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Q9NTG1

- PKDRE_HUMAN

UniProt

Q9NTG1 - PKDRE_HUMAN

Protein

Polycystic kidney disease and receptor for egg jelly-related protein

Gene

PKDREJ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    May have a central role in fertilization. May generate a Ca2+ transporting channel directly involved in initiating the acrosome reaction of the sperm.

    GO - Molecular functioni

    1. calcium channel activity Source: RefGenome
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. acrosome reaction Source: ProtInc
    2. calcium ion transmembrane transport Source: GOC
    3. detection of mechanical stimulus Source: RefGenome
    4. neuropeptide signaling pathway Source: InterPro
    5. regulation of acrosome reaction Source: Ensembl

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polycystic kidney disease and receptor for egg jelly-related protein
    Alternative name(s):
    PKD and REJ homolog
    Gene namesi
    Name:PKDREJ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:9015. PKDREJ.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: ProtInc
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33347.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 22532234Polycystic kidney disease and receptor for egg jelly-related proteinPRO_0000024299Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi849 – 8491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi890 – 8901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi923 – 9231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi939 – 9391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi958 – 9581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi965 – 9651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1836 – 18361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1893 – 18931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1944 – 19441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NTG1.
    PRIDEiQ9NTG1.

    PTM databases

    PhosphoSiteiQ9NTG1.

    Expressioni

    Tissue specificityi

    Exclusively expressed in testis.

    Gene expression databases

    ArrayExpressiQ9NTG1.
    BgeeiQ9NTG1.
    CleanExiHS_PKDREJ.
    GenevestigatoriQ9NTG1.

    Organism-specific databases

    HPAiHPA034587.

    Interactioni

    Subunit structurei

    May form homomultimers or heteromultimers in combination with an as yet unidentified subunits.

    Protein-protein interaction databases

    BioGridi115625. 2 interactions.
    IntActiQ9NTG1. 1 interaction.
    STRINGi9606.ENSP00000253255.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NTG1.
    SMRiQ9NTG1. Positions 1232-1336.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 11841165ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1206 – 1389184CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1411 – 142717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1449 – 1576128CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1598 – 160710ExtracellularSequence Analysis
    Topological domaini1629 – 170880CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1730 – 1966237ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1988 – 19969CytoplasmicSequence Analysis
    Topological domaini2018 – 204225ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2064 – 209128CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2113 – 214533ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2167 – 225387CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1185 – 120521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1390 – 141021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1428 – 144821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1577 – 159721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1608 – 162821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1709 – 172921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1967 – 198721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1997 – 201721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2043 – 206321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2092 – 211221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2146 – 216621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini215 – 913699REJPROSITE-ProRule annotationAdd
    BLAST
    Domaini1230 – 1347118PLATPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polycystin family.Curated
    Contains 1 PLAT domain.PROSITE-ProRule annotation
    Contains 1 REJ domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303643.
    HOVERGENiHBG053603.
    InParanoidiQ9NTG1.
    OMAiCRNCFYP.
    OrthoDBiEOG7BW0HJ.
    PhylomeDBiQ9NTG1.
    TreeFamiTF316484.

    Family and domain databases

    Gene3Di2.60.60.20. 1 hit.
    InterProiIPR000203. GPS.
    IPR008976. Lipase_LipOase.
    IPR002859. PKD/REJ-like.
    IPR013122. PKD1_2_channel.
    IPR003915. PKD_2.
    IPR001024. PLAT/LH2_dom.
    IPR014010. REJ-like.
    [Graphical view]
    PfamiPF08016. PKD_channel. 1 hit.
    PF01477. PLAT. 1 hit.
    PF02010. REJ. 1 hit.
    [Graphical view]
    PRINTSiPR01433. POLYCYSTIN2.
    SMARTiSM00303. GPS. 1 hit.
    [Graphical view]
    SUPFAMiSSF49723. SSF49723. 1 hit.
    PROSITEiPS50095. PLAT. 1 hit.
    PS51111. REJ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NTG1-1 [UniParc]FASTAAdd to Basket

