Q9NTI5 (PDS5B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sister chromatid cohesion protein PDS5 homolog B

Alternative name(s):
Androgen-induced proliferation inhibitor
Androgen-induced prostate proliferative shutoff-associated protein AS3

Gene names

Name:	PDS5B
Synonyms:	APRIN, AS3, KIAA0979

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1447 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. Ref.9 Ref.10 Ref.18
Subunit structure	Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive Probable. Ref.10 Ref.18 Ref.21
Subcellular location	Nucleus By similarity UniProtKB Q6TRW4.
Tissue specificity	Widely expressed. Ref.1
Induction	By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure. Ref.1
Sequence similarities	Belongs to the PDS5 family. Contains 3 A.T hook DNA-binding domains. Contains 1 HEAT repeat.
Sequence caution	The sequence BAA76823.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Traceable author statement Ref.9. Source: ProtInc mitotic sister chromatid cohesion Inferred from mutant phenotype Ref.10. Source: UniProtKB negative regulation of cell proliferation Inferred from direct assay Ref.9. Source: UniProtKB
Cellular_component	chromatin Inferred from direct assay PubMed 16682347. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Traceable author statement Ref.2. Source: ProtInc DNA binding Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RAD21	O60216	3	EBI-1175604,EBI-80739
SMC3	Q9UQE7	6	EBI-1175604,EBI-80718
STAG1	Q8WVM7	3	EBI-1175604,EBI-1175097
STAG2	Q8N3U4	3	EBI-1175604,EBI-1057252
WAPAL	Q7Z5K2	9	EBI-1175604,EBI-1022242

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.3 (identifier: Q9NTI5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.2 (identifier: Q9NTI5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1392-1447: Missing.

Isoform 3 Ref.8 (identifier: Q9NTI5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     491-529: ALNEMWKCQN...ASVKAIFSKV → YVSNIKFCSF...KCNLCSVNIV
     530-1447: Missing.

Note: No experimental confirmation available.

Isoform 4 Ref.8 (identifier: Q9NTI5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     105-122: DIFMFITRQLKGLEDTKS → ASTDLNNSKIDRYFDLSF
     123-1447: Missing.

Note: No experimental confirmation available.

Isoform 5 Ref.5 (identifier: Q9NTI5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1230: Missing.
     1356-1447: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1447	1447	Sister chromatid cohesion protein PDS5 homolog B		PRO_0000287424
Regions
	Repeat	383 – 419	37	HEAT
	DNA binding	1249 – 1261	13	A.T hook 1
	DNA binding	1287 – 1299	13	A.T hook 2
	DNA binding	1372 – 1384	13	A.T hook 3
Amino acid modifications
	Modified residue	1136	1	N6-acetyllysine Ref.20
	Modified residue	1162	1	Phosphoserine Ref.19
	Modified residue	1166	1	Phosphoserine Ref.19 Ref.22 Ref.24 PubMed 15302935
	Modified residue	1176	1	Phosphoserine Ref.19
	Modified residue	1182	1	Phosphoserine Ref.15 Ref.19 Ref.22 Ref.24
	Modified residue	1191	1	Phosphoserine Ref.19
	Modified residue	1257	1	Phosphoserine Ref.11 Ref.16 Ref.19
	Modified residue	1259	1	Phosphoserine By similarity
	Modified residue	1283	1	Phosphoserine Ref.15 Ref.19 Ref.22 Ref.24
	Modified residue	1334	1	Phosphoserine Ref.16
	Modified residue	1358	1	Phosphoserine Ref.12 Ref.14 Ref.15 Ref.19 Ref.22 Ref.24 PubMed 15302935
	Modified residue	1367	1	Phosphothreonine Ref.13
	Modified residue	1370	1	Phosphothreonine Ref.12 Ref.19
	Modified residue	1379	1	Phosphoserine Ref.5 Ref.17
	Modified residue	1381	1	Phosphothreonine Ref.24
	Modified residue	1383	1	Phosphoserine Ref.11 Ref.24
Natural variations
	Alternative sequence	1 – 1230	1230	Missing in isoform 5. Ref.5		VSP_052396
	Alternative sequence	105 – 122	18	DIFMF…EDTKS → ASTDLNNSKIDRYFDLSF in isoform 4. Ref.8		VSP_052397
	Alternative sequence	123 – 1447	1325	Missing in isoform 4. Ref.8		VSP_052398
	Alternative sequence	491 – 529	39	ALNEM…IFSKV → YVSNIKFCSFHPLQYIGFYG KETTNTCILKCNLCSVNIV in isoform 3. Ref.8		VSP_052399
	Alternative sequence	530 – 1447	918	Missing in isoform 3. Ref.8		VSP_052400
	Alternative sequence	1356 – 1447	92	Missing in isoform 5. Ref.5		VSP_052401
	Alternative sequence	1392 – 1447	56	Missing in isoform 2. Ref.2		VSP_052402
Experimental info
	Sequence conflict	256	1	F → S in AAD22134. Ref.2
	Sequence conflict	326	1	H → N in AAH39256. Ref.8
	Sequence conflict	394	1	R → G in AAD22134. Ref.2
	Sequence conflict	535	1	N → S in AAD22134. Ref.2
	Sequence conflict	742	1	T → A in AAD22134. Ref.2
	Sequence conflict	1115	1	E → G in AAD22134. Ref.2
	Sequence conflict	1156	1	S → G in AAD22134. Ref.2
	Sequence conflict	1197	1	K → R in AAD22134. Ref.2
	Sequence conflict	1225	1	Q → R in AAD22134. Ref.2
	Sequence conflict	1242	1	K → R in AAD22134. Ref.2
	Sequence conflict	1359	1	P → S in AAD22134. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 145C30308EA3EFD5	FASTA	1,447	164,667
	10 20 30 40 50 60 MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE EEKELYLNLA 70 80 90 100 110 120 LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP DKLKDIFMFI TRQLKGLEDT 130 140 150 160 170 180 KSPQFNRYFY LLENIAWVKS YNICFELEDS NEIFTQLYRT LFSVINNGHN QKVHMHMVDL 190 200 210 220 230 240 MSSIICEGDT VSQELLDTVL VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV 250 260 270 280 290 300 LMLGKTSISD LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF 310 320 330 340 350 360 GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD LTEYLKVRSH 370 380 390 400 410 420 DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK RWRVRKEAMM GLAQIYKKYA 430 440 450 460 470 480 LQSAAGKDAA KQIAWIKDKL LHIYYQNSID DRLLVERIFA QYMVPHNLET TERMKCLYYL 490 500 510 520 530 540 YATLDLNAVK ALNEMWKCQN LLRHQVKDLL DLIKQPKTDA SVKAIFSKVM VITRNLPDPG 550 560 570 580 590 600 KAQDFMKKFT QVLEDDEKIR KQLEVLVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM 610 620 630 640 650 660 IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL ELLKVLSFTH 670 680 690 700 710 720 PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE EDFPHIRSAL LPVLHHKSKK 730 740 750 760 770 780 GPPRQAKYAI HCIHAIFSSK ETQFAQIFEP LHKSLDPSNL EHLITPLVTI GHIALLAPDQ 790 800 810 820 830 840 FAAPLKSLVA TFIVKDLLMN DRLPGKKTTK LWVPDEEVSP ETMVKIQAIK MMVRWLLGMK 850 860 870 880 890 900 NNHSKSGTST LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT 910 920 930 940 950 960 LEQYQLCALA INDECYQVRQ VFAQKLHKGL SRLRLPLEYM AICALCAKDP VKERRAHARQ 970 980 990 1000 1010 1020 CLVKNINVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA HDPDYVKVQD IEQLKDVKEC 1030 1040 1050 1060 1070 1080 LWFVLEILMA KNENNSHAFI RKMVENIKQT KDAQGPDDAK MNEKLYTVCD VAMNIIMSKS 1090 1100 1110 1120 1130 1140 TTYSLESPKD PVLPARFFTQ PDKNFSNTKN YLPPEMKSFF TPGKPKTTNV LGAVNKPLSS 1150 1160 1170 1180 1190 1200 AGKQSQTKSS RMETVSNASS SSNPSSPGRI KGRLDSSEMD HSENEDYTMS SPLPGKKSDK 1210 1220 1230 1240 1250 1260 RDDSDLVRSE LEKPRGRKKT PVTEQEEKLG MDDLTKLVQE QKPKGSQRSR KRGHTASESD 1270 1280 1290 1300 1310 1320 EQQWPEEKRL KEDILENEDE QNSPPKKGKR GRPPKPLGGG TPKEEPTMKT SKKGSKKKSG 1330 1340 1350 1360 1370 1380 PPAPEEEEEE ERQSGNTEQK SKSKQHRVSR RAQQRAESPE SSAIESTQST PQKGRGRPSK 1390 1400 1410 1420 1430 1440 TPSPSQPKKN VRVGRSKQAA TKENDSSEEV DVFQGSSPVD DIPQEETEEE EVSTVNVRRR SAKRERR
