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Q9NTM9

- CUTC_HUMAN

UniProt

Q9NTM9 - CUTC_HUMAN

Protein

Copper homeostasis protein cutC homolog

Gene

CUTC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May play a role in copper homeostasis. Can bind one Cu1+ per subunit.2 Publications

    GO - Molecular functioni

    1. copper ion binding Source: UniProtKB

    GO - Biological processi

    1. copper ion homeostasis Source: UniProtKB
    2. copper ion transport Source: UniProtKB
    3. protein tetramerization Source: UniProtKB

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Copper homeostasis protein cutC homolog
    Gene namesi
    Name:CUTC
    ORF Names:CGI-32
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:24271. CUTC.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: The overexpressed protein is detected in the cytoplasm, and depending on the cell line, also in the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleolus Source: HPA
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi31 – 311C → A: Reduces copper binding. Reduces copper binding by 75%; when associated with A-52. 1 Publication
    Mutagenesisi52 – 521C → A: Reduces copper binding. Reduces copper binding by 75%; when associated with A-31. 1 Publication

    Organism-specific databases

    PharmGKBiPA134901980.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Copper homeostasis protein cutC homologPRO_0000215088Add
    BLAST

    Proteomic databases

    MaxQBiQ9NTM9.
    PaxDbiQ9NTM9.
    PeptideAtlasiQ9NTM9.
    PRIDEiQ9NTM9.

    PTM databases

    PhosphoSiteiQ9NTM9.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9NTM9.
    BgeeiQ9NTM9.
    CleanExiHS_CUTC.
    GenevestigatoriQ9NTM9.

    Organism-specific databases

    HPAiHPA038619.

    Interactioni

    Subunit structurei

    Homotetramer.1 Publication

    Protein-protein interaction databases

    BioGridi119267. 16 interactions.
    IntActiQ9NTM9. 4 interactions.
    MINTiMINT-1387697.
    STRINGi9606.ENSP00000359507.

    Structurei

    Secondary structure

    1
    273
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 349
    Helixi35 – 4410
    Beta strandi47 – 515
    Helixi55 – 573
    Helixi64 – 718
    Beta strandi78 – 814
    Beta strandi84 – 874
    Helixi93 – 10816
    Beta strandi112 – 1165
    Helixi127 – 13711
    Beta strandi142 – 1443
    Helixi146 – 1505
    Helixi154 – 16411
    Beta strandi167 – 1715
    Beta strandi175 – 1773
    Turni178 – 1814
    Helixi182 – 19211
    Beta strandi195 – 2006
    Turni206 – 2083
    Helixi209 – 2168
    Beta strandi219 – 2235
    Beta strandi226 – 2294
    Turni244 – 2463
    Beta strandi253 – 2564
    Helixi258 – 27114

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IWPX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-273[»]
    ProteinModelPortaliQ9NTM9.
    SMRiQ9NTM9. Positions 24-272.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NTM9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CutC family.Curated

    Phylogenomic databases

    eggNOGiCOG3142.
    HOGENOMiHOG000100908.
    HOVERGENiHBG051267.
    InParanoidiQ9NTM9.
    KOiK06201.
    OMAiGVSMCSE.
    OrthoDBiEOG7HXCSJ.
    PhylomeDBiQ9NTM9.
    TreeFamiTF105937.

    Family and domain databases

    Gene3Di3.20.20.380. 1 hit.
    HAMAPiMF_00795. CutC.
    InterProiIPR005627. Cu_homeostasis_CutC.
    IPR023648. Cu_homeostasis_CutC_dom.
    [Graphical view]
    PANTHERiPTHR12598. PTHR12598. 1 hit.
    PfamiPF03932. CutC. 1 hit.
    [Graphical view]
    SUPFAMiSSF110395. SSF110395. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9NTM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRQGASSER KRARIPSGKA GAANGFLMEV CVDSVESAVN AERGGADRIE    50
    LCSGLSEGGT TPSMGVLQVV KQSVQIPVFV MIRPRGGDFL YSDREIEVMK 100
    ADIRLAKLYG ADGLVFGALT EDGHIDKELC MSLMAICRPL PVTFHRAFDM 150
    VHDPMAALET LLTLGFERVL TSGCDSSALE GLPLIKRLIE QAKGRIVVMP 200
    GGGITDRNLQ RILEGSGATE FHCSARSTRD SGMKFRNSSV AMGASLSCSE 250
    YSLKVTDVTK VRTLNAIAKN ILV 273
    Length:273
    Mass (Da):29,341
    Last modified:October 1, 2000 - v1
    Checksum:i63C007AAB05C5492
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti108 – 1081L → P in AAD27741. (PubMed:10810093)Curated
    Sequence conflicti186 – 1861K → N in AAD27741. (PubMed:10810093)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771P → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036363

