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Protein

Protein DEPP

Gene

DEPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in autophagy.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DEPP
Alternative name(s):
Decidual protein induced by progesterone
Fasting-induced gene protein
Short name:
FIG
Gene namesi
Name:DEPP
Synonyms:C10orf10, FIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23355. C10orf10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394583.

Polymorphism and mutation databases

BioMutaiDEPP.
DMDMi68565547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Protein DEPPPRO_0000079867Add
BLAST

Proteomic databases

PaxDbiQ9NTK1.
PRIDEiQ9NTK1.

PTM databases

iPTMnetiQ9NTK1.

Expressioni

Tissue specificityi

Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney.1 Publication

Developmental stagei

High levels in first trimester deciduas. Higher levels in the endometria during secretory phase than the proliferative phase, especially after the mid-secretory phase.1 Publication

Inductioni

By progesterone, testosterone and, to a much lower extent, estrogen. Up-regulated by hypoxia (at protein level).2 Publications

Gene expression databases

BgeeiQ9NTK1.
CleanExiHS_C10orf10.
ExpressionAtlasiQ9NTK1. baseline and differential.
GenevisibleiQ9NTK1. HS.

Organism-specific databases

HPAiCAB013687.
HPA037819.

Interactioni

Protein-protein interaction databases

BioGridi116251. 7 interactions.
IntActiQ9NTK1. 7 interactions.
MINTiMINT-1438823.
STRINGi9606.ENSP00000298295.

Structurei

3D structure databases

ProteinModelPortaliQ9NTK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZM8. Eukaryota.
ENOG41115QP. LUCA.
GeneTreeiENSGT00390000017909.
HOGENOMiHOG000059546.
HOVERGENiHBG081432.
InParanoidiQ9NTK1.
OMAiHLPVIHE.
OrthoDBiEOG73BVF6.
PhylomeDBiQ9NTK1.

Family and domain databases

InterProiIPR020133. DEPP.
[Graphical view]
PANTHERiPTHR15426. PTHR15426. 1 hit.
PfamiPF15343. DEPP. 1 hit.
[Graphical view]
ProDomiPD209750. DEPP. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9NTK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRLLLSVA HLPTIRETTE EMLLGGPGQE PPPSPSLDDY VRSISRLAQP
60 70 80 90 100
TSVLDKATAQ GQPRPPHRPA QACRKGRPAV SLRDITARFS GQQPTLPMAD
110 120 130 140 150
TVDPLDWLFG ESQEKQPSQR DLPRRTGPSA GLWGPHRQMD SSKPMGAPRG
160 170 180 190 200
RLCEARMPGH SLARPPQDGQ QSSDLRSWTF GQSAQAMASR HRPRPSSVLR
210
TLYSHLPVIH EL
Length:212
Mass (Da):23,406
Last modified:July 5, 2005 - v2
Checksum:i9EEF82C7E15638A0
GO

Sequence cautioni

The sequence CAI13066.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1393RQM → QTDS in BAC87794 (Ref. 2) Curated
Sequence conflicti145 – 1451M → T in CAB66588 (PubMed:11230166).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441I → M.
Corresponds to variant rs11555140 [ dbSNP | Ensembl ].
VAR_050951

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022718 mRNA. Translation: BAA74504.1.
AB025244 mRNA. Translation: BAC87794.1.
AL136653 mRNA. Translation: CAB66588.1.
AK002191 mRNA. Translation: BAG51027.1.
AK312496 mRNA. Translation: BAG35398.1.
AL353801 Genomic DNA. Translation: CAI13065.1.
AL353801 Genomic DNA. Translation: CAI13066.1. Sequence problems.
CH471160 Genomic DNA. Translation: EAW86629.1.
BC011402 mRNA. Translation: AAH11402.1.
CCDSiCCDS7210.1.
PIRiT46271.
RefSeqiNP_008952.1. NM_007021.3.
UniGeneiHs.93675.

Genome annotation databases

EnsembliENST00000298295; ENSP00000298295; ENSG00000165507.
GeneIDi11067.
KEGGihsa:11067.
UCSCiuc001jbr.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022718 mRNA. Translation: BAA74504.1.
AB025244 mRNA. Translation: BAC87794.1.
AL136653 mRNA. Translation: CAB66588.1.
AK002191 mRNA. Translation: BAG51027.1.
AK312496 mRNA. Translation: BAG35398.1.
AL353801 Genomic DNA. Translation: CAI13065.1.
AL353801 Genomic DNA. Translation: CAI13066.1. Sequence problems.
CH471160 Genomic DNA. Translation: EAW86629.1.
BC011402 mRNA. Translation: AAH11402.1.
CCDSiCCDS7210.1.
PIRiT46271.
RefSeqiNP_008952.1. NM_007021.3.
UniGeneiHs.93675.

3D structure databases

ProteinModelPortaliQ9NTK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116251. 7 interactions.
IntActiQ9NTK1. 7 interactions.
MINTiMINT-1438823.
STRINGi9606.ENSP00000298295.

PTM databases

iPTMnetiQ9NTK1.

Polymorphism and mutation databases

BioMutaiDEPP.
DMDMi68565547.

Proteomic databases

PaxDbiQ9NTK1.
PRIDEiQ9NTK1.

Protocols and materials databases

DNASUi11067.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298295; ENSP00000298295; ENSG00000165507.
GeneIDi11067.
KEGGihsa:11067.
UCSCiuc001jbr.5. human.

Organism-specific databases

CTDi11067.
GeneCardsiC10orf10.
HGNCiHGNC:23355. C10orf10.
HPAiCAB013687.
HPA037819.
MIMi611309. gene.
neXtProtiNX_Q9NTK1.
PharmGKBiPA128394583.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZM8. Eukaryota.
ENOG41115QP. LUCA.
GeneTreeiENSGT00390000017909.
HOGENOMiHOG000059546.
HOVERGENiHBG081432.
InParanoidiQ9NTK1.
OMAiHLPVIHE.
OrthoDBiEOG73BVF6.
PhylomeDBiQ9NTK1.

Miscellaneous databases

GeneWikiiC10orf10.
GenomeRNAii11067.
PROiQ9NTK1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NTK1.
CleanExiHS_C10orf10.
ExpressionAtlasiQ9NTK1. baseline and differential.
GenevisibleiQ9NTK1. HS.

Family and domain databases

InterProiIPR020133. DEPP.
[Graphical view]
PANTHERiPTHR15426. PTHR15426. 1 hit.
PfamiPF15343. DEPP. 1 hit.
[Graphical view]
ProDomiPD209750. DEPP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor."
    Watanabe H., Nonoguchi K., Sakurai T., Masuda T., Itoh K., Fujita J.
    Mol. Hum. Reprod. 11:471-476(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Endometrium.
  2. "Molecular cloning and characterization of a novel fasting induced gene transcript from adipose tissue."
    Matsuda M., Kuriyama H., Kishida K., Funahashi T., Shimomura I., Yamashita S., Matsuzawa Y.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adipose tissue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Thalamus.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  8. "FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells."
    Chen S., Gai J., Wang Y., Li H.
    FEBS Lett. 585:1796-1800(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY HYPOXIA.
  9. "The c10orf10 gene product is a new link between oxidative stress and autophagy."
    Stepp M.W., Folz R.J., Yu J., Zelko I.N.
    Biochim. Biophys. Acta 1843:1076-1088(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDEPP_HUMAN
AccessioniPrimary (citable) accession number: Q9NTK1
Secondary accession number(s): B2R6A1
, O94997, Q5T735, Q76MX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.