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Q9NT68 (TEN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Teneurin-2
Short name=Ten-2
Alternative name(s):
Protein Odd Oz/ten-m homolog 2
Tenascin-M2
Short name=Ten-m2
Gene names
Name:ODZ2
Synonyms:KIAA1127, TNM2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length2774 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as a cellular signal transducer.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein Probable.

Tissue specificity

Highly expressed in heart, followed by brain, liver, kidney and fetal brain and weakly expressed in lung and testis. No expression was detected in skeletal muscle, pancreas, spleen, ovary and fetal liver. Ref.2

Domain

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.

Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

Sequence similarities

Belongs to the tenascin family. Teneurin subfamily.

Contains 8 EGF-like domains.

Contains 5 NHL repeats.

Contains 1 teneurin N-terminal domain.

Contains 23 YD repeats.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainEGF-like domain
Repeat
Signal-anchor
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncarboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 27742774Teneurin-2
PRO_0000259501

Regions

Topological domain1 – 379379Cytoplasmic Potential
Transmembrane380 – 40021Helical; Potential
Topological domain401 – 27742374Extracellular Potential
Domain1 – 375375Teneurin N-terminal
Domain575 – 60329EGF-like 1
Domain598 – 63437EGF-like 2
Domain636 – 66833EGF-like 3
Domain669 – 70133EGF-like 4
Domain702 – 73534EGF-like 5
Domain738 – 76629EGF-like 6
Domain769 – 79729EGF-like 7
Domain808 – 84134EGF-like 8
Repeat1272 – 131645NHL 1
Repeat1342 – 138645NHL 2
Repeat1401 – 145252NHL 3
Repeat1474 – 150128NHL 4
Repeat1530 – 157344NHL 5
Repeat1583 – 160220YD 1
Repeat1619 – 163921YD 2
Repeat1682 – 170120YD 3
Repeat1702 – 172423YD 4
Repeat1895 – 191420YD 5
Repeat1936 – 195419YD 6
Repeat1955 – 197521YD 7
Repeat1982 – 199918YD 8
Repeat2000 – 202122YD 9
Repeat2022 – 203918YD 10
Repeat2042 – 206221YD 11
Repeat2065 – 208521YD 12
Repeat2093 – 211321YD 13
Repeat2119 – 213618YD 14
Repeat2137 – 216327YD 15
Repeat2165 – 217814YD 16
Repeat2179 – 220224YD 17
Repeat2205 – 222521YD 18
Repeat2226 – 224621YD 19
Repeat2248 – 226821YD 20
Repeat2280 – 230021YD 21
Repeat2302 – 232221YD 22
Repeat2348 – 238942YD 23
Compositional bias331 – 3344Poly-Ser

Amino acid modifications

Modified residue5231Phosphoserine Ref.4
Modified residue11501Phosphotyrosine Ref.5
Glycosylation4431N-linked (GlcNAc...) Potential
Glycosylation4821N-linked (GlcNAc...) Potential
Glycosylation9251N-linked (GlcNAc...) Potential
Glycosylation9481N-linked (GlcNAc...) Potential
Glycosylation12671N-linked (GlcNAc...) Potential
Glycosylation16161N-linked (GlcNAc...) Potential
Glycosylation17121N-linked (GlcNAc...) Potential
Glycosylation17491N-linked (GlcNAc...) Potential
Glycosylation17731N-linked (GlcNAc...) Potential
Glycosylation18071N-linked (GlcNAc...) Potential
Glycosylation18921N-linked (GlcNAc...) Potential
Glycosylation19931N-linked (GlcNAc...) Potential
Glycosylation21971N-linked (GlcNAc...) Potential
Glycosylation23371N-linked (GlcNAc...) Potential
Glycosylation26481N-linked (GlcNAc...) Potential
Disulfide bond576 ↔ 586 By similarity
Disulfide bond580 ↔ 591 By similarity
Disulfide bond593 ↔ 602 By similarity
Disulfide bond611 ↔ 622 By similarity
Disulfide bond624 ↔ 633 By similarity
Disulfide bond640 ↔ 651 By similarity
Disulfide bond645 ↔ 656 By similarity
Disulfide bond658 ↔ 667 By similarity
Disulfide bond672 ↔ 683 By similarity
Disulfide bond677 ↔ 688 By similarity
Disulfide bond690 ↔ 699 By similarity
Disulfide bond710 ↔ 723 By similarity
Disulfide bond725 ↔ 734 By similarity
Disulfide bond739 ↔ 749 By similarity
Disulfide bond743 ↔ 754 By similarity
Disulfide bond756 ↔ 765 By similarity
Disulfide bond770 ↔ 780 By similarity
Disulfide bond774 ↔ 785 By similarity
Disulfide bond787 ↔ 796 By similarity
Disulfide bond810 ↔ 820 By similarity
Disulfide bond814 ↔ 829 By similarity
Disulfide bond831 ↔ 840 By similarity

