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Protein

Bromodomain and WD repeat-containing protein 1

Gene

BRWD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.By similarity1 Publication

GO - Biological processi

  • cytoskeleton organization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:G66-33735-MONOMER.
ReactomeiR-HSA-1266695. Interleukin-7 signaling.
R-HSA-3247509. Chromatin modifying enzymes.
SignaLinkiQ9NSI6.

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain and WD repeat-containing protein 1
Alternative name(s):
WD repeat-containing protein 9
Gene namesi
Name:BRWD1
Synonyms:C21orf107, WDR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:12760. BRWD1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54014.
OpenTargetsiENSG00000185658.
PharmGKBiPA134906879.

Chemistry databases

ChEMBLiCHEMBL3351192.

Polymorphism and mutation databases

BioMutaiBRWD1.
DMDMi313104296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508881 – 2320Bromodomain and WD repeat-containing protein 1Add BLAST2320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei687PhosphothreonineBy similarity1
Modified residuei696PhosphoserineCombined sources1
Modified residuei701PhosphoserineCombined sources1
Modified residuei710PhosphoserineCombined sources1
Modified residuei1289PhosphoserineCombined sources1
Modified residuei1475PhosphoserineCombined sources1
Modified residuei1477PhosphothreonineCombined sources1
Modified residuei1479PhosphoserineCombined sources1
Modified residuei1605PhosphoserineCombined sources1
Modified residuei1607PhosphoserineCombined sources1
Modified residuei1678PhosphoserineCombined sources1
Modified residuei1683PhosphoserineCombined sources1
Modified residuei1686PhosphoserineCombined sources1
Modified residuei1755PhosphoserineBy similarity1
Modified residuei1756PhosphoserineBy similarity1
Modified residuei1786PhosphoserineBy similarity1
Modified residuei1788PhosphoserineBy similarity1
Modified residuei1793PhosphoserineBy similarity1
Modified residuei1820PhosphoserineBy similarity1
Modified residuei1867PhosphothreonineBy similarity1
Modified residuei1871PhosphoserineBy similarity1
Modified residuei1904PhosphoserineCombined sources1
Modified residuei1905PhosphoserineCombined sources1
Modified residuei1907PhosphoserineCombined sources1
Modified residuei1910PhosphoserineCombined sources1
Modified residuei1943PhosphoserineCombined sources1
Modified residuei1955PhosphothreonineBy similarity1
Modified residuei2018PhosphoserineCombined sources1
Modified residuei2020PhosphoserineCombined sources1
Modified residuei2052PhosphoserineBy similarity1
Modified residuei2164PhosphothreonineBy similarity1
Modified residuei2166PhosphoserineBy similarity1
Isoform B (identifier: Q9NSI6-2)
Modified residuei2214PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NSI6.
MaxQBiQ9NSI6.
PaxDbiQ9NSI6.
PeptideAtlasiQ9NSI6.
PRIDEiQ9NSI6.

PTM databases

iPTMnetiQ9NSI6.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000185658.
CleanExiHS_BRWD1.
ExpressionAtlasiQ9NSI6. baseline and differential.
GenevisibleiQ9NSI6. HS.

Organism-specific databases

HPAiCAB034184.
HPA030943.
HPA030944.
HPA030945.

Interactioni

Subunit structurei

Interacts with SMARCA4.By similarity

Protein-protein interaction databases

BioGridi119828. 19 interactors.
IntActiQ9NSI6. 14 interactors.
STRINGi9606.ENSP00000330753.

Chemistry databases

BindingDBiQ9NSI6.

Structurei

Secondary structure

12320
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1318 – 1330Combined sources13
Helixi1333 – 1338Combined sources6
Turni1344 – 1346Combined sources3
Helixi1350 – 1353Combined sources4
Helixi1360 – 1368Combined sources9
Helixi1375 – 1392Combined sources18
Helixi1399 – 1422Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q2EX-ray1.74A1310-1430[»]
ProteinModelPortaliQ9NSI6.
SMRiQ9NSI6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NSI6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati184 – 223WD 1Add BLAST40
Repeati226 – 265WD 2Add BLAST40
Repeati268 – 311WD 3Add BLAST44
Repeati322 – 365WD 4Add BLAST44
Repeati366 – 405WD 5Add BLAST40
Repeati424 – 463WD 6Add BLAST40
Repeati466 – 506WD 7Add BLAST41
Repeati514 – 553WD 8Add BLAST40
Domaini1177 – 1247Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1330 – 1400Bromo 2PROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi661 – 668Poly-Gln8
Compositional biasi821 – 824Poly-Ser4
Compositional biasi1539 – 1548Poly-Ser10
Compositional biasi1687 – 1692Poly-Glu6

