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Protein

Kinesin light chain 4

Gene

KLC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-5625970. RHO GTPases activate KTN1.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 4
Short name:
KLC 4
Alternative name(s):
Kinesin-like protein 8
Gene namesi
Name:KLC4
Synonyms:KNSL8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21624. KLC4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137171.
PharmGKBiPA134934134.

Polymorphism and mutation databases

BioMutaiKLC4.
DMDMi116242607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002150972 – 619Kinesin light chain 4Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei174PhosphoserineBy similarity1
Modified residuei449PhosphotyrosineBy similarity1
Modified residuei460PhosphoserineCombined sources1
Modified residuei519PhosphoserineBy similarity1
Modified residuei565PhosphoserineBy similarity1
Modified residuei566PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei612PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NSK0.
MaxQBiQ9NSK0.
PaxDbiQ9NSK0.
PeptideAtlasiQ9NSK0.
PRIDEiQ9NSK0.

PTM databases

iPTMnetiQ9NSK0.
PhosphoSitePlusiQ9NSK0.

Expressioni

Gene expression databases

BgeeiENSG00000137171.
CleanExiHS_KLC4.
ExpressionAtlasiQ9NSK0. baseline and differential.
GenevisibleiQ9NSK0. HS.

Organism-specific databases

HPAiHPA030168.
HPA030169.

Interactioni

Subunit structurei

Oligomeric complex composed of two heavy chains and two light chains.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI3Q9P2A43EBI-949319,EBI-742038
CEP57L1Q8IYX8-23EBI-949319,EBI-10181988
KATNAL1Q9BW625EBI-949319,EBI-743591
KRT13A1A4E93EBI-949319,EBI-10171552
KRT15P190123EBI-949319,EBI-739566
KRT31Q153235EBI-949319,EBI-948001
MEOX2A4D1273EBI-949319,EBI-10172134
NECAB2H3BTW25EBI-949319,EBI-10172876
SLC16A9Q7RTY13EBI-949319,EBI-10232636
SYNE4Q8N2053EBI-949319,EBI-7131783
TADA2AO754783EBI-949319,EBI-742268
USHBP1Q8N6Y03EBI-949319,EBI-739895

Protein-protein interaction databases

BioGridi124648. 62 interactors.
IntActiQ9NSK0. 42 interactors.
MINTiMINT-4999921.
STRINGi9606.ENSP00000259708.

Structurei

3D structure databases

ProteinModelPortaliQ9NSK0.
SMRiQ9NSK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati55 – 88TPR 1Add BLAST34
Repeati211 – 244TPR 2Add BLAST34
Repeati253 – 286TPR 3Add BLAST34
Repeati295 – 328TPR 4Add BLAST34
Repeati337 – 370TPR 5Add BLAST34
Repeati379 – 412TPR 6Add BLAST34
Repeati464 – 497TPR 7Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 150Sequence analysisAdd BLAST119

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated
Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000015357.
HOVERGENiHBG006217.
InParanoidiQ9NSK0.
KOiK10407.
OMAiMSKSRHR.
OrthoDBiEOG091G05DM.
PhylomeDBiQ9NSK0.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 2 hits.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS01160. KINESIN_LIGHT. 3 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSK0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLEALRSEH QAVLQSLSQT
60 70 80 90 100
IECLQQGGHE EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES
110 120 130 140 150
EKQKLRAQVR RLCQENQWLR DELAGTQQRL QRSEQAVAQL EEEKKHLEFL
160 170 180 190 200
GQLRQYDEDG HTSEEKEGDA TKDSLDDLFP NEEEEDPSNG LSRGQGATAA
210 220 230 240 250
QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED LERTSGRGHP
260 270 280 290 300
DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGPD HPAVAATLNN
310 320 330 340 350
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TNHPDVAKQL NNLALLCQNQ
360 370 380 390 400
GKYEAVERYY QRALAIYEGQ LGPDNPNVAR TKNNLASCYL KQGKYAEAET
410 420 430 440 450
LYKEILTRAH VQEFGSVDDD HKPIWMHAEE REEMSKSRHH EGGTPYAEYG
460 470 480 490 500
GWYKACKVSS PTVNTTLRNL GALYRRQGKL EAAETLEECA LRSRRQGTDP
510 520 530 540 550
ISQTKVAELL GESDGRRTSQ EGPGDSVKFE GGEDASVAVE WSGDGSGTLQ
560 570 580 590 600
RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSNMKRAAS LNYLNQPSAA
610
PLQVSRGLSA STMDLSSSS
Length:619
Mass (Da):68,640
Last modified:October 17, 2006 - v3
Checksum:i32DFC2A9A91B5574
GO
Isoform 2 (identifier: Q9NSK0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-131: VMLALASHLS...ELAGTQQRLQ → NLELRGCAHL...AMPGEPVAAG
     132-619: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:131
Mass (Da):13,682
Checksum:i18DB578896960243
GO
Isoform 3 (identifier: Q9NSK0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEVTGFGVTRPGKVPQARM

