [Q9NTN9-1]
GeneIDi57715.
KEGGihsa:57715.
UCSCiuc001krw.2. human. [Q9NTN9-2]
uc001krx.3. human. [Q9NTN9-3]
uc010qpt.1. human. [Q9NTN9-1]

Organism-specific databases

CTDi57715.
GeneCardsiGC10P102729.
HGNCiHGNC:10735. SEMA4G.
HPAiHPA038362.
neXtProtiNX_Q9NTN9.
PharmGKBiPA35657.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG309161.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000116087.
HOVERGENiHBG061165.
InParanoidiQ9NTN9.
KOiK06521.
OMAiHMEAVYI.
OrthoDBiEOG7M6D6N.
PhylomeDBiQ9NTN9.
TreeFamiTF316102.

Miscellaneous databases

ChiTaRSiSEMA4G. human.
GeneWikiiSEMA4G.
GenomeRNAii57715.
NextBioi64634.
PROiQ9NTN9.

Gene expression databases

BgeeiQ9NTN9.
CleanExiHS_SEMA4G.
ExpressionAtlasiQ9NTN9. baseline and differential.
GenevestigatoriQ9NTN9.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain.

Entry informationi

Entry nameiSEM4G_HUMAN
AccessioniPrimary (citable) accession number: Q9NTN9
Secondary accession number(s): A1A5C6
, A6NJY8, Q58EY1, Q9HCF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: March 4, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.