Sequence similaritiesi

Contains 2 bromo domains.PROSITE-ProRule annotation
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IRXQ. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00720000108687.
HOVERGENiHBG080933.
InParanoidiQ9NSI6.
KOiK11798.
OMAiWRSDRKS.
OrthoDBiEOG091G00HZ.
PhylomeDBiQ9NSI6.
TreeFamiTF324197.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
2.130.10.10. 2 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q9NSI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK
60 70 80 90 100
RLDWEGNEHN RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV
110 120 130 140 150
TSLLGAGRQS LLRTAKDCRH TVWKGSAFAA LHRGRPPEMP VNYGSPPNLV
160 170 180 190 200
EIHRGKQLTG CSTFSTAFPG TMYQHIKMHR RILGHLSAVY CVAFDRTGHR
210 220 230 240 250
IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN TMIAAGSCDK
260 270 280 290 300
IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGSQRYMV STGADGTVCF
310 320 330 340 350
WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM
360 370 380 390 400
YFLGFEAPEK IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL
410 420 430 440 450
EWRSILLDMA TRISGDLSSE EERFMKPKVT MIAWNQNDSI VVTAVNDHVL
460 470 480 490 500
KVWNSYTGQL LHNLMGHADE VFVLETHPFD SRIMLSAGHD GSIFIWDITK
510 520 530 540 550
GTKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL LIFGFGCSKP
560 570 580 590 600
YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH
610 620 630 640 650
PTKYQRLVPG RENSADEHLI PQLGYVATSD GEVIEQIISL QTNDNDERSP
660 670 680 690 700
ESSILDGMIR QLQQQQDQRM GADQDTIPRG LSNGEETPRR GFRRLSLDIQ
710 720 730 740 750
SPPNIGLRRS GQVEGVRQMH QNAPRSQIAT ERDLQAWKRR VVVPEVPLGI
760 770 780 790 800
FRKLEDFRLE KGEEERNLYI IGRKRKTLQL SHKSDSVVLV SQSRQRTCRR
810 820 830 840 850
KYPNYGRRNR SWRELSSGNE SSSSVRHETS CDQSEGSGSS EEDEWRSDRK
860 870 880 890 900
SESYSESSSD SSSRYSDWTA DAGINLQPPL RTSCRRRITR FCSSSEDEIS
910 920 930 940 950
TENLSPPKRR RKRKKENKPK KENLRRMTPA ELANMEHLYE FHPPVWITDT
960 970 980 990 1000
TLRKSPFVPQ MGDEVIYFRQ GHEAYIEAVR RNNIYELNPN KEPWRKMDLR
1010 1020 1030 1040 1050
DQELVKIVGI RYEVGPPTLC CLKLAFIDPA TGKLMDKSFS IRYHDMPDVI
1060 1070 1080 1090 1100
DFLVLRQFYD EARQRNWQSC DRFRSIIDDA WWFGTVLSQE PYQPQYPDSH
1110 1120 1130 1140 1150
FQCYIVRWDN TEIEKLSPWD MEPIPDNVDP PEELGASISV TTDELEKLLY
1160 1170 1180 1190 1200
KPQAGEWGQK SRDEECDRII SGIDQLLNLD IAAAFAGPVD LCTYPKYCTV
1210 1220 1230 1240 1250
VAYPTDLYTI RMRLVNRFYR RLSALVWEVR YIEHNARTFN EPESVIARSA
1260 1270 1280 1290 1300
KKITDQLLKF IKNQHCTNIS ELSNTSENDE QNAEDLDDSD LPKTSSGRRR
1310 1320 1330 1340 1350
VHDGKKSIRA TNYVESNWKK QCKELVNLIF QCEDSEPFRQ PVDLVEYPDY
1360 1370 1380 1390 1400
RDIIDTPMDF GTVRETLDAG NYDSPLEFCK DIRLIFSNAK AYTPNKRSKI
1410 1420 1430 1440 1450
YSMTLRLSAL FEEKMKKISS DFKIGQKFNE KLRRSQRFKQ RQNCKGDSQP
1460 1470 1480 1490 1500
NKSIRNLKPK RLKSQTKIIP ELVGSPTQST SSRTAYLGTH KTSAGISSGV
1510 1520 1530 1540 1550
TSGDSSDSAE SSERRKRNRP ITNGSTLSES EVEDSLATSL SSSASSSSEE
1560 1570 1580 1590 1600
SKESSRARES SSRSGLSRSS NLRVTRTRAA QRKTGPVSLA NGCGRKATRK
1610 1620 1630 1640 1650
RVYLSDSDNN SLETGEILKA RAGNNRKVLR KCAAVAANKI KLMSDVEENS
1660 1670 1680 1690 1700
SSESVCSGRK LPHRNASAVA RKKLLHNSED EQSLKSEIEE EELKDENQLL
1710 1720 1730 1740 1750
PVSSSHTAQS NVDESENRDS ESESDLRVAR KNWHANGYKS HTPAPSKTKF
1760 1770 1780 1790 1800
LKIESSEEDS KSHDSDHACN RTAGPSTSVQ KLKAESISEE ADSEPGRSGG
1810 1820 1830 1840 1850
RKYNTFHKNA SFFKKTKILS DSEDSESEEQ DREDGKCHKM EMNPISGNLN
1860 1870 1880 1890 1900
CDPIAMSQCS SDHGCETDLD SDDDKIEKPN NFMKDSASQD NGLSRKISRK
1910 1920 1930 1940 1950
RVCSSDSDSS LQVVKKSSKA RTGLLRITRR CAATAANKIK LMSDVEDVSL
1960 1970 1980 1990 2000
ENVHTRSKNG RKKPLHLACT TAKKKLSDCE GSVHCEVPSE QYACEGKPPD
2010 2020 2030 2040 2050
PDSEGSTKVL SQALNGDSDS EDMLNSEHKH RHTNIHKIDA PSKRKSSSVT
2060 2070 2080 2090 2100
SSGEDSKSHI PGSETDRTFS SESTLAQKAT AENNFEVELN YGLRRWNGRR
2110 2120 2130 2140 2150
LRTYGKAPFS KTKVIHDSQE TAEKEVKRKR SHPELENVKI SETTGNSKFR
2160 2170 2180 2190 2200
PDTSSKSSDL GSVTESDIDC TDNTKTKRRK TKGKAKVVRK EFVPRDREPN
2210 2220 2230 2240 2250
TKVRTCMHNQ KDAVQMPSET LKAKMVPEKV PRRCATVAAN KIKIMSNLKE
2260 2270 2280 2290 2300
TISGPENVWI RKSSRKLPHR NASAAAKKKL LNVYKEDDTT INSESEKELE
2310 2320
DINRKMLFLR GFRSWKENAQ
Length:2,320
Mass (Da):262,936
Last modified:November 30, 2010 - v4
Checksum:i109714D79B9057E9
GO
Isoform B (identifier: Q9NSI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2191-2320: EFVPRDREPN...GFRSWKENAQ → GKTFTANISK...NVLDFNGCTL