Show »
Length:637
Mass (Da):70,552
Checksum:iCAA62901967C6918
GO
Isoform 4 (identifier: Q9NSK0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-315: AATLNNLAVLYGKRGKYKEAE → SIPCPPHPTPRTPHHCCFGLS
     316-619: Missing.

Note: No experimental confirmation available.
Show »
Length:315
Mass (Da):35,102
Checksum:iB2F27C231C949391
GO
Isoform 5 (identifier: Q9NSK0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-163: Missing.

Note: No experimental confirmation available.
Show »
Length:542
Mass (Da):59,640
Checksum:i85687792E15F896D
GO

Sequence cautioni

The sequence BAC86788 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54L → LQTIECL in BAC87179 (PubMed:14702039).Curated1
Sequence conflicti286T → S in BAG51695 (PubMed:14702039).Curated1
Sequence conflicti366I → T in BAG51695 (PubMed:14702039).Curated1
Sequence conflicti434M → L in BAG52815 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04970872R → H.1 PublicationCorresponds to variant rs11558979dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0380831M → MEVTGFGVTRPGKVPQARM in isoform 3. 1 Publication1
Alternative sequenceiVSP_05723187 – 163Missing in isoform 5. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_03787587 – 131VMLAL…QQRLQ → NLELRGCAHLGDAGSSQPPE HSGVGETEAAGSGAAAMPGE PVAAG in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_037876132 – 619Missing in isoform 2. 1 PublicationAdd BLAST488
Alternative sequenceiVSP_043324295 – 315AATLN…YKEAE → SIPCPPHPTPRTPHHCCFGL S in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_043325316 – 619Missing in isoform 4. 1 PublicationAdd BLAST304

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055293 mRNA. Translation: BAG51496.1.
AK056393 mRNA. Translation: BAG51695.1.
AK094102 mRNA. Translation: BAG52815.1.
AK127018 mRNA. Translation: BAC86788.1. Sequence problems.
AK127894 mRNA. Translation: BAC87179.1.
AK297433 mRNA. Translation: BAG59861.1.
AL162078 mRNA. Translation: CAB82411.1.
AL136304 Genomic DNA. No translation available.
AL355385 Genomic DNA. Translation: CAI13781.1.
CH471081 Genomic DNA. Translation: EAX04149.1.
BC012357 mRNA. Translation: AAH12357.1.
BC080637 mRNA. Translation: AAH80637.1.
BC103727 mRNA. Translation: AAI03728.1.
BX640717 mRNA. Translation: CAE45836.1.
CCDSiCCDS47429.1. [Q9NSK0-4]
CCDS4882.1. [Q9NSK0-3]
CCDS4883.1. [Q9NSK0-1]
CCDS75459.1. [Q9NSK0-5]
PIRiT47147.
RefSeqiNP_001275963.1. NM_001289034.1. [Q9NSK0-1]
NP_001275964.1. NM_001289035.1. [Q9NSK0-5]
NP_612352.1. NM_138343.3. [Q9NSK0-4]
NP_958929.1. NM_201521.2. [Q9NSK0-1]
NP_958930.1. NM_201522.2. [Q9NSK0-1]
NP_958931.1. NM_201523.2. [Q9NSK0-3]
UniGeneiHs.655123.