Natural variations

Natural variant7281N → S.
Corresponds to variant rs6862925 [ dbSNP | Ensembl ].
VAR_060129
Natural variant17191V → F.
Corresponds to variant rs11957063 [ dbSNP | Ensembl ].
VAR_028946

Experimental info

Sequence conflict23841L → P in BAA86441. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9NT68 [UniParc].

Last modified March 2, 2010. Version 3.
Checksum: C23DFD9BCD9D3F60

FASTA2,774307,787
        10         20         30         40         50         60 
MDVKDRRHRS LTRGRCGKEC RYTSSSLDSE DCRVPTQKSY SSSETLKAYD HDSRMHYGNR 

        70         80         90        100        110        120 
VTDLIHRESD EFPRQGTNFT LAELGICEPS PHRSGYCSDM GILHQGYSLS TGSDADSDTE 

       130        140        150        160        170        180 
GGMSPEHAIR LWGRGIKSRR SSGLSSRENS ALTLTDSDNE NKSDDENGRP IPPTSSPSLL 

       190        200        210        220        230        240 
PSAQLPSSHN PPPVSCQMPL LDSNTSHQIM DTNPDEEFSP NSYLLRACSG PQQASSSGPP 

       250        260        270        280        290        300 
NHHSQSTLRP PLPPPHNHTL SHHHSSANSL NRNSLTNRRS QIHAPAPAPN DLATTPESVQ 

       310        320        330        340        350        360 
LQDSWVLNSN VPLETRHFLF KTSSGSTPLF SSSSPGYPLT SGTVYTPPPR LLPRNTFSRK 

       370        380        390        400        410        420 
AFKLKKPSKY CSWKCAALSA IAAALLLAIL LAYFIAMHLL GLNWQLQPAD GHTFNNGIRT 

       430        440        450        460        470        480 
GLPGNDDVAT MPSGGKVPWS LKNSSIDSGE AEVGRRVTQE VPPGVFWRSQ IHISQPQFLK 

       490        500        510        520        530        540 
FNISLGKDAL FGVYIRRGLP PSHAQYDFME RLDGKEKWSV VESPRERRSI QTLVQNEAVF 

       550        560        570        580        590        600 
VQYLDVGLWH LAFYNDGKDK EMVSFNTVVL DSVQDCPRNC HGNGECVSGV CHCFPGFLGA 

       610        620        630        640        650        660 
DCAKAACPVL CSGNGQYSKG TCQCYSGWKG AECDVPMNQC IDPSCGGHGS CIDGNCVCSA 

       670        680        690        700        710        720 
GYKGEHCEEV DCLDPTCSSH GVCVNGECLC SPGWGGLNCE LARVQCPDQC SGHGTYLPDT 

       730        740        750        760        770        780 
GLCSCDPNWM GPDCSVEVCS VDCGTHGVCI GGACRCEEGW TGAACDQRVC HPRCIEHGTC 

       790        800        810        820        830        840 
KDGKCECREG WNGEHCTIGR QTAGTETDGC PDLCNGNGRC TLGQNSWQCV CQTGWRGPGC 

       850        860        870        880        890        900 
NVAMETSCAD NKDNEGDGLV DCLDPDCCLQ SACQNSLLCR GSRDPLDIIQ QGQTDWPAVK 

       910        920        930        940        950        960 
SFYDRIKLLA GKDSTHIIPG ENPFNSSLVS LIRGQVVTTD GTPLVGVNVS FVKYPKYGYT 

       970        980        990       1000       1010       1020 
ITRQDGTFDL IANGGASLTL HFERAPFMSQ ERTVWLPWNS FYAMDTLVMK TEENSIPSCD 

      1030       1040       1050       1060       1070       1080 
LSGFVRPDPI IISSPLSTFF SAAPGQNPIV PETQVLHEEI ELPGSNVKLR YLSSRTAGYK 

