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Protein
Submitted name:

Homeobox protein SIX3 (NP_005404)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  3. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. apoptotic process involved in development Source: Ensembl
  2. cell proliferation in forebrain Source: Ensembl
  3. circadian behavior Source: Ensembl
  4. epithelial cell maturation Source: Ensembl
  5. forebrain anterior/posterior pattern specification Source: Ensembl
  6. lens fiber cell apoptotic process Source: Ensembl
  7. lens fiber cell differentiation Source: Ensembl
  8. lens induction in camera-type eye Source: Ensembl
  9. negative regulation of neuron differentiation Source: Ensembl
  10. negative regulation of transcription, DNA-templated Source: Ensembl
  11. negative regulation of Wnt signaling pathway Source: Ensembl
  12. neuroblast differentiation Source: Ensembl
  13. neuroblast migration Source: Ensembl
  14. optic vesicle morphogenesis Source: Ensembl
  15. pituitary gland development Source: Ensembl
  16. protein import into nucleus, translocation Source: Ensembl
  17. proximal/distal axis specification Source: Ensembl
  18. regulation of cell cycle phase transition Source: Ensembl
  19. regulation of neural retina development Source: Ensembl
  20. regulation of neuroblast proliferation Source: Ensembl
  21. telencephalon regionalization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein SIX3 (NP_005404)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9NSJ2.
ExpressionAtlasiQ9NSJ2. baseline and differential.

Family & Domainsi

Keywords - Domaini

HomeoboxImported

Phylogenomic databases

HOVERGENiHBG003609.

Sequencei

Sequence statusi: Fragment.

Q9NSJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFRSPLDLY SSHFLLPNFA DSHHRSILLA SSGGGNGAGG GGGAGGGSGG
60 70 80 90 100
GNGAGGGGAG GAGGGGGGGS RAPPEELSMF QLPTLNFSPE QVASVCETLE
110 120 130 140 150
ETGDIERLGR FLWSLPVAPG ACEAINKHES ILRARAVVAF HTGNFRDLYH
160
ILENHKFTKE SHGK
Length:164
Mass (Da):16,684
Last modified:October 1, 2000 - v1
Checksum:iC5F49E2F5EED7A98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei164 – 1641Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162671 mRNA. Translation: CAB83141.1.
UniGeneiHs.567336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162671 mRNA. Translation: CAB83141.1.
UniGeneiHs.567336.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG003609.

Gene expression databases

BgeeiQ9NSJ2.
ExpressionAtlasiQ9NSJ2. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The European IMAGE consortium for integrated Molecular analysis of human gene transcripts."
    Auffray C., Ansorge W., Ballabio A., Estivill X., Gibson K., Lehrach H., Poustka A., Lundeberg J.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Bassi M.T., Manzoni M., Banfi S., Riboni M., Ballabio A., Borsani G.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9NSJ2_HUMAN
AccessioniPrimary (citable) accession number: Q9NSJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: March 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.