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    MRPGPALLLL GVGLSLSVGR LPLPPVPRGA QAAVSGAPGG LLRGAPGLGV     50
    RGGRALLSLR PSAVRAGGAV LSGRGSLCFP HGGTGRRWYC LDLRVLLSAQ 100
    RLPWPAAPAL ALVDLQLSAR GGRLSLTWSV RLPRSPGRLA WAFRLRLLGP 150
    GAARPASPAA RVSPRSAAPG PRPQQGFVAR TECPTDGPAR VMLQAVNSSS 200
    HRAVESSVSC QINACVIQRV RINTDQKGAP VRLSMQAEAT INASVQLDCP 250
    AARAIAQYWQ VFSVPAVGQA PDWTQPLDLP QLEIRNSPLF IHIPNNSLQW 300
    GVYVFNFTVS ITTGNPKMPE VKDSDAVYVW IVRSSLQAVM LGDANITANF 350
    TEQLILDGST SSDPDADSPL QGLQFFWYCT TDPRNYGGDR IILGSKEVCH 400
    PEQANLKWPW ASGPVLTLLP ETLKGDHVYF FRMVIRKDSR TAFSDKRVHV 450
    LQGPKAIAHI TCIENCERNF IVSDRFSLFL NCTNCASRDF YKWSILSSSG 500
    GEMLFDWMGE TVTGRNGAYL SIKAFAFRHF LEAEFSISLY LACWSGVTSV 550
    FRHSFIINHG PQIGECKINP AKGIALITKF VVQCSNFRDK HVPLTYKIIV 600
    SDLHSVGEIS SVKENTLGTI LYLGPQSTVP PSFLPVGMLA SQYGLKIYAQ 650
    VYDSLGAFSQ VTLHATAQAP TDKNSSKTVL NQLLSFTVGP SSLLSTLIQK 700
    KDFLPAGYLL YIVASVLNNM KTELPLRDDR VNLRKHLIDQ SFLLPVSTLV 750
    EIGQVVMTIT KLTQKPSEFT WDAQKRATMR VWQANQALQE YQQKDKRFRS 800
    EQIEIVSTGI LMSLSNILKM TSPHQVVKDP FYVIESLSDT ILANKVPGNK 850
    TTSMRTPNFN MYVKKVEKWG INQLFRNEKH CRNCFYPTLN VSSVPGLSAN 900
    GPISTMFCDF TNDLFPWLND QENTSVEVSG FRMTGVADNG SVLEITPDVA 950
    EVYLVRKNLT FAAFNLTVGP NSEVDGSLKK TTGGFSFQVD STVLREVLVH 1000
    IVTEVMVLFT VLVYTGSQIT PTALVATFLV PHDIPPFASQ SALFDPACTV 1050
    KKARVVCLPV SLLQLIAQHS HSPHCTVSIV LQAPRFVMKL NDKLVRISIF 1100
    SVQCLDMYGI QSEWREGYCI LGEKTSWYEV HCICKNVVRA RRQLGTIGLT 1150
    GIHLHTHYVM AKVIVIPNPV DLRLNIIKSL HQNPVTLFTV LFIILLYVGL 1200
    AFWALYRDEM DQHLRGHVIV LPDNDPYDNL CYLVTIFTGS RWGSGTRANV 1250
    FVQLRGTVST SDVHCLSHPH FTTLYRGSIN TFLLTTKSDL GDIHSIRVWH 1300
    NNEGRSPSWY LSRIKVENLF SRHIWLFICQ KWLSVDTTLD RTFHVTHPDE 1350
    RLTRKDFFFI DVSSNLRKNH MWFSIFASVV AKTFNRLQRL SCCLAMLLSS 1400
    LLCNIMFFNL NRQEQTESRE RKYMRSMMIG IESVLITIPV QLLITFLFTC 1450
    SQRKPQADLK EVSPQKHPLM SEASEHWEEY LRKWHAYETA KVHPREVAKP 1500
    ASKGKPRLPK ASPKATSKPK HRHRKAQIKT PETLGPNTNS NNNIEDDQDV 1550
    HSEQHPSQKD LQQLKKKPRI VLPWWCVYVA WFLVFATSSI SSFFIVFYGL 1600
    TYGYDKSIEW LFASFCSFCQ SVLLVQPSKI ILLSGFRTNK PKYCKNLSWS 1650
    TKYKYTEIRL DGMRMHPEEM QRIHDQIVRI RGTRMYQPLT EDEIRIFKRK 1700
