Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NTN9 (SEM4G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Semaphorin-4G
Gene names
Name:SEMA4G
Synonyms:KIAA1619
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length838 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cell surface receptor for PLXNB2. May play a role in axon guidance By similarity.

Subunit structure

Interacts with PLXNB2 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the semaphorin family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 PSI domain.

Contains 1 Sema domain.

Sequence caution

The sequence BAB13445.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NTN9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NTN9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     543-543: R → RSQGSR
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9NTN9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     543-543: R → RSQGSR
     565-838: PPPPLKTRSV...LVEQLDESSV → RALQVHMGSM...PHSPWSFSRV
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 838821Semaphorin-4G
PRO_0000032333

Regions

Topological domain18 – 675658Extracellular Potential
Transmembrane676 – 69621Helical; Potential
Topological domain697 – 838142Cytoplasmic Potential
Domain35 – 505471Sema
Domain507 – 55852PSI
Domain567 – 64983Ig-like C2-type
Compositional bias565 – 5684Poly-Pro
Compositional bias763 – 77412Poly-Pro

Amino acid modifications

Modified residue8371Phosphoserine By similarity
Glycosylation551N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation3881N-linked (GlcNAc...) Potential
Glycosylation5421N-linked (GlcNAc...) Potential
Glycosylation5981N-linked (GlcNAc...) Potential
Disulfide bond104 ↔ 115 By similarity
Disulfide bond133 ↔ 142 By similarity
Disulfide bond270 ↔ 377 By similarity
Disulfide bond294 ↔ 337 By similarity
Disulfide bond508 ↔ 525 By similarity
Disulfide bond517 ↔ 534 By similarity
Disulfide bond584 ↔ 632 By similarity

Natural variations

Alternative sequence5431R → RSQGSR in isoform 2 and isoform 3.
VSP_035067
Alternative sequence565 – 838274PPPPL…DESSV → RALQVHMGSMSPPSAWPCVL DGPETRQDLCQPPKPCVHSH AHMEECLSAGLQCPHPHLLL VHSCFIPASGLGVPSQLPHP IWSSSPAPCGDLFVKSLGTG QPGEVRLHHSPPLPSCVALV NQPPHSPWSFSRV in isoform 3.
VSP_043883

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 9B281AEE8681F245

FASTA83891,497
        10         20         30         40         50         60 
MWGRLWPLLL SILTATAVPG PSLRRPSREL DATPRMTIPY EELSGTRHFK GQAQNYSTLL 

        70         80         90        100        110        120 
LEEASARLLV GARGALFSLS ANDIGDGAHK EIHWEASPEM QSKCHQKGKN NQTECFNHVR 

       130        140        150        160        170        180 
FLQRLNSTHL YACGTHAFQP LCAAIDAEAF TLPTSFEEGK EKCPYDPARG FTGLIIDGGL 

       190        200        210        220        230        240 
YTATRYEFRS IPDIRRSRHP HSLRTEETPM HWLNDAEFVF SVLVRESKAS AVGDDDKVYY 

       250        260        270        280        290        300 
FFTERATEEG SGSFTQSRSS HRVARVARVC KGDLGGKKIL QKKWTSFLKA RLICHIPLYE 

       310        320        330        340        350        360 
TLRGVCSLDA ETSSRTHFYA AFTLSTQWKT LEASAICRYD LAEIQAVFAG PYMEYQDGSR 

       370        380        390        400        410        420 
RWGRYEGGVP EPRPGSCITD SLRSQGYNSS QDLPSLVLDF VKLHPLMARP VVPTRGRPLL 

       430        440        450        460        470        480 
LKRNIRYTHL TGTPVTTPAG PTYDLLFLGT ADGWIHKAVV LGSGMHIIEE TQVFRESQSV 

       490        500        510        520        530        540 
ENLVISLLQH SLYVGAPSGV IQLPLSSCSR YRSCYDCILA RDPYCGWDPG THACAAATTI 

       550        560        570        580        590        600 
ANRTALIQDI ERGNRGCESS RDTGPPPPLK TRSVLRGDDV LLPCDQPSNL ARALWLLNGS 

       610        620        630        640        650        660 
MGLSDGQGGY RVGVDGLLVT DAQPEHSGNY GCYAEENGLR TLLASYSLTV RPATPAPAPK 

       670        680        690        700        710        720 
APATPGAQLA PDVRLLYVLA IAALGGLCLI LASSLLYVAC LREGRRGRRR KYSLGRASRA 

       730        740        750        760        770        780 
GGSAVQLQTV SGQCPGEEDE GDDEGAGGLE GSCLQIIPGE GAPAPPPPPP PPPPAELTNG 

       790        800        810        820        830 
LVALPSRLRR MNGNSYVLLR QSNNGVPAGP CSFAEELSRI LEKRKHTQLV EQLDESSV 

« Hide

Isoform 2 [UniParc].

Checksum: 6AEE7436BCEC60CD
Show »

FASTA84392,012
Isoform 3 [UniParc].

Checksum: C1D05183AF6793CA
Show »

FASTA70277,577

References

[1]"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB046839 mRNA. Translation: BAB13445.1. Different initiation.
AL133215 Genomic DNA. No translation available.
BC051030 mRNA. Translation: AAH51030.1.
BC128579 mRNA. Translation: AAI28580.1.
RefSeqNP_001190173.1. NM_001203244.1.
NP_060363.2. NM_017893.3.
XP_005270065.1. XM_005270008.1.
XP_005270066.1. XM_005270009.2.
XP_005270067.1. XM_005270010.1.
UniGeneHs.591923.
Hs.735152.

3D structure databases

ProteinModelPortalQ9NTN9.
SMRQ9NTN9. Positions 34-636.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121738. 3 interactions.
IntActQ9NTN9. 1 interaction.
MINTMINT-1475595.
STRING9606.ENSP00000210633.

PTM databases

PhosphoSiteQ9NTN9.

Polymorphism databases

DMDM13633937.

Proteomic databases

PaxDbQ9NTN9.
PRIDEQ9NTN9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000210633; ENSP00000210633; ENSG00000095539. [Q9NTN9-2]
ENST00000370250; ENSP00000359270; ENSG00000095539. [Q9NTN9-1]
ENST00000517724; ENSP00000430175; ENSG00000095539. [Q9NTN9-3]
ENST00000521006; ENSP00000430881; ENSG00000095539. [Q9NTN9-1]
GeneID57715.
KEGGhsa:57715.
UCSCuc001krw.2. human. [Q9NTN9-2]
uc001krx.3. human. [Q9NTN9-3]
uc010qpt.1. human. [Q9NTN9-1]

Organism-specific databases

CTD57715.
GeneCardsGC10P102719.
HGNCHGNC:10735. SEMA4G.
HPAHPA038362.
neXtProtNX_Q9NTN9.
PharmGKBPA35657.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG309161.
HOGENOMHOG000116087.
HOVERGENHBG061165.
KOK06521.
OMAGPYMESQ.
OrthoDBEOG7M6D6N.
PhylomeDBQ9NTN9.
TreeFamTF316102.

Gene expression databases

ArrayExpressQ9NTN9.
BgeeQ9NTN9.
CleanExHS_SEMA4G.
GenevestigatorQ9NTN9.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERPTHR11036. PTHR11036. 1 hit.
PfamPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSEMA4G. human.
GeneWikiSEMA4G.
GenomeRNAi57715.
NextBio64634.
PROQ9NTN9.

Entry information

Entry nameSEM4G_HUMAN
AccessionPrimary (citable) accession number: Q9NTN9
Secondary accession number(s): A1A5C6 expand/collapse secondary AC list , A6NJY8, Q58EY1, Q9HCF3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM