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Q9NSN8 (SNTG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-1-syntrophin

Short name=G1SYN
Alternative name(s):
Syntrophin-4
Short name=SYN4
Gene names
Name:SNTG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex By similarity. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.

Subunit structure

Isoform 1, but not isoform 2, interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Interacts with DGKZ. Ref.1 Ref.4

Subcellular location

Cytoplasmcytoskeleton. Nucleus. Note: Mainly cytoplasmic and weakly nuclear.

Tissue specificity

Brain specific. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia. No expression in muscle cells. Ref.1

Domain

The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.

Sequence similarities

Belongs to the syntrophin family.

Contains 1 PDZ (DHR) domain.

Contains 1 PH domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Nucleus
   Coding sequence diversityAlternative splicing
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell communication

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15485858. Source: UniProtKB

cytoskeleton

Inferred from direct assay. Source: LIFEdb

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

ruffle membrane

Inferred from direct assay PubMed 15485858. Source: UniProtKB

syntrophin complex

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionprotein C-terminus binding

Inferred from physical interaction PubMed 15485858. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NSN8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NSN8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     428-464: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Gamma-1-syntrophin
PRO_0000184013

Regions

Domain57 – 14084PDZ
Domain283 – 390108PH

Natural variations

Alternative sequence428 – 46437Missing in isoform 2.
VSP_006360

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: FB0C87AB18CB5D79

FASTA51757,969
        10         20         30         40         50         60 
MDFRTACEET KTGICLLQDG NQEPFKVRLH LAKDILMIQE QDVICVSGEP FYSGERTVTI 

        70         80         90        100        110        120 
RRQTVGGFGL SIKGGAEHNI PVVVSKISKE QRAELSGLLF IGDAILQING INVRKCRHEE 

       130        140        150        160        170        180 
VVQVLRNAGE EVTLTVSFLK RAPAFLKLPL NEDCACAPSD QSSGTSSPLC DSGLHLNYHP 

       190        200        210        220        230        240 
NNTDTLSCSS WPTSPGLRWE KRWCDLRLIP LLHSRFSQYV PGTDLSRQNA FQVIAVDGVC 

       250        260        270        280        290        300 
TGIIQCLSAE DCVDWLQAIA TNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQDPLQD 

       310        320        330        340        350        360 
RVYSPTFLAL RGSCLYKFLA PPVTTWDWTR AEKTFSVYEI MCKILKDSDL LDRRKQCFTV 

       370        380        390        400        410        420 
QSESGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT YACVLESHLM GLTIDFSTGF 

       430        440        450        460        470        480 
ICFDAATKAV LWRYKFSQLK GSSDDGKSKI KFLFQNPDTK QIEAKELEFS NLFAVLHCIH 

       490        500        510 
SFFAAKVACL DPLFLGNQAT ASTAASSATT SKAKYTT 

« Hide

Isoform 2 [UniParc].

Checksum: 6DC6FF96D40EC447
Show »

FASTA48053,684

References

« Hide 'large scale' references
[1]"Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells."
Piluso G., Mirabella M., Ricci E., Belsito A., Abbondanza C., Servidei S., Puca A.A., Tonali P., Puca G.A., Nigro V.
J. Biol. Chem. 275:15851-15860(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH DMD; DTNA AND DTNB.
Tissue: Fetal brain and Neuron.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions."
Hogan A., Shepherd L., Chabot J., Quenneville S., Prescott S.M., Topham M.K., Gee S.H.
J. Biol. Chem. 276:26526-26533(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DGKZ.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ003030 mRNA. Translation: CAB92968.1.
AL161971 mRNA. Translation: CAB82311.1.
BC075072 mRNA. Translation: AAH75072.1.
BC104829 mRNA. Translation: AAI04830.1.
PIRT47134.
RefSeqNP_001274742.1. NM_001287813.1.
NP_001274743.1. NM_001287814.1.
NP_061840.1. NM_018967.3.
UniGeneHs.584914.
Hs.591869.

3D structure databases

ProteinModelPortalQ9NSN8.
SMRQ9NSN8. Positions 7-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119928. 4 interactions.
MINTMINT-198152.
STRING9606.ENSP00000342804.

PTM databases

PhosphoSiteQ9NSN8.

Polymorphism databases

DMDM23822220.

Proteomic databases

PaxDbQ9NSN8.
PRIDEQ9NSN8.

Protocols and materials databases

DNASU54212.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276467; ENSP00000276467; ENSG00000147481. [Q9NSN8-2]
ENST00000517473; ENSP00000431123; ENSG00000147481. [Q9NSN8-2]
ENST00000518864; ENSP00000429276; ENSG00000147481. [Q9NSN8-1]
ENST00000522124; ENSP00000429842; ENSG00000147481. [Q9NSN8-1]
GeneID54212.
KEGGhsa:54212.
UCSCuc003xqs.1. human. [Q9NSN8-1]
uc010lxz.1. human. [Q9NSN8-2]

Organism-specific databases

CTD54212.
GeneCardsGC08P050874.
HGNCHGNC:13740. SNTG1.
MIM608714. gene.
neXtProtNX_Q9NSN8.
PharmGKBPA37806.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG253217.
HOGENOMHOG000230749.
HOVERGENHBG060412.
InParanoidQ9NSN8.
OMAGFVCFDA.
OrthoDBEOG7S7SDC.
PhylomeDBQ9NSN8.
TreeFamTF317932.

Gene expression databases

ArrayExpressQ9NSN8.
BgeeQ9NSN8.
CleanExHS_SNTG1.
GenevestigatorQ9NSN8.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProIPR001478. PDZ.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR015482. Syntrophin.
IPR015483. Syntrophin_gamma.
[Graphical view]
PANTHERPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF2. PTHR10554:SF2. 1 hit.
PfamPF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSNTG1.
GenomeRNAi54212.
NextBio56550.
PROQ9NSN8.
SOURCESearch...

Entry information

Entry nameSNTG1_HUMAN
AccessionPrimary (citable) accession number: Q9NSN8
Secondary accession number(s): Q2M3Q0, Q9NY98
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM