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Q9NTM9

- CUTC_HUMAN

UniProt

Q9NTM9 - CUTC_HUMAN

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Protein
Copper homeostasis protein cutC homolog
Gene
CUTC, CGI-32
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in copper homeostasis. Can bind one Cu1+ per subunit.2 Publications

GO - Molecular functioni

  1. copper ion binding Source: UniProtKB

GO - Biological processi

  1. copper ion homeostasis Source: UniProtKB
  2. copper ion transport Source: UniProtKB
  3. protein tetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Copper homeostasis protein cutC homolog
Gene namesi
Name:CUTC
ORF Names:CGI-32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:24271. CUTC.

Subcellular locationi

Cytoplasm. Nucleus
Note: The overexpressed protein is detected in the cytoplasm, and depending on the cell line, also in the nucleus.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleolus Source: HPA
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi31 – 311C → A: Reduces copper binding. Reduces copper binding by 75%; when associated with A-52. 1 Publication
Mutagenesisi52 – 521C → A: Reduces copper binding. Reduces copper binding by 75%; when associated with A-31. 1 Publication

Organism-specific databases

PharmGKBiPA134901980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Copper homeostasis protein cutC homologUniRule annotation
PRO_0000215088Add
BLAST

Proteomic databases

MaxQBiQ9NTM9.
PaxDbiQ9NTM9.
PeptideAtlasiQ9NTM9.
PRIDEiQ9NTM9.

PTM databases

PhosphoSiteiQ9NTM9.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ArrayExpressiQ9NTM9.
BgeeiQ9NTM9.
CleanExiHS_CUTC.
GenevestigatoriQ9NTM9.

Organism-specific databases

HPAiHPA038619.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

BioGridi119267. 16 interactions.
IntActiQ9NTM9. 4 interactions.
MINTiMINT-1387697.
STRINGi9606.ENSP00000359507.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 349
Helixi35 – 4410
Beta strandi47 – 515
Helixi55 – 573
Helixi64 – 718
Beta strandi78 – 814
Beta strandi84 – 874
Helixi93 – 10816
Beta strandi112 – 1165
Helixi127 – 13711
Beta strandi142 – 1443
Helixi146 – 1505
Helixi154 – 16411
Beta strandi167 – 1715
Beta strandi175 – 1773
Turni178 – 1814
Helixi182 – 19211
Beta strandi195 – 2006
Turni206 – 2083
Helixi209 – 2168
Beta strandi219 – 2235
Beta strandi226 – 2294
Turni244 – 2463
Beta strandi253 – 2564
Helixi258 – 27114

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IWPX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-273[»]
ProteinModelPortaliQ9NTM9.
SMRiQ9NTM9. Positions 24-272.

Miscellaneous databases

EvolutionaryTraceiQ9NTM9.

Family & Domainsi

Sequence similaritiesi

Belongs to the CutC family.

Phylogenomic databases

eggNOGiCOG3142.
HOGENOMiHOG000100908.
HOVERGENiHBG051267.
InParanoidiQ9NTM9.
KOiK06201.
OMAiGVSMCSE.
OrthoDBiEOG7HXCSJ.
PhylomeDBiQ9NTM9.
TreeFamiTF105937.

Family and domain databases

Gene3Di3.20.20.380. 1 hit.
HAMAPiMF_00795. CutC.
InterProiIPR005627. Cu_homeostasis_CutC.
IPR023648. Cu_homeostasis_CutC_dom.
[Graphical view]
PANTHERiPTHR12598. PTHR12598. 1 hit.
PfamiPF03932. CutC. 1 hit.
[Graphical view]
SUPFAMiSSF110395. SSF110395. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NTM9-1 [UniParc]FASTAAdd to Basket

« Hide

MKRQGASSER KRARIPSGKA GAANGFLMEV CVDSVESAVN AERGGADRIE    50
LCSGLSEGGT TPSMGVLQVV KQSVQIPVFV MIRPRGGDFL YSDREIEVMK 100
ADIRLAKLYG ADGLVFGALT EDGHIDKELC MSLMAICRPL PVTFHRAFDM 150
VHDPMAALET LLTLGFERVL TSGCDSSALE GLPLIKRLIE QAKGRIVVMP 200
GGGITDRNLQ RILEGSGATE FHCSARSTRD SGMKFRNSSV AMGASLSCSE 250
YSLKVTDVTK VRTLNAIAKN ILV 273
Length:273
Mass (Da):29,341
Last modified:October 1, 2000 - v1
Checksum:i63C007AAB05C5492
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771P → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_036363

