ID   PKDRE_HUMAN             Reviewed;        2253 AA.
AC   Q9NTG1; B1AJY3; O95850;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2002, sequence version 2.
DT   27-MAR-2024, entry version 169.
DE   RecName: Full=Polycystin family receptor for egg jelly {ECO:0000312|HGNC:HGNC:9015};
DE   AltName: Full=PKD and REJ homolog;
DE   AltName: Full=Polycystic kidney disease and receptor for egg jelly-related protein;
DE   Flags: Precursor;
GN   Name=PKDREJ;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=9949214; DOI=10.1093/hmg/8.3.543;
RA   Hughes J., Ward C.J., Aspinwall R., Butler R., Harris P.C.;
RT   "Identification of a human homologue of the sea urchin receptor for egg
RT   jelly: a polycystic kidney disease-like protein.";
RL   Hum. Mol. Genet. 8:543-549(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1829-2253.
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   REVIEW.
RX   PubMed=11698076; DOI=10.1016/s0165-6147(00)01832-0;
RA   Stayner C., Zhou J.;
RT   "Polycystin channels and kidney disease.";
RL   Trends Pharmacol. Sci. 22:543-546(2001).
RN   [6]
RP   VARIANTS [LARGE SCALE ANALYSIS] GLY-669 AND ILE-1875.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May have a central role in fertilization. May generate a
CC       Ca(2+) transporting channel directly involved in initiating the
CC       acrosome reaction of the sperm.
CC   -!- SUBUNIT: May form homomultimers or heteromultimers in combination with
CC       an as yet unidentified subunits.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Exclusively expressed in testis.
CC   -!- SIMILARITY: Belongs to the polycystin family. {ECO:0000305}.
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DR   EMBL; AF116458; AAD18021.1; -; mRNA.
DR   EMBL; AL031034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL078611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z93024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471138; EAW73411.1; -; Genomic_DNA.
DR   EMBL; AL137288; CAB70680.1; -; mRNA.
DR   CCDS; CCDS14073.1; -.
DR   PIR; T46355; T46355.
DR   RefSeq; NP_006062.1; NM_006071.1.
DR   AlphaFoldDB; Q9NTG1; -.
DR   SMR; Q9NTG1; -.
DR   BioGRID; 115625; 6.
DR   IntAct; Q9NTG1; 3.
DR   STRING; 9606.ENSP00000253255; -.
DR   GlyCosmos; Q9NTG1; 17 sites, No reported glycans.
DR   GlyGen; Q9NTG1; 17 sites.
DR   iPTMnet; Q9NTG1; -.
DR   PhosphoSitePlus; Q9NTG1; -.
DR   BioMuta; PKDREJ; -.
DR   DMDM; 23396800; -.
DR   MassIVE; Q9NTG1; -.
DR   PaxDb; 9606-ENSP00000253255; -.
DR   PeptideAtlas; Q9NTG1; -.
DR   ProteomicsDB; 82605; -.
DR   Antibodypedia; 28028; 31 antibodies from 13 providers.
DR   DNASU; 10343; -.
DR   Ensembl; ENST00000253255.7; ENSP00000253255.5; ENSG00000130943.7.
DR   GeneID; 10343; -.
DR   KEGG; hsa:10343; -.
DR   MANE-Select; ENST00000253255.7; ENSP00000253255.5; NM_006071.2; NP_006062.1.
DR   UCSC; uc003bhh.4; human.
DR   AGR; HGNC:9015; -.
DR   CTD; 10343; -.
DR   DisGeNET; 10343; -.
DR   GeneCards; PKDREJ; -.
DR   HGNC; HGNC:9015; PKDREJ.
DR   HPA; ENSG00000130943; Tissue enriched (testis).
DR   MIM; 604670; gene.
DR   neXtProt; NX_Q9NTG1; -.
DR   OpenTargets; ENSG00000130943; -.
DR   PharmGKB; PA33347; -.
DR   VEuPathDB; HostDB:ENSG00000130943; -.
DR   eggNOG; KOG3599; Eukaryota.
DR   GeneTree; ENSGT00940000162080; -.
DR   HOGENOM; CLU_001765_0_0_1; -.
DR   InParanoid; Q9NTG1; -.
DR   OMA; KNHMWFS; -.
DR   OrthoDB; 52189at2759; -.
DR   PhylomeDB; Q9NTG1; -.
DR   TreeFam; TF316484; -.
DR   PathwayCommons; Q9NTG1; -.
DR   SignaLink; Q9NTG1; -.
DR   BioGRID-ORCS; 10343; 8 hits in 1136 CRISPR screens.
DR   GenomeRNAi; 10343; -.