Show »
Length:2,269
Mass (Da):257,238
Checksum:iEF2D6F3B745BB4EE
GO
Isoform C (identifier: Q9NSI6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2191-2285: EFVPRDREPN...AKKKLLNVYK → DKTFSPVYL
     2286-2320: Missing.

Show »
Length:2,199
Mass (Da):248,953
Checksum:iD0B8757ED0AF6E32
GO
Isoform D (identifier: Q9NSI6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-120: DCRH → GTLI
     121-2320: Missing.

Show »
Length:120
Mass (Da):13,558
Checksum:iF31E4C9728C92359
GO

Sequence cautioni

The sequence CAA10896 differs from that shown. Reason: Frameshift at positions 1762 and 1770.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1560 – 1562SSS → GTR in CAA10896 (PubMed:9480850).Curated3
Sequence conflicti1840M → V in AK002177 (PubMed:14702039).Curated1
Sequence conflicti2134E → G in AK002177 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02643583Q → E.1 PublicationCorresponds to variant rs2056844dbSNPEnsembl.1
Natural variantiVAR_0264361511S → P.1 PublicationCorresponds to variant rs2183573dbSNPEnsembl.1
Natural variantiVAR_0264371699L → P.5 PublicationsCorresponds to variant rs1041439dbSNPEnsembl.1
Natural variantiVAR_0575842156K → R.Corresponds to variant rs2234548dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044245117 – 120DCRH → GTLI in isoform D. 1 Publication4
Alternative sequenceiVSP_044246121 – 2320Missing in isoform D. 1 PublicationAdd BLAST2200
Alternative sequenceiVSP_0185262191 – 2320EFVPR…KENAQ → GKTFTANISKTVRRQRQSKR PRLSVDDNDWEDLDYAKSKR VLRRSKIKTRNQGRRTVRYH DGDDDRSLENVLDFNGCTL in isoform B. 4 PublicationsAdd BLAST130
Alternative sequenceiVSP_0185272191 – 2285EFVPR…LNVYK → DKTFSPVYL in isoform C. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0185282286 – 2320Missing in isoform C. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238214 mRNA. Translation: CAC37033.2.
AJ292465 mRNA. Translation: CAC44371.1.
AJ292466 mRNA. Translation: CAC44372.1.
AB080586 mRNA. Translation: BAD74071.1.
AB080587 mRNA. Translation: BAD74072.1.
AF064861 Genomic DNA. No translation available.
AF129408 Genomic DNA. No translation available.
BC064602 mRNA. Translation: AAH64602.1.
AL163279 Genomic DNA. Translation: CAB90452.1.
AJ222636 mRNA. Translation: CAA10896.1. Frameshift.
AK002177 mRNA. No translation available.
CCDSiCCDS13662.1. [Q9NSI6-1]
CCDS13663.1. [Q9NSI6-2]
CCDS33557.1. [Q9NSI6-4]
RefSeqiNP_001007247.1. NM_001007246.2. [Q9NSI6-4]
NP_061836.2. NM_018963.4. [Q9NSI6-1]
NP_387505.1. NM_033656.3. [Q9NSI6-2]
UniGeneiHs.627139.
Hs.654740.