    KRIKRRALLF LSYILTHFIF LALLLILIVL LRHTDCFYYN QFIRDRFSMD 1750
    LATVTKLEDI YRWLNSVLLP LLHNDLNPTF LPESSSKILG LPLMRQVRAK 1800
    SSEKMCLPAE KFVQNSIRRE IHCHPKYGID PEDTKNYSGF WNEVDKQAID 1850
    ESTNGFTYKP QGTQWLYYSY GLLHTYGSGG YALYFFPEQQ RFNSTLRLKE 1900
    LQESNWLDEK TWAVVLELTT FNPDINLFCS ISVIFEVSQL GVVNTSISLH 1950
    SFSLADFDRK ASAEIYLYVA ILIFFLAYVV DEGCIIMQER ASYVRSVYNL 2000
    LNFALKCIFT VLIVLFLRKH FLATGIIRFY LSNPEDFIPF HAVSQVDHIM 2050
    RIILGFLLFL TILKTLRYSR FFYDVRLAQR AIQAALPGIC HMAFVVSVYF 2100
    FVYMAFGYLV FGQHEWNYSN LIHSTQTVFS YCVSAFQNTE FSNNRILGVL 2150
    FLSSFMLVMI CVLINLFQAV ILSAYEEMKQ PVYEEPSDEV EAMTYLCRKL 2200
    RTMFSFLTSQ SKAKDEPEFF IDMLYGQPEK NSHRYLGLKT RNINGKKMVY 2250
    LVV 2253
    Length:2,253
    Mass (Da):255,449
    Last modified:September 19, 2002 - v2
    Checksum:i0878D9FE9106AAE4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti26 – 261V → A.
    Corresponds to variant rs7293071 [ dbSNP | Ensembl ].
    VAR_059550
    Natural varianti528 – 5281R → Q.
    Corresponds to variant rs6008394 [ dbSNP | Ensembl ].
    VAR_050544
    Natural varianti669 – 6691A → G in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036573
    Natural varianti914 – 9141L → P.
    Corresponds to variant rs6519993 [ dbSNP | Ensembl ].
    VAR_050545
    Natural varianti992 – 9921T → P.
    Corresponds to variant rs7291444 [ dbSNP | Ensembl ].
    VAR_050546
    Natural varianti993 – 9931V → A.
    Corresponds to variant rs34798212 [ dbSNP | Ensembl ].
    VAR_050547
    Natural varianti1091 – 10911N → S.
    Corresponds to variant rs6008384 [ dbSNP | Ensembl ].
    VAR_050548
    Natural varianti1147 – 11471I → M.
    Corresponds to variant rs36125344 [ dbSNP | Ensembl ].
    VAR_034386
    Natural varianti1411 – 14111N → D.
    Corresponds to variant rs35276226 [ dbSNP | Ensembl ].
    VAR_050549
    Natural varianti1528 – 15281I → M.
    Corresponds to variant rs4823496 [ dbSNP | Ensembl ].
    VAR_050550
    Natural varianti1729 – 17291V → I.
    Corresponds to variant rs9626829 [ dbSNP | Ensembl ].
    VAR_050551
    Natural varianti1875 – 18751T → I in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036574

