Q9NTK1 (DEPP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein DEPP

Alternative name(s):
Decidual protein induced by progesterone
Fasting-induced gene protein
Short name=FIG

Gene names

Name:	DEPP
Synonyms:	C10orf10, FIG

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney. Ref.1
Developmental stage	High levels in first trimester deciduas. Higher levels in the endometria during secretory phase than the proliferative phase, especially after the mid-secretory phase. Ref.1
Induction	By progesterone, testosterone and, to a much lower extent, estrogen. Ref.1
Sequence caution	The sequence CAI13066.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Protein DEPP		PRO_0000079867
Natural variations
	Natural variant	44	1	I → M. Corresponds to variant rs11555140 [ dbSNP | Ensembl ].		VAR_050951
Experimental info
	Sequence conflict	137 – 139	3	RQM → QTDS in BAC87794. Ref.2
	Sequence conflict	145	1	M → T in CAB66588. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9NTK1 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: 9EEF82C7E15638A0	FASTA	212	23,406
	10 20 30 40 50 60 MRSRLLLSVA HLPTIRETTE EMLLGGPGQE PPPSPSLDDY VRSISRLAQP TSVLDKATAQ 70 80 90 100 110 120 GQPRPPHRPA QACRKGRPAV SLRDITARFS GQQPTLPMAD TVDPLDWLFG ESQEKQPSQR 130 140 150 160 170 180 DLPRRTGPSA GLWGPHRQMD SSKPMGAPRG RLCEARMPGH SLARPPQDGQ QSSDLRSWTF 190 200 210 GQSAQAMASR HRPRPSSVLR TLYSHLPVIH EL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor." Watanabe H., Nonoguchi K., Sakurai T., Masuda T., Itoh K., Fujita J. Mol. Hum. Reprod. 11:471-476(2005) [PubMed: 16123073] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Endometrium.
[2]	"Molecular cloning and characterization of a novel fasting induced gene transcript from adipose tissue." Matsuda M., Kuriyama H., Kishida K., Funahashi T., Shimomura I., Yamashita S., Matsuzawa Y. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adipose tissue.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal brain.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB022718 mRNA. Translation: BAA74504.1. AB025244 mRNA. Translation: BAC87794.1. AL136653 mRNA. Translation: CAB66588.1. AL353801 Genomic DNA. Translation: CAI13065.1. AL353801 Genomic DNA. Translation: CAI13066.1. Sequence problems. BC011402 mRNA. Translation: AAH11402.1.
IPI	IPI00550786.
PIR	T46271.
RefSeq	NP_008952.1. NM_007021.3.
UniGene	Hs.728826. Hs.93675.
3D structure databases
ProteinModelPortal	Q9NTK1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NTK1. 7 interactions.
MINT	MINT-1438823.
STRING	Q9NTK1.
Polymorphism databases
DMDM	68565547.
Proteomic databases
PRIDE	Q9NTK1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298295; ENSP00000298295; ENSG00000165507.
GeneID	11067.
KEGG	hsa:11067.
UCSC	uc001jbr.2. human.
Organism-specific databases
CTD	11067.
GeneCards	GC10M045466.
H-InvDB	HIX0008786.
HGNC	HGNC:23355. C10orf10.
HPA	CAB013687.
MIM	611309. gene.
neXtProt	NX_Q9NTK1.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06765.
GeneTree	ENSGT00390000017909.
HOGENOM	HBG126608.
HOVERGEN	HBG081432.
InParanoid	Q9NTK1.
OMA	HLPVIHE.
OrthoDB	EOG47WNPV.
PhylomeDB	Q9NTK1.
Gene expression databases
ArrayExpress	Q9NTK1.
Bgee	Q9NTK1.
CleanEx	HS_C10orf10.
Genevestigator	Q9NTK1.
GermOnline	ENSG00000165507. Homo sapiens.
Family and domain databases
InterPro	IPR020133. Decidual_prot_progesterone_ind. [Graphical view]
ProDom	PD209750. DEPP. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	42072.
SOURCE	Search...

Entry information

Entry name

DEPP_HUMAN

Accession

Primary (citable) accession number: Q9NTK1
Secondary accession number(s): O94997, Q5T735, Q76MX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2005
Last modified:	January 25, 2012
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.