Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cystathionine beta-synthase

Gene

DKFZp727E011

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-serine + L-homocysteine = L-cystathionine + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cystathionine beta-synthaseUniRule annotation (EC:4.2.1.22UniRule annotation)
Gene namesi
Name:DKFZp727E011Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26123.

PTM / Processingi

Proteomic databases

PaxDbiQ9NTF0.
PeptideAtlasiQ9NTF0.
PRIDEiQ9NTF0.

Expressioni

Gene expression databases

GenevisibleiQ9NTF0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344460.

Structurei

3D structure databases

ProteinModelPortaliQ9NTF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini342 – 40059CBSInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cysteine synthase/cystathionine beta-synthase family.UniRule annotation
Contains 1 CBS domain.UniRule annotation

Keywords - Domaini

CBS domainUniRule annotation

Phylogenomic databases

eggNOGiKOG1252. Eukaryota.
COG0031. LUCA.
HOVERGENiHBG000918.
KOiK01697.

Family and domain databases

InterProiIPR000644. CBS_dom.
IPR005857. Cysta_beta_synth.
IPR001216. P-phosphate_BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF00291. PALP. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01137. cysta_beta. 1 hit.
PROSITEiPS51371. CBS. 1 hit.
PS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9NTF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RPDILKKIGD TPMVRINKIG KKFGLKCELL AKCEFFNAGG SVKDRISLRM
60 70 80 90 100
IEDAERDGTL KPGDTIIEPT SGNTGIGLAL AAAVRGYRCI IVMPEKMSSE
110 120 130 140 150
KVDVLRALGA EIVRTPTNAR FDSPESHVGV AWRLKNEIPN SHILDQYRNA
160 170 180 190 200
SNPLPHYDTT ADEILQQCDG KLDMLVASVG TGGTITGIAR KLKEKCPGCR
210 220 230 240 250
IIGVDPEGSI LAEPEELNQT EQTTYEVEGI GYDFIPTVLD RTVVDKWFKS
260 270 280 290 300
NDEEAFTLAR MLIAQEGLLC GGSAGSTVAV AVKAAQELQE GQRCVVILPD
310 320 330 340 350
SVRNYMTKFL SDRWMLQKGF LKEEDLTEKK PWWWHLRVQE LGLSAPLTVL
360 370 380 390 400
PTITCGHTIE ILREKGFDQA PVVDEAGVIL GMVTLGNMLS SLLAGKVQPS
410 420 430 440 450
DQVGKVIYKQ FKQIRLTDTL GRLSHILEMD HFALVVHEQI QYHSTGKSSQ
460 470
RQMVFGVVTA IDLLNFVAAQ ERDQK
Length:475
Mass (Da):52,487
Last modified:October 1, 2000 - v1
Checksum:i3F5E2D613783A1EF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137314 mRNA. Translation: CAB70691.1.
RefSeqiNP_000062.1. NM_000071.2.
UniGeneiHs.533013.

Genome annotation databases

GeneIDi875.
KEGGihsa:875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137314 mRNA. Translation: CAB70691.1.
RefSeqiNP_000062.1. NM_000071.2.
UniGeneiHs.533013.

3D structure databases

ProteinModelPortaliQ9NTF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344460.

Proteomic databases

PaxDbiQ9NTF0.
PeptideAtlasiQ9NTF0.
PRIDEiQ9NTF0.

Protocols and materials databases

DNASUi875.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi875.
KEGGihsa:875.

Organism-specific databases

CTDi875.
PharmGKBiPA26123.

Phylogenomic databases

eggNOGiKOG1252. Eukaryota.
COG0031. LUCA.
HOVERGENiHBG000918.
KOiK01697.

Miscellaneous databases

GenomeRNAii875.

Gene expression databases

GenevisibleiQ9NTF0. HS.

Family and domain databases

InterProiIPR000644. CBS_dom.
IPR005857. Cysta_beta_synth.
IPR001216. P-phosphate_BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF00291. PALP. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01137. cysta_beta. 1 hit.
PROSITEiPS51371. CBS. 1 hit.
PS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Poustka A., Klein M., Mewes H.W., Weil B., Wiemann S.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Breast cancerImported.

Entry informationi

Entry nameiQ9NTF0_HUMAN
AccessioniPrimary (citable) accession number: Q9NTF0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.