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132966 mRNA. Translation: AAD27741.1.
    AK314687 mRNA. Translation: BAG37239.1.
    AL133353 Genomic DNA. Translation: CAB88199.1.
    CH471066 Genomic DNA. Translation: EAW49854.1.
    BC021105 mRNA. Translation: AAH21105.1.
    BC028948 mRNA. Translation: AAH28948.1.
    CCDSiCCDS7483.1.
    RefSeqiNP_057044.2. NM_015960.2.
    UniGeneiHs.16606.

    Genome annotation databases

    EnsembliENST00000370476; ENSP00000359507; ENSG00000119929.
    GeneIDi51076.
    KEGGihsa:51076.
    UCSCiuc001kqd.4. human.

    Polymorphism databases

    DMDMi54035909.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132966 mRNA. Translation: AAD27741.1 .
    AK314687 mRNA. Translation: BAG37239.1 .
    AL133353 Genomic DNA. Translation: CAB88199.1 .
    CH471066 Genomic DNA. Translation: EAW49854.1 .
    BC021105 mRNA. Translation: AAH21105.1 .
    BC028948 mRNA. Translation: AAH28948.1 .
    CCDSi CCDS7483.1.
    RefSeqi NP_057044.2. NM_015960.2.
    UniGenei Hs.16606.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IWP X-ray 2.50 A/B/C/D/E/F/G/H/I/J/K/L 1-273 [» ]
    ProteinModelPortali Q9NTM9.
    SMRi Q9NTM9. Positions 24-272.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119267. 16 interactions.
    IntActi Q9NTM9. 4 interactions.
    MINTi MINT-1387697.
    STRINGi 9606.ENSP00000359507.

    PTM databases

    PhosphoSitei Q9NTM9.

    Polymorphism databases

    DMDMi 54035909.

    Proteomic databases

    MaxQBi Q9NTM9.
    PaxDbi Q9NTM9.
    PeptideAtlasi Q9NTM9.
    PRIDEi Q9NTM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370476 ; ENSP00000359507 ; ENSG00000119929 .
    GeneIDi 51076.
    KEGGi hsa:51076.
    UCSCi uc001kqd.4. human.

    Organism-specific databases

    CTDi 51076.
    GeneCardsi GC10P101481.
    HGNCi HGNC:24271. CUTC.
    HPAi HPA038619.
    MIMi 610101. gene.
    neXtProti NX_Q9NTM9.
    PharmGKBi PA134901980.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3142.
    HOGENOMi HOG000100908.
    HOVERGENi HBG051267.
    InParanoidi Q9NTM9.
    KOi K06201.
    OMAi GVSMCSE.
    OrthoDBi EOG7HXCSJ.
    PhylomeDBi Q9NTM9.
    TreeFami TF105937.

    Miscellaneous databases

    EvolutionaryTracei Q9NTM9.
    GeneWikii CUTC_(gene).
    GenomeRNAii 51076.
    NextBioi 53707.
    PROi Q9NTM9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NTM9.
    Bgeei Q9NTM9.
    CleanExi HS_CUTC.
    Genevestigatori Q9NTM9.

    Family and domain databases

    Gene3Di 3.20.20.380. 1 hit.
    HAMAPi MF_00795. CutC.
    InterProi IPR005627. Cu_homeostasis_CutC.
    IPR023648. Cu_homeostasis_CutC_dom.
    [Graphical view ]
    PANTHERi PTHR12598. PTHR12598. 1 hit.
    Pfami PF03932. CutC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110395. SSF110395. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Skin.
    6. "Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC."
      Li J., Ji C., Chen J., Yang Z., Wang Y., Fei X., Zheng M., Gu X., Wen G., Xie Y., Mao Y.
      Biochem. Biophys. Res. Commun. 337:179-183(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site."
      Li Y., Du J., Zhang P., Ding J.
      J. Struct. Biol. 169:399-405(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), COPPER-BINDING, FUNCTION, SUBUNIT, MUTAGENESIS OF CYS-31 AND CYS-52.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-77.

    Entry informationi

    Entry nameiCUTC_HUMAN
    AccessioniPrimary (citable) accession number: Q9NTM9
    Secondary accession number(s): Q5TCZ8, Q9Y321
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3