Q9NST1 (PLPL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Patatin-like phospholipase domain-containing protein 3
EC=3.1.1.3

Alternative name(s):
Acylglycerol O-acyltransferase
EC=2.3.1.-
Adiponutrin
Calcium-independent phospholipase A2-epsilon
Short name=iPLA2-epsilon

Gene names

Name:	PNPLA3
Synonyms:	ADPN, C22orf20

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Ref.7
Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Pathway	Glycerolipid metabolism; triacylglycerol degradation.
Subcellular location	Membrane; Single-pass type II membrane protein Ref.7.
Induction	By changes in energy balance: down-regulated following very low-calorie diet, whereas refeeding elevates the mRNA level. Ref.8
Polymorphism	Polymorphic variation at position 148 influences insulin secretion levels and obesity. In obese subjects the body mass index and waist are higher in carriers of the Ile-148 allele. The Ile-148 carriers also display decreased insulin secretion in response to oral glucose tolerance test. Met-148 allele carriers are seemingly more insulin resistant at a lower body mass index.
Involvement in disease	Non-alcoholic fatty liver disease 1 (NAFLD1) [MIM:613282]: A condition characterized by accumulation of triglycerides in the liver. It is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.10 Ref.11 Ref.13
Sequence similarities	Contains 1 patatin domain.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Obesity
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Acyltransferase Hydrolase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acylglycerol acyl-chain remodeling Traceable author statement. Source: Reactome glycerophospholipid biosynthetic process Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome triglyceride biosynthetic process Inferred from direct assay Ref.7. Source: UniProtKB triglyceride catabolic process Inferred from direct assay Ref.7. Source: UniProtKB
Cellular_component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	diolein transacylation activity Inferred from direct assay Ref.7. Source: UniProtKB mono-olein transacylation activity Inferred from direct assay Ref.7. Source: UniProtKB phospholipase A2 activity Inferred from direct assay Ref.7. Source: UniProtKB retinyl-palmitate esterase activity Inferred from electronic annotation. Source: EC triglyceride lipase activity Inferred from direct assay Ref.7. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NST1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NST1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     59-62: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	Patatin-like phospholipase domain-containing protein 3		PRO_0000064458
Regions
	Topological domain	1 – 41	41	Cytoplasmic Potential
	Transmembrane	42 – 62	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	63 – 481	419	Lumenal Potential
	Domain	10 – 179	170	Patatin
	Motif	45 – 49	5	GXSXG
Sites
	Active site	47	1	By similarity
Amino acid modifications
	Glycosylation	89	1	N-linked (GlcNAc...) Potential
	Glycosylation	280	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	59 – 62	4	Missing in isoform 2.		VSP_036222
	Natural variant	99	1	C → G. Ref.6 Corresponds to variant rs2076213 [ dbSNP | Ensembl ].		VAR_015845
	Natural variant	115	1	G → C. Ref.3 Corresponds to variant rs2076212 [ dbSNP | Ensembl ].		VAR_015846
	Natural variant	148	1	I → M Common polymorphism; fails to hydrolyze emulsified triglycerides; associated with increased hepatic fat content and serum aspartate aminotransferase concentrations. Ref.3 Ref.6 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Corresponds to variant rs738409 [ dbSNP | Ensembl ].		VAR_019961
	Natural variant	216	1	T → P. Corresponds to variant rs35726887 [ dbSNP | Ensembl ].		VAR_053814
	Natural variant	434	1	K → E. Ref.2 Ref.3 Ref.5 Ref.6 Corresponds to variant rs2294918 [ dbSNP | Ensembl ].		VAR_015847
	Natural variant	453	1	S → I Common polymorphism; associated with lower hepatic fat content in African Americans. Ref.10 Corresponds to variant rs6006460 [ dbSNP | Ensembl ].		VAR_053815

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 2. Checksum: 1ED0341B5AF5B6CB	FASTA	481	52,865
	10 20 30 40 50 60 MYDAERGWSL SFAGCGFLGF YHVGATRCLS EHAPHLLRDA RMLFGASAGA LHCVGVLSGI 70 80 90 100 110 120 PLEQTLQVLS DLVRKARSRN IGIFHPSFNL SKFLRQGLCK CLPANVHQLI SGKIGISLTR 130 140 150 160 170 180 VSDGENVLVS DFRSKDEVVD ALVCSCFIPF YSGLIPPSFR GVRYVDGGVS DNVPFIDAKT 190 200 210 220 230 240 TITVSPFYGE YDICPKVKST NFLHVDITKL SLRLCTGNLY LLSRAFVPPD LKVLGEICLR 250 260 270 280 290 300 GYLDAFRFLE EKGICNRPQP GLKSSSEGMD PEVAMPSWAN MSLDSSPESA ALAVRLEGDE 310 320 330 340 350 360 LLDHLRLSIL PWDESILDTL SPRLATALSE EMKDKGGYMS KICNLLPIRI MSYVMLPCTL 370 380 390 400 410 420 PVESAIAIVQ RLVTWLPDMP DDVLWLQWVT SQVFTRVLMC LLPASRSQMP VSSQQASPCT 430 440 450 460 470 480 PEQDWPCWTP CSPKGCPAET KAEATPRSIL RSSLNFFLGN KVPAGAEGLS TFPSFSLEKS L
	Isoform 2 [UniParc]. Checksum: 1E9811016FDC88C1	FASTA	477	52,485
	10 20 30 40 50 60 MYDAERGWSL SFAGCGFLGF YHVGATRCLS EHAPHLLRDA RMLFGASAGA LHCVGVLSEQ 70 80 90 100 110 120 TLQVLSDLVR KARSRNIGIF HPSFNLSKFL RQGLCKCLPA NVHQLISGKI GISLTRVSDG 130 140 150 160 170 180 ENVLVSDFRS KDEVVDALVC SCFIPFYSGL IPPSFRGVRY VDGGVSDNVP FIDAKTTITV 190 200 210 220 230 240 SPFYGEYDIC PKVKSTNFLH VDITKLSLRL CTGNLYLLSR AFVPPDLKVL GEICLRGYLD 250 260 270 280 290 300 AFRFLEEKGI CNRPQPGLKS SSEGMDPEVA MPSWANMSLD SSPESAALAV RLEGDELLDH 310 320 330 340 350 360 LRLSILPWDE SILDTLSPRL ATALSEEMKD KGGYMSKICN LLPIRIMSYV MLPCTLPVES 370 380 390 400 410 420 AIAIVQRLVT WLPDMPDDVL WLQWVTSQVF TRVLMCLLPA SRSQMPVSSQ QASPCTPEQD 430 440 450 460 470 WPCWTPCSPK GCPAETKAEA TPRSILRSSL NFFLGNKVPA GAEGLSTFPS FSLEKSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Reevaluating human gene annotation: a second-generation analysis of chromosome 22." Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I. Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-434.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS CYS-115; MET-148 AND GLU-434. Tissue: Brain and Teratocarcinoma.
[4]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-434.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-99; MET-148 AND GLU-434. Tissue: Brain and Skin.
[7]	"Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities." Jenkins C.M., Mancuso D.J., Yan W., Sims H.F., Gibson B., Gross R.W. J. Biol. Chem. 279:48968-48975(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]	"Adiponutrin: A new gene regulated by energy balance in human adipose tissue." Liu Y.-M., Moldes M., Bastard J.-P., Bruckert E., Viguerie N., Hainque B., Basdevant A., Langin D., Pairault J., Clement K. J. Clin. Endocrinol. Metab. 89:2684-2689(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[9]	"Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity." Johansson L.E., Lindblad U., Larsson C.A., Raastam L., Ridderstraale M. Eur. J. Endocrinol. 159:577-583(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MET-148, POLYMORPHISM.
[10]	"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease." Romeo S., Kozlitina J., Xing C., Pertsemlidis A., Cox D., Pennacchio L.A., Boerwinkle E., Cohen J.C., Hobbs H.H. Nat. Genet. 40:1461-1465(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MET-148 AND ILE-453, INVOLVEMENT IN SUSCEPTIBILITY TO NAFLD1.