	Isoform 2 [UniParc]. Checksum: 9C5FD7A7F8C4A18F	FASTA	1,391	158,280
	10 20 30 40 50 60 MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE EEKELYLNLA 70 80 90 100 110 120 LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP DKLKDIFMFI TRQLKGLEDT 130 140 150 160 170 180 KSPQFNRYFY LLENIAWVKS YNICFELEDS NEIFTQLYRT LFSVINNGHN QKVHMHMVDL 190 200 210 220 230 240 MSSIICEGDT VSQELLDTVL VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV 250 260 270 280 290 300 LMLGKTSISD LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF 310 320 330 340 350 360 GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD LTEYLKVRSH 370 380 390 400 410 420 DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK RWRVRKEAMM GLAQIYKKYA 430 440 450 460 470 480 LQSAAGKDAA KQIAWIKDKL LHIYYQNSID DRLLVERIFA QYMVPHNLET TERMKCLYYL 490 500 510 520 530 540 YATLDLNAVK ALNEMWKCQN LLRHQVKDLL DLIKQPKTDA SVKAIFSKVM VITRNLPDPG 550 560 570 580 590 600 KAQDFMKKFT QVLEDDEKIR KQLEVLVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM 610 620 630 640 650 660 IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL ELLKVLSFTH 670 680 690 700 710 720 PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE EDFPHIRSAL LPVLHHKSKK 730 740 750 760 770 780 GPPRQAKYAI HCIHAIFSSK ETQFAQIFEP LHKSLDPSNL EHLITPLVTI GHIALLAPDQ 790 800 810 820 830 840 FAAPLKSLVA TFIVKDLLMN DRLPGKKTTK LWVPDEEVSP ETMVKIQAIK MMVRWLLGMK 850 860 870 880 890 900 NNHSKSGTST LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT 910 920 930 940 950 960 LEQYQLCALA INDECYQVRQ VFAQKLHKGL SRLRLPLEYM AICALCAKDP VKERRAHARQ 970 980 990 1000 1010 1020 CLVKNINVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA HDPDYVKVQD IEQLKDVKEC 1030 1040 1050 1060 1070 1080 LWFVLEILMA KNENNSHAFI RKMVENIKQT KDAQGPDDAK MNEKLYTVCD VAMNIIMSKS 1090 1100 1110 1120 1130 1140 TTYSLESPKD PVLPARFFTQ PDKNFSNTKN YLPPEMKSFF TPGKPKTTNV LGAVNKPLSS 1150 1160 1170 1180 1190 1200 AGKQSQTKSS RMETVSNASS SSNPSSPGRI KGRLDSSEMD HSENEDYTMS SPLPGKKSDK 1210 1220 1230 1240 1250 1260 RDDSDLVRSE LEKPRGRKKT PVTEQEEKLG MDDLTKLVQE QKPKGSQRSR KRGHTASESD 1270 1280 1290 1300 1310 1320 EQQWPEEKRL KEDILENEDE QNSPPKKGKR GRPPKPLGGG TPKEEPTMKT SKKGSKKKSG 1330 1340 1350 1360 1370 1380 PPAPEEEEEE ERQSGNTEQK SKSKQHRVSR RAQQRAESPE SSAIESTQST PQKGRGRPSK 1390 TPSPSQPKKN V
	Isoform 3 [UniParc]. Checksum: 05CDB3E2A92F46DD	FASTA	529	61,437
	10 20 30 40 50 60 MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE EEKELYLNLA 70 80 90 100 110 120 LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP DKLKDIFMFI TRQLKGLEDT 130 140 150 160 170 180 KSPQFNRYFY LLENIAWVKS YNICFELEDS NEIFTQLYRT LFSVINNGHN QKVHMHMVDL 190 200 210 220 230 240 MSSIICEGDT VSQELLDTVL VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV 250 260 270 280 290 300 LMLGKTSISD LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF 310 320 330 340 350 360 GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD LTEYLKVRSH 370 380 390 400 410 420 DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK RWRVRKEAMM GLAQIYKKYA 430 440 450 460 470 480 LQSAAGKDAA KQIAWIKDKL LHIYYQNSID DRLLVERIFA QYMVPHNLET TERMKCLYYL 490 500 510 520 YATLDLNAVK YVSNIKFCSF HPLQYIGFYG KETTNTCILK CNLCSVNIV
	Isoform 4 [UniParc]. Checksum: B8EAB2D511A217CB	FASTA	122	14,108
	10 20 30 40 50 60 MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE EEKELYLNLA 70 80 90 100 110 120 LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP DKLKASTDLN NSKIDRYFDL SF
	Isoform 5 [UniParc]. Checksum: 492809836D3665D3	FASTA	125	14,281
	10 20 30 40 50 60 MDDLTKLVQE QKPKGSQRSR KRGHTASESD EQQWPEEKRL KEDILENEDE QNSPPKKGKR 70 80 90 100 110 120 GRPPKPLGGG TPKEEPTMKT SKKGSKKKSG PPAPEEEEEE ERQSGNTEQK SKSKQHRVSR RAQQR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of novel genes linked to the androgen-induced, proliferative shutoff in prostate cancer cells." Geck P., Szelei J., Jimenez J., Lin T.-M., Sonnenschein C., Soto A.M. J. Steroid Biochem. Mol. Biol. 63:211-218(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
