Q9NSY2 (STAR5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
StAR-related lipid transfer protein 5

Alternative name(s):
START domain-containing protein 5
Short name=StARD5

Gene names

Name:

STARD5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols By similarity.
Sequence similarities	Contains 1 START domain.

Ontologies

Keywords
Biological process	Lipid transport Transport
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Lipid-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	C21-steroid hormone biosynthetic process Traceable author statement. Source: Reactome lipid transport Inferred from electronic annotation. Source: UniProtKB-KW small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NSY2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NSY2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     34-63: NGVSVSWRPSVEFPGNLYRGEGIVYGTLEE → VPRRRHCIWDTRGGVGLCEASCWRPTSEVG
     64-213: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 213

213

StAR-related lipid transfer protein 5

PRO_0000220669

Regions

Domain

1 – 213

213

START

Natural variations

Alternative sequence

34 – 63

30

NGVSV…GTLEE → VPRRRHCIWDTRGGVGLCEA SCWRPTSEVG in isoform 2.

VSP_014871

Alternative sequence

64 – 213

150

Missing in isoform 2.

VSP_014872

Natural variant

74

1

G → S.
Corresponds to variant rs4384572 [ dbSNP | Ensembl ].

VAR_052071

Secondary structure

1

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213

Helix Strand Turn

Details...

Helix

6 – 22

17

Beta strand

28 – 31

4

Beta strand

34 – 42

9

Beta strand

44 – 59

16

Helix

61 – 68

8

Helix

76 – 79

4

Beta strand

84 – 91

8

Beta strand

93 – 102

10

Turn

107 – 110

4

Beta strand

114 – 124

11

Beta strand

130 – 136

7

Beta strand

149 – 153

5

Beta strand

155 – 162

8

Beta strand

170 – 176

7

Helix

186 – 209

24

Helix

210 – 212

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 15, 2002. Version 2. Checksum: EE5547A7846AB3C4	FASTA	213	23,794
	10 20 30 40 50 60 MDPALAAQMS EAVAEKMLQY RRDTAGWKIC REGNGVSVSW RPSVEFPGNL YRGEGIVYGT 70 80 90 100 110 120 LEEVWDCVKP AVGGLRVKWD ENVTGFEIIQ SITDTLCVSR TSTPSAAMKL ISPRDFVDLV 130 140 150 160 170 180 LVKRYEDGTI SSNATHVEHP LCPPKPGFVR GFNHPCGCFC EPLPGEPTKT NLVTFFHTDL 190 200 210 SGYLPQNVVD SFFPRSMTRF YANLQKAVKQ FHE
	Isoform 2 [UniParc]. Checksum: 1D457C21C9A0FDE1	FASTA	63	7,094
	10 20 30 40 50 60 MDPALAAQMS EAVAEKMLQY RRDTAGWKIC REGVPRRRHC IWDTRGGVGL CEASCWRPTS EVG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6." Soccio R.E., Adams R.M., Romanowski M.J., Sehayek E., Burley S.K., Breslow J.L. Proc. Natl. Acad. Sci. U.S.A. 99:6943-6948(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Liver.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-213 (ISOFORM 1). Tissue: Small intestine.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pancreas.
[5]	"Comparative structural analysis of lipid binding START domains." Thorsell A.G., Lee W.H., Persson C., Siponen M.I., Nilsson M., Busam R.D., Kotenyova T., Schuler H., Lehtio L. PLoS ONE 6:E19521-E19521(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 6-213.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF480304 mRNA. Translation: AAL89654.1.
AL137657 mRNA. Translation: CAB70862.2.
AK026352 mRNA. No translation available.
BC004365 mRNA. Translation: AAH04365.2.

IPI

IPI00164831.
IPI00394786.

PIR

T46357.

RefSeq

NP_871629.1. NM_181900.2.

UniGene

Hs.513075.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2R55	X-ray	2.50	A/B	6-213	[»]

ProteinModelPortal

Q9NSY2.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000304032.

Polymorphism databases

DMDM

25091329.

Proteomic databases

PaxDb

Q9NSY2.

PRIDE

Q9NSY2.

Protocols and materials databases

DNASU

80765.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000302824; ENSP00000304032; ENSG00000172345.
ENST00000325346; ENSP00000317519; ENSG00000172345.

GeneID

80765.

KEGG

hsa:80765.

UCSC

uc002bgm.3. human.

Organism-specific databases

CTD

80765.

GeneCards

GC15M081601.

HGNC

HGNC:18065. STARD5.

HPA

HPA040662.
HPA040682.

MIM

607050. gene.

neXtProt

NX_Q9NSY2.

PharmGKB

PA38286.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG255993.

HOGENOM

HOG000137345.

HOVERGEN

HBG055194.

InParanoid

Q9NSY2.

OMA

CFCEPVP.

OrthoDB

EOG43TZWF.

PhylomeDB

Q9NSY2.

Enzyme and pathway databases

Reactome

REACT_111217. Metabolism.
REACT_15493. Steroid hormones.

Gene expression databases

ArrayExpress

Q9NSY2.

Bgee

Q9NSY2.

CleanEx

HS_STARD5.

Genevestigator

Q9NSY2.

GermOnline

ENSG00000172345. Homo sapiens.

Family and domain databases

Gene3D

3.30.530.20. 1 hit.

InterPro

IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]

Pfam

PF01852. START. 1 hit.
[Graphical view]

SMART

SM00234. START. 1 hit.
[Graphical view]

PROSITE

PS50848. START. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9NSY2.

GenomeRNAi

80765.

NextBio

71151.

SOURCE

Search...

Entry information

Entry name

STAR5_HUMAN

Accession

Primary (citable) accession number: Q9NSY2
Secondary accession number(s): P59094

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 15, 2002
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.