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Q9NSY0

- NRBP2_HUMAN

UniProt

Q9NSY0 - NRBP2_HUMAN

Protein

Nuclear receptor-binding protein 2

Gene

NRBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    May regulate apoptosis of neural progenitor cells during their differentiation.By similarity

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. protein kinase activity Source: InterPro

    GO - Biological processi

    1. negative regulation of macroautophagy Source: BHF-UCL
    2. negative regulation of neuron apoptotic process Source: UniProtKB
    3. neuron differentiation Source: UniProtKB

    Keywords - Biological processi

    Neurogenesis

    Enzyme and pathway databases

    SignaLinkiQ9NSY0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor-binding protein 2
    Alternative name(s):
    Transformation-related gene 16 protein
    Short name:
    TRG-16
    Gene namesi
    Name:NRBP2Imported
    ORF Names:PP9320, TRG16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:19339. NRBP2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891143.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Nuclear receptor-binding protein 2PRO_0000225608Add
    BLAST

    Proteomic databases

    MaxQBiQ9NSY0.
    PaxDbiQ9NSY0.
    PRIDEiQ9NSY0.

    PTM databases

    PhosphoSiteiQ9NSY0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NSY0.
    BgeeiQ9NSY0.
    CleanExiHS_NRBP2.
    GenevestigatoriQ9NSY0.

    Organism-specific databases

    HPAiCAB020944.
    HPA029052.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000330271.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSY0.
    SMRiQ9NSY0. Positions 35-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 306269Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG282910.
    HOGENOMiHOG000267147.
    HOVERGENiHBG057400.
    InParanoidiQ9NSY0.
    KOiK08875.
    OMAiKIQTMFE.
    PhylomeDBiQ9NSY0.
    TreeFamiTF315519.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NSY0-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAPEPAPRR ARERERERED ESEDESDILE ESPCGRWQKR REQVNQGNMP    50
    GLQSTFLAMD TEEGVEVVWN ELHFGDRKAF AAHEEKIQTV FEQLVLVDHP 100
    NIVKLHKYWL DTSEACARVI FITEYVSSGS LKQFLKKTKK NHKAMNARAW 150
    KRWCTQILSA LSFLHACSPP IIHGNLTSDT IFIQHNGLIK IGSVWHRIFS 200
    NALPDDLRSP IRAEREELRN LHFFPPEYGE VADGTAVDIF SFGMCALEMA 250
    VLEIQTNGDT RVTEEAIARA RHSLSDPNMR EFILCCLARD PARRPSAHSL 300
    LFHRVLFEVH SLKLLAAHCF IQHQYLMPEN VVEEKTKAMD LHAVLAELPR 350
    PRRPPLQWRY SEVSFMELDK FLEDVRNGIY PLMNFAATRP LGLPRVLAPP 400
    PEEVQKAKTP TPEPFDSETR KVIQMQCNLE RSEDKARWHL TLLLVLEDRL 450
    HRQLTYDLLP TDSAQDLASE LVHYGFLHED DRMKLAAFLE STFLKYRGTQ 500
    A 501
    Length:501
    Mass (Da):57,803
    Last modified:June 15, 2010 - v2
    Checksum:iB3F246DBA7E2AC6C
    GO
    Isoform 22 Publications (identifier: Q9NSY0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-243: Missing.
         244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ

    Note: No experimental confirmation available.

    Show »
    Length:293
    Mass (Da):33,141
    Checksum:iB37F0F45BD8AC99B
    GO
    Isoform 3 (identifier: Q9NSY0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-243: Missing.
         244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ
         461-501: TDSAQDLASE...TFLKYRGTQA → SRLGRGLGRR...LPQVPWDPGL

    Note: No experimental confirmation available.Curated

    Show »
    Length:324
    Mass (Da):36,072
    Checksum:i45EDFCB9AFCB5660
    GO
    Isoform 4 (identifier: Q9NSY0-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-48: Missing.
         149-171: AWKRWCTQILSALSFLHACSPPI → VWGAGWGSHGDRTGLGQPRGLGW
         172-501: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:123
    Mass (Da):13,910
    Checksum:iA24C99DA3D502C1C
    GO