[2]	"Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus." Geck P., Szelei J., Jimenez J., Sonnenschein C., Soto A.M. J. Steroid Biochem. Mol. Biol. 68:41-50(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Prostate.
[3]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Colon.
[6]	Rhodes S., Huckle E. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Prostate and Testis.
[9]	"Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator." Geck P., Maffini M.V., Szelei J., Sonnenschein C., Soto A.M. Proc. Natl. Acad. Sci. U.S.A. 97:10185-10190(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts." Losada A., Yokochi T., Hirano T. J. Cell Sci. 118:2133-2141(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH COHESIN COMPLEX.
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1358 AND THR-1370, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1367, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[14]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1358, MASS SPECTROMETRY. Tissue: T-cell.
[15]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1182; SER-1283 AND SER-1358, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1257 AND SER-1334, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	Carrascal M., Abian J. Submitted (JAN-2008) to UniProtKB Cited for: PHOSPHORYLATION AT SER-1379, MASS SPECTROMETRY. Tissue: T-cell.
[18]	"Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1." Shintomi K., Hirano T. Genes Dev. 23:2224-2236(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH WAPAL AND RAD21.
[19]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1162; SER-1166; SER-1176; SER-1182; SER-1191; SER-1257; SER-1283; SER-1358 AND THR-1370, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[20]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1136, MASS SPECTROMETRY.
[21]	"Sororin mediates sister chromatid cohesion by antagonizing wapl." Nishiyama T., Ladurner R., Schmitz J., Kreidl E., Schleiffer A., Bhaskara V., Bando M., Shirahige K., Hyman A.A., Mechtler K., Peters J.M. Cell 143:737-749(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH WAPAL AND CDCA5.
[22]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1166; SER-1182; SER-1283 AND SER-1358, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[23]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[24]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1166; SER-1182; SER-1283; SER-1358; THR-1381 AND SER-1383, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U95825 mRNA. Translation: AAD22134.2. AB023196 mRNA. Translation: BAA76823.2. Different initiation. AK026889 mRNA. Translation: BAB15584.1. AL137201 mRNA. Translation: CAB69911.1. AL138820, Z75889 Genomic DNA. Translation: CAH73160.2. Z75889, AL138820 Genomic DNA. Translation: CAI10806.2. BC039256 mRNA. Translation: AAH39256.1. BC070274 mRNA. Translation: AAH70274.1.
IPI	IPI00240812. IPI00845253. IPI00845353. IPI00845446. IPI00845459.
RefSeq	NP_055847.1. NM_015032.3.
UniGene	Hs.646051.
3D structure databases
ProteinModelPortal	Q9NTI5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NTI5. 12 interactions.
STRING	9606.ENSP00000313851.
PTM databases
PhosphoSite	Q9NTI5.
Polymorphism databases
DMDM	74725312.
Proteomic databases
PaxDb	Q9NTI5.
PRIDE	Q9NTI5.
Protocols and materials databases
DNASU	23047.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315596; ENSP00000313851; ENSG00000083642. ENST00000450460; ENSP00000401619; ENSG00000083642.
GeneID	23047.
KEGG	hsa:23047.
UCSC	uc001uun.3. human. uc001uuo.3. human. uc010abf.3. human.
Organism-specific databases
CTD	23047.
GeneCards	GC13P033160.
HGNC	HGNC:20418. PDS5B.
HPA	HPA039513. HPA040015.
MIM	605333. gene.
neXtProt	NX_Q9NTI5.
PharmGKB	PA162399098.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG268017.
HOVERGEN	HBG108241.
KO	K11267.
OMA	AKKGPPR.
OrthoDB	EOG46T30N.
Enzyme and pathway databases
Reactome	REACT_115566. Cell Cycle. REACT_21300. Mitotic M-M/G1 phases.
Gene expression databases
ArrayExpress	Q9NTI5.
Bgee	Q9NTI5.
CleanEx	HS_PDS5B.
Genevestigator	Q9NTI5.
Family and domain databases
Gene3D	1.25.10.10. 4 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR017956. AT_hook_DNA-bd_motif. [Graphical view]
SMART	SM00384. AT_hook. 2 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PDS5B. human.
GenomeRNAi	23047.
NextBio	44084.
SOURCE	Search...

Entry information

Entry name

PDS5B_HUMAN

Accession

Primary (citable) accession number: Q9NTI5
Secondary accession number(s): Q5R3S3 , Q5W0K8, Q6NSC3, Q8IXT6, Q9H5N8, Q9Y2I5, Q9Y451

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.