ID   Q9NSM3_HUMAN            Unreviewed;       227 AA.
AC   Q9NSM3;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   SubName: Full=Uncharacterized protein DKFZp434B1272 {ECO:0000313|EMBL:CAB82385.1};
DE   Flags: Fragment;
GN   Name=DKFZp434B1272 {ECO:0000313|EMBL:CAB82385.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAB82385.1};
RN   [1] {ECO:0000313|EMBL:CAB82385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:CAB82385.1};
RA   Poustka A., Wellenreuther R., Mewes H.W., Weil B., Wiemann S.;
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AL162032; CAB82385.1; -; mRNA.
DR   PIR; T47186; T47186.
DR   RefSeq; NP_001317426.1; NM_001330497.1.
DR   RefSeq; NP_942122.2; NM_198827.4.
DR   AlphaFoldDB; Q9NSM3; -.
DR   MEROPS; P02.021; -.
DR   PeptideAtlas; Q9NSM3; -.
DR   DNASU; 283383; -.
DR   GeneID; 283383; -.
DR   KEGG; hsa:283383; -.
DR   CTD; 283383; -.
DR   PharmGKB; PA134923933; -.
DR   OrthoDB; 1114672at2759; -.
DR   BioGRID-ORCS; 283383; 14 hits in 1155 CRISPR screens.
DR   GenomeRNAi; 283383; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   InterPro; IPR000203; GPS.
DR   PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR12011:SF216; ADHESION G-PROTEIN COUPLED RECEPTOR D1; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF01825; GPS; 1.
DR   SMART; SM00303; GPS; 1.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   Genevisible; Q9NSM3; HS.
PE   2: Evidence at transcript level;
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transducer {ECO:0000256|ARBA:ARBA00023040};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        110..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        139..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          48..163
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   REGION          207..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAB82385.1"
SQ   SEQUENCE   227 AA;  24792 MW;  2BDFAF60269364E3 CRC64;
     HGVSARDVLE SRTRKQHSEA TNSSNRVFVY CAFLDFSSGE GVWSNHGCAL TRGNLTYSVC
     RCTHLTNFAI LMQVVPLEVN IGILIAVTRV ISQISADNYK IHGDPSAFKL TAKAVAVLLP
     ILGTSWVFGV LAVNGCAVVF QYMFATLNSL QGLFIFLFHC LLNSEVRAAF KHKTKVWSLT
     SSSARTSNAK PFHSDLMNGT RPGMASTKLS PWDKSSHSAH RVDLSAV
//