Genome annotation databases

EnsembliENST00000333229; ENSP00000330753; ENSG00000185658. [Q9NSI6-1]
ENST00000341322; ENSP00000342106; ENSG00000185658. [Q9NSI6-4]
ENST00000342449; ENSP00000344333; ENSG00000185658. [Q9NSI6-2]
ENST00000380800; ENSP00000370178; ENSG00000185658. [Q9NSI6-3]
GeneIDi54014.
KEGGihsa:54014.
UCSCiuc002yxk.3. human. [Q9NSI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238214 mRNA. Translation: CAC37033.2.
AJ292465 mRNA. Translation: CAC44371.1.
AJ292466 mRNA. Translation: CAC44372.1.
AB080586 mRNA. Translation: BAD74071.1.
AB080587 mRNA. Translation: BAD74072.1.
AF064861 Genomic DNA. No translation available.
AF129408 Genomic DNA. No translation available.
BC064602 mRNA. Translation: AAH64602.1.
AL163279 Genomic DNA. Translation: CAB90452.1.
AJ222636 mRNA. Translation: CAA10896.1. Frameshift.
AK002177 mRNA. No translation available.
CCDSiCCDS13662.1. [Q9NSI6-1]
CCDS13663.1. [Q9NSI6-2]
CCDS33557.1. [Q9NSI6-4]
RefSeqiNP_001007247.1. NM_001007246.2. [Q9NSI6-4]
NP_061836.2. NM_018963.4. [Q9NSI6-1]
NP_387505.1. NM_033656.3. [Q9NSI6-2]
UniGeneiHs.627139.
Hs.654740.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q2EX-ray1.74A1310-1430[»]
ProteinModelPortaliQ9NSI6.
SMRiQ9NSI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119828. 19 interactors.
IntActiQ9NSI6. 14 interactors.
STRINGi9606.ENSP00000330753.

Chemistry databases

BindingDBiQ9NSI6.
ChEMBLiCHEMBL3351192.

PTM databases

iPTMnetiQ9NSI6.

Polymorphism and mutation databases

BioMutaiBRWD1.
DMDMi313104296.

Proteomic databases

EPDiQ9NSI6.
MaxQBiQ9NSI6.
PaxDbiQ9NSI6.
PeptideAtlasiQ9NSI6.
PRIDEiQ9NSI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333229; ENSP00000330753; ENSG00000185658. [Q9NSI6-1]
ENST00000341322; ENSP00000342106; ENSG00000185658. [Q9NSI6-4]
ENST00000342449; ENSP00000344333; ENSG00000185658. [Q9NSI6-2]
ENST00000380800; ENSP00000370178; ENSG00000185658. [Q9NSI6-3]
GeneIDi54014.
KEGGihsa:54014.
UCSCiuc002yxk.3. human. [Q9NSI6-1]

Organism-specific databases

CTDi54014.
DisGeNETi54014.
GeneCardsiBRWD1.
HGNCiHGNC:12760. BRWD1.
HPAiCAB034184.
HPA030943.
HPA030944.
HPA030945.
neXtProtiNX_Q9NSI6.
OpenTargetsiENSG00000185658.
PharmGKBiPA134906879.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRXQ. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00720000108687.
HOVERGENiHBG080933.
InParanoidiQ9NSI6.
KOiK11798.
OMAiWRSDRKS.
OrthoDBiEOG091G00HZ.
PhylomeDBiQ9NSI6.
TreeFamiTF324197.

Enzyme and pathway databases

BioCyciZFISH:G66-33735-MONOMER.
ReactomeiR-HSA-1266695. Interleukin-7 signaling.
R-HSA-3247509. Chromatin modifying enzymes.
SignaLinkiQ9NSI6.

Miscellaneous databases

ChiTaRSiBRWD1. human.
EvolutionaryTraceiQ9NSI6.
GeneWikiiBRWD1.
GenomeRNAii54014.
PROiQ9NSI6.

Gene expression databases

BgeeiENSG00000185658.
CleanExiHS_BRWD1.
ExpressionAtlasiQ9NSI6. baseline and differential.
GenevisibleiQ9NSI6. HS.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
2.130.10.10. 2 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRWD1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSI6
Secondary accession number(s): C9JK25
, O43721, Q5R2V0, Q5R2V1, Q6P2D1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 165 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.