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116458 mRNA. Translation: AAD18021.1.
    Z93024, AL031034, AL078611 Genomic DNA. Translation: CAI18792.1.
    AL031034, AL078611, Z93024 Genomic DNA. Translation: CAI18795.1.
    CH471138 Genomic DNA. Translation: EAW73411.1.
    AL137288 mRNA. Translation: CAB70680.1.
    CCDSiCCDS14073.1.
    PIRiT46355.
    RefSeqiNP_006062.1. NM_006071.1.
    UniGeneiHs.241383.

    Genome annotation databases

    EnsembliENST00000253255; ENSP00000253255; ENSG00000130943.
    GeneIDi10343.
    KEGGihsa:10343.
    UCSCiuc003bhh.3. human.

    Polymorphism databases

    DMDMi23396800.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116458 mRNA. Translation: AAD18021.1 .
    Z93024 , AL031034 , AL078611 Genomic DNA. Translation: CAI18792.1 .
    AL031034 , AL078611 , Z93024 Genomic DNA. Translation: CAI18795.1 .
    CH471138 Genomic DNA. Translation: EAW73411.1 .
    AL137288 mRNA. Translation: CAB70680.1 .
    CCDSi CCDS14073.1.
    PIRi T46355.
    RefSeqi NP_006062.1. NM_006071.1.
    UniGenei Hs.241383.

    3D structure databases

    ProteinModelPortali Q9NTG1.
    SMRi Q9NTG1. Positions 1232-1336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115625. 2 interactions.
    IntActi Q9NTG1. 1 interaction.
    STRINGi 9606.ENSP00000253255.

    PTM databases

    PhosphoSitei Q9NTG1.

    Polymorphism databases

    DMDMi 23396800.

    Proteomic databases

    PaxDbi Q9NTG1.
    PRIDEi Q9NTG1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253255 ; ENSP00000253255 ; ENSG00000130943 .
    GeneIDi 10343.
    KEGGi hsa:10343.
    UCSCi uc003bhh.3. human.

    Organism-specific databases

    CTDi 10343.
    GeneCardsi GC22M046651.
    HGNCi HGNC:9015. PKDREJ.
    HPAi HPA034587.
    MIMi 604670. gene.
    neXtProti NX_Q9NTG1.
    PharmGKBi PA33347.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303643.
    HOVERGENi HBG053603.
    InParanoidi Q9NTG1.
    OMAi CRNCFYP.
    OrthoDBi EOG7BW0HJ.
    PhylomeDBi Q9NTG1.
    TreeFami TF316484.

    Miscellaneous databases

    GenomeRNAii 10343.
    NextBioi 39223.
    PROi Q9NTG1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NTG1.
    Bgeei Q9NTG1.
    CleanExi HS_PKDREJ.
    Genevestigatori Q9NTG1.

    Family and domain databases

    Gene3Di 2.60.60.20. 1 hit.
    InterProi IPR000203. GPS.
    IPR008976. Lipase_LipOase.
    IPR002859. PKD/REJ-like.
    IPR013122. PKD1_2_channel.
    IPR003915. PKD_2.
    IPR001024. PLAT/LH2_dom.
    IPR014010. REJ-like.
    [Graphical view ]
    Pfami PF08016. PKD_channel. 1 hit.
    PF01477. PLAT. 1 hit.
    PF02010. REJ. 1 hit.
    [Graphical view ]
    PRINTSi PR01433. POLYCYSTIN2.
    SMARTi SM00303. GPS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49723. SSF49723. 1 hit.
    PROSITEi PS50095. PLAT. 1 hit.
    PS51111. REJ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein."
      Hughes J., Ward C.J., Aspinwall R., Butler R., Harris P.C.
      Hum. Mol. Genet. 8:543-549(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1829-2253.
      Tissue: Testis.
    5. Cited for: REVIEW.
    6. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-669 AND ILE-1875.

    Entry informationi

    Entry nameiPKDRE_HUMAN
    AccessioniPrimary (citable) accession number: Q9NTG1
    Secondary accession number(s): B1AJY3, O95850
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3