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Q9NSP4

- CENPM_HUMAN

UniProt

Q9NSP4 - CENPM_HUMAN

Protein

Centromere protein M

Gene

CENPM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.1 Publication

    GO - Biological processi

    1. mitotic cell cycle Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_682. Mitotic Prometaphase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein M
    Short name:
    CENP-M
    Alternative name(s):
    Interphase centromere complex protein 39
    Proliferation-associated nuclear element protein 1
    Gene namesi
    Name:CENPM
    Synonyms:C22orf18, ICEN39, PANE1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:18352. CENPM.

    Subcellular locationi

    Nucleus. Cytoplasm. Chromosomecentromerekinetochore
    Note: Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells By similarity. Localizes in the kinetochore domain of centromeres.By similarity

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytosol Source: Reactome
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25885.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180Centromere protein MPRO_0000058224Add
    BLAST

    Proteomic databases

    MaxQBiQ9NSP4.
    PaxDbiQ9NSP4.
    PRIDEiQ9NSP4.

    Expressioni

    Tissue specificityi

    Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.

    Gene expression databases

    ArrayExpressiQ9NSP4.
    BgeeiQ9NSP4.
    CleanExiHS_CENPM.
    GenevestigatoriQ9NSP4.

    Organism-specific databases

    HPAiCAB006330.
    HPA042404.

    Interactioni

    Subunit structurei

    Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.1 Publication

    Protein-protein interaction databases

    BioGridi122488. 12 interactions.
    STRINGi9606.ENSP00000215980.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSP4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG25434.
    HOGENOMiHOG000261677.
    HOVERGENiHBG081086.
    InParanoidiQ9NSP4.
    KOiK11505.
    OMAiESHCSVH.
    OrthoDBiEOG7R8333.
    PhylomeDBiQ9NSP4.
    TreeFamiTF328778.

    Family and domain databases

    InterProiIPR020987. Centromere_Cenp-M.
    [Graphical view]
    PfamiPF11111. CENP-M. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NSP4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVLRPLDKL PGLNTATILL VGTEDALLQQ LADSMLKEDC ASELKVHLAK    50
    SLPLPSSVNR PRIDLIVFVV NLHSKYSLQN TEESLRHVDA SFFLGKVCFL 100
    ATGAGRESHC SIHRHTVVKL AHTYQSPLLY CDLEVEGFRA TMAQRLVRVL 150
    QICAGHVPGV SALNLLSLLR SSEGPSLEDL 180
    Length:180
    Mass (Da):19,737
    Last modified:October 1, 2000 - v1
    Checksum:i37DB044092BF63F4
    GO
    Isoform 2 (identifier: Q9NSP4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         104-132: AGRESHCSIHRHTVVKLAHTYQSPLLYCD → GKYVPRLLLPTPSQGKAGAAVGFLLRHPG
         133-180: Missing.

    Note: Due to intron retention. No experimental confirmation available.

    Show »
    Length:132
    Mass (Da):14,287
    Checksum:i3A8E77D553024B38
    GO
    Isoform 3 (identifier: Q9NSP4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-122: Missing.
         123-134: TYQSPLLYCDLE → MGRVWDLPGVLK

    Show »
    Length:58
    Mass (Da):6,257
    Checksum:iD5B353502075D069
    GO
    Isoform 4 (identifier: Q9NSP4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         104-179: AGRESHCSIH...RSSEGPSLED → GGR

    Note: No experimental confirmation available.

    Show »
    Length:107
    Mass (Da):11,687
    Checksum:i4FBAB92E26A66A1F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 122122Missing in isoform 3. 1 PublicationVSP_017726Add
    BLAST
    Alternative sequencei104 – 17976AGRES…PSLED → GGR in isoform 4. 1 PublicationVSP_046189Add
    BLAST
    Alternative sequencei104 – 13229AGRES…LLYCD → GKYVPRLLLPTPSQGKAGAA VGFLLRHPG in isoform 2. 1 PublicationVSP_010259Add
    BLAST
    Alternative sequencei123 – 13412TYQSP…YCDLE → MGRVWDLPGVLK in isoform 3. 1 PublicationVSP_017725Add
    BLAST
    Alternative sequencei133 – 18048Missing in isoform 2. 1 PublicationVSP_010260Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU035297 mRNA. Translation: ABS84666.1.
    AL160131 mRNA. Translation: CAB77147.1.
    AK123479 mRNA. Translation: BAC85624.1.
    CR456399 mRNA. Translation: CAG30285.1.
    CR457392 mRNA. Translation: CAG33673.1.
    Z99716 Genomic DNA. Translation: CAI41691.1.
    BC000705 mRNA. Translation: AAH00705.1.
    BC007495 mRNA. Translation: AAH07495.1.
    BU194618 mRNA. No translation available.
    CCDSiCCDS14025.1. [Q9NSP4-1]
    CCDS46719.1. [Q9NSP4-3]
    CCDS46720.1. [Q9NSP4-4]
    RefSeqiNP_001002876.1. NM_001002876.1. [Q9NSP4-4]
    NP_001103685.1. NM_001110215.1. [Q9NSP4-3]
    NP_076958.1. NM_024053.3. [Q9NSP4-1]
    UniGeneiHs.208912.

