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Protein

Protein DEPP

Gene

DEPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in autophagy.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DEPP
Alternative name(s):
Decidual protein induced by progesterone
Fasting-induced gene protein
Short name:
FIG
Gene namesi
Name:DEPP
Synonyms:C10orf10, FIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23355. C10orf10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi11067.
OpenTargetsiENSG00000165507.
PharmGKBiPA128394583.

Polymorphism and mutation databases

BioMutaiDEPP.
DMDMi68565547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798671 – 212Protein DEPPAdd BLAST212

Proteomic databases

PaxDbiQ9NTK1.
PeptideAtlasiQ9NTK1.
PRIDEiQ9NTK1.

PTM databases

iPTMnetiQ9NTK1.
PhosphoSitePlusiQ9NTK1.

Expressioni

Tissue specificityi

Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney.1 Publication

Developmental stagei

High levels in first trimester deciduas. Higher levels in the endometria during secretory phase than the proliferative phase, especially after the mid-secretory phase.1 Publication

Inductioni

By progesterone, testosterone and, to a much lower extent, estrogen. Up-regulated by hypoxia (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000165507.
CleanExiHS_C10orf10.
ExpressionAtlasiQ9NTK1. baseline and differential.
GenevisibleiQ9NTK1. HS.

Organism-specific databases

HPAiCAB013687.
HPA037819.

Interactioni

Protein-protein interaction databases

BioGridi116251. 7 interactors.
IntActiQ9NTK1. 7 interactors.
MINTiMINT-1438823.
STRINGi9606.ENSP00000298295.

Structurei

3D structure databases

ProteinModelPortaliQ9NTK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZM8. Eukaryota.
ENOG41115QP. LUCA.
GeneTreeiENSGT00390000017909.
HOGENOMiHOG000059546.
HOVERGENiHBG081432.
InParanoidiQ9NTK1.
OMAiHLPVIHE.
OrthoDBiEOG091G0N8Y.
PhylomeDBiQ9NTK1.

Family and domain databases

InterProiIPR020133. DEPP.
[Graphical view]
PANTHERiPTHR15426. PTHR15426. 1 hit.
PfamiPF15343. DEPP. 1 hit.
[Graphical view]
ProDomiPD209750. DEPP. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9NTK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRLLLSVA HLPTIRETTE EMLLGGPGQE PPPSPSLDDY VRSISRLAQP
60 70 80 90 100
TSVLDKATAQ GQPRPPHRPA QACRKGRPAV SLRDITARFS GQQPTLPMAD
110 120 130 140 150
TVDPLDWLFG ESQEKQPSQR DLPRRTGPSA GLWGPHRQMD SSKPMGAPRG
160 170 180 190 200
RLCEARMPGH SLARPPQDGQ QSSDLRSWTF GQSAQAMASR HRPRPSSVLR
210
TLYSHLPVIH EL
Length:212
Mass (Da):23,406
Last modified:July 5, 2005 - v2
Checksum:i9EEF82C7E15638A0
GO

Sequence cautioni

The sequence CAI13066 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137 – 139RQM → QTDS in BAC87794 (Ref. 2) Curated3
Sequence conflicti145M → T in CAB66588 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05095144I → M.Corresponds to variant rs11555140dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022718 mRNA. Translation: BAA74504.1.
AB025244 mRNA. Translation: BAC87794.1.
AL136653 mRNA. Translation: CAB66588.1.
AK002191 mRNA. Translation: BAG51027.1.
AK312496 mRNA. Translation: BAG35398.1.
AL353801 Genomic DNA. Translation: CAI13065.1.
AL353801 Genomic DNA. Translation: CAI13066.1. Sequence problems.
CH471160 Genomic DNA. Translation: EAW86629.1.
BC011402 mRNA. Translation: AAH11402.1.
CCDSiCCDS7210.1.
PIRiT46271.
RefSeqiNP_008952.1. NM_007021.3.
UniGeneiHs.93675.

Genome annotation databases

EnsembliENST00000298295; ENSP00000298295; ENSG00000165507.
GeneIDi11067.
KEGGihsa:11067.
UCSCiuc001jbr.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022718 mRNA. Translation: BAA74504.1.
AB025244 mRNA. Translation: BAC87794.1.
AL136653 mRNA. Translation: CAB66588.1.
AK002191 mRNA. Translation: BAG51027.1.
AK312496 mRNA. Translation: BAG35398.1.
AL353801 Genomic DNA. Translation: CAI13065.1.
AL353801 Genomic DNA. Translation: CAI13066.1. Sequence problems.
CH471160 Genomic DNA. Translation: EAW86629.1.
BC011402 mRNA. Translation: AAH11402.1.
CCDSiCCDS7210.1.
PIRiT46271.
RefSeqiNP_008952.1. NM_007021.3.
UniGeneiHs.93675.

3D structure databases

ProteinModelPortaliQ9NTK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116251. 7 interactors.
IntActiQ9NTK1. 7 interactors.
MINTiMINT-1438823.
STRINGi9606.ENSP00000298295.

PTM databases

iPTMnetiQ9NTK1.
PhosphoSitePlusiQ9NTK1.

Polymorphism and mutation databases

BioMutaiDEPP.
DMDMi68565547.

Proteomic databases

PaxDbiQ9NTK1.
PeptideAtlasiQ9NTK1.
PRIDEiQ9NTK1.

Protocols and materials databases

DNASUi11067.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298295; ENSP00000298295; ENSG00000165507.
GeneIDi11067.
KEGGihsa:11067.
UCSCiuc001jbr.5. human.

Organism-specific databases

CTDi11067.
DisGeNETi11067.
GeneCardsiC10orf10.
HGNCiHGNC:23355. C10orf10.
HPAiCAB013687.
HPA037819.
MIMi611309. gene.
neXtProtiNX_Q9NTK1.
OpenTargetsiENSG00000165507.
PharmGKBiPA128394583.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZM8. Eukaryota.
ENOG41115QP. LUCA.
GeneTreeiENSGT00390000017909.
HOGENOMiHOG000059546.
HOVERGENiHBG081432.
InParanoidiQ9NTK1.
OMAiHLPVIHE.
OrthoDBiEOG091G0N8Y.
PhylomeDBiQ9NTK1.

Miscellaneous databases

GeneWikiiC10orf10.
GenomeRNAii11067.
PROiQ9NTK1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165507.
CleanExiHS_C10orf10.
ExpressionAtlasiQ9NTK1. baseline and differential.
GenevisibleiQ9NTK1. HS.

Family and domain databases

InterProiIPR020133. DEPP.
[Graphical view]
PANTHERiPTHR15426. PTHR15426. 1 hit.
PfamiPF15343. DEPP. 1 hit.
[Graphical view]
ProDomiPD209750. DEPP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiDEPP_HUMAN
AccessioniPrimary (citable) accession number: Q9NTK1
Secondary accession number(s): B2R6A1
, O94997, Q5T735, Q76MX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.