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Protein

BMP-2-inducible protein kinase

Gene

BMP2K

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in osteoblast differentiation.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79ATPPROSITE-ProRule annotation1
Active sitei180Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi57 – 65ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS06548-MONOMER.
SignaLinkiQ9NSY1.

Names & Taxonomyi

Protein namesi
Recommended name:
BMP-2-inducible protein kinase (EC:2.7.11.1)
Short name:
BIKe
Gene namesi
Name:BMP2K
Synonyms:BIKE
ORF Names:HRIHFB2017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:18041. BMP2K.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55589.
OpenTargetsiENSG00000138756.
PharmGKBiPA134992822.

Chemistry databases

ChEMBLiCHEMBL4522.
GuidetoPHARMACOLOGYi1941.

Polymorphism and mutation databases

BioMutaiBMP2K.
DMDMi34222653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856631 – 1161BMP-2-inducible protein kinaseAdd BLAST1161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei818PhosphoserineCombined sources1
Modified residuei834PhosphothreonineCombined sources1
Modified residuei928PhosphoserineBy similarity1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1031PhosphoserineBy similarity1
Modified residuei1032PhosphoserineCombined sources1
Modified residuei1039PhosphoserineCombined sources1
Modified residuei1041PhosphoserineCombined sources1
Modified residuei1076PhosphoserineCombined sources1
Modified residuei1107PhosphoserineCombined sources1
Modified residuei1111PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NSY1.
MaxQBiQ9NSY1.
PaxDbiQ9NSY1.
PeptideAtlasiQ9NSY1.
PRIDEiQ9NSY1.

PTM databases

iPTMnetiQ9NSY1.
PhosphoSitePlusiQ9NSY1.

Expressioni

Gene expression databases

BgeeiENSG00000138756.
CleanExiHS_BMP2K.
ExpressionAtlasiQ9NSY1. baseline and differential.
GenevisibleiQ9NSY1. HS.

Organism-specific databases

HPAiHPA026436.
HPA026451.
HPA026501.

Interactioni

Protein-protein interaction databases

BioGridi120735. 50 interactors.
IntActiQ9NSY1. 38 interactors.
STRINGi9606.ENSP00000334836.

Chemistry databases

BindingDBiQ9NSY1.

Structurei

Secondary structure

11161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi43 – 46Combined sources4
Beta strandi49 – 59Combined sources11
Beta strandi64 – 70Combined sources7
Beta strandi75 – 85Combined sources11
Helixi86 – 102Combined sources17
Beta strandi111 – 118Combined sources8
Beta strandi120 – 122Combined sources3
Beta strandi124 – 131Combined sources8
Helixi138 – 144Combined sources7
Turni145 – 148Combined sources4
Helixi152 – 170Combined sources19
Beta strandi172 – 174Combined sources3
Helixi183 – 185Combined sources3
Beta strandi186 – 188Combined sources3
Beta strandi194 – 196Combined sources3
Helixi199 – 201Combined sources3
Helixi209 – 212Combined sources4
Helixi214 – 224Combined sources11
Helixi227 – 229Combined sources3
Helixi232 – 234Combined sources3
Helixi245 – 261Combined sources17
Turni265 – 268Combined sources4
Helixi270 – 275Combined sources6
Helixi288 – 297Combined sources10
Helixi302 – 304Combined sources3
Helixi308 – 318Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4W9WX-ray1.72A39-344[»]
4W9XX-ray2.14A38-345[»]
5I3OX-ray2.40A/B42-343[»]
5I3RX-ray2.40A/B42-343[»]
5IKWX-ray2.41A38-345[»]
ProteinModelPortaliQ9NSY1.
SMRiQ9NSY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 316Protein kinasePROSITE-ProRule annotationAdd BLAST266

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 40Gly-richAdd BLAST29
Compositional biasi425 – 559Gln/His-richAdd BLAST135

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1989. Eukaryota.
ENOG410Y515. LUCA.
GeneTreeiENSGT00810000125451.
HOGENOMiHOG000232173.
HOVERGENiHBG050703.
InParanoidiQ9NSY1.
KOiK08854.
OMAiVPFISHP.
OrthoDBiEOG091G02KI.
PhylomeDBiQ9NSY1.
TreeFamiTF335936.

