Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NSY0

- NRBP2_HUMAN

UniProt

Q9NSY0 - NRBP2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nuclear receptor-binding protein 2

Gene

NRBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May regulate apoptosis of neural progenitor cells during their differentiation.By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein kinase activity Source: InterPro

GO - Biological processi

  1. negative regulation of macroautophagy Source: BHF-UCL
  2. negative regulation of neuron apoptotic process Source: UniProtKB
  3. neuron differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

SignaLinkiQ9NSY0.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor-binding protein 2
Alternative name(s):
Transformation-related gene 16 protein
Short name:
TRG-16
Gene namesi
Name:NRBP2Imported
ORF Names:PP9320, TRG16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:19339. NRBP2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891143.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Nuclear receptor-binding protein 2PRO_0000225608Add
BLAST

Proteomic databases

MaxQBiQ9NSY0.
PaxDbiQ9NSY0.
PRIDEiQ9NSY0.

PTM databases

PhosphoSiteiQ9NSY0.

Expressioni

Gene expression databases

BgeeiQ9NSY0.
CleanExiHS_NRBP2.
ExpressionAtlasiQ9NSY0. baseline.
GenevestigatoriQ9NSY0.

Organism-specific databases

HPAiCAB020944.
HPA029052.

Interactioni

Protein-protein interaction databases

BioGridi131044. 1 interaction.
STRINGi9606.ENSP00000330271.

Structurei

3D structure databases

ProteinModelPortaliQ9NSY0.
SMRiQ9NSY0. Positions 35-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 306269Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG282910.
GeneTreeiENSGT00550000074385.
HOGENOMiHOG000267147.
HOVERGENiHBG057400.
InParanoidiQ9NSY0.
KOiK08875.
OMAiKIQTMFE.
PhylomeDBiQ9NSY0.
TreeFamiTF315519.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NSY0-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPEPAPRR ARERERERED ESEDESDILE ESPCGRWQKR REQVNQGNMP
60 70 80 90 100
GLQSTFLAMD TEEGVEVVWN ELHFGDRKAF AAHEEKIQTV FEQLVLVDHP
110 120 130 140 150
NIVKLHKYWL DTSEACARVI FITEYVSSGS LKQFLKKTKK NHKAMNARAW
160 170 180 190 200
KRWCTQILSA LSFLHACSPP IIHGNLTSDT IFIQHNGLIK IGSVWHRIFS
210 220 230 240 250
NALPDDLRSP IRAEREELRN LHFFPPEYGE VADGTAVDIF SFGMCALEMA
260 270 280 290 300
VLEIQTNGDT RVTEEAIARA RHSLSDPNMR EFILCCLARD PARRPSAHSL
310 320 330 340 350
LFHRVLFEVH SLKLLAAHCF IQHQYLMPEN VVEEKTKAMD LHAVLAELPR
360 370 380 390 400
PRRPPLQWRY SEVSFMELDK FLEDVRNGIY PLMNFAATRP LGLPRVLAPP
410 420 430 440 450
PEEVQKAKTP TPEPFDSETR KVIQMQCNLE RSEDKARWHL TLLLVLEDRL
460 470 480 490 500
HRQLTYDLLP TDSAQDLASE LVHYGFLHED DRMKLAAFLE STFLKYRGTQ

A
Length:501
Mass (Da):57,803
Last modified:June 15, 2010 - v2
Checksum:iB3F246DBA7E2AC6C
GO
Isoform 22 Publications (identifier: Q9NSY0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ

Note: No experimental confirmation available.

Show »
Length:293
Mass (Da):33,141
Checksum:iB37F0F45BD8AC99B
GO
Isoform 3 (identifier: Q9NSY0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ
     461-501: TDSAQDLASE...TFLKYRGTQA → SRLGRGLGRR...LPQVPWDPGL

Note: No experimental confirmation available.Curated

Show »
Length:324
Mass (Da):36,072
Checksum:i45EDFCB9AFCB5660
GO
Isoform 4 (identifier: Q9NSY0-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     149-171: AWKRWCTQILSALSFLHACSPPI → VWGAGWGSHGDRTGLGQPRGLGW
     172-501: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:123
Mass (Da):13,910
Checksum:iA24C99DA3D502C1C
GO