      1090       1100       1110       1120       1130       1140 
SLLKITMTQS TVPLNLIRVH LMVAVEGHLF QKSFQASPNL AYTFIWDKTD AYGQRVYGLS 

      1150       1160       1170       1180       1190       1200 
DAVVSVGFEY ETCPSLILWE KRTALLQGFE LDPSNLGGWS LDKHHILNVK SGILHKGTGE 

      1210       1220       1230       1240       1250       1260 
NQFLTQQPAI ITSIMGNGRR RSISCPSCNG LAEGNKLLAP VALAVGIDGS LYVGDFNYIR 

      1270       1280       1290       1300       1310       1320 
RIFPSRNVTS ILELRNKEFK HSNNPAHKYY LAVDPVSGSL YVSDTNSRRI YRVKSLSGTK 

      1330       1340       1350       1360       1370       1380 
DLAGNSEVVA GTGEQCLPFD EARCGDGGKA IDATLMSPRG IAVDKNGLMY FVDATMIRKV 

      1390       1400       1410       1420       1430       1440 
DQNGIISTLL GSNDLTAVRP LSCDSSMDVA QVRLEWPTDL AVNPMDNSLY VLENNVILRI 

      1450       1460       1470       1480       1490       1500 
TENHQVSIIA GRPMHCQVPG IDYSLSKLAI HSALESASAI AISHTGVLYI TETDEKKINR 

      1510       1520       1530       1540       1550       1560 
LRQVTTNGEI CLLAGAASDC DCKNDVNCNC YSGDDAYATD AILNSPSSLA VAPDGTIYIA 

      1570       1580       1590       1600       1610       1620 
DLGNIRIRAV SKNKPVLNAF NQYEAASPGE QELYVFNADG IHQYTVSLVT GEYLYNFTYS 

      1630       1640       1650       1660       1670       1680 
TDNDVTELID NNGNSLKIRR DSSGMPRHLL MPDNQIITLT VGTNGGLKVV STQNLELGLM 

      1690       1700       1710       1720       1730       1740 
TYDGNTGLLA TKSDETGWTT FYDYDHEGRL TNVTRPTGVV TSLHREMEKS ITIDIENSNR 

      1750       1760       1770       1780       1790       1800 
DDDVTVITNL SSVEASYTVV QDQVRNSYQL CNNGTLRVMY ANGMGISFHS EPHVLAGTIT 

      1810       1820       1830       1840       1850       1860 
PTIGRCNISL PMENGLNSIE WRLRKEQIKG KVTIFGRKLR VHGRNLLSID YDRNIRTEKI 

      1870       1880       1890       1900       1910       1920 
YDDHRKFTLR IIYDQVGRPF LWLPSSGLAA VNVSYFFNGR LAGLQRGAMS ERTDIDKQGR 

      1930       1940       1950       1960       1970       1980 
IVSRMFADGK VWSYSYLDKS MVLLLQSQRQ YIFEYDSSDR LLAVTMPSVA RHSMSTHTSI 

      1990       2000       2010       2020       2030       2040 
GYIRNIYNPP ESNASVIFDY SDDGRILKTS FLGTGRQVFY KYGKLSKLSE IVYDSTAVTF 

      2050       2060       2070       2080       2090       2100 
GYDETTGVLK MVNLQSGGFS CTIRYRKIGP LVDKQIYRFS EEGMVNARFD YTYHDNSFRI 

      2110       2120       2130       2140       2150       2160 
ASIKPVISET PLPVDLYRYD EISGKVEHFG KFGVIYYDIN QIITTAVMTL SKHFDTHGRI 

      2170       2180       2190       2200       2210       2220 
KEVQYEMFRS LMYWMTVQYD SMGRVIKREL KLGPYANTTK YTYDYDGDGQ LQSVAVNDRP 

      2230       2240       2250       2260       2270       2280 
TWRYSYDLNG NLHLLNPGNS VRLMPLRYDL RDRITRLGDV QYKIDDDGYL CQRGSDIFEY 

      2290       2300       2310       2320       2330       2340 
NSKGLLTRAY NKASGWSVQY RYDGVGRRAS YKTNLGHHLQ YFYSDLHNPT RITHVYNHSN 

      2350       2360       2370       2380       2390       2400 
SEITSLYYDL QGHLFAMESS SGEEYYVASD NTGTPLAVFS INGLMIKQLQ YTAYGEIYYD 