DR   Pharos; Q9NTG1; Tdark.
DR   PRO; PR:Q9NTG1; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; Q9NTG1; Protein.
DR   Bgee; ENSG00000130943; Expressed in adult organism and 50 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007340; P:acrosome reaction; TAS:ProtInc.
DR   GO; GO:0050982; P:detection of mechanical stimulus; IBA:GO_Central.
DR   CDD; cd01752; PLAT_polycystin; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR002859; PKD/REJ-like.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   InterPro; IPR003915; PKD_2.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR042060; PLAT_polycystin1.
DR   InterPro; IPR046791; Polycystin_dom.
DR   InterPro; IPR014010; REJ_dom.
DR   PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR   PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR   Pfam; PF08016; PKD_channel; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   Pfam; PF20519; Polycystin_dom; 1.
DR   Pfam; PF02010; REJ; 1.
DR   PRINTS; PR01433; POLYCYSTIN2.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR   PROSITE; PS50095; PLAT; 1.
DR   PROSITE; PS51111; REJ; 1.
DR   Genevisible; Q9NTG1; HS.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..2253
FT                   /note="Polycystin family receptor for egg jelly"
FT                   /id="PRO_0000024299"
FT   TOPO_DOM        20..1184
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1185..1205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1206..1389
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1390..1410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1411..1427
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1428..1448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1449..1576
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1577..1597
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1598..1607
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1608..1628
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1629..1708
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1709..1729
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1730..1966
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1967..1987
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1988..1996
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1997..2017
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        2018..2042
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2043..2063
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        2064..2091
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2092..2112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        2113..2145
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2146..2166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        2167..2253
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          215..913
FT                   /note="REJ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00511"
FT   DOMAIN          1230..1347
FT                   /note="PLAT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00152"
FT   REGION          154..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1494..1562
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1531..1545
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1546..1562
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        197
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        242
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        295
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        306
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        345
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        349
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        481
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        674
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        849
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        890
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        923
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        939
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        958
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        965
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1836
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1893