Family and domain databases

InterProiIPR026105. BMP-2-ind_kinase.
IPR028182. BMP2K_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22967:SF10. PTHR22967:SF10. 1 hit.
PfamiPF15282. BMP2K_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKFSRMPKS EGGSGGGAAG GGAGGAGAGA GCGSGGSSVG VRVFAVGRHQ
60 70 80 90 100
VTLEESLAEG GFSTVFLVRT HGGIRCALKR MYVNNMPDLN VCKREITIMK
110 120 130 140 150
ELSGHKNIVG YLDCAVNSIS DNVWEVLILM EYCRAGQVVN QMNKKLQTGF
160 170 180 190 200
TEPEVLQIFC DTCEAVARLH QCKTPIIHRD LKVENILLND GGNYVLCDFG
210 220 230 240 250
SATNKFLNPQ KDGVNVVEEE IKKYTTLSYR APEMINLYGG KPITTKADIW
260 270 280 290 300
ALGCLLYKLC FFTLPFGESQ VAICDGNFTI PDNSRYSRNI HCLIRFMLEP
310 320 330 340 350
DPEHRPDIFQ VSYFAFKFAK KDCPVSNINN SSIPSALPEP MTASEAAARK
360 370 380 390 400
SQIKARITDT IGPTETSIAP RQRPKANSAT TATPSVLTIQ SSATPVKVLA
410 420 430 440 450
PGEFGNHRPK GALRPGNGPE ILLGQGPPQQ PPQQHRVLQQ LQQGDWRLQQ
460 470 480 490 500
LHLQHRHPHQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQHHHH HHHHLLQDAY
510 520 530 540 550
MQQYQHATQQ QQMLQQQFLM HSVYQPQPSA SQYPTMMPQY QQAFFQQQML
560 570 580 590 600
AQHQPSQQQA SPEYLTSPQE FSPALVSYTS SLPAQVGTIM DSSYSANRSV
610 620 630 640 650
ADKEAIANFT NQKNISNPPD MSGWNPFGED NFSKLTEEEL LDREFDLLRS
660 670 680 690 700
NRLEERASSD KNVDSLSAPH NHPPEDPFGS VPFISHSGSP EKKAEHSSIN
710 720 730 740 750
QENGTANPIK NGKTSPASKD QRTGKKTSVQ GQVQKGNDES ESDFESDPPS
760 770 780 790 800
PKSSEEEEQD DEEVLQGEQG DFNDDDTEPE NLGHRPLLMD SEDEEEEEKH
810 820 830 840 850
SSDSDYEQAK AKYSDMSSVY RDRSGSGPTQ DLNTILLTSA QLSSDVAVET
860 870 880 890 900
PKQEFDVFGA VPFFAVRAQQ PQQEKNEKNL PQHRFPAAGL EQEEFDVFTK
910 920 930 940 950
APFSKKVNVQ ECHAVGPEAH TIPGYPKSVD VFGSTPFQPF LTSTSKSESN
960 970 980 990 1000
EDLFGLVPFD EITGSQQQKV KQRSLQKLSS RQRRTKQDMS KSNGKRHHGT
1010 1020 1030 1040 1050
PTSTKKTLKP TYRTPERARR HKKVGRRDSQ SSNEFLTISD SKENISVALT
1060 1070 1080 1090 1100
DGKDRGNVLQ PEESLLDPFG AKPFHSPDLS WHPPHQGLSD IRADHNTVLP
1110 1120 1130 1140 1150
GRPRQNSLHG SFHSADVLKM DDFGAVPFTE LVVQSITPHQ SQQSQPVELD
1160
PFGAAPFPSK Q
Length:1,161
Mass (Da):129,172
Last modified:August 22, 2003 - v2
Checksum:i5C38A86E95935EC2
GO
Isoform 2 (identifier: Q9NSY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     651-662: NRLEERASSDKN → SKGHLKAYFASQ
     663-1161: Missing.

Show »
Length:662
Mass (Da):73,838
Checksum:iED443E4DC0696FF3
GO
Isoform 3 (identifier: Q9NSY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-340: NSSIPSALPEP → KCCKQLLRHGALLTEILLFLQLFLNR
     651-662: NRLEERASSDKN → SKGHLKAYFASQ
     663-1161: Missing.

Note: No experimental confirmation available.
Show »
Length:677
Mass (Da):75,812
Checksum:iFF17E464DB5F952C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti342T → A in AAH36021 (PubMed:15489334).Curated1
Sequence conflicti471 – 486Missing in CAB70863 (PubMed:17974005).CuratedAdd BLAST16
Sequence conflicti478Q → R in AAH36021 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04038868V → M in a lung squamous cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs770167074dbSNPEnsembl.1
Natural variantiVAR_040389212D → V.1 PublicationCorresponds to variant rs56143363dbSNPEnsembl.1
Natural variantiVAR_040390288R → H.1 PublicationCorresponds to variant rs55782848dbSNPEnsembl.1
Natural variantiVAR_051618405G → S.1 PublicationCorresponds to variant rs2288255dbSNPEnsembl.1
Natural variantiVAR_059765486Q → H.Corresponds to variant rs2114202dbSNPEnsembl.1
Natural variantiVAR_0516191002T → S.Corresponds to variant rs12507099dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008093330 – 340NSSIPSALPEP → KCCKQLLRHGALLTEILLFL QLFLNR in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_008091651 – 662NRLEE…SSDKN → SKGHLKAYFASQ in isoform 2 and isoform 3. 4 PublicationsAdd BLAST12
Alternative sequenceiVSP_008092663 – 1161Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST499

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075278 mRNA. Translation: BAC11515.1.
AK292147 mRNA. Translation: BAF84836.1.
AL137275 mRNA. Translation: CAB70673.1.
AL137661 mRNA. Translation: CAB70863.1.
AC098818 Genomic DNA. Translation: AAY40926.1.
BC036021 mRNA. Translation: AAH36021.1.
AF527532 mRNA. Translation: AAM88867.1.
AB015331 mRNA. Translation: BAA34790.1.
CCDSiCCDS34019.1. [Q9NSY1-2]
CCDS47083.1. [Q9NSY1-1]
PIRiT46347.
T46364.
RefSeqiNP_060063.2. NM_017593.3. [Q9NSY1-2]
NP_942595.1. NM_198892.1. [Q9NSY1-1]
UniGeneiHs.146551.

Genome annotation databases

EnsembliENST00000335016; ENSP00000334836; ENSG00000138756. [Q9NSY1-1]
ENST00000502871; ENSP00000421768; ENSG00000138756. [Q9NSY1-2]
GeneIDi55589.
KEGGihsa:55589.
UCSCiuc003hlj.4. human. [Q9NSY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075278 mRNA. Translation: BAC11515.1.
AK292147 mRNA. Translation: BAF84836.1.
AL137275 mRNA. Translation: CAB70673.1.
AL137661 mRNA. Translation: CAB70863.1.
AC098818 Genomic DNA. Translation: AAY40926.1.
BC036021 mRNA. Translation: AAH36021.1.
AF527532 mRNA. Translation: AAM88867.1.
AB015331 mRNA. Translation: BAA34790.1.
CCDSiCCDS34019.1. [Q9NSY1-2]
CCDS47083.1. [Q9NSY1-1]
PIRiT46347.
T46364.
RefSeqiNP_060063.2. NM_017593.3. [Q9NSY1-2]
NP_942595.1. NM_198892.1. [Q9NSY1-1]
UniGeneiHs.146551.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4W9WX-ray1.72A39-344[»]
4W9XX-ray2.14A38-345[»]
5I3OX-ray2.40A/B42-343[»]
5I3RX-ray2.40A/B42-343[»]
5IKWX-ray2.41A38-345[»]
ProteinModelPortaliQ9NSY1.
SMRiQ9NSY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120735. 50 interactors.
IntActiQ9NSY1. 38 interactors.
STRINGi9606.ENSP00000334836.

Chemistry databases

BindingDBiQ9NSY1.
ChEMBLiCHEMBL4522.
GuidetoPHARMACOLOGYi1941.

PTM databases

iPTMnetiQ9NSY1.
PhosphoSitePlusiQ9NSY1.

Polymorphism and mutation databases

BioMutaiBMP2K.
DMDMi34222653.

Proteomic databases

EPDiQ9NSY1.
MaxQBiQ9NSY1.
PaxDbiQ9NSY1.
PeptideAtlasiQ9NSY1.
PRIDEiQ9NSY1.

Protocols and materials databases

DNASUi55589.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335016; ENSP00000334836; ENSG00000138756. [Q9NSY1-1]
ENST00000502871; ENSP00000421768; ENSG00000138756. [Q9NSY1-2]
GeneIDi55589.
KEGGihsa:55589.
UCSCiuc003hlj.4. human. [Q9NSY1-1]

Organism-specific databases

CTDi55589.
DisGeNETi55589.
GeneCardsiBMP2K.
HGNCiHGNC:18041. BMP2K.
HPAiHPA026436.
HPA026451.
HPA026501.
neXtProtiNX_Q9NSY1.
OpenTargetsiENSG00000138756.
PharmGKBiPA134992822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1989. Eukaryota.
ENOG410Y515. LUCA.
GeneTreeiENSGT00810000125451.
HOGENOMiHOG000232173.
HOVERGENiHBG050703.
InParanoidiQ9NSY1.
KOiK08854.
OMAiVPFISHP.
OrthoDBiEOG091G02KI.
PhylomeDBiQ9NSY1.
TreeFamiTF335936.

Enzyme and pathway databases

BioCyciZFISH:HS06548-MONOMER.
SignaLinkiQ9NSY1.

Miscellaneous databases

ChiTaRSiBMP2K. human.
GeneWikiiBMP2K.
GenomeRNAii55589.
PROiQ9NSY1.

Gene expression databases

BgeeiENSG00000138756.
CleanExiHS_BMP2K.
ExpressionAtlasiQ9NSY1. baseline and differential.
GenevisibleiQ9NSY1. HS.

Family and domain databases

InterProiIPR026105. BMP-2-ind_kinase.
IPR028182. BMP2K_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22967:SF10. PTHR22967:SF10. 1 hit.
PfamiPF15282. BMP2K_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMP2K_HUMAN
AccessioniPrimary (citable) accession number: Q9NSY1
Secondary accession number(s): O94791
, Q4W5H2, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.