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Protein

Protein DEPP1

Gene

DEPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.3 Publications

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • regulation of autophagy Source: UniProtKB

Keywordsi

Biological processAutophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DEPP1Curated
Alternative name(s):
Decidual protein induced by progesterone1 Publication
Fasting-induced gene protein1 Publication
Short name:
FIG1 Publication
Gene namesi
Name:DEPP1Imported
Synonyms:C10orf10, DEPP1 Publication, FIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165507.8
HGNCiHGNC:23355 DEPP1
MIMi611309 gene
neXtProtiNX_Q9NTK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi11067
OpenTargetsiENSG00000165507
PharmGKBiPA128394583

Polymorphism and mutation databases

BioMutaiDEPP
DMDMi68565547

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798671 – 212Protein DEPP1Add BLAST212

Proteomic databases

PaxDbiQ9NTK1
PeptideAtlasiQ9NTK1
PRIDEiQ9NTK1
ProteomicsDBi82621

PTM databases

iPTMnetiQ9NTK1
PhosphoSitePlusiQ9NTK1

Expressioni

Tissue specificityi

Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney.1 Publication

Developmental stagei

High levels in first trimester deciduas. Higher levels in the endometria during secretory phase than the proliferative phase, especially after the mid-secretory phase.1 Publication

Inductioni

By progesterone, testosterone and, to a much lower extent, estrogen. Induced by oxidative stress via FOXO3 activation (PubMed:28545464). Up-regulated by hypoxia (at protein level).3 Publications

Gene expression databases

BgeeiENSG00000165507
CleanExiHS_C10orf10
ExpressionAtlasiQ9NTK1 baseline and differential
GenevisibleiQ9NTK1 HS

Organism-specific databases

HPAiCAB013687
HPA037819

Interactioni

Protein-protein interaction databases

BioGridi116251, 7 interactors
IntActiQ9NTK1, 7 interactors
STRINGi9606.ENSP00000298295

Structurei

3D structure databases

ProteinModelPortaliQ9NTK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZM8 Eukaryota
ENOG41115QP LUCA
GeneTreeiENSGT00390000017909
HOGENOMiHOG000059546
HOVERGENiHBG081432
InParanoidiQ9NTK1
OMAiHLPVIHE
OrthoDBiEOG091G0N8Y
PhylomeDBiQ9NTK1

Family and domain databases

InterProiView protein in InterPro
IPR020133 DEPP
PANTHERiPTHR15426 PTHR15426, 1 hit
PfamiView protein in Pfam
PF15343 DEPP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD209750 DEPP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NTK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRLLLSVA HLPTIRETTE EMLLGGPGQE PPPSPSLDDY VRSISRLAQP
60 70 80 90 100
TSVLDKATAQ GQPRPPHRPA QACRKGRPAV SLRDITARFS GQQPTLPMAD
110 120 130 140 150
TVDPLDWLFG ESQEKQPSQR DLPRRTGPSA GLWGPHRQMD SSKPMGAPRG
160 170 180 190 200
RLCEARMPGH SLARPPQDGQ QSSDLRSWTF GQSAQAMASR HRPRPSSVLR
210
TLYSHLPVIH EL
Length:212
Mass (Da):23,406
Last modified:July 5, 2005 - v2
Checksum:i9EEF82C7E15638A0
GO

Sequence cautioni

The sequence CAI13066 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137 – 139RQM → QTDS in BAC87794 (Ref. 2) Curated3
Sequence conflicti145M → T in CAB66588 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05095144I → M. Corresponds to variant dbSNP:rs11555140Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022718 mRNA Translation: BAA74504.1
AB025244 mRNA Translation: BAC87794.1
AL136653 mRNA Translation: CAB66588.1
AK002191 mRNA Translation: BAG51027.1
AK312496 mRNA Translation: BAG35398.1
AL353801 Genomic DNA Translation: CAI13065.1
AL353801 Genomic DNA Translation: CAI13066.1 Sequence problems.
CH471160 Genomic DNA Translation: EAW86629.1
BC011402 mRNA Translation: AAH11402.1
CCDSiCCDS7210.1
PIRiT46271
RefSeqiNP_008952.1, NM_007021.3
UniGeneiHs.93675

Genome annotation databases

EnsembliENST00000298295; ENSP00000298295; ENSG00000165507
GeneIDi11067
KEGGihsa:11067
UCSCiuc001jbr.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDEPP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NTK1
Secondary accession number(s): B2R6A1
, O94997, Q5T735, Q76MX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 20, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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