      2410       2420       2430       2440       2450       2460 
SNPDFQMVIG FHGGLYDPLT KLVHFTQRDY DVLAGRWTSP DYTMWKNVGK EPAPFNLYMF 

      2470       2480       2490       2500       2510       2520 
KSNNPLSSEL DLKNYVTDVK SWLVMFGFQL SNIIPGFPRA KMYFVPPPYE LSESQASENG 

      2530       2540       2550       2560       2570       2580 
QLITGVQQTT ERHNQAFMAL EGQVITKKLH ASIREKAGHW FATTTPIIGK GIMFAIKEGR 

      2590       2600       2610       2620       2630       2640 
VTTGVSSIAS EDSRKVASVL NNAYYLDKMH YSIEGKDTHY FVKIGSADGD LVTLGTTIGR 

      2650       2660       2670       2680       2690       2700 
KVLESGVNVT VSQPTLLVNG RTRRFTNIEF QYSTLLLSIR YGLTPDTLDE EKARVLDQAR 

      2710       2720       2730       2740       2750       2760 
QRALGTAWAK EQQKARDGRE GSRLWTEGEK QQLLSTGRVQ GYEGYYVLPV EQYPELADSS 

      2770 
SNIQFLRQNE MGKR

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed: 15372022] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
DNA Res. 6:329-336(1999) [PubMed: 10574461] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 631-2774, TISSUE SPECIFICITY.
Tissue: Brain.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1926-2774.
Tissue: Amygdala.
[4]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[5]"Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling."
Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A., Lottspeich F., Chen Z.
EMBO J. 25:5058-5070(2006) [PubMed: 17053785] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1150, MASS SPECTROMETRY.
Tissue: Embryonic kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC008464 Genomic DNA. No translation available.
AC008601 Genomic DNA. No translation available.
AC008634 Genomic DNA. No translation available.
AC008637 Genomic DNA. No translation available.
AC008642 Genomic DNA. No translation available.
AC008705 Genomic DNA. No translation available.
AC008708 Genomic DNA. No translation available.
AC011369 Genomic DNA. No translation available.
AC011384 Genomic DNA. No translation available.
AC026689 Genomic DNA. No translation available.
AC091820 Genomic DNA. No translation available.
AC093304 Genomic DNA. No translation available.
AC113372 Genomic DNA. No translation available.
AB032953 mRNA. Translation: BAA86441.2.
AL137500 mRNA. Translation: CAB70774.1.
IPIIPI00182194.
PIRT46253.
UniGeneHs.631957.

3D structure databases

ProteinModelPortalQ9NT68.
SMRQ9NT68. Positions 575-879, 1237-1451, 1473-1570.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9NT68. 1 interaction.
STRINGQ9NT68.

PTM databases

PhosphoSiteQ9NT68.

Polymorphism databases

DMDM290457667.

Proteomic databases

PRIDEQ9NT68.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000388903; ENSP00000373555; ENSG00000145934.
UCSCuc003lzr.2. human.

Organism-specific databases

GeneCardsGC05P166646.
H-InvDBHIX0005389.
HGNCHGNC:29943. ODZ2.
HPAHPA038420.
MIM610119. gene.
neXtProtNX_Q9NT68.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG13000.
GeneTreeENSGT00580000081247.
HOGENOMHBG444169.
HOVERGENHBG080306.
InParanoidQ9NT68.
OrthoDBEOG4QC14D.

Gene expression databases

ArrayExpressQ9NT68.
BgeeQ9NT68.
CleanExHS_ODZ2.
GenevestigatorQ9NT68.
GermOnlineENSG00000145934. Homo sapiens.

Family and domain databases

InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR006210. EGF-like.
IPR013032. EGF-like_reg_CS.
IPR000742. EGF_3.
IPR013111. EGF_extracell.
IPR022385. Rhs_assc_core.
IPR009471. Ten_N.
IPR006530. YD.
[Graphical view]
Gene3DG3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit.
G3DSA:2.60.40.1120. CarboxyPept_regulatory. 1 hit.
PfamPF07974. EGF_2. 2 hits.
PF06484. Ten_N. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 7 hits.
[Graphical view]
SUPFAMSSF49464. CarboxypepD_reg. 1 hit.
TIGRFAMsTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 1 hit.
PROSITEPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 5 hits.
PS51125. NHL. False negative.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameTEN2_HUMAN
AccessionPrimary (citable) accession number: Q9NT68
Secondary accession number(s): Q9ULU2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 2, 2010
Last modified: January 25, 2012
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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