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Q9NSN8

- SNTG1_HUMAN

UniProt

Q9NSN8 - SNTG1_HUMAN

Protein

Gamma-1-syntrophin

Gene

SNTG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex By similarity. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.By similarity

    GO - Molecular functioni

    1. protein C-terminus binding Source: UniProtKB

    GO - Biological processi

    1. cell communication Source: ProtInc

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-1-syntrophin
    Short name:
    G1SYN
    Alternative name(s):
    Syntrophin-4
    Short name:
    SYN4
    Gene namesi
    Name:SNTG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:13740. SNTG1.

    Subcellular locationi

    Cytoplasmcytoskeleton. Nucleus
    Note: Mainly cytoplasmic and weakly nuclear.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoskeleton Source: LIFEdb
    3. nucleus Source: UniProtKB-SubCell
    4. ruffle membrane Source: UniProtKB
    5. syntrophin complex Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37806.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Gamma-1-syntrophinPRO_0000184013Add
    BLAST

    Proteomic databases

    PaxDbiQ9NSN8.
    PRIDEiQ9NSN8.

    PTM databases

    PhosphoSiteiQ9NSN8.

    Expressioni

    Tissue specificityi

    Brain specific. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia. No expression in muscle cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9NSN8.
    BgeeiQ9NSN8.
    CleanExiHS_SNTG1.
    GenevestigatoriQ9NSN8.

    Interactioni

    Subunit structurei

    Isoform 1, but not isoform 2, interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Interacts with DGKZ.2 Publications

    Protein-protein interaction databases

    BioGridi119928. 4 interactions.
    MINTiMINT-198152.
    STRINGi9606.ENSP00000342804.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSN8.
    SMRiQ9NSN8. Positions 56-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 14084PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini283 – 390108PHPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.

    Sequence similaritiesi

    Belongs to the syntrophin family.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG253217.
    HOGENOMiHOG000230749.
    HOVERGENiHBG060412.
    InParanoidiQ9NSN8.
    OMAiGFVCFDA.
    OrthoDBiEOG7S7SDC.
    PhylomeDBiQ9NSN8.
    TreeFamiTF317932.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015482. Syntrophin.
    IPR015483. Syntrophin_gamma.
    [Graphical view]
    PANTHERiPTHR10554. PTHR10554. 1 hit.
    PTHR10554:SF2. PTHR10554:SF2. 1 hit.
    PfamiPF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    SM00233. PH. 2 hits.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NSN8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDFRTACEET KTGICLLQDG NQEPFKVRLH LAKDILMIQE QDVICVSGEP    50
    FYSGERTVTI RRQTVGGFGL SIKGGAEHNI PVVVSKISKE QRAELSGLLF 100
    IGDAILQING INVRKCRHEE VVQVLRNAGE EVTLTVSFLK RAPAFLKLPL 150
    NEDCACAPSD QSSGTSSPLC DSGLHLNYHP NNTDTLSCSS WPTSPGLRWE 200
    KRWCDLRLIP LLHSRFSQYV PGTDLSRQNA FQVIAVDGVC TGIIQCLSAE 250
    DCVDWLQAIA TNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQDPLQD 300
    RVYSPTFLAL RGSCLYKFLA PPVTTWDWTR AEKTFSVYEI MCKILKDSDL 350
    LDRRKQCFTV QSESGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT 400
    YACVLESHLM GLTIDFSTGF ICFDAATKAV LWRYKFSQLK GSSDDGKSKI 450
    KFLFQNPDTK QIEAKELEFS NLFAVLHCIH SFFAAKVACL DPLFLGNQAT 500
    ASTAASSATT SKAKYTT 517
    Length:517
    Mass (Da):57,969
    Last modified:October 1, 2000 - v1
    Checksum:iFB0C87AB18CB5D79
    GO
    Isoform 2 (identifier: Q9NSN8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         428-464: Missing.

    Show »
    Length:480
    Mass (Da):53,684
    Checksum:i6DC6FF96D40EC447
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei428 – 46437Missing in isoform 2. 1 PublicationVSP_006360Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ003030 mRNA. Translation: CAB92968.1.
    AL161971 mRNA. Translation: CAB82311.1.
    BC075072 mRNA. Translation: AAH75072.1.
    BC104829 mRNA. Translation: AAI04830.1.
    CCDSiCCDS6147.1. [Q9NSN8-1]
    PIRiT47134.
    RefSeqiNP_001274742.1. NM_001287813.1. [Q9NSN8-1]
    NP_001274743.1. NM_001287814.1. [Q9NSN8-2]
    NP_061840.1. NM_018967.3. [Q9NSN8-1]
    UniGeneiHs.584914.
    Hs.591869.