    Genome annotation databases

    EnsembliENST00000215980; ENSP00000215980; ENSG00000100162. [Q9NSP4-1]
    ENST00000407253; ENSP00000384743; ENSG00000100162. [Q9NSP4-4]
    ENST00000472374; ENSP00000430624; ENSG00000100162. [Q9NSP4-3]
    GeneIDi79019.
    KEGGihsa:79019.
    UCSCiuc003bbn.3. human. [Q9NSP4-1]
    uc003bbp.1. human. [Q9NSP4-2]
    uc010gyq.3. human. [Q9NSP4-3]

    Polymorphism databases

    DMDMi47117330.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU035297 mRNA. Translation: ABS84666.1 .
    AL160131 mRNA. Translation: CAB77147.1 .
    AK123479 mRNA. Translation: BAC85624.1 .
    CR456399 mRNA. Translation: CAG30285.1 .
    CR457392 mRNA. Translation: CAG33673.1 .
    Z99716 Genomic DNA. Translation: CAI41691.1 .
    BC000705 mRNA. Translation: AAH00705.1 .
    BC007495 mRNA. Translation: AAH07495.1 .
    BU194618 mRNA. No translation available.
    CCDSi CCDS14025.1. [Q9NSP4-1 ]
    CCDS46719.1. [Q9NSP4-3 ]
    CCDS46720.1. [Q9NSP4-4 ]
    RefSeqi NP_001002876.1. NM_001002876.1. [Q9NSP4-4 ]
    NP_001103685.1. NM_001110215.1. [Q9NSP4-3 ]
    NP_076958.1. NM_024053.3. [Q9NSP4-1 ]
    UniGenei Hs.208912.

    3D structure databases

    ProteinModelPortali Q9NSP4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122488. 12 interactions.
    STRINGi 9606.ENSP00000215980.

    Polymorphism databases

    DMDMi 47117330.

    Proteomic databases

    MaxQBi Q9NSP4.
    PaxDbi Q9NSP4.
    PRIDEi Q9NSP4.

    Protocols and materials databases

    DNASUi 79019.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000215980 ; ENSP00000215980 ; ENSG00000100162 . [Q9NSP4-1 ]
    ENST00000407253 ; ENSP00000384743 ; ENSG00000100162 . [Q9NSP4-4 ]
    ENST00000472374 ; ENSP00000430624 ; ENSG00000100162 . [Q9NSP4-3 ]
    GeneIDi 79019.
    KEGGi hsa:79019.
    UCSCi uc003bbn.3. human. [Q9NSP4-1 ]
    uc003bbp.1. human. [Q9NSP4-2 ]
    uc010gyq.3. human. [Q9NSP4-3 ]

    Organism-specific databases

    CTDi 79019.
    GeneCardsi GC22M042334.
    HGNCi HGNC:18352. CENPM.
    HPAi CAB006330.
    HPA042404.
    MIMi 610152. gene.
    neXtProti NX_Q9NSP4.
    PharmGKBi PA25885.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25434.
    HOGENOMi HOG000261677.
    HOVERGENi HBG081086.
    InParanoidi Q9NSP4.
    KOi K11505.
    OMAi ESHCSVH.
    OrthoDBi EOG7R8333.
    PhylomeDBi Q9NSP4.
    TreeFami TF328778.

    Enzyme and pathway databases

    Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_682. Mitotic Prometaphase.

    Miscellaneous databases

    GeneWikii CENPM.
    GenomeRNAii 79019.
    NextBioi 67686.
    PROi Q9NSP4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NSP4.
    Bgeei Q9NSP4.
    CleanExi HS_CENPM.
    Genevestigatori Q9NSP4.

    Family and domain databases

    InterProi IPR020987. Centromere_Cenp-M.
    [Graphical view ]
    Pfami PF11111. CENP-M. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL."
      Brickner A.G., Evans A.M., Mito J.K., Xuereb S.M., Feng X., Nishida T., Fairfull L., Ferrell R.E., Foon K.A., Hunt D.F., Shabanowitz J., Engelhard V.H., Riddell S.R., Warren E.H.
      Blood 107:3779-3786(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY.
    2. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
      Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
      Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thalamus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Cervix, Lymph and Melanoma.
    8. "The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells."
      Bierie B., Edwin M., Melenhorst J.J., Hennighausen L.
      Gene Expr. Patterns 4:389-395(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
      Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K.
      Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    10. Cited for: IDENTIFICATION IN THE CENPA-NAC COMPLEX WITH CENPA; CENPC; CENPH; CENPN; CENPT AND CENPU.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCENPM_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSP4
    Secondary accession number(s): A7LM22, B1AHQ9, Q6I9W3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3