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1944
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         26
FT                   /note="V -> A (in dbSNP:rs7293071)"
FT                   /id="VAR_059550"
FT   VARIANT         528
FT                   /note="R -> Q (in dbSNP:rs6008394)"
FT                   /id="VAR_050544"
FT   VARIANT         669
FT                   /note="A -> G (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036573"
FT   VARIANT         914
FT                   /note="L -> P (in dbSNP:rs6519993)"
FT                   /id="VAR_050545"
FT   VARIANT         992
FT                   /note="T -> P (in dbSNP:rs7291444)"
FT                   /id="VAR_050546"
FT   VARIANT         993
FT                   /note="V -> A (in dbSNP:rs34798212)"
FT                   /id="VAR_050547"
FT   VARIANT         1091
FT                   /note="N -> S (in dbSNP:rs6008384)"
FT                   /id="VAR_050548"
FT   VARIANT         1147
FT                   /note="I -> M (in dbSNP:rs36125344)"
FT                   /id="VAR_034386"
FT   VARIANT         1411
FT                   /note="N -> D (in dbSNP:rs35276226)"
FT                   /id="VAR_050549"
FT   VARIANT         1528
FT                   /note="I -> M (in dbSNP:rs4823496)"
FT                   /id="VAR_050550"
FT   VARIANT         1729
FT                   /note="V -> I (in dbSNP:rs9626829)"
FT                   /id="VAR_050551"
FT   VARIANT         1875
FT                   /note="T -> I (in a breast cancer sample; somatic mutation;
FT                   dbSNP:rs1203491707)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036574"
SQ   SEQUENCE   2253 AA;  255449 MW;  0878D9FE9106AAE4 CRC64;
     MRPGPALLLL GVGLSLSVGR LPLPPVPRGA QAAVSGAPGG LLRGAPGLGV RGGRALLSLR
     PSAVRAGGAV LSGRGSLCFP HGGTGRRWYC LDLRVLLSAQ RLPWPAAPAL ALVDLQLSAR
     GGRLSLTWSV RLPRSPGRLA WAFRLRLLGP GAARPASPAA RVSPRSAAPG PRPQQGFVAR
     TECPTDGPAR VMLQAVNSSS HRAVESSVSC QINACVIQRV RINTDQKGAP VRLSMQAEAT
     INASVQLDCP AARAIAQYWQ VFSVPAVGQA PDWTQPLDLP QLEIRNSPLF IHIPNNSLQW
     GVYVFNFTVS ITTGNPKMPE VKDSDAVYVW IVRSSLQAVM LGDANITANF TEQLILDGST
     SSDPDADSPL QGLQFFWYCT TDPRNYGGDR IILGSKEVCH PEQANLKWPW ASGPVLTLLP
     ETLKGDHVYF FRMVIRKDSR TAFSDKRVHV LQGPKAIAHI TCIENCERNF IVSDRFSLFL
     NCTNCASRDF YKWSILSSSG GEMLFDWMGE TVTGRNGAYL SIKAFAFRHF LEAEFSISLY
     LACWSGVTSV FRHSFIINHG PQIGECKINP AKGIALITKF VVQCSNFRDK HVPLTYKIIV
     SDLHSVGEIS SVKENTLGTI LYLGPQSTVP PSFLPVGMLA SQYGLKIYAQ VYDSLGAFSQ
     VTLHATAQAP TDKNSSKTVL NQLLSFTVGP SSLLSTLIQK KDFLPAGYLL YIVASVLNNM
     KTELPLRDDR VNLRKHLIDQ SFLLPVSTLV EIGQVVMTIT KLTQKPSEFT WDAQKRATMR
     VWQANQALQE YQQKDKRFRS EQIEIVSTGI LMSLSNILKM TSPHQVVKDP FYVIESLSDT
     ILANKVPGNK TTSMRTPNFN MYVKKVEKWG INQLFRNEKH CRNCFYPTLN VSSVPGLSAN
     GPISTMFCDF TNDLFPWLND QENTSVEVSG FRMTGVADNG SVLEITPDVA EVYLVRKNLT
     FAAFNLTVGP NSEVDGSLKK TTGGFSFQVD STVLREVLVH IVTEVMVLFT VLVYTGSQIT
     PTALVATFLV PHDIPPFASQ SALFDPACTV KKARVVCLPV SLLQLIAQHS HSPHCTVSIV
     LQAPRFVMKL NDKLVRISIF SVQCLDMYGI QSEWREGYCI LGEKTSWYEV HCICKNVVRA
     RRQLGTIGLT GIHLHTHYVM AKVIVIPNPV DLRLNIIKSL HQNPVTLFTV LFIILLYVGL
     AFWALYRDEM DQHLRGHVIV LPDNDPYDNL CYLVTIFTGS RWGSGTRANV FVQLRGTVST
     SDVHCLSHPH FTTLYRGSIN TFLLTTKSDL GDIHSIRVWH NNEGRSPSWY LSRIKVENLF
     SRHIWLFICQ KWLSVDTTLD RTFHVTHPDE RLTRKDFFFI DVSSNLRKNH MWFSIFASVV
     AKTFNRLQRL SCCLAMLLSS LLCNIMFFNL NRQEQTESRE RKYMRSMMIG IESVLITIPV
     QLLITFLFTC SQRKPQADLK EVSPQKHPLM SEASEHWEEY LRKWHAYETA KVHPREVAKP
     ASKGKPRLPK ASPKATSKPK HRHRKAQIKT PETLGPNTNS NNNIEDDQDV HSEQHPSQKD
     LQQLKKKPRI VLPWWCVYVA WFLVFATSSI SSFFIVFYGL TYGYDKSIEW LFASFCSFCQ
     SVLLVQPSKI ILLSGFRTNK PKYCKNLSWS TKYKYTEIRL DGMRMHPEEM QRIHDQIVRI
     RGTRMYQPLT EDEIRIFKRK KRIKRRALLF LSYILTHFIF LALLLILIVL LRHTDCFYYN
     QFIRDRFSMD LATVTKLEDI YRWLNSVLLP LLHNDLNPTF LPESSSKILG LPLMRQVRAK
     SSEKMCLPAE KFVQNSIRRE IHCHPKYGID PEDTKNYSGF WNEVDKQAID ESTNGFTYKP
     QGTQWLYYSY GLLHTYGSGG YALYFFPEQQ RFNSTLRLKE LQESNWLDEK TWAVVLELTT
     FNPDINLFCS ISVIFEVSQL GVVNTSISLH SFSLADFDRK ASAEIYLYVA ILIFFLAYVV
     DEGCIIMQER ASYVRSVYNL LNFALKCIFT VLIVLFLRKH FLATGIIRFY LSNPEDFIPF
     HAVSQVDHIM RIILGFLLFL TILKTLRYSR FFYDVRLAQR AIQAALPGIC HMAFVVSVYF
     FVYMAFGYLV FGQHEWNYSN LIHSTQTVFS YCVSAFQNTE FSNNRILGVL FLSSFMLVMI
     CVLINLFQAV ILSAYEEMKQ PVYEEPSDEV EAMTYLCRKL RTMFSFLTSQ SKAKDEPEFF
     IDMLYGQPEK NSHRYLGLKT RNINGKKMVY LVV
//