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Protein

Gamma-1-syntrophin

Gene

SNTG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • protein C-terminus binding Source: UniProtKB
  • structural molecule activity Source: InterPro

GO - Biological processi

  • cell communication Source: ProtInc

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-1-syntrophin
Short name:
G1SYN
Alternative name(s):
Syntrophin-4
Short name:
SYN4
Gene namesi
Name:SNTG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147481.13
HGNCiHGNC:13740 SNTG1
MIMi608714 gene
neXtProtiNX_Q9NSN8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54212
OpenTargetsiENSG00000147481
PharmGKBiPA37806

Polymorphism and mutation databases

DMDMi23822220

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840131 – 517Gamma-1-syntrophinAdd BLAST517

Proteomic databases

PaxDbiQ9NSN8
PeptideAtlasiQ9NSN8
PRIDEiQ9NSN8

PTM databases

iPTMnetiQ9NSN8
PhosphoSitePlusiQ9NSN8

Expressioni

Tissue specificityi

Brain specific. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia. No expression in muscle cells.1 Publication

Gene expression databases

BgeeiENSG00000147481
CleanExiHS_SNTG1
ExpressionAtlasiQ9NSN8 baseline and differential
GenevisibleiQ9NSN8 HS

Organism-specific databases

HPAiHPA072282

Interactioni

Subunit structurei

Isoform 1, but not isoform 2, interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Interacts with DGKZ.2 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi1199284 interactors.
STRINGi9606.ENSP00000429276

Structurei

3D structure databases

ProteinModelPortaliQ9NSN8
SMRiQ9NSN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 140PDZPROSITE-ProRule annotationAdd BLAST84
Domaini283 – 390PHPROSITE-ProRule annotationAdd BLAST108

Domaini

The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Phylogenomic databases

eggNOGiKOG3549 Eukaryota
ENOG410XQXQ LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000230749
HOVERGENiHBG060412
InParanoidiQ9NSN8
OMAiLQDRVYS
OrthoDBiEOG091G04YZ
PhylomeDBiQ9NSN8
TreeFamiTF317932

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001849 PH_domain
IPR015482 Syntrophin
IPR015483 Syntrophin_gamma
PANTHERiPTHR10554 PTHR10554, 1 hit
PTHR10554:SF2 PTHR10554:SF2, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFRTACEET KTGICLLQDG NQEPFKVRLH LAKDILMIQE QDVICVSGEP
60 70 80 90 100
FYSGERTVTI RRQTVGGFGL SIKGGAEHNI PVVVSKISKE QRAELSGLLF
110 120 130 140 150
IGDAILQING INVRKCRHEE VVQVLRNAGE EVTLTVSFLK RAPAFLKLPL
160 170 180 190 200
NEDCACAPSD QSSGTSSPLC DSGLHLNYHP NNTDTLSCSS WPTSPGLRWE
210 220 230 240 250
KRWCDLRLIP LLHSRFSQYV PGTDLSRQNA FQVIAVDGVC TGIIQCLSAE
260 270 280 290 300
DCVDWLQAIA TNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQDPLQD
310 320 330 340 350
RVYSPTFLAL RGSCLYKFLA PPVTTWDWTR AEKTFSVYEI MCKILKDSDL
360 370 380 390 400
LDRRKQCFTV QSESGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT
410 420 430 440 450
YACVLESHLM GLTIDFSTGF ICFDAATKAV LWRYKFSQLK GSSDDGKSKI
460 470 480 490 500
KFLFQNPDTK QIEAKELEFS NLFAVLHCIH SFFAAKVACL DPLFLGNQAT
510
ASTAASSATT SKAKYTT
Length:517
Mass (Da):57,969
Last modified:October 1, 2000 - v1
Checksum:iFB0C87AB18CB5D79
GO
Isoform 2 (identifier: Q9NSN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     428-464: Missing.

Show »
Length:480
Mass (Da):53,684
Checksum:i6DC6FF96D40EC447
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006360428 – 464Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003030 mRNA Translation: CAB92968.1
AL161971 mRNA Translation: CAB82311.1
BC075072 mRNA Translation: AAH75072.1
BC104829 mRNA Translation: AAI04830.1
CCDSiCCDS6147.1 [Q9NSN8-1]
CCDS75737.1 [Q9NSN8-2]
PIRiT47134
RefSeqiNP_001274742.1, NM_001287813.2 [Q9NSN8-1]
NP_001274743.1, NM_001287814.2 [Q9NSN8-2]
NP_001308702.1, NM_001321773.1 [Q9NSN8-1]
NP_001308705.1, NM_001321776.1
NP_001308706.1, NM_001321777.1
NP_061840.1, NM_018967.4 [Q9NSN8-1]
XP_016869068.1, XM_017013579.1 [Q9NSN8-1]
XP_016869069.1, XM_017013580.1 [Q9NSN8-1]
UniGeneiHs.584914
Hs.591869

Genome annotation databases

EnsembliENST00000517473; ENSP00000431123; ENSG00000147481 [Q9NSN8-2]
ENST00000518864; ENSP00000429276; ENSG00000147481 [Q9NSN8-1]
ENST00000522124; ENSP00000429842; ENSG00000147481 [Q9NSN8-1]
GeneIDi54212
KEGGihsa:54212
UCSCiuc003xqs.3 human [Q9NSN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNTG1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSN8
Secondary accession number(s): Q2M3Q0, Q9NY98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome