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Protein

Copper homeostasis protein cutC homolog

Gene

CUTC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in copper homeostasis. Can bind one Cu1+ per subunit.2 Publications

GO - Molecular functioni

  • copper ion binding Source: UniProtKB

GO - Biological processi

  • copper ion homeostasis Source: UniProtKB
  • copper ion transport Source: UniProtKB
  • protein tetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119929-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi9.B.158.1.1. the cut copper homeostasis (cut) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper homeostasis protein cutC homolog
Gene namesi
Name:CUTC
ORF Names:CGI-32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:24271. CUTC.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31C → A: Reduces copper binding. Reduces copper binding by 75%; when associated with A-52. 1 Publication1
Mutagenesisi52C → A: Reduces copper binding. Reduces copper binding by 75%; when associated with A-31. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000119929.
PharmGKBiPA134901980.

Polymorphism and mutation databases

BioMutaiCUTC.
DMDMi54035909.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150881 – 273Copper homeostasis protein cutC homologAdd BLAST273

Proteomic databases

EPDiQ9NTM9.
MaxQBiQ9NTM9.
PaxDbiQ9NTM9.
PeptideAtlasiQ9NTM9.
PRIDEiQ9NTM9.

PTM databases

iPTMnetiQ9NTM9.
PhosphoSitePlusiQ9NTM9.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000119929.
CleanExiHS_CUTC.
ExpressionAtlasiQ9NTM9. baseline and differential.
GenevisibleiQ9NTM9. HS.

Organism-specific databases

HPAiHPA038619.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL6P411823EBI-714918,EBI-765407
CEP76Q8TAP63EBI-714918,EBI-742887
SDCBPO005605EBI-714918,EBI-727004
SPG21Q9NZD85EBI-714918,EBI-742688

Protein-protein interaction databases

BioGridi119267. 17 interactors.
IntActiQ9NTM9. 15 interactors.
MINTiMINT-1387697.
STRINGi9606.ENSP00000359507.

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 34Combined sources9
Helixi35 – 44Combined sources10
Beta strandi47 – 51Combined sources5
Helixi55 – 57Combined sources3
Helixi64 – 71Combined sources8
Beta strandi78 – 81Combined sources4
Beta strandi84 – 87Combined sources4
Helixi93 – 108Combined sources16
Beta strandi112 – 116Combined sources5
Helixi127 – 137Combined sources11
Beta strandi142 – 144Combined sources3
Helixi146 – 150Combined sources5
Helixi154 – 164Combined sources11
Beta strandi167 – 171Combined sources5
Beta strandi175 – 177Combined sources3
Turni178 – 181Combined sources4
Helixi182 – 192Combined sources11
Beta strandi195 – 200Combined sources6
Turni206 – 208Combined sources3
Helixi209 – 216Combined sources8
Beta strandi219 – 223Combined sources5
Beta strandi226 – 229Combined sources4
Turni244 – 246Combined sources3
Beta strandi253 – 256Combined sources4
Helixi258 – 271Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IWPX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-273[»]
ProteinModelPortaliQ9NTM9.
SMRiQ9NTM9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NTM9.

Family & Domainsi

Sequence similaritiesi

Belongs to the CutC family.Curated

Phylogenomic databases

eggNOGiKOG4013. Eukaryota.
COG3142. LUCA.
GeneTreeiENSGT00390000008454.
HOGENOMiHOG000100908.
HOVERGENiHBG051267.
InParanoidiQ9NTM9.
KOiK06201.
OMAiRIELCAG.
OrthoDBiEOG091G0INY.
PhylomeDBiQ9NTM9.
TreeFamiTF105937.

Family and domain databases

Gene3Di3.20.20.380. 1 hit.
HAMAPiMF_00795. CutC. 1 hit.
InterProiIPR005627. Cu_homeostasis_CutC.
IPR023648. Cu_homeostasis_CutC_dom.
[Graphical view]
PANTHERiPTHR12598. PTHR12598. 1 hit.
PfamiPF03932. CutC. 1 hit.
[Graphical view]
SUPFAMiSSF110395. SSF110395. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NTM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQGASSER KRARIPSGKA GAANGFLMEV CVDSVESAVN AERGGADRIE
60 70 80 90 100
LCSGLSEGGT TPSMGVLQVV KQSVQIPVFV MIRPRGGDFL YSDREIEVMK
110 120 130 140 150
ADIRLAKLYG ADGLVFGALT EDGHIDKELC MSLMAICRPL PVTFHRAFDM
160 170 180 190 200
VHDPMAALET LLTLGFERVL TSGCDSSALE GLPLIKRLIE QAKGRIVVMP
210 220 230 240 250
GGGITDRNLQ RILEGSGATE FHCSARSTRD SGMKFRNSSV AMGASLSCSE
260 270
YSLKVTDVTK VRTLNAIAKN ILV
Length:273
Mass (Da):29,341
Last modified:October 1, 2000 - v1
Checksum:i63C007AAB05C5492
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108L → P in AAD27741 (PubMed:10810093).Curated1
Sequence conflicti186K → N in AAD27741 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03636377P → L in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132966 mRNA. Translation: AAD27741.1.
AK314687 mRNA. Translation: BAG37239.1.
AL133353 Genomic DNA. Translation: CAB88199.1.
CH471066 Genomic DNA. Translation: EAW49854.1.
BC021105 mRNA. Translation: AAH21105.1.
BC028948 mRNA. Translation: AAH28948.1.
CCDSiCCDS7483.1.
RefSeqiNP_057044.2. NM_015960.2.
UniGeneiHs.16606.

Genome annotation databases

EnsembliENST00000370476; ENSP00000359507; ENSG00000119929.
GeneIDi51076.
KEGGihsa:51076.
UCSCiuc001kqd.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132966 mRNA. Translation: AAD27741.1.
AK314687 mRNA. Translation: BAG37239.1.
AL133353 Genomic DNA. Translation: CAB88199.1.
CH471066 Genomic DNA. Translation: EAW49854.1.
BC021105 mRNA. Translation: AAH21105.1.
BC028948 mRNA. Translation: AAH28948.1.
CCDSiCCDS7483.1.
RefSeqiNP_057044.2. NM_015960.2.
UniGeneiHs.16606.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IWPX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-273[»]
ProteinModelPortaliQ9NTM9.
SMRiQ9NTM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119267. 17 interactors.
IntActiQ9NTM9. 15 interactors.
MINTiMINT-1387697.
STRINGi9606.ENSP00000359507.

Protein family/group databases

TCDBi9.B.158.1.1. the cut copper homeostasis (cut) family.

PTM databases

iPTMnetiQ9NTM9.
PhosphoSitePlusiQ9NTM9.

Polymorphism and mutation databases

BioMutaiCUTC.
DMDMi54035909.

Proteomic databases

EPDiQ9NTM9.
MaxQBiQ9NTM9.
PaxDbiQ9NTM9.
PeptideAtlasiQ9NTM9.
PRIDEiQ9NTM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370476; ENSP00000359507; ENSG00000119929.
GeneIDi51076.
KEGGihsa:51076.
UCSCiuc001kqd.5. human.

Organism-specific databases

CTDi51076.
GeneCardsiCUTC.
HGNCiHGNC:24271. CUTC.
HPAiHPA038619.
MIMi610101. gene.
neXtProtiNX_Q9NTM9.
OpenTargetsiENSG00000119929.
PharmGKBiPA134901980.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4013. Eukaryota.
COG3142. LUCA.
GeneTreeiENSGT00390000008454.
HOGENOMiHOG000100908.
HOVERGENiHBG051267.
InParanoidiQ9NTM9.
KOiK06201.
OMAiRIELCAG.
OrthoDBiEOG091G0INY.
PhylomeDBiQ9NTM9.
TreeFamiTF105937.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119929-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

EvolutionaryTraceiQ9NTM9.
GeneWikiiCUTC_(gene).
GenomeRNAii51076.
PROiQ9NTM9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119929.
CleanExiHS_CUTC.
ExpressionAtlasiQ9NTM9. baseline and differential.
GenevisibleiQ9NTM9. HS.

Family and domain databases

Gene3Di3.20.20.380. 1 hit.
HAMAPiMF_00795. CutC. 1 hit.
InterProiIPR005627. Cu_homeostasis_CutC.
IPR023648. Cu_homeostasis_CutC_dom.
[Graphical view]
PANTHERiPTHR12598. PTHR12598. 1 hit.
PfamiPF03932. CutC. 1 hit.
[Graphical view]
SUPFAMiSSF110395. SSF110395. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCUTC_HUMAN
AccessioniPrimary (citable) accession number: Q9NTM9
Secondary accession number(s): Q5TCZ8, Q9Y321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.