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Protein

Gamma-1-syntrophin

Gene

SNTG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.By similarity

GO - Molecular functioni

  1. protein C-terminus binding Source: UniProtKB

GO - Biological processi

  1. cell communication Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-1-syntrophin
Short name:
G1SYN
Alternative name(s):
Syntrophin-4
Short name:
SYN4
Gene namesi
Name:SNTG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:13740. SNTG1.

Subcellular locationi

Cytoplasmcytoskeleton. Nucleus
Note: Mainly cytoplasmic and weakly nuclear.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoskeleton Source: LIFEdb
  3. nucleus Source: UniProtKB-SubCell
  4. ruffle membrane Source: UniProtKB
  5. syntrophin complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Gamma-1-syntrophinPRO_0000184013Add
BLAST

Proteomic databases

PaxDbiQ9NSN8.
PRIDEiQ9NSN8.

PTM databases

PhosphoSiteiQ9NSN8.

Expressioni

Tissue specificityi

Brain specific. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia. No expression in muscle cells.1 Publication

Gene expression databases

BgeeiQ9NSN8.
CleanExiHS_SNTG1.
ExpressionAtlasiQ9NSN8. baseline and differential.
GenevestigatoriQ9NSN8.

Interactioni

Subunit structurei

Isoform 1, but not isoform 2, interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Interacts with DGKZ.2 Publications

Protein-protein interaction databases

BioGridi119928. 4 interactions.
MINTiMINT-198152.
STRINGi9606.ENSP00000342804.

Structurei

3D structure databases

ProteinModelPortaliQ9NSN8.
SMRiQ9NSN8. Positions 56-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 14084PDZPROSITE-ProRule annotationAdd
BLAST
Domaini283 – 390108PHPROSITE-ProRule annotationAdd
BLAST

Domaini

The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.

Sequence similaritiesi

Belongs to the syntrophin family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG253217.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000230749.
HOVERGENiHBG060412.
InParanoidiQ9NSN8.
OMAiGFVCFDA.
OrthoDBiEOG7S7SDC.
PhylomeDBiQ9NSN8.
TreeFamiTF317932.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015482. Syntrophin.
IPR015483. Syntrophin_gamma.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF2. PTHR10554:SF2. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFRTACEET KTGICLLQDG NQEPFKVRLH LAKDILMIQE QDVICVSGEP
60 70 80 90 100
FYSGERTVTI RRQTVGGFGL SIKGGAEHNI PVVVSKISKE QRAELSGLLF
110 120 130 140 150
IGDAILQING INVRKCRHEE VVQVLRNAGE EVTLTVSFLK RAPAFLKLPL
160 170 180 190 200
NEDCACAPSD QSSGTSSPLC DSGLHLNYHP NNTDTLSCSS WPTSPGLRWE
210 220 230 240 250
KRWCDLRLIP LLHSRFSQYV PGTDLSRQNA FQVIAVDGVC TGIIQCLSAE
260 270 280 290 300
DCVDWLQAIA TNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQDPLQD
310 320 330 340 350
RVYSPTFLAL RGSCLYKFLA PPVTTWDWTR AEKTFSVYEI MCKILKDSDL
360 370 380 390 400
LDRRKQCFTV QSESGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT
410 420 430 440 450
YACVLESHLM GLTIDFSTGF ICFDAATKAV LWRYKFSQLK GSSDDGKSKI
460 470 480 490 500
KFLFQNPDTK QIEAKELEFS NLFAVLHCIH SFFAAKVACL DPLFLGNQAT
510
ASTAASSATT SKAKYTT
Length:517
Mass (Da):57,969
Last modified:September 30, 2000 - v1
Checksum:iFB0C87AB18CB5D79
GO
Isoform 2 (identifier: Q9NSN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     428-464: Missing.

Show »
Length:480
Mass (Da):53,684
Checksum:i6DC6FF96D40EC447
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei428 – 46437Missing in isoform 2. 1 PublicationVSP_006360Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003030 mRNA. Translation: CAB92968.1.
AL161971 mRNA. Translation: CAB82311.1.
BC075072 mRNA. Translation: AAH75072.1.
BC104829 mRNA. Translation: AAI04830.1.
CCDSiCCDS6147.1. [Q9NSN8-1]
CCDS75737.1. [Q9NSN8-2]
PIRiT47134.
RefSeqiNP_001274742.1. NM_001287813.1. [Q9NSN8-1]
NP_001274743.1. NM_001287814.1. [Q9NSN8-2]
NP_061840.1. NM_018967.3. [Q9NSN8-1]
UniGeneiHs.584914.
Hs.591869.

