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Q9NSP4

- CENPM_HUMAN

UniProt

Q9NSP4 - CENPM_HUMAN

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Protein

Centromere protein M

Gene
CENPM, C22orf18, ICEN39, PANE1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.1 Publication

GO - Biological processi

  1. mitotic cell cycle Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_682. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein M
Short name:
CENP-M
Alternative name(s):
Interphase centromere complex protein 39
Proliferation-associated nuclear element protein 1
Gene namesi
Name:CENPM
Synonyms:C22orf18, ICEN39, PANE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:18352. CENPM.

Subcellular locationi

Nucleus. Cytoplasm. Chromosomecentromerekinetochore
Note: Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells By similarity. Localizes in the kinetochore domain of centromeres.2 Publications

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Centromere protein MPRO_0000058224Add
BLAST

Proteomic databases

MaxQBiQ9NSP4.
PaxDbiQ9NSP4.
PRIDEiQ9NSP4.

Expressioni

Tissue specificityi

Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.

Gene expression databases

ArrayExpressiQ9NSP4.
BgeeiQ9NSP4.
CleanExiHS_CENPM.
GenevestigatoriQ9NSP4.

Organism-specific databases

HPAiCAB006330.
HPA042404.

Interactioni

Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.1 Publication

Protein-protein interaction databases

BioGridi122488. 12 interactions.
STRINGi9606.ENSP00000215980.

Structurei

3D structure databases

ProteinModelPortaliQ9NSP4.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG25434.
HOGENOMiHOG000261677.
HOVERGENiHBG081086.
InParanoidiQ9NSP4.
KOiK11505.
OMAiESHCSVH.
OrthoDBiEOG7R8333.
PhylomeDBiQ9NSP4.
TreeFamiTF328778.

Family and domain databases

InterProiIPR020987. Centromere_Cenp-M.
[Graphical view]
PfamiPF11111. CENP-M. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NSP4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSVLRPLDKL PGLNTATILL VGTEDALLQQ LADSMLKEDC ASELKVHLAK    50
SLPLPSSVNR PRIDLIVFVV NLHSKYSLQN TEESLRHVDA SFFLGKVCFL 100
ATGAGRESHC SIHRHTVVKL AHTYQSPLLY CDLEVEGFRA TMAQRLVRVL 150
QICAGHVPGV SALNLLSLLR SSEGPSLEDL 180
Length:180
Mass (Da):19,737
Last modified:October 1, 2000 - v1
Checksum:i37DB044092BF63F4
GO
Isoform 2 (identifier: Q9NSP4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-132: AGRESHCSIHRHTVVKLAHTYQSPLLYCD → GKYVPRLLLPTPSQGKAGAAVGFLLRHPG
     133-180: Missing.

Note: Due to intron retention. No experimental confirmation available.

Show »
Length:132
Mass (Da):14,287
Checksum:i3A8E77D553024B38
GO
Isoform 3 (identifier: Q9NSP4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     123-134: TYQSPLLYCDLE → MGRVWDLPGVLK

Show »
Length:58
Mass (Da):6,257
Checksum:iD5B353502075D069
GO
Isoform 4 (identifier: Q9NSP4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-179: AGRESHCSIH...RSSEGPSLED → GGR

Note: No experimental confirmation available.

Show »
Length:107
Mass (Da):11,687
Checksum:i4FBAB92E26A66A1F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 122122Missing in isoform 3. VSP_017726Add
BLAST
Alternative sequencei104 – 17976AGRES…PSLED → GGR in isoform 4. VSP_046189Add
BLAST
Alternative sequencei104 – 13229AGRES…LLYCD → GKYVPRLLLPTPSQGKAGAA VGFLLRHPG in isoform 2. VSP_010259Add
BLAST
Alternative sequencei123 – 13412TYQSP…YCDLE → MGRVWDLPGVLK in isoform 3. VSP_017725Add
BLAST
Alternative sequencei133 – 18048Missing in isoform 2. VSP_010260Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU035297 mRNA. Translation: ABS84666.1.
AL160131 mRNA. Translation: CAB77147.1.
AK123479 mRNA. Translation: BAC85624.1.
CR456399 mRNA. Translation: CAG30285.1.
CR457392 mRNA. Translation: CAG33673.1.
Z99716 Genomic DNA. Translation: CAI41691.1.
BC000705 mRNA. Translation: AAH00705.1.
BC007495 mRNA. Translation: AAH07495.1.
BU194618 mRNA. No translation available.
CCDSiCCDS14025.1. [Q9NSP4-1]
CCDS46719.1. [Q9NSP4-3]
CCDS46720.1. [Q9NSP4-4]
RefSeqiNP_001002876.1. NM_001002876.1. [Q9NSP4-4]
NP_001103685.1. NM_001110215.1. [Q9NSP4-3]
NP_076958.1. NM_024053.3. [Q9NSP4-1]
UniGeneiHs.208912.