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081L → P in AAD27741. 1 Publication
Sequence conflicti186 – 1861K → N in AAD27741. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132966 mRNA. Translation: AAD27741.1.
AK314687 mRNA. Translation: BAG37239.1.
AL133353 Genomic DNA. Translation: CAB88199.1.
CH471066 Genomic DNA. Translation: EAW49854.1.
BC021105 mRNA. Translation: AAH21105.1.
BC028948 mRNA. Translation: AAH28948.1.
CCDSiCCDS7483.1.
RefSeqiNP_057044.2. NM_015960.2.
UniGeneiHs.16606.

Genome annotation databases

EnsembliENST00000370476; ENSP00000359507; ENSG00000119929.
GeneIDi51076.
KEGGihsa:51076.
UCSCiuc001kqd.4. human.

Polymorphism databases

DMDMi54035909.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132966 mRNA. Translation: AAD27741.1 .
AK314687 mRNA. Translation: BAG37239.1 .
AL133353 Genomic DNA. Translation: CAB88199.1 .
CH471066 Genomic DNA. Translation: EAW49854.1 .
BC021105 mRNA. Translation: AAH21105.1 .
BC028948 mRNA. Translation: AAH28948.1 .
CCDSi CCDS7483.1.
RefSeqi NP_057044.2. NM_015960.2.
UniGenei Hs.16606.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3IWP X-ray 2.50 A/B/C/D/E/F/G/H/I/J/K/L 1-273 [» ]
ProteinModelPortali Q9NTM9.
SMRi Q9NTM9. Positions 24-272.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119267. 16 interactions.
IntActi Q9NTM9. 4 interactions.
MINTi MINT-1387697.
STRINGi 9606.ENSP00000359507.

PTM databases

PhosphoSitei Q9NTM9.

Polymorphism databases

DMDMi 54035909.

Proteomic databases

MaxQBi Q9NTM9.
PaxDbi Q9NTM9.
PeptideAtlasi Q9NTM9.
PRIDEi Q9NTM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370476 ; ENSP00000359507 ; ENSG00000119929 .
GeneIDi 51076.
KEGGi hsa:51076.
UCSCi uc001kqd.4. human.

Organism-specific databases

CTDi 51076.
GeneCardsi GC10P101481.
HGNCi HGNC:24271. CUTC.
HPAi HPA038619.
MIMi 610101. gene.
neXtProti NX_Q9NTM9.
PharmGKBi PA134901980.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3142.
HOGENOMi HOG000100908.
HOVERGENi HBG051267.
InParanoidi Q9NTM9.
KOi K06201.
OMAi GVSMCSE.
OrthoDBi EOG7HXCSJ.
PhylomeDBi Q9NTM9.
TreeFami TF105937.

Miscellaneous databases

EvolutionaryTracei Q9NTM9.
GeneWikii CUTC_(gene).
GenomeRNAii 51076.
NextBioi 53707.
PROi Q9NTM9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NTM9.
Bgeei Q9NTM9.
CleanExi HS_CUTC.
Genevestigatori Q9NTM9.

Family and domain databases

Gene3Di 3.20.20.380. 1 hit.
HAMAPi MF_00795. CutC.
InterProi IPR005627. Cu_homeostasis_CutC.
IPR023648. Cu_homeostasis_CutC_dom.
[Graphical view ]
PANTHERi PTHR12598. PTHR12598. 1 hit.
Pfami PF03932. CutC. 1 hit.
[Graphical view ]
SUPFAMi SSF110395. SSF110395. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Skin.
  6. "Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC."
    Li J., Ji C., Chen J., Yang Z., Wang Y., Fei X., Zheng M., Gu X., Wen G., Xie Y., Mao Y.
    Biochem. Biophys. Res. Commun. 337:179-183(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site."
    Li Y., Du J., Zhang P., Ding J.
    J. Struct. Biol. 169:399-405(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), COPPER-BINDING, FUNCTION, SUBUNIT, MUTAGENESIS OF CYS-31 AND CYS-52.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-77.

Entry informationi

Entry nameiCUTC_HUMAN
AccessioniPrimary (citable) accession number: Q9NTM9
Secondary accession number(s): Q5TCZ8, Q9Y321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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