Genome annotation databases

EnsembliENST00000276467; ENSP00000276467; ENSG00000147481. [Q9NSN8-2]
ENST00000517473; ENSP00000431123; ENSG00000147481. [Q9NSN8-2]
ENST00000518864; ENSP00000429276; ENSG00000147481. [Q9NSN8-1]
ENST00000522124; ENSP00000429842; ENSG00000147481. [Q9NSN8-1]
ENST00000620202; ENSP00000483474; ENSG00000147481. [Q9NSN8-1]
GeneIDi54212.
KEGGihsa:54212.
UCSCiuc003xqs.1. human. [Q9NSN8-1]
uc010lxz.1. human. [Q9NSN8-2]

Polymorphism databases

DMDMi23822220.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003030 mRNA. Translation: CAB92968.1.
AL161971 mRNA. Translation: CAB82311.1.
BC075072 mRNA. Translation: AAH75072.1.
BC104829 mRNA. Translation: AAI04830.1.
CCDSiCCDS6147.1. [Q9NSN8-1]
CCDS75737.1. [Q9NSN8-2]
PIRiT47134.
RefSeqiNP_001274742.1. NM_001287813.1. [Q9NSN8-1]
NP_001274743.1. NM_001287814.1. [Q9NSN8-2]
NP_061840.1. NM_018967.3. [Q9NSN8-1]
UniGeneiHs.584914.
Hs.591869.

3D structure databases

ProteinModelPortaliQ9NSN8.
SMRiQ9NSN8. Positions 56-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119928. 4 interactions.
MINTiMINT-198152.
STRINGi9606.ENSP00000342804.

PTM databases

PhosphoSiteiQ9NSN8.

Polymorphism databases

DMDMi23822220.

Proteomic databases

PaxDbiQ9NSN8.
PRIDEiQ9NSN8.

Protocols and materials databases

DNASUi54212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276467; ENSP00000276467; ENSG00000147481. [Q9NSN8-2]
ENST00000517473; ENSP00000431123; ENSG00000147481. [Q9NSN8-2]
ENST00000518864; ENSP00000429276; ENSG00000147481. [Q9NSN8-1]
ENST00000522124; ENSP00000429842; ENSG00000147481. [Q9NSN8-1]
ENST00000620202; ENSP00000483474; ENSG00000147481. [Q9NSN8-1]
GeneIDi54212.
KEGGihsa:54212.
UCSCiuc003xqs.1. human. [Q9NSN8-1]
uc010lxz.1. human. [Q9NSN8-2]

Organism-specific databases

CTDi54212.
GeneCardsiGC08P050823.
HGNCiHGNC:13740. SNTG1.
MIMi608714. gene.
neXtProtiNX_Q9NSN8.
PharmGKBiPA37806.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG253217.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000230749.
HOVERGENiHBG060412.
InParanoidiQ9NSN8.
OMAiGFVCFDA.
OrthoDBiEOG7S7SDC.
PhylomeDBiQ9NSN8.
TreeFamiTF317932.

Miscellaneous databases

ChiTaRSiSNTG1. human.
GeneWikiiSNTG1.
GenomeRNAii54212.
NextBioi56550.
PROiQ9NSN8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NSN8.
CleanExiHS_SNTG1.
ExpressionAtlasiQ9NSN8. baseline and differential.
GenevestigatoriQ9NSN8.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015482. Syntrophin.
IPR015483. Syntrophin_gamma.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF2. PTHR10554:SF2. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells."
    Piluso G., Mirabella M., Ricci E., Belsito A., Abbondanza C., Servidei S., Puca A.A., Tonali P., Puca G.A., Nigro V.
    J. Biol. Chem. 275:15851-15860(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH DMD; DTNA AND DTNB.
    Tissue: Fetal brain and Neuron.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions."
    Hogan A., Shepherd L., Chabot J., Quenneville S., Prescott S.M., Topham M.K., Gee S.H.
    J. Biol. Chem. 276:26526-26533(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DGKZ.

Entry informationi

Entry nameiSNTG1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSN8
Secondary accession number(s): Q2M3Q0, Q9NY98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 9, 2002
Last sequence update: September 30, 2000
Last modified: January 6, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.