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Protein

Nuclear receptor-binding protein 2

Gene

NRBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate apoptosis of neural progenitor cells during their differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurogenesis

Enzyme and pathway databases

SignaLinkiQ9NSY0.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor-binding protein 2
Alternative name(s):
Transformation-related gene 16 protein
Short name:
TRG-16
Gene namesi
Name:NRBP2Imported
ORF Names:PP9320, TRG16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000185189.15.
HGNCiHGNC:19339. NRBP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi340371.
OpenTargetsiENSG00000185189.
PharmGKBiPA134891143.

Polymorphism and mutation databases

BioMutaiNRBP2.
DMDMi298286835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256081 – 501Nuclear receptor-binding protein 2Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei409PhosphothreonineBy similarity1
Modified residuei411PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NSY0.
PaxDbiQ9NSY0.
PeptideAtlasiQ9NSY0.
PRIDEiQ9NSY0.

PTM databases

iPTMnetiQ9NSY0.
PhosphoSitePlusiQ9NSY0.

Expressioni

Gene expression databases

BgeeiENSG00000185189.
CleanExiHS_NRBP2.
ExpressionAtlasiQ9NSY0. baseline and differential.
GenevisibleiQ9NSY0. HS.

Organism-specific databases

HPAiCAB020944.
HPA029051.
HPA029052.

Interactioni

Protein-protein interaction databases

BioGridi131044. 6 interactors.
IntActiQ9NSY0. 4 interactors.
STRINGi9606.ENSP00000414055.

Structurei

3D structure databases

ProteinModelPortaliQ9NSY0.
SMRiQ9NSY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 306Protein kinasePROSITE-ProRule annotationAdd BLAST269

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1266. Eukaryota.
ENOG410XSIC. LUCA.
GeneTreeiENSGT00800000124049.
HOGENOMiHOG000267147.
HOVERGENiHBG057400.
InParanoidiQ9NSY0.
KOiK08875.
OMAiQVEHPNI.
OrthoDBiEOG091G031V.
PhylomeDBiQ9NSY0.
TreeFamiTF315519.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSY0-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPEPAPRR ARERERERED ESEDESDILE ESPCGRWQKR REQVNQGNMP
60 70 80 90 100
GLQSTFLAMD TEEGVEVVWN ELHFGDRKAF AAHEEKIQTV FEQLVLVDHP
110 120 130 140 150
NIVKLHKYWL DTSEACARVI FITEYVSSGS LKQFLKKTKK NHKAMNARAW
160 170 180 190 200
KRWCTQILSA LSFLHACSPP IIHGNLTSDT IFIQHNGLIK IGSVWHRIFS
210 220 230 240 250
NALPDDLRSP IRAEREELRN LHFFPPEYGE VADGTAVDIF SFGMCALEMA
260 270 280 290 300
VLEIQTNGDT RVTEEAIARA RHSLSDPNMR EFILCCLARD PARRPSAHSL
310 320 330 340 350
LFHRVLFEVH SLKLLAAHCF IQHQYLMPEN VVEEKTKAMD LHAVLAELPR
360 370 380 390 400
PRRPPLQWRY SEVSFMELDK FLEDVRNGIY PLMNFAATRP LGLPRVLAPP
410 420 430 440 450
PEEVQKAKTP TPEPFDSETR KVIQMQCNLE RSEDKARWHL TLLLVLEDRL
460 470 480 490 500
HRQLTYDLLP TDSAQDLASE LVHYGFLHED DRMKLAAFLE STFLKYRGTQ

A
Length:501
Mass (Da):57,803
Last modified:June 15, 2010 - v2
Checksum:iB3F246DBA7E2AC6C
GO
Isoform 22 Publications (identifier: Q9NSY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ

Note: No experimental confirmation available.
Show »
Length:293
Mass (Da):33,141
Checksum:iB37F0F45BD8AC99B
GO
Isoform 3 (identifier: Q9NSY0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ
     461-501: TDSAQDLASE...TFLKYRGTQA → SRLGRGLGRR...LPQVPWDPGL

Note: No experimental confirmation available.Curated
Show »
Length:324
Mass (Da):36,072
Checksum:i45EDFCB9AFCB5660
GO
Isoform 4 (identifier: Q9NSY0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     149-171: AWKRWCTQILSALSFLHACSPPI → VWGAGWGSHGDRTGLGQPRGLGW
     172-501: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:123
Mass (Da):13,910
Checksum:iA24C99DA3D502C1C
GO

Sequence cautioni

The sequence AAI13874 differs from that shown. Probable cloning artifact.Curated
The sequence CAB70864 differs from that shown. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q9NSY0-4)
Sequence conflicti10V → A in AAQ18040 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0393081 – 243Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST243
Alternative sequenceiVSP_0393111 – 48Missing in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_039312149 – 171AWKRW…CSPPI → VWGAGWGSHGDRTGLGQPRG LGW in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_039313172 – 501Missing in isoform 4. 1 PublicationAdd BLAST330
Alternative sequenceiVSP_039309244 – 280MCALE…DPNMR → MVLQSQNPAVLKLRGPGPGL AAAAGTPPYGHPCMSCVSLR RDMGNSGATSPRTAGPEQRA LAHHQPLLPVPQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST37
Alternative sequenceiVSP_039310461 – 501TDSAQ…RGTQA → SRLGRGLGRRAVTPGGGWAA ASCLALRHCLSGQRPGPRLG ARALWLPPRGRPDEAGRLPG EHLPQVPWDPGL in isoform 3. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY277601 mRNA. Translation: AAQ18040.1.
AK293943 mRNA. Translation: BAG57320.1.
AF318376 mRNA. Translation: AAL55883.1.
AL137662 mRNA. Translation: CAB70864.1. Sequence problems.
AL834530 mRNA. Translation: CAD39186.1.
AC105049 Genomic DNA. No translation available.
BC113873 mRNA. Translation: AAI13874.1. Sequence problems.
CR457350 mRNA. Translation: CAG33631.1.
CCDSiCCDS34959.2. [Q9NSY0-3]
PIRiT46491.
RefSeqiNP_848659.2. NM_178564.3. [Q9NSY0-3]
UniGeneiHs.521926.

Genome annotation databases

EnsembliENST00000442628; ENSP00000414055; ENSG00000185189. [Q9NSY0-3]
GeneIDi340371.
KEGGihsa:340371.
UCSCiuc011lkt.3. human. [Q9NSY0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNRBP2_HUMAN
AccessioniPrimary (citable) accession number: Q9NSY0
Secondary accession number(s): B4DF59
, Q2HIX8, Q597G7, Q8NCX8, Q8WYS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 15, 2010
Last modified: November 22, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families