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Q9NTN9

- SEM4G_HUMAN

UniProt

Q9NTN9 - SEM4G_HUMAN

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Protein

Semaphorin-4G

Gene
SEMA4G, KIAA1619
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cell surface receptor for PLXNB2. May play a role in axon guidance By similarity.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4G
Gene namesi
Name:SEMA4G
Synonyms:KIAA1619
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:10735. SEMA4G.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 675658Extracellular Reviewed predictionAdd
BLAST
Transmembranei676 – 69621Helical; Reviewed predictionAdd
BLAST
Topological domaini697 – 838142Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35657.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 838821Semaphorin-4GPRO_0000032333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi104 ↔ 115 By similarity
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi126 – 1261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi133 ↔ 142 By similarity
Disulfide bondi270 ↔ 377 By similarity
Disulfide bondi294 ↔ 337 By similarity
Glycosylationi388 – 3881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi508 ↔ 525 By similarity
Disulfide bondi517 ↔ 534 By similarity
Glycosylationi542 – 5421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi584 ↔ 632 By similarity
Glycosylationi598 – 5981N-linked (GlcNAc...) Reviewed prediction
Modified residuei837 – 8371Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NTN9.
PaxDbiQ9NTN9.
PRIDEiQ9NTN9.

PTM databases

PhosphoSiteiQ9NTN9.

Expressioni

Gene expression databases

ArrayExpressiQ9NTN9.
BgeeiQ9NTN9.
CleanExiHS_SEMA4G.
GenevestigatoriQ9NTN9.

Organism-specific databases

HPAiHPA038362.

Interactioni

Subunit structurei

Interacts with PLXNB2 By similarity.

Protein-protein interaction databases

BioGridi121738. 3 interactions.
IntActiQ9NTN9. 2 interactions.
MINTiMINT-1475595.
STRINGi9606.ENSP00000210633.

Structurei

3D structure databases

ProteinModelPortaliQ9NTN9.
SMRiQ9NTN9. Positions 34-636.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 505471SemaAdd
BLAST
Domaini507 – 55852PSIAdd
BLAST
Domaini567 – 64983Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi565 – 5684Poly-Pro
Compositional biasi763 – 77412Poly-ProAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG309161.
HOGENOMiHOG000116087.
HOVERGENiHBG061165.
KOiK06521.
OMAiHMEAVYI.
OrthoDBiEOG7M6D6N.
PhylomeDBiQ9NTN9.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NTN9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWGRLWPLLL SILTATAVPG PSLRRPSREL DATPRMTIPY EELSGTRHFK    50
GQAQNYSTLL LEEASARLLV GARGALFSLS ANDIGDGAHK EIHWEASPEM 100
QSKCHQKGKN NQTECFNHVR FLQRLNSTHL YACGTHAFQP LCAAIDAEAF 150
TLPTSFEEGK EKCPYDPARG FTGLIIDGGL YTATRYEFRS IPDIRRSRHP 200
HSLRTEETPM HWLNDAEFVF SVLVRESKAS AVGDDDKVYY FFTERATEEG 250
SGSFTQSRSS HRVARVARVC KGDLGGKKIL QKKWTSFLKA RLICHIPLYE 300
TLRGVCSLDA ETSSRTHFYA AFTLSTQWKT LEASAICRYD LAEIQAVFAG 350
PYMEYQDGSR RWGRYEGGVP EPRPGSCITD SLRSQGYNSS QDLPSLVLDF 400
VKLHPLMARP VVPTRGRPLL LKRNIRYTHL TGTPVTTPAG PTYDLLFLGT 450
ADGWIHKAVV LGSGMHIIEE TQVFRESQSV ENLVISLLQH SLYVGAPSGV 500
IQLPLSSCSR YRSCYDCILA RDPYCGWDPG THACAAATTI ANRTALIQDI 550
ERGNRGCESS RDTGPPPPLK TRSVLRGDDV LLPCDQPSNL ARALWLLNGS 600
MGLSDGQGGY RVGVDGLLVT DAQPEHSGNY GCYAEENGLR TLLASYSLTV 650
RPATPAPAPK APATPGAQLA PDVRLLYVLA IAALGGLCLI LASSLLYVAC 700
LREGRRGRRR KYSLGRASRA GGSAVQLQTV SGQCPGEEDE GDDEGAGGLE 750
GSCLQIIPGE GAPAPPPPPP PPPPAELTNG LVALPSRLRR MNGNSYVLLR 800
QSNNGVPAGP CSFAEELSRI LEKRKHTQLV EQLDESSV 838
Length:838
Mass (Da):91,497
Last modified:October 1, 2000 - v1
Checksum:i9B281AEE8681F245
GO
Isoform 2 (identifier: Q9NTN9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-543: R → RSQGSR

Note: No experimental confirmation available.

Show »
Length:843
Mass (Da):92,012
Checksum:i6AEE7436BCEC60CD
GO
Isoform 3 (identifier: Q9NTN9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-543: R → RSQGSR
     565-838: PPPPLKTRSV...LVEQLDESSV → RALQVHMGSM...PHSPWSFSRV

Note: No experimental confirmation available.