Genome annotation databases

EnsembliENST00000259708; ENSP00000259708; ENSG00000137171. [Q9NSK0-3]
ENST00000347162; ENSP00000340221; ENSG00000137171. [Q9NSK0-1]
ENST00000394056; ENSP00000377620; ENSG00000137171. [Q9NSK0-1]
ENST00000453940; ENSP00000395806; ENSG00000137171. [Q9NSK0-5]
ENST00000458460; ENSP00000410358; ENSG00000137171. [Q9NSK0-4]
ENST00000467906; ENSP00000418759; ENSG00000137171. [Q9NSK0-2]
ENST00000479388; ENSP00000418031; ENSG00000137171. [Q9NSK0-1]
GeneIDi89953.
KEGGihsa:89953.
UCSCiuc003otu.4. human. [Q9NSK0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055293 mRNA. Translation: BAG51496.1.
AK056393 mRNA. Translation: BAG51695.1.
AK094102 mRNA. Translation: BAG52815.1.
AK127018 mRNA. Translation: BAC86788.1. Sequence problems.
AK127894 mRNA. Translation: BAC87179.1.
AK297433 mRNA. Translation: BAG59861.1.
AL162078 mRNA. Translation: CAB82411.1.
AL136304 Genomic DNA. No translation available.
AL355385 Genomic DNA. Translation: CAI13781.1.
CH471081 Genomic DNA. Translation: EAX04149.1.
BC012357 mRNA. Translation: AAH12357.1.
BC080637 mRNA. Translation: AAH80637.1.
BC103727 mRNA. Translation: AAI03728.1.
BX640717 mRNA. Translation: CAE45836.1.
CCDSiCCDS47429.1. [Q9NSK0-4]
CCDS4882.1. [Q9NSK0-3]
CCDS4883.1. [Q9NSK0-1]
CCDS75459.1. [Q9NSK0-5]
PIRiT47147.
RefSeqiNP_001275963.1. NM_001289034.1. [Q9NSK0-1]
NP_001275964.1. NM_001289035.1. [Q9NSK0-5]
NP_612352.1. NM_138343.3. [Q9NSK0-4]
NP_958929.1. NM_201521.2. [Q9NSK0-1]
NP_958930.1. NM_201522.2. [Q9NSK0-1]
NP_958931.1. NM_201523.2. [Q9NSK0-3]
UniGeneiHs.655123.

3D structure databases

ProteinModelPortaliQ9NSK0.
SMRiQ9NSK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124648. 62 interactors.
IntActiQ9NSK0. 42 interactors.
MINTiMINT-4999921.
STRINGi9606.ENSP00000259708.

PTM databases

iPTMnetiQ9NSK0.
PhosphoSitePlusiQ9NSK0.

Polymorphism and mutation databases

BioMutaiKLC4.
DMDMi116242607.

Proteomic databases

EPDiQ9NSK0.
MaxQBiQ9NSK0.
PaxDbiQ9NSK0.
PeptideAtlasiQ9NSK0.
PRIDEiQ9NSK0.

Protocols and materials databases

DNASUi89953.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259708; ENSP00000259708; ENSG00000137171. [Q9NSK0-3]
ENST00000347162; ENSP00000340221; ENSG00000137171. [Q9NSK0-1]
ENST00000394056; ENSP00000377620; ENSG00000137171. [Q9NSK0-1]
ENST00000453940; ENSP00000395806; ENSG00000137171. [Q9NSK0-5]
ENST00000458460; ENSP00000410358; ENSG00000137171. [Q9NSK0-4]
ENST00000467906; ENSP00000418759; ENSG00000137171. [Q9NSK0-2]
ENST00000479388; ENSP00000418031; ENSG00000137171. [Q9NSK0-1]
GeneIDi89953.
KEGGihsa:89953.
UCSCiuc003otu.4. human. [Q9NSK0-1]

Organism-specific databases

CTDi89953.
GeneCardsiKLC4.
HGNCiHGNC:21624. KLC4.
HPAiHPA030168.
HPA030169.
neXtProtiNX_Q9NSK0.
OpenTargetsiENSG00000137171.
PharmGKBiPA134934134.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000015357.
HOVERGENiHBG006217.
InParanoidiQ9NSK0.
KOiK10407.
OMAiMSKSRHR.
OrthoDBiEOG091G05DM.
PhylomeDBiQ9NSK0.
TreeFamiTF314010.

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-5625970. RHO GTPases activate KTN1.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKLC4. human.
GeneWikiiKLC4.
GenomeRNAii89953.
PROiQ9NSK0.

Gene expression databases

BgeeiENSG00000137171.
CleanExiHS_KLC4.
ExpressionAtlasiQ9NSK0. baseline and differential.
GenevisibleiQ9NSK0. HS.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 2 hits.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS01160. KINESIN_LIGHT. 3 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLC4_HUMAN
AccessioniPrimary (citable) accession number: Q9NSK0
Secondary accession number(s): B3KNY4
, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.