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Protein

Centromere protein M

Gene

CENPM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-HSA-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein M
Short name:
CENP-M
Alternative name(s):
Interphase centromere complex protein 39
Proliferation-associated nuclear element protein 1
Gene namesi
Name:CENPM
Synonyms:C22orf18, ICEN39, PANE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18352. CENPM.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100162.
PharmGKBiPA25885.

Polymorphism and mutation databases

BioMutaiCENPM.
DMDMi47117330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582241 – 180Centromere protein MAdd BLAST180

Proteomic databases

EPDiQ9NSP4.
MaxQBiQ9NSP4.
PaxDbiQ9NSP4.
PeptideAtlasiQ9NSP4.
PRIDEiQ9NSP4.

PTM databases

iPTMnetiQ9NSP4.
PhosphoSitePlusiQ9NSP4.

Expressioni

Tissue specificityi

Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.

Gene expression databases

BgeeiENSG00000100162.
CleanExiHS_CENPM.
ExpressionAtlasiQ9NSP4. baseline and differential.
GenevisibleiQ9NSP4. HS.

Organism-specific databases

HPAiHPA042404.
HPA056500.

Interactioni

Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.1 Publication

Protein-protein interaction databases

BioGridi122488. 18 interactors.
IntActiQ9NSP4. 5 interactors.
STRINGi9606.ENSP00000215980.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi16 – 21Combined sources6
Helixi25 – 36Combined sources12
Beta strandi44 – 53Combined sources10
Beta strandi65 – 71Combined sources7
Helixi75 – 85Combined sources11
Helixi90 – 93Combined sources4
Beta strandi97 – 103Combined sources7
Helixi111 – 123Combined sources13
Beta strandi128 – 130Combined sources3
Helixi136 – 153Combined sources18
Helixi162 – 165Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P0TX-ray1.49A/B1-171[»]
4WAUX-ray2.20A/B1-171[»]
ProteinModelPortaliQ9NSP4.
SMRiQ9NSP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ5U. Eukaryota.
ENOG4111PTI. LUCA.
GeneTreeiENSGT00390000017504.
HOGENOMiHOG000048739.
HOVERGENiHBG081086.
InParanoidiQ9NSP4.
KOiK11505.
OMAiMLQICAG.
OrthoDBiEOG091G0PZ0.
PhylomeDBiQ9NSP4.
TreeFamiTF328778.

Family and domain databases

InterProiView protein in InterPro
IPR020987. Centromere_Cenp-M.
PfamiView protein in Pfam
PF11111. CENP-M. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSP4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVLRPLDKL PGLNTATILL VGTEDALLQQ LADSMLKEDC ASELKVHLAK
60 70 80 90 100
SLPLPSSVNR PRIDLIVFVV NLHSKYSLQN TEESLRHVDA SFFLGKVCFL
110 120 130 140 150
ATGAGRESHC SIHRHTVVKL AHTYQSPLLY CDLEVEGFRA TMAQRLVRVL
160 170 180
QICAGHVPGV SALNLLSLLR SSEGPSLEDL
Length:180
Mass (Da):19,737
Last modified:October 1, 2000 - v1
Checksum:i37DB044092BF63F4
GO
Isoform 2 (identifier: Q9NSP4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-132: AGRESHCSIHRHTVVKLAHTYQSPLLYCD → GKYVPRLLLPTPSQGKAGAAVGFLLRHPG
     133-180: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:132
Mass (Da):14,287
Checksum:i3A8E77D553024B38
GO
Isoform 3 (identifier: Q9NSP4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     123-134: TYQSPLLYCDLE → MGRVWDLPGVLK

Show »
Length:58
Mass (Da):6,257
Checksum:iD5B353502075D069
GO
Isoform 4 (identifier: Q9NSP4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-179: AGRESHCSIH...RSSEGPSLED → GGR

Note: No experimental confirmation available.
Show »
Length:107
Mass (Da):11,687
Checksum:i4FBAB92E26A66A1F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0177261 – 122Missing in isoform 3. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_046189104 – 179AGRES…PSLED → GGR in isoform 4. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_010259104 – 132AGRES…LLYCD → GKYVPRLLLPTPSQGKAGAA VGFLLRHPG in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_017725123 – 134TYQSP…YCDLE → MGRVWDLPGVLK in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_010260133 – 180Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU035297 mRNA. Translation: ABS84666.1.
AL160131 mRNA. Translation: CAB77147.1.
AK123479 mRNA. Translation: BAC85624.1.
CR456399 mRNA. Translation: CAG30285.1.
CR457392 mRNA. Translation: CAG33673.1.
Z99716 Genomic DNA. Translation: CAI41691.1.
BC000705 mRNA. Translation: AAH00705.1.
BC007495 mRNA. Translation: AAH07495.1.
BU194618 mRNA. No translation available.
CCDSiCCDS14025.1. [Q9NSP4-1]
CCDS46719.1. [Q9NSP4-3]
CCDS46720.1. [Q9NSP4-4]
RefSeqiNP_001002876.1. NM_001002876.2. [Q9NSP4-4]
NP_001103685.1. NM_001110215.2. [Q9NSP4-3]
NP_001291299.1. NM_001304370.1.
NP_001291300.1. NM_001304371.1. [Q9NSP4-2]
NP_001291301.1. NM_001304372.1.
NP_001291302.1. NM_001304373.1.
NP_076958.1. NM_024053.4. [Q9NSP4-1]
UniGeneiHs.208912.

Genome annotation databases

EnsembliENST00000215980; ENSP00000215980; ENSG00000100162. [Q9NSP4-1]
ENST00000407253; ENSP00000384743; ENSG00000100162. [Q9NSP4-4]
ENST00000472374; ENSP00000430624; ENSG00000100162. [Q9NSP4-3]
GeneIDi79019.
KEGGihsa:79019.
UCSCiuc003bbn.4. human. [Q9NSP4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCENPM_HUMAN
AccessioniPrimary (citable) accession number: Q9NSP4
Secondary accession number(s): A7LM22, B1AHQ9, Q6I9W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references