Sequence cautioni

The sequence AAI13874.1 differs from that shown. Reason: Probable cloning artifact.Curated
The sequence CAB70864.1 differs from that shown. Reason: Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 3 (identifier: Q9NSY0-4)
Sequence conflicti10 – 101V → A in AAQ18040. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 243243Missing in isoform 2 and isoform 3. 2 PublicationsVSP_039308Add
BLAST
Alternative sequencei1 – 4848Missing in isoform 4. 1 PublicationVSP_039311Add
BLAST
Alternative sequencei149 – 17123AWKRW…CSPPI → VWGAGWGSHGDRTGLGQPRG LGW in isoform 4. 1 PublicationVSP_039312Add
BLAST
Alternative sequencei172 – 501330Missing in isoform 4. 1 PublicationVSP_039313Add
BLAST
Alternative sequencei244 – 28037MCALE…DPNMR → MVLQSQNPAVLKLRGPGPGL AAAAGTPPYGHPCMSCVSLR RDMGNSGATSPRTAGPEQRA LAHHQPLLPVPQ in isoform 2 and isoform 3. 2 PublicationsVSP_039309Add
BLAST
Alternative sequencei461 – 50141TDSAQ…RGTQA → SRLGRGLGRRAVTPGGGWAA ASCLALRHCLSGQRPGPRLG ARALWLPPRGRPDEAGRLPG EHLPQVPWDPGL in isoform 3. 1 PublicationVSP_039310Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY277601 mRNA. Translation: AAQ18040.1.
AK293943 mRNA. Translation: BAG57320.1.
AF318376 mRNA. Translation: AAL55883.1.
AL137662 mRNA. Translation: CAB70864.1. Sequence problems.
AL834530 mRNA. Translation: CAD39186.1.
AC105049 Genomic DNA. No translation available.
BC113873 mRNA. Translation: AAI13874.1. Sequence problems.
CR457350 mRNA. Translation: CAG33631.1.
CCDSiCCDS34959.2. [Q9NSY0-3]
PIRiT46491.
RefSeqiNP_848659.2. NM_178564.3. [Q9NSY0-3]
XP_005250962.1. XM_005250905.2.
UniGeneiHs.521926.

Genome annotation databases

EnsembliENST00000442628; ENSP00000414055; ENSG00000185189. [Q9NSY0-3]
GeneIDi340371.
KEGGihsa:340371.
UCSCiuc003yzw.3. human. [Q9NSY0-2]
uc003yzy.3. human. [Q9NSY0-3]
uc010mfl.3. human. [Q9NSY0-4]

Polymorphism databases

DMDMi298286835.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY277601 mRNA. Translation: AAQ18040.1 .
AK293943 mRNA. Translation: BAG57320.1 .
AF318376 mRNA. Translation: AAL55883.1 .
AL137662 mRNA. Translation: CAB70864.1 . Sequence problems.
AL834530 mRNA. Translation: CAD39186.1 .
AC105049 Genomic DNA. No translation available.
BC113873 mRNA. Translation: AAI13874.1 . Sequence problems.
CR457350 mRNA. Translation: CAG33631.1 .
CCDSi CCDS34959.2. [Q9NSY0-3 ]
PIRi T46491.
RefSeqi NP_848659.2. NM_178564.3. [Q9NSY0-3 ]
XP_005250962.1. XM_005250905.2.
UniGenei Hs.521926.

3D structure databases

ProteinModelPortali Q9NSY0.
SMRi Q9NSY0. Positions 35-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131044. 1 interaction.
STRINGi 9606.ENSP00000330271.

PTM databases

PhosphoSitei Q9NSY0.

Polymorphism databases

DMDMi 298286835.

Proteomic databases

MaxQBi Q9NSY0.
PaxDbi Q9NSY0.
PRIDEi Q9NSY0.

Protocols and materials databases

DNASUi 340371.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000442628 ; ENSP00000414055 ; ENSG00000185189 . [Q9NSY0-3 ]
GeneIDi 340371.
KEGGi hsa:340371.
UCSCi uc003yzw.3. human. [Q9NSY0-2 ]
uc003yzy.3. human. [Q9NSY0-3 ]
uc010mfl.3. human. [Q9NSY0-4 ]

Organism-specific databases

CTDi 340371.
GeneCardsi GC08M144919.
H-InvDB HIX0021894.
HGNCi HGNC:19339. NRBP2.
HPAi CAB020944.
HPA029052.
MIMi 615563. gene.
neXtProti NX_Q9NSY0.
PharmGKBi PA134891143.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282910.
GeneTreei ENSGT00550000074385.
HOGENOMi HOG000267147.
HOVERGENi HBG057400.
InParanoidi Q9NSY0.
KOi K08875.
OMAi KIQTMFE.
PhylomeDBi Q9NSY0.
TreeFami TF315519.

Enzyme and pathway databases

SignaLinki Q9NSY0.

Miscellaneous databases

ChiTaRSi NRBP2. human.
GenomeRNAii 340371.
NextBioi 97840.
PROi Q9NSY0.
SOURCEi Search...

Gene expression databases

Bgeei Q9NSY0.
CleanExi HS_NRBP2.
ExpressionAtlasi Q9NSY0. baseline.
Genevestigatori Q9NSY0.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a human transforming gene."
    Kim J.W.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-501 (ISOFORM 1).
    Tissue: Testis.
  5. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-501 (ISOFORM 1).
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 149-501 (ISOFORM 1).

Entry informationi

Entry nameiNRBP2_HUMAN
AccessioniPrimary (citable) accession number: Q9NSY0
Secondary accession number(s): B4DF59
, Q2HIX8, Q597G7, Q8NCX8, Q8WYS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 15, 2010
Last modified: November 26, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3