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Q9NTN9

- SEM4G_HUMAN

UniProt

Q9NTN9 - SEM4G_HUMAN

Protein

Semaphorin-4G

Gene

SEMA4G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Cell surface receptor for PLXNB2. May play a role in axon guidance By similarity.By similarity

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. nervous system development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-4G
    Gene namesi
    Name:SEMA4G
    Synonyms:KIAA1619
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:10735. SEMA4G.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35657.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 838821Semaphorin-4GPRO_0000032333Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 115By similarity
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 142By similarity
    Disulfide bondi270 ↔ 377By similarity
    Disulfide bondi294 ↔ 337By similarity
    Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi508 ↔ 525By similarity
    Disulfide bondi517 ↔ 534By similarity
    Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi584 ↔ 632By similarity
    Glycosylationi598 – 5981N-linked (GlcNAc...)Sequence Analysis
    Modified residuei837 – 8371PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NTN9.
    PaxDbiQ9NTN9.
    PRIDEiQ9NTN9.

    PTM databases

    PhosphoSiteiQ9NTN9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NTN9.
    BgeeiQ9NTN9.
    CleanExiHS_SEMA4G.
    GenevestigatoriQ9NTN9.

    Organism-specific databases

    HPAiHPA038362.

    Interactioni

    Subunit structurei

    Interacts with PLXNB2.By similarity

    Protein-protein interaction databases

    BioGridi121738. 3 interactions.
    IntActiQ9NTN9. 2 interactions.
    MINTiMINT-1475595.
    STRINGi9606.ENSP00000210633.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NTN9.
    SMRiQ9NTN9. Positions 34-636.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 675658ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini697 – 838142CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei676 – 69621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 505471SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini507 – 55852PSIAdd
    BLAST
    Domaini567 – 64983Ig-like C2-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi565 – 5684Poly-Pro
    Compositional biasi763 – 77412Poly-ProAdd
    BLAST

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG309161.
    HOGENOMiHOG000116087.
    HOVERGENiHBG061165.
    KOiK06521.
    OMAiHMEAVYI.
    OrthoDBiEOG7M6D6N.
    PhylomeDBiQ9NTN9.
    TreeFamiTF316102.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PfamiPF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NTN9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWGRLWPLLL SILTATAVPG PSLRRPSREL DATPRMTIPY EELSGTRHFK    50
    GQAQNYSTLL LEEASARLLV GARGALFSLS ANDIGDGAHK EIHWEASPEM 100
    QSKCHQKGKN NQTECFNHVR FLQRLNSTHL YACGTHAFQP LCAAIDAEAF 150
    TLPTSFEEGK EKCPYDPARG FTGLIIDGGL YTATRYEFRS IPDIRRSRHP 200
    HSLRTEETPM HWLNDAEFVF SVLVRESKAS AVGDDDKVYY FFTERATEEG 250
    SGSFTQSRSS HRVARVARVC KGDLGGKKIL QKKWTSFLKA RLICHIPLYE 300
    TLRGVCSLDA ETSSRTHFYA AFTLSTQWKT LEASAICRYD LAEIQAVFAG 350
    PYMEYQDGSR RWGRYEGGVP EPRPGSCITD SLRSQGYNSS QDLPSLVLDF 400
    VKLHPLMARP VVPTRGRPLL LKRNIRYTHL TGTPVTTPAG PTYDLLFLGT 450
    ADGWIHKAVV LGSGMHIIEE TQVFRESQSV ENLVISLLQH SLYVGAPSGV 500
    IQLPLSSCSR YRSCYDCILA RDPYCGWDPG THACAAATTI ANRTALIQDI 550
    ERGNRGCESS RDTGPPPPLK TRSVLRGDDV LLPCDQPSNL ARALWLLNGS 600
    MGLSDGQGGY RVGVDGLLVT DAQPEHSGNY GCYAEENGLR TLLASYSLTV 650
    RPATPAPAPK APATPGAQLA PDVRLLYVLA IAALGGLCLI LASSLLYVAC 700
    LREGRRGRRR KYSLGRASRA GGSAVQLQTV SGQCPGEEDE GDDEGAGGLE 750
    GSCLQIIPGE GAPAPPPPPP PPPPAELTNG LVALPSRLRR MNGNSYVLLR 800
    QSNNGVPAGP CSFAEELSRI LEKRKHTQLV EQLDESSV 838
    Length:838
    Mass (Da):91,497
    Last modified:October 1, 2000 - v1
    Checksum:i9B281AEE8681F245
    GO
    Isoform 2 (identifier: Q9NTN9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         543-543: R → RSQGSR

    Note: No experimental confirmation available.

    Show »
    Length:843
    Mass (Da):92,012
    Checksum:i6AEE7436BCEC60CD
    GO
    Isoform 3 (identifier: Q9NTN9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         543-543: R → RSQGSR
         565-838: PPPPLKTRSV...LVEQLDESSV → RALQVHMGSM...PHSPWSFSRV

    Note: No experimental confirmation available.