Show »
Length:702
Mass (Da):77,577
Checksum:iC1D05183AF6793CA
GO

Sequence cautioni

The sequence BAB13445.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei543 – 5431R → RSQGSR in isoform 2 and isoform 3. VSP_035067
Alternative sequencei565 – 838274PPPPL…DESSV → RALQVHMGSMSPPSAWPCVL DGPETRQDLCQPPKPCVHSH AHMEECLSAGLQCPHPHLLL VHSCFIPASGLGVPSQLPHP IWSSSPAPCGDLFVKSLGTG QPGEVRLHHSPPLPSCVALV NQPPHSPWSFSRV in isoform 3. VSP_043883Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB046839 mRNA. Translation: BAB13445.1. Different initiation.
AL133215 Genomic DNA. No translation available.
BC051030 mRNA. Translation: AAH51030.1.
BC128579 mRNA. Translation: AAI28580.1.
CCDSiCCDS55724.1. [Q9NTN9-3]
CCDS7501.1. [Q9NTN9-2]
RefSeqiNP_001190173.1. NM_001203244.1. [Q9NTN9-3]
NP_060363.2. NM_017893.3. [Q9NTN9-2]
XP_005270065.1. XM_005270008.1. [Q9NTN9-2]
XP_005270066.1. XM_005270009.2. [Q9NTN9-2]
XP_005270067.1. XM_005270010.1. [Q9NTN9-1]
UniGeneiHs.591923.
Hs.735152.

Genome annotation databases

EnsembliENST00000210633; ENSP00000210633; ENSG00000095539. [Q9NTN9-2]
ENST00000370250; ENSP00000359270; ENSG00000095539. [Q9NTN9-1]
ENST00000517724; ENSP00000430175; ENSG00000095539. [Q9NTN9-3]
ENST00000521006; ENSP00000430881; ENSG00000095539. [Q9NTN9-1]
GeneIDi57715.
KEGGihsa:57715.
UCSCiuc001krw.2. human. [Q9NTN9-2]
uc001krx.3. human. [Q9NTN9-3]
uc010qpt.1. human. [Q9NTN9-1]

Polymorphism databases

DMDMi13633937.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB046839 mRNA. Translation: BAB13445.1 . Different initiation.
AL133215 Genomic DNA. No translation available.
BC051030 mRNA. Translation: AAH51030.1 .
BC128579 mRNA. Translation: AAI28580.1 .
CCDSi CCDS55724.1. [Q9NTN9-3 ]
CCDS7501.1. [Q9NTN9-2 ]
RefSeqi NP_001190173.1. NM_001203244.1. [Q9NTN9-3 ]
NP_060363.2. NM_017893.3. [Q9NTN9-2 ]
XP_005270065.1. XM_005270008.1. [Q9NTN9-2 ]
XP_005270066.1. XM_005270009.2. [Q9NTN9-2 ]
XP_005270067.1. XM_005270010.1. [Q9NTN9-1 ]
UniGenei Hs.591923.
Hs.735152.

3D structure databases

ProteinModelPortali Q9NTN9.
SMRi Q9NTN9. Positions 34-636.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121738. 3 interactions.
IntActi Q9NTN9. 2 interactions.
MINTi MINT-1475595.
STRINGi 9606.ENSP00000210633.

PTM databases

PhosphoSitei Q9NTN9.

Polymorphism databases

DMDMi 13633937.

Proteomic databases

MaxQBi Q9NTN9.
PaxDbi Q9NTN9.
PRIDEi Q9NTN9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000210633 ; ENSP00000210633 ; ENSG00000095539 . [Q9NTN9-2 ]
ENST00000370250 ; ENSP00000359270 ; ENSG00000095539 . [Q9NTN9-1 ]
ENST00000517724 ; ENSP00000430175 ; ENSG00000095539 . [Q9NTN9-3 ]
ENST00000521006 ; ENSP00000430881 ; ENSG00000095539 . [Q9NTN9-1 ]
GeneIDi 57715.
KEGGi hsa:57715.
UCSCi uc001krw.2. human. [Q9NTN9-2 ]
uc001krx.3. human. [Q9NTN9-3 ]
uc010qpt.1. human. [Q9NTN9-1 ]

Organism-specific databases

CTDi 57715.
GeneCardsi GC10P102719.
HGNCi HGNC:10735. SEMA4G.
HPAi HPA038362.
neXtProti NX_Q9NTN9.
PharmGKBi PA35657.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309161.
HOGENOMi HOG000116087.
HOVERGENi HBG061165.
KOi K06521.
OMAi HMEAVYI.
OrthoDBi EOG7M6D6N.
PhylomeDBi Q9NTN9.
TreeFami TF316102.

Miscellaneous databases

ChiTaRSi SEMA4G. human.
GeneWikii SEMA4G.
GenomeRNAii 57715.
NextBioi 64634.
PROi Q9NTN9.

Gene expression databases

ArrayExpressi Q9NTN9.
Bgeei Q9NTN9.
CleanExi HS_SEMA4G.
Genevestigatori Q9NTN9.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain.

Entry informationi

Entry nameiSEM4G_HUMAN
AccessioniPrimary (citable) accession number: Q9NTN9
Secondary accession number(s): A1A5C6
, A6NJY8, Q58EY1, Q9HCF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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