[11]	"A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans." Kotronen A., Johansson L.E., Johansson L.M., Roos C., Westerbacka J., Hamsten A., Bergholm R., Arkkila P., Arola J., Kiviluoto T., Fisher R.M., Ehrenborg E., Orho-Melander M., Ridderstrale M., Groop L., Yki-Jarvinen H. Diabetologia 52:1056-1060(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MET-148, INVOLVEMENT IN SUSCEPTIBILITY TO NAFLD1.
[12]	"A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis." He S., McPhaul C., Li J.Z., Garuti R., Kinch L., Grishin N.V., Cohen J.C., Hobbs H.H. J. Biol. Chem. 285:6706-6715(2010) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF VARIANT MET-148.
[13]	"A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity." Sookoian S., Castano G.O., Burgueno A.L., Gianotti T.F., Rosselli M.S., Pirola C.J. J. Lipid Res. 50:2111-2116(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MET-148, INVOLVEMENT IN SUSCEPTIBILITY TO NAFLD1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL138578 mRNA. Translation: CAB71238.2. CR456476 mRNA. Translation: CAG30362.1. AK123806 mRNA. Translation: BAG53962.1. AK315166 mRNA. Translation: BAG37610.1. AL023654, AL035398 Genomic DNA. Translation: CAI21791.1. AL035398, AL023654 Genomic DNA. Translation: CAI22840.1. AL023654, AL035398 Genomic DNA. Translation: CAQ07959.1. AL035398, AL023654 Genomic DNA. Translation: CAQ09484.1. CH471138 Genomic DNA. Translation: EAW73324.1. BC014449 mRNA. Translation: AAH14449.2. BC065195 mRNA. Translation: AAH65195.1.
IPI	IPI00019245. IPI00878819.
RefSeq	NP_079501.2. NM_025225.2.
UniGene	Hs.654800.
3D structure databases
ProteinModelPortal	Q9NST1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NST1. 2 interactions.
STRING	9606.ENSP00000216180.
PTM databases
PhosphoSite	Q9NST1.
Polymorphism databases
DMDM	32469599.
Proteomic databases
PaxDb	Q9NST1.
PRIDE	Q9NST1.
Protocols and materials databases
DNASU	80339.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216180; ENSP00000216180; ENSG00000100344. ENST00000423180; ENSP00000397987; ENSG00000100344.
GeneID	80339.
KEGG	hsa:80339.
UCSC	uc003bei.1. human.
Organism-specific databases
CTD	80339.
GeneCards	GC22P044319.
H-InvDB	HIX0159175.
HGNC	HGNC:18590. PNPLA3.
MIM	609567. gene. 613282. phenotype.
neXtProt	NX_Q9NST1.
Orphanet	33271. Non-alcoholic steatohepatitis.
PharmGKB	PA38592.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG261571.
HOGENOM	HOG000007467.
HOVERGEN	HBG007046.
InParanoid	Q9NST1.
KO	K13534.
OMA	EEKGICN.
OrthoDB	EOG4T7839.
PhylomeDB	Q9NST1.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
UniPathway	UPA00256.
Gene expression databases
ArrayExpress	Q9NST1.
Bgee	Q9NST1.
CleanEx	HS_PNPLA3.
Genevestigator	Q9NST1.
GermOnline	ENSG00000100344. Homo sapiens.
Family and domain databases
InterPro	IPR016035. Acyl_Trfase/lysoPLipase. IPR002641. Patatin/PLipase_A2-rel. [Graphical view]
Pfam	PF01734. Patatin. 1 hit. [Graphical view]
SUPFAM	SSF52151. Acyl_Trfase/lysoPlipase. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	80339.
NextBio	70910.
SOURCE	Search...

Entry information

Entry name

PLPL3_HUMAN

Accession

Primary (citable) accession number: Q9NST1
Secondary accession number(s): B0QYI0 , B2RCL3, B3KW00, Q6P1A1, Q96CB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.