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Q9NSY0 (NRBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear receptor-binding protein 2
Alternative name(s):
Transformation-related gene 16 protein
Short name=TRG-16
Gene names
Name:NRBP2
ORF Names:PP9320, TRG16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate apoptosis of neural progenitor cells during their differentiation By similarity.

Subcellular location

Cytoplasm By similarity.

Domain

The protein kinase domain is predicted to be catalytically inactive.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAI13874.1 differs from that shown. Reason: Probable cloning artifact.

The sequence CAB70864.1 differs from that shown. Reason: Wrong choice of CDS.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.4 Ref.5 PubMed 11230166 (identifier: Q9NSY0-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 Ref.3 (identifier: Q9NSY0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9NSY0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ
     461-501: TDSAQDLASE...TFLKYRGTQA → SRLGRGLGRR...LPQVPWDPGL
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9NSY0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     149-171: AWKRWCTQILSALSFLHACSPPI → VWGAGWGSHGDRTGLGQPRGLGW
     172-501: Missing.
Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Nuclear receptor-binding protein 2
PRO_0000225608

Regions

Domain38 – 306269Protein kinase

Natural variations

Alternative sequence1 – 243243Missing in isoform 2 and isoform 3.
VSP_039308
Alternative sequence1 – 4848Missing in isoform 4.
VSP_039311
Alternative sequence149 – 17123AWKRW…CSPPI → VWGAGWGSHGDRTGLGQPRG LGW in isoform 4.
VSP_039312
Alternative sequence172 – 501330Missing in isoform 4.
VSP_039313
Alternative sequence244 – 28037MCALE…DPNMR → MVLQSQNPAVLKLRGPGPGL AAAAGTPPYGHPCMSCVSLR RDMGNSGATSPRTAGPEQRA LAHHQPLLPVPQ in isoform 2 and isoform 3.
VSP_039309
Alternative sequence461 – 50141TDSAQ…RGTQA → SRLGRGLGRRAVTPGGGWAA ASCLALRHCLSGQRPGPRLG ARALWLPPRGRPDEAGRLPG EHLPQVPWDPGL in isoform 3.
VSP_039310

Experimental info

Isoform 3:
Sequence conflict101V → A in AAQ18040. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 15, 2010. Version 2.
Checksum: B3F246DBA7E2AC6C

FASTA50157,803
        10         20         30         40         50         60 
MAAPEPAPRR ARERERERED ESEDESDILE ESPCGRWQKR REQVNQGNMP GLQSTFLAMD 

        70         80         90        100        110        120 
TEEGVEVVWN ELHFGDRKAF AAHEEKIQTV FEQLVLVDHP NIVKLHKYWL DTSEACARVI 

       130        140        150        160        170        180 
FITEYVSSGS LKQFLKKTKK NHKAMNARAW KRWCTQILSA LSFLHACSPP IIHGNLTSDT 

       190        200        210        220        230        240 
IFIQHNGLIK IGSVWHRIFS NALPDDLRSP IRAEREELRN LHFFPPEYGE VADGTAVDIF 

       250        260        270        280        290        300 
SFGMCALEMA VLEIQTNGDT RVTEEAIARA RHSLSDPNMR EFILCCLARD PARRPSAHSL 

       310        320        330        340        350        360 
LFHRVLFEVH SLKLLAAHCF IQHQYLMPEN VVEEKTKAMD LHAVLAELPR PRRPPLQWRY 

       370        380        390        400        410        420 
SEVSFMELDK FLEDVRNGIY PLMNFAATRP LGLPRVLAPP PEEVQKAKTP TPEPFDSETR 

       430        440        450        460        470        480 
KVIQMQCNLE RSEDKARWHL TLLLVLEDRL HRQLTYDLLP TDSAQDLASE LVHYGFLHED 

       490        500 
DRMKLAAFLE STFLKYRGTQ A 

« Hide

Isoform 2 [UniParc].

Checksum: B37F0F45BD8AC99B
Show »

FASTA29333,141
Isoform 3 [UniParc].

Checksum: 45EDFCB9AFCB5660
Show »

FASTA32436,072
Isoform 4 [UniParc].

Checksum: A24C99DA3D502C1C
Show »

FASTA12313,910

References

[1]"Identification of a human transforming gene."
Kim J.W.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Cerebellum.
[3]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-501 (ISOFORM 1).
Tissue: Testis.
[5]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-501 (ISOFORM 1).
[7]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 149-501 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY277601 mRNA. Translation: AAQ18040.1.
AK293943 mRNA. Translation: BAG57320.1.
AF318376 mRNA. Translation: AAL55883.1.
AL137662 mRNA. Translation: CAB70864.1. Sequence problems.
AL834530 mRNA. Translation: CAD39186.1.
AC105049 Genomic DNA. No translation available.
BC113873 mRNA. Translation: AAI13874.1. Sequence problems.
CR457350 mRNA. Translation: CAG33631.1.
PIRT46491.
RefSeqNP_848659.2. NM_178564.3.
XP_005250962.1. XM_005250905.2.
UniGeneHs.521926.

3D structure databases

ProteinModelPortalQ9NSY0.
SMRQ9NSY0. Positions 35-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000330271.

PTM databases

PhosphoSiteQ9NSY0.

Polymorphism databases

DMDM298286835.

Proteomic databases

PaxDbQ9NSY0.
PRIDEQ9NSY0.

Protocols and materials databases

DNASU340371.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000442628; ENSP00000414055; ENSG00000185189. [Q9NSY0-3]
ENST00000568732; ENSP00000457135; ENSG00000260533. [Q9NSY0-3]
GeneID340371.
KEGGhsa:340371.
UCSCuc003yzw.3. human. [Q9NSY0-2]
uc003yzy.3. human. [Q9NSY0-3]
uc010mfl.3. human. [Q9NSY0-4]

Organism-specific databases

CTD340371.
GeneCardsGC08M144917.
H-InvDBHIX0021894.
HGNCHGNC:19339. NRBP2.
HPACAB020944.
HPA029052.
MIM615563. gene.
neXtProtNX_Q9NSY0.
PharmGKBPA134891143.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282910.
HOGENOMHOG000267147.
HOVERGENHBG057400.
InParanoidQ9NSY0.
KOK08875.
OMAKIQTMFE.
PhylomeDBQ9NSY0.
TreeFamTF315519.

Enzyme and pathway databases

SignaLinkQ9NSY0.

Gene expression databases

ArrayExpressQ9NSY0.
BgeeQ9NSY0.
CleanExHS_NRBP2.
GenevestigatorQ9NSY0.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi340371.
NextBio97840.
PROQ9NSY0.
SOURCESearch...

Entry information

Entry nameNRBP2_HUMAN
AccessionPrimary (citable) accession number: Q9NSY0
Secondary accession number(s): B4DF59 expand/collapse secondary AC list , Q2HIX8, Q597G7, Q8NCX8, Q8WYS5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM