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Q9NSI8

- SAMN1_HUMAN

UniProt

Q9NSI8 - SAMN1_HUMAN

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Protein

SAM domain-containing protein SAMSN-1

Gene

SAMSN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).By similarity

GO - Molecular functioni

  1. phosphotyrosine binding Source: MGI
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of adaptive immune response Source: UniProtKB
  2. negative regulation of B cell activation Source: UniProtKB
  3. negative regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SAM domain-containing protein SAMSN-1
Alternative name(s):
Hematopoietic adaptor containing SH3 and SAM domains 1
Nash1
SAM domain, SH3 domain and nuclear localization signals protein 1
SH3-SAM adaptor protein
Gene namesi
Name:SAMSN1
Synonyms:HACS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:10528. SAMSN1.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm By similarity. Cell projectionruffle By similarity
Note: Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By similarity).By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytosol Source: Ensembl
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373SAM domain-containing protein SAMSN-1PRO_0000097574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901PhosphoserineBy similarity
Modified residuei160 – 1601PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NSI8.
PaxDbiQ9NSI8.
PRIDEiQ9NSI8.

PTM databases

PhosphoSiteiQ9NSI8.

Expressioni

Tissue specificityi

Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.2 Publications

Inductioni

Up-regulated in peripheral blood B-cells by IL4, IL13 and by CD40 stimulation.1 Publication

Gene expression databases

BgeeiQ9NSI8.
CleanExiHS_SAMSN1.
ExpressionAtlasiQ9NSI8. baseline and differential.
GenevestigatoriQ9NSI8.

Organism-specific databases

HPAiHPA010645.
HPA017055.

Interactioni

Subunit structurei

Interacts with FASLG. Interacts with phosphotyrosine containing proteins. Interacts (via SH3 domain) with CTTN. Interacts (phosphorylated at Ser-23) with YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ and SFN. Interacts directly with SAP30 and HDAC1. Identified in a complex with SAP30 and HDAC1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi122054. 13 interactions.
IntActiQ9NSI8. 2 interactions.
STRINGi9606.ENSP00000383411.

Structurei

Secondary structure

1
373
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi167 – 1704Combined sources
Beta strandi181 – 1833Combined sources
Beta strandi191 – 1966Combined sources
Beta strandi203 – 2075Combined sources
Beta strandi210 – 2145Combined sources
Helixi216 – 2183Combined sources
Beta strandi219 – 2213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KEANMR-A162-224[»]
ProteinModelPortaliQ9NSI8.
SMRiQ9NSI8. Positions 162-224, 234-303.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NSI8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini166 – 22257SH3Add
BLAST
Domaini241 – 30565SAMPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi20 – 256Important for interaction with 14-3-3 proteinsBy similarity

Sequence similaritiesi

Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG293245.
GeneTreeiENSGT00390000014672.
HOGENOMiHOG000049202.
HOVERGENiHBG000461.
InParanoidiQ9NSI8.
OMAiGPYSGPF.
OrthoDBiEOG7KQ20X.
PhylomeDBiQ9NSI8.
TreeFamiTF350709.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021090. rSAM/SH3_domain-containing.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
PF07653. SH3_2. 1 hit.
PF12485. SLY. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NSI8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKRKPSNVS EKEKHQKPKR SSSFGNFDRF RNNSLSKPDD STEAHEGDPT
60 70 80 90 100
NGSGEQSKTS NNGGGLGKKM RAISWTMKKK VGKKYIKALS EEKDEEDGEN
110 120 130 140 150
AHPYRNSDPV IGTHTEKVSL KASDSMDSLY SGQSSSSGIT SCSDGTSNRD
160 170 180 190 200
SFRLDDDGPY SGPFCGRARV HTDFTPSPYD TDSLKIKKGD IIDIICKTPM
210 220 230 240 250
GMWTGMLNNK VGNFKFIYVD VISEEEAAPK KIKANRRSNS KKSKTLQEFL
260 270 280 290 300
ERIHLQEYTS TLLLNGYETL EDLKDIKESH LIELNIENPD DRRRLLSAAE
310 320 330 340 350
NFLEEEIIQE QENEPEPLSL SSDISLNKSQ LDDCPRDSGC YISSGNSDNG
360 370
KEDLESENLS DMVHKIIITE PSD
Length:373
Mass (Da):41,708
Last modified:October 1, 2000 - v1
Checksum:i964B852ADBA2D777
GO
Isoform 2 (identifier: Q9NSI8-2) [UniParc]FASTAAdd to Basket

Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     19-186: Missing.

Show »
Length:205
Mass (Da):23,466
Checksum:i362B2FB490B972BE
GO
Isoform 3 (identifier: Q9NSI8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MLKRKPSNVSEKEKHQKPK → MEIRLDTLSA...CSDMDLLHSW

Show »
Length:441
Mass (Da):49,627
Checksum:iC2757916D880F563
GO

Sequence cautioni

The sequence AAK07746.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051R → G in BAG54155. (PubMed:14702039)Curated
Isoform 3 (identifier: Q9NSI8-3)
Sequence conflicti20 – 201N → D in AAK07746. (PubMed:11536050)Curated
Sequence conflicti64 – 641H → Y in AAK07746. (PubMed:11536050)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631G → A.
Corresponds to variant rs34607574 [ dbSNP | Ensembl ].
VAR_051331

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919MLKRK…HQKPK → MEIRLDTLSASLGRSSTLNN CNLEDKLAWYEGEAYMWHHW KPFPENPLWTCLDFQIAQVG PWDHCSSCIRHTRLKSSCSD MDLLHSW in isoform 3. 1 PublicationVSP_008120Add
BLAST
Alternative sequencei19 – 186168Missing in isoform 2. 1 PublicationVSP_008119Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222927 mRNA. Translation: AAG23355.1.
AF218085 mRNA. Translation: AAK07746.1. Different initiation.
AF519621 mRNA. Translation: AAM75349.1.
AK125144 mRNA. Translation: BAG54155.1.
AL163206 Genomic DNA. Translation: CAB90391.1.
AF165138 Genomic DNA. No translation available.
BC029112 mRNA. Translation: AAH29112.1.
CCDSiCCDS42906.1. [Q9NSI8-1]
CCDS58786.1. [Q9NSI8-3]
RefSeqiNP_001243299.1. NM_001256370.1. [Q9NSI8-3]
NP_001273452.1. NM_001286523.1.
NP_071419.3. NM_022136.4. [Q9NSI8-1]
UniGeneiHs.473341.
Hs.719474.

Genome annotation databases

EnsembliENST00000285670; ENSP00000285670; ENSG00000155307. [Q9NSI8-3]
ENST00000400564; ENSP00000383409; ENSG00000155307. [Q9NSI8-2]
ENST00000400566; ENSP00000383411; ENSG00000155307. [Q9NSI8-1]
GeneIDi64092.
KEGGihsa:64092.
UCSCiuc002yju.2. human. [Q9NSI8-1]
uc010gky.2. human. [Q9NSI8-2]

Polymorphism databases

DMDMi12230638.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222927 mRNA. Translation: AAG23355.1 .
AF218085 mRNA. Translation: AAK07746.1 . Different initiation.
AF519621 mRNA. Translation: AAM75349.1 .
AK125144 mRNA. Translation: BAG54155.1 .
AL163206 Genomic DNA. Translation: CAB90391.1 .
AF165138 Genomic DNA. No translation available.
BC029112 mRNA. Translation: AAH29112.1 .
CCDSi CCDS42906.1. [Q9NSI8-1 ]
CCDS58786.1. [Q9NSI8-3 ]
RefSeqi NP_001243299.1. NM_001256370.1. [Q9NSI8-3 ]
NP_001273452.1. NM_001286523.1.
NP_071419.3. NM_022136.4. [Q9NSI8-1 ]
UniGenei Hs.473341.
Hs.719474.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KEA NMR - A 162-224 [» ]
ProteinModelPortali Q9NSI8.
SMRi Q9NSI8. Positions 162-224, 234-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122054. 13 interactions.
IntActi Q9NSI8. 2 interactions.
STRINGi 9606.ENSP00000383411.

PTM databases

PhosphoSitei Q9NSI8.

Polymorphism databases

DMDMi 12230638.

Proteomic databases

MaxQBi Q9NSI8.
PaxDbi Q9NSI8.
PRIDEi Q9NSI8.

Protocols and materials databases

DNASUi 64092.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285670 ; ENSP00000285670 ; ENSG00000155307 . [Q9NSI8-3 ]
ENST00000400564 ; ENSP00000383409 ; ENSG00000155307 . [Q9NSI8-2 ]
ENST00000400566 ; ENSP00000383411 ; ENSG00000155307 . [Q9NSI8-1 ]
GeneIDi 64092.
KEGGi hsa:64092.
UCSCi uc002yju.2. human. [Q9NSI8-1 ]
uc010gky.2. human. [Q9NSI8-2 ]

Organism-specific databases

CTDi 64092.
GeneCardsi GC21M015857.
H-InvDB HIX0016027.
HGNCi HGNC:10528. SAMSN1.
HPAi HPA010645.
HPA017055.
MIMi 607978. gene.
neXtProti NX_Q9NSI8.
PharmGKBi PA34939.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293245.
GeneTreei ENSGT00390000014672.
HOGENOMi HOG000049202.
HOVERGENi HBG000461.
InParanoidi Q9NSI8.
OMAi GPYSGPF.
OrthoDBi EOG7KQ20X.
PhylomeDBi Q9NSI8.
TreeFami TF350709.

Miscellaneous databases

EvolutionaryTracei Q9NSI8.
GenomeRNAii 64092.
NextBioi 65904.
PROi Q9NSI8.
SOURCEi Search...

Gene expression databases

Bgeei Q9NSI8.
CleanExi HS_SAMSN1.
ExpressionAtlasi Q9NSI8. baseline and differential.
Genevestigatori Q9NSI8.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
InterProi IPR021090. rSAM/SH3_domain-containing.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF07647. SAM_2. 1 hit.
PF07653. SH3_2. 1 hit.
PF12485. SLY. 1 hit.
[Graphical view ]
SMARTi SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50105. SAM_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene, located on human chromosome 21q11."
    Groet J., Blechschmidt K., Yaspo M., Rosenthal A., Nizetic D.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "HACS1 encodes a novel SH3-SAM adaptor protein differentially expressed in normal and malignant hematopoietic cells."
    Claudio J.O., Zhu Y.X., Benn S.J., Shukla A.H., McGlade C.J., Falcioni N., Stewart A.K.
    Oncogene 20:5373-5377(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Transcriptional map of the juxtacentromeric region of human chromosome 21."
    Brun M.-E., Ruault M., Roizes G., De Sario A.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Thymus.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph.
  7. "Identification of Nash1, a novel protein containing a nuclear localization signal, a sterile alpha motif, and an SH3 domain preferentially expressed in mast cells."
    Uchida T., Nakao A., Nakano N., Kuramasu A., Saito H., Okumura K., Ra C., Ogawa H.
    Biochem. Biophys. Res. Commun. 288:137-141(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades."
    Zhu Y.X., Benn S., Li Z.H., Wei E., Masih-Khan E., Trieu Y., Bali M., McGlade C.J., Claudio J.O., Stewart A.K.
    J. Exp. Med. 200:737-747(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
  9. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "NMR solution structure of the HACS1 SH3 domain."
    Donaldson L.
    Submitted (FEB-2010) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 162-224.

Entry informationi

Entry nameiSAMN1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSI8
Secondary accession number(s): B3KWJ3
, F8WAA1, Q8NFF7, Q9C041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3