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Protein

PAK4-inhibitor INKA2

Gene

FAM212B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.By similarity

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein serine/threonine kinase inhibitor activity Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
PAK4-inhibitor INKA2Curated
Alternative name(s):
Induced in neural crest by AP2-alpha protein-related homolog1 Publication
Short name:
HInca-r1 Publication
Gene namesi
Name:FAM212BImported
Synonyms:C1orf183Imported, INKA21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197852.9.
HGNCiHGNC:28045. FAM212B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55924.
OpenTargetsiENSG00000197852.
PharmGKBiPA142672431.

Polymorphism and mutation databases

BioMutaiFAM212B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049941 – 297PAK4-inhibitor INKA2Add BLAST297

Proteomic databases

PaxDbiQ9NTI7.
PRIDEiQ9NTI7.

PTM databases

iPTMnetiQ9NTI7.
PhosphoSitePlusiQ9NTI7.

Expressioni

Gene expression databases

BgeeiENSG00000197852.
CleanExiHS_C1orf183.
ExpressionAtlasiQ9NTI7. baseline and differential.
GenevisibleiQ9NTI7. HS.

Organism-specific databases

HPAiHPA027809.
HPA027811.

Interactioni

Subunit structurei

Interacts with PAK4 (PubMed:26607847).1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121003. 9 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9NTI7.
SMRiQ9NTI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 180Inka boxBy similarityAdd BLAST44

Domaini

The Inka box (also named iBox or inca box) binds and inhibits PAK4 by binding a substrate-like manner.By similarity

Sequence similaritiesi

Belongs to the INKA family.Curated

Phylogenomic databases

eggNOGiENOG410IF94. Eukaryota.
ENOG4111HME. LUCA.
GeneTreeiENSGT00530000063849.
HOGENOMiHOG000111266.
HOVERGENiHBG107564.
InParanoidiQ9NTI7.
OMAiDYNTAVW.
OrthoDBiEOG091G0ADX.
PhylomeDBiQ9NTI7.
TreeFamiTF332839.

Family and domain databases

InterProiView protein in InterPro
IPR029267. FAM212.
PfamiView protein in Pfam
PF15342. FAM212. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NTI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMESREMDC YLRRLKQELM SMKEVGDGLQ DQMNCMMGAL QELKLLQVQT
60 70 80 90 100
ALEQLEISGG GPVPGSPEGP RTQCEHPCWE GGRGPARPTV CSPSSQPSLG
110 120 130 140 150
SSTKFPSHRS VCGRDLAPLP RTQPHQSCAQ QGPERVEPDD WTSTLMSRGR
160 170 180 190 200
NRQPLVLGDN VFADLVGNWL DLPELEKGGE KGETGGAREP KGEKGQPQEL
210 220 230 240 250
GRRFALTANI FKKFLRSVRP DRDRLLKEKP GWVTPMVPES RTGRSQKVKK
260 270 280 290
RSLSKGSGHF PFPGTGEHRR GENPPTSCPK ALEHSPSGFD INTAVWV
Length:297
Mass (Da):32,759
Last modified:October 1, 2000 - v1
Checksum:iAC9E28218271E5E2
GO

Sequence cautioni

The sequence BAG57355 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB69909 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137198 mRNA. Translation: CAB69908.1.
AL137199 mRNA. Translation: CAB69909.1. Different initiation.
AK055667 mRNA. Translation: BAG51550.1.
AK293989 mRNA. Translation: BAG57355.1. Different initiation.
AL049557 Genomic DNA. No translation available.
CH471122 Genomic DNA. Translation: EAW56505.1.
BC031558 mRNA. Translation: AAH31558.1.
CCDSiCCDS841.1.
RefSeqiNP_061972.1. NM_019099.4.
NP_945120.1. NM_198926.2.
UniGeneiHs.193406.

Genome annotation databases

EnsembliENST00000357260; ENSP00000349805; ENSG00000197852.
GeneIDi55924.
KEGGihsa:55924.
UCSCiuc001ebo.2. human.

Similar proteinsi

Entry informationi

Entry nameiINKA2_HUMAN
AccessioniPrimary (citable) accession number: Q9NTI7
Secondary accession number(s): B3KP38, B4DF94, Q9NTI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families