    Genome annotation databases

    EnsembliENST00000276467; ENSP00000276467; ENSG00000147481. [Q9NSN8-2]
    ENST00000517473; ENSP00000431123; ENSG00000147481. [Q9NSN8-2]
    ENST00000518864; ENSP00000429276; ENSG00000147481. [Q9NSN8-1]
    ENST00000522124; ENSP00000429842; ENSG00000147481. [Q9NSN8-1]
    GeneIDi54212.
    KEGGihsa:54212.
    UCSCiuc003xqs.1. human. [Q9NSN8-1]
    uc010lxz.1. human. [Q9NSN8-2]

    Polymorphism databases

    DMDMi23822220.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ003030 mRNA. Translation: CAB92968.1 .
    AL161971 mRNA. Translation: CAB82311.1 .
    BC075072 mRNA. Translation: AAH75072.1 .
    BC104829 mRNA. Translation: AAI04830.1 .
    CCDSi CCDS6147.1. [Q9NSN8-1 ]
    PIRi T47134.
    RefSeqi NP_001274742.1. NM_001287813.1. [Q9NSN8-1 ]
    NP_001274743.1. NM_001287814.1. [Q9NSN8-2 ]
    NP_061840.1. NM_018967.3. [Q9NSN8-1 ]
    UniGenei Hs.584914.
    Hs.591869.

    3D structure databases

    ProteinModelPortali Q9NSN8.
    SMRi Q9NSN8. Positions 56-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119928. 4 interactions.
    MINTi MINT-198152.
    STRINGi 9606.ENSP00000342804.

    PTM databases

    PhosphoSitei Q9NSN8.

    Polymorphism databases

    DMDMi 23822220.

    Proteomic databases

    PaxDbi Q9NSN8.
    PRIDEi Q9NSN8.

    Protocols and materials databases

    DNASUi 54212.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276467 ; ENSP00000276467 ; ENSG00000147481 . [Q9NSN8-2 ]
    ENST00000517473 ; ENSP00000431123 ; ENSG00000147481 . [Q9NSN8-2 ]
    ENST00000518864 ; ENSP00000429276 ; ENSG00000147481 . [Q9NSN8-1 ]
    ENST00000522124 ; ENSP00000429842 ; ENSG00000147481 . [Q9NSN8-1 ]
    GeneIDi 54212.
    KEGGi hsa:54212.
    UCSCi uc003xqs.1. human. [Q9NSN8-1 ]
    uc010lxz.1. human. [Q9NSN8-2 ]

    Organism-specific databases

    CTDi 54212.
    GeneCardsi GC08P050874.
    HGNCi HGNC:13740. SNTG1.
    MIMi 608714. gene.
    neXtProti NX_Q9NSN8.
    PharmGKBi PA37806.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253217.
    HOGENOMi HOG000230749.
    HOVERGENi HBG060412.
    InParanoidi Q9NSN8.
    OMAi GFVCFDA.
    OrthoDBi EOG7S7SDC.
    PhylomeDBi Q9NSN8.
    TreeFami TF317932.

    Miscellaneous databases

    GeneWikii SNTG1.
    GenomeRNAii 54212.
    NextBioi 56550.
    PROi Q9NSN8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NSN8.
    Bgeei Q9NSN8.
    CleanExi HS_SNTG1.
    Genevestigatori Q9NSN8.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015482. Syntrophin.
    IPR015483. Syntrophin_gamma.
    [Graphical view ]
    PANTHERi PTHR10554. PTHR10554. 1 hit.
    PTHR10554:SF2. PTHR10554:SF2. 1 hit.
    Pfami PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    SM00233. PH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells."
      Piluso G., Mirabella M., Ricci E., Belsito A., Abbondanza C., Servidei S., Puca A.A., Tonali P., Puca G.A., Nigro V.
      J. Biol. Chem. 275:15851-15860(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH DMD; DTNA AND DTNB.
      Tissue: Fetal brain and Neuron.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions."
      Hogan A., Shepherd L., Chabot J., Quenneville S., Prescott S.M., Topham M.K., Gee S.H.
      J. Biol. Chem. 276:26526-26533(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DGKZ.

    Entry informationi

    Entry nameiSNTG1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSN8
    Secondary accession number(s): Q2M3Q0, Q9NY98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3