    Sequence cautioni

    The sequence AAI13874.1 differs from that shown. Reason: Probable cloning artifact.
    The sequence CAB70864.1 differs from that shown. Reason: Wrong choice of CDS.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 3 (identifier: Q9NSY0-4)
    Sequence conflicti10 – 101V → A in AAQ18040. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 243243Missing in isoform 2 and isoform 3. 2 PublicationsVSP_039308Add
    BLAST
    Alternative sequencei1 – 4848Missing in isoform 4. 1 PublicationVSP_039311Add
    BLAST
    Alternative sequencei149 – 17123AWKRW…CSPPI → VWGAGWGSHGDRTGLGQPRG LGW in isoform 4. 1 PublicationVSP_039312Add
    BLAST
    Alternative sequencei172 – 501330Missing in isoform 4. 1 PublicationVSP_039313Add
    BLAST
    Alternative sequencei244 – 28037MCALE…DPNMR → MVLQSQNPAVLKLRGPGPGL AAAAGTPPYGHPCMSCVSLR RDMGNSGATSPRTAGPEQRA LAHHQPLLPVPQ in isoform 2 and isoform 3. 2 PublicationsVSP_039309Add
    BLAST
    Alternative sequencei461 – 50141TDSAQ…RGTQA → SRLGRGLGRRAVTPGGGWAA ASCLALRHCLSGQRPGPRLG ARALWLPPRGRPDEAGRLPG EHLPQVPWDPGL in isoform 3. 1 PublicationVSP_039310Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY277601 mRNA. Translation: AAQ18040.1.
    AK293943 mRNA. Translation: BAG57320.1.
    AF318376 mRNA. Translation: AAL55883.1.
    AL137662 mRNA. Translation: CAB70864.1. Sequence problems.
    AL834530 mRNA. Translation: CAD39186.1.
    AC105049 Genomic DNA. No translation available.
    BC113873 mRNA. Translation: AAI13874.1. Sequence problems.
    CR457350 mRNA. Translation: CAG33631.1.
    CCDSiCCDS34959.2. [Q9NSY0-3]
    PIRiT46491.
    RefSeqiNP_848659.2. NM_178564.3. [Q9NSY0-3]
    XP_005250962.1. XM_005250905.2.
    UniGeneiHs.521926.

    Genome annotation databases

    GeneIDi340371.
    KEGGihsa:340371.
    UCSCiuc003yzw.3. human. [Q9NSY0-2]
    uc003yzy.3. human. [Q9NSY0-3]
    uc010mfl.3. human. [Q9NSY0-4]

    Polymorphism databases

    DMDMi298286835.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY277601 mRNA. Translation: AAQ18040.1 .
    AK293943 mRNA. Translation: BAG57320.1 .
    AF318376 mRNA. Translation: AAL55883.1 .
    AL137662 mRNA. Translation: CAB70864.1 . Sequence problems.
    AL834530 mRNA. Translation: CAD39186.1 .
    AC105049 Genomic DNA. No translation available.
    BC113873 mRNA. Translation: AAI13874.1 . Sequence problems.
    CR457350 mRNA. Translation: CAG33631.1 .
    CCDSi CCDS34959.2. [Q9NSY0-3 ]
    PIRi T46491.
    RefSeqi NP_848659.2. NM_178564.3. [Q9NSY0-3 ]
    XP_005250962.1. XM_005250905.2.
    UniGenei Hs.521926.

    3D structure databases

    ProteinModelPortali Q9NSY0.
    SMRi Q9NSY0. Positions 35-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000330271.

    PTM databases

    PhosphoSitei Q9NSY0.

    Polymorphism databases

    DMDMi 298286835.

    Proteomic databases

    MaxQBi Q9NSY0.
    PaxDbi Q9NSY0.
    PRIDEi Q9NSY0.

    Protocols and materials databases

    DNASUi 340371.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 340371.
    KEGGi hsa:340371.
    UCSCi uc003yzw.3. human. [Q9NSY0-2 ]
    uc003yzy.3. human. [Q9NSY0-3 ]
    uc010mfl.3. human. [Q9NSY0-4 ]

    Organism-specific databases

    CTDi 340371.
    GeneCardsi GC08M144917.
    H-InvDB HIX0021894.
    HGNCi HGNC:19339. NRBP2.
    HPAi CAB020944.
    HPA029052.
    MIMi 615563. gene.
    neXtProti NX_Q9NSY0.
    PharmGKBi PA134891143.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282910.
    HOGENOMi HOG000267147.
    HOVERGENi HBG057400.
    InParanoidi Q9NSY0.
    KOi K08875.
    OMAi KIQTMFE.
    PhylomeDBi Q9NSY0.
    TreeFami TF315519.

    Enzyme and pathway databases

    SignaLinki Q9NSY0.

    Miscellaneous databases

    GenomeRNAii 340371.
    NextBioi 97840.
    PROi Q9NSY0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NSY0.
    Bgeei Q9NSY0.
    CleanExi HS_NRBP2.
    Genevestigatori Q9NSY0.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a human transforming gene."
      Kim J.W.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cerebellum.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-501 (ISOFORM 1).
      Tissue: Testis.
    5. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-501 (ISOFORM 1).
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 149-501 (ISOFORM 1).

    Entry informationi

    Entry nameiNRBP2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSY0
    Secondary accession number(s): B4DF59
    , Q2HIX8, Q597G7, Q8NCX8, Q8WYS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3