    Show »
    Length:702
    Mass (Da):77,577
    Checksum:iC1D05183AF6793CA
    GO

    Sequence cautioni

    The sequence BAB13445.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei543 – 5431R → RSQGSR in isoform 2 and isoform 3. 1 PublicationVSP_035067
    Alternative sequencei565 – 838274PPPPL…DESSV → RALQVHMGSMSPPSAWPCVL DGPETRQDLCQPPKPCVHSH AHMEECLSAGLQCPHPHLLL VHSCFIPASGLGVPSQLPHP IWSSSPAPCGDLFVKSLGTG QPGEVRLHHSPPLPSCVALV NQPPHSPWSFSRV in isoform 3. 1 PublicationVSP_043883Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046839 mRNA. Translation: BAB13445.1. Different initiation.
    AL133215 Genomic DNA. No translation available.
    BC051030 mRNA. Translation: AAH51030.1.
    BC128579 mRNA. Translation: AAI28580.1.
    CCDSiCCDS55724.1. [Q9NTN9-3]
    CCDS7501.1. [Q9NTN9-2]
    RefSeqiNP_001190173.1. NM_001203244.1. [Q9NTN9-3]
    NP_060363.2. NM_017893.3. [Q9NTN9-2]
    XP_005270065.1. XM_005270008.1. [Q9NTN9-2]
    XP_005270066.1. XM_005270009.2. [Q9NTN9-2]
    XP_005270067.1. XM_005270010.1. [Q9NTN9-1]
    UniGeneiHs.591923.
    Hs.735152.

    Genome annotation databases

    EnsembliENST00000210633; ENSP00000210633; ENSG00000095539. [Q9NTN9-2]
    ENST00000370250; ENSP00000359270; ENSG00000095539. [Q9NTN9-1]
    ENST00000517724; ENSP00000430175; ENSG00000095539. [Q9NTN9-3]
    ENST00000521006; ENSP00000430881; ENSG00000095539. [Q9NTN9-1]
    GeneIDi57715.
    KEGGihsa:57715.
    UCSCiuc001krw.2. human. [Q9NTN9-2]
    uc001krx.3. human. [Q9NTN9-3]
    uc010qpt.1. human. [Q9NTN9-1]

    Polymorphism databases

    DMDMi13633937.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046839 mRNA. Translation: BAB13445.1 . Different initiation.
    AL133215 Genomic DNA. No translation available.
    BC051030 mRNA. Translation: AAH51030.1 .
    BC128579 mRNA. Translation: AAI28580.1 .
    CCDSi CCDS55724.1. [Q9NTN9-3 ]
    CCDS7501.1. [Q9NTN9-2 ]
    RefSeqi NP_001190173.1. NM_001203244.1. [Q9NTN9-3 ]
    NP_060363.2. NM_017893.3. [Q9NTN9-2 ]
    XP_005270065.1. XM_005270008.1. [Q9NTN9-2 ]
    XP_005270066.1. XM_005270009.2. [Q9NTN9-2 ]
    XP_005270067.1. XM_005270010.1. [Q9NTN9-1 ]
    UniGenei Hs.591923.
    Hs.735152.

    3D structure databases

    ProteinModelPortali Q9NTN9.
    SMRi Q9NTN9. Positions 34-636.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121738. 3 interactions.
    IntActi Q9NTN9. 2 interactions.
    MINTi MINT-1475595.
    STRINGi 9606.ENSP00000210633.

    PTM databases

    PhosphoSitei Q9NTN9.

    Polymorphism databases

    DMDMi 13633937.

    Proteomic databases

    MaxQBi Q9NTN9.
    PaxDbi Q9NTN9.
    PRIDEi Q9NTN9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000210633 ; ENSP00000210633 ; ENSG00000095539 . [Q9NTN9-2 ]
    ENST00000370250 ; ENSP00000359270 ; ENSG00000095539 . [Q9NTN9-1 ]
    ENST00000517724 ; ENSP00000430175 ; ENSG00000095539 . [Q9NTN9-3 ]
    ENST00000521006 ; ENSP00000430881 ; ENSG00000095539 . [Q9NTN9-1 ]
    GeneIDi 57715.
    KEGGi hsa:57715.
    UCSCi uc001krw.2. human. [Q9NTN9-2 ]
    uc001krx.3. human. [Q9NTN9-3 ]
    uc010qpt.1. human. [Q9NTN9-1 ]

    Organism-specific databases

    CTDi 57715.
    GeneCardsi GC10P102719.
    HGNCi HGNC:10735. SEMA4G.
    HPAi HPA038362.
    neXtProti NX_Q9NTN9.
    PharmGKBi PA35657.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309161.
    HOGENOMi HOG000116087.
    HOVERGENi HBG061165.
    KOi K06521.
    OMAi HMEAVYI.
    OrthoDBi EOG7M6D6N.
    PhylomeDBi Q9NTN9.
    TreeFami TF316102.

    Miscellaneous databases

    ChiTaRSi SEMA4G. human.
    GeneWikii SEMA4G.
    GenomeRNAii 57715.
    NextBioi 64634.
    PROi Q9NTN9.

    Gene expression databases

    ArrayExpressi Q9NTN9.
    Bgeei Q9NTN9.
    CleanExi HS_SEMA4G.
    Genevestigatori Q9NTN9.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    Pfami PF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain.

    Entry informationi

    Entry nameiSEM4G_HUMAN
    AccessioniPrimary (citable) accession number: Q9NTN9
    Secondary accession number(s): A1A5C6
    , A6NJY8, Q58EY1, Q9HCF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3