Genome annotation databases

EnsembliENST00000215980; ENSP00000215980; ENSG00000100162. [Q9NSP4-1]
ENST00000407253; ENSP00000384743; ENSG00000100162. [Q9NSP4-4]
ENST00000472374; ENSP00000430624; ENSG00000100162. [Q9NSP4-3]
GeneIDi79019.
KEGGihsa:79019.
UCSCiuc003bbn.3. human. [Q9NSP4-1]
uc003bbp.1. human. [Q9NSP4-2]
uc010gyq.3. human. [Q9NSP4-3]

Polymorphism databases

DMDMi47117330.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU035297 mRNA. Translation: ABS84666.1 .
AL160131 mRNA. Translation: CAB77147.1 .
AK123479 mRNA. Translation: BAC85624.1 .
CR456399 mRNA. Translation: CAG30285.1 .
CR457392 mRNA. Translation: CAG33673.1 .
Z99716 Genomic DNA. Translation: CAI41691.1 .
BC000705 mRNA. Translation: AAH00705.1 .
BC007495 mRNA. Translation: AAH07495.1 .
BU194618 mRNA. No translation available.
CCDSi CCDS14025.1. [Q9NSP4-1 ]
CCDS46719.1. [Q9NSP4-3 ]
CCDS46720.1. [Q9NSP4-4 ]
RefSeqi NP_001002876.1. NM_001002876.1. [Q9NSP4-4 ]
NP_001103685.1. NM_001110215.1. [Q9NSP4-3 ]
NP_076958.1. NM_024053.3. [Q9NSP4-1 ]
UniGenei Hs.208912.

3D structure databases

ProteinModelPortali Q9NSP4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122488. 12 interactions.
STRINGi 9606.ENSP00000215980.

Polymorphism databases

DMDMi 47117330.

Proteomic databases

MaxQBi Q9NSP4.
PaxDbi Q9NSP4.
PRIDEi Q9NSP4.

Protocols and materials databases

DNASUi 79019.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000215980 ; ENSP00000215980 ; ENSG00000100162 . [Q9NSP4-1 ]
ENST00000407253 ; ENSP00000384743 ; ENSG00000100162 . [Q9NSP4-4 ]
ENST00000472374 ; ENSP00000430624 ; ENSG00000100162 . [Q9NSP4-3 ]
GeneIDi 79019.
KEGGi hsa:79019.
UCSCi uc003bbn.3. human. [Q9NSP4-1 ]
uc003bbp.1. human. [Q9NSP4-2 ]
uc010gyq.3. human. [Q9NSP4-3 ]

Organism-specific databases

CTDi 79019.
GeneCardsi GC22M042334.
HGNCi HGNC:18352. CENPM.
HPAi CAB006330.
HPA042404.
MIMi 610152. gene.
neXtProti NX_Q9NSP4.
PharmGKBi PA25885.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25434.
HOGENOMi HOG000261677.
HOVERGENi HBG081086.
InParanoidi Q9NSP4.
KOi K11505.
OMAi ESHCSVH.
OrthoDBi EOG7R8333.
PhylomeDBi Q9NSP4.
TreeFami TF328778.

Enzyme and pathway databases

Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_682. Mitotic Prometaphase.

Miscellaneous databases

GeneWikii CENPM.
GenomeRNAii 79019.
NextBioi 67686.
PROi Q9NSP4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NSP4.
Bgeei Q9NSP4.
CleanExi HS_CENPM.
Genevestigatori Q9NSP4.

Family and domain databases

InterProi IPR020987. Centromere_Cenp-M.
[Graphical view ]
Pfami PF11111. CENP-M. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL."
    Brickner A.G., Evans A.M., Mito J.K., Xuereb S.M., Feng X., Nishida T., Fairfull L., Ferrell R.E., Foon K.A., Hunt D.F., Shabanowitz J., Engelhard V.H., Riddell S.R., Warren E.H.
    Blood 107:3779-3786(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY.
  2. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
    Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
    Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thalamus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Cervix, Lymph and Melanoma.
  8. "The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells."
    Bierie B., Edwin M., Melenhorst J.J., Hennighausen L.
    Gene Expr. Patterns 4:389-395(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
    Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K.
    Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. Cited for: IDENTIFICATION IN THE CENPA-NAC COMPLEX WITH CENPA; CENPC; CENPH; CENPN; CENPT AND CENPU.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCENPM_HUMAN
AccessioniPrimary (citable) accession number: Q9NSP4
Secondary accession number(s): A7LM22, B1AHQ9, Q6I9W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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