Q9NSI6 (BRWD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bromodomain and WD repeat-containing protein 1

Alternative name(s):
WD repeat-containing protein 9

Gene names

Name:	BRWD1
Synonyms:	C21orf107, WDR9

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2320 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a transcriptional activator. May be involved in chromatin remodeling By similarity. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Ref.10
Subunit structure	Interacts with SMARCA4 By similarity.
Subcellular location	Cytoplasm. Nucleus By similarity.
Tissue specificity	Ubiquitously expressed. Ref.1
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. Ref.7 Ref.8 Ref.9
Sequence similarities	Contains 2 bromo domains. Contains 8 WD repeats.
Sequence caution	The sequence CAA10896.1 differs from that shown. Reason: Frameshift at positions 1762 and 1770.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Bromodomain Repeat WD repeat
Molecular function	Activator
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cytoskeleton organization Inferred from mutant phenotype Ref.10. Source: UniProtKB regulation of cell shape Inferred from mutant phenotype Ref.10. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9NSI6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9NSI6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2191-2320: EFVPRDREPN...GFRSWKENAQ → GKTFTANISK...NVLDFNGCTL

Isoform C (identifier: Q9NSI6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2191-2285: EFVPRDREPN...AKKKLLNVYK → DKTFSPVYL
     2286-2320: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2320

2320

Bromodomain and WD repeat-containing protein 1

PRO_0000050888

Regions

Repeat

184 – 223

40

WD 1

Repeat

226 – 265

40

WD 2

Repeat

268 – 311

44

WD 3

Repeat

322 – 365

44

WD 4

Repeat

366 – 405

40

WD 5

Repeat

424 – 463

40

WD 6

Repeat

466 – 506

41

WD 7

Repeat

514 – 553

40

WD 8

Domain

1177 – 1247

71

Bromo 1

Domain

1330 – 1400

71

Bromo 2

Compositional bias

661 – 668

8

Poly-Gln

Compositional bias

821 – 824

4

Poly-Ser

Compositional bias

1539 – 1548

10

Poly-Ser

Compositional bias

1687 – 1692

6

Poly-Glu

Amino acid modifications

Modified residue

418

1

Phosphoserine Ref.7

Modified residue

696

1

Phosphoserine Ref.8

Modified residue

701

1

Phosphoserine Ref.8

Modified residue

791

1

Phosphoserine Ref.7

Modified residue

1275

1

Phosphothreonine Ref.8

Modified residue

1289

1

Phosphoserine Ref.8

Modified residue

1475

1

Phosphoserine Ref.9

Modified residue

1605

1

Phosphoserine Ref.8 Ref.9

Modified residue

1607

1

Phosphoserine Ref.8 Ref.9

Modified residue

1755

1

Phosphoserine By similarity

Modified residue

1756

1

Phosphoserine By similarity

Modified residue

1786

1

Phosphoserine Ref.8

Modified residue

1788

1

Phosphoserine Ref.8

Modified residue

1793

1

Phosphoserine Ref.8

Modified residue

1904

1

Phosphoserine Ref.8

Modified residue

1905

1

Phosphoserine Ref.8

Modified residue

1907

1

Phosphoserine Ref.8

Modified residue

1910

1

Phosphoserine Ref.8

Modified residue

2018

1

Phosphoserine Ref.8 Ref.9

Modified residue

2020

1

Phosphoserine Ref.8 Ref.9

Modified residue

2052

1

Phosphoserine By similarity

Natural variations

Alternative sequence

2191 – 2320

130

EFVPR…KENAQ → GKTFTANISKTVRRQRQSKR PRLSVDDNDWEDLDYAKSKR VLRRSKIKTRNQGRRTVRYH DGDDDRSLENVLDFNGCTL in isoform B.

VSP_018526

Alternative sequence

2191 – 2285

95

EFVPR…LNVYK → DKTFSPVYL in isoform C.

VSP_018527

Alternative sequence

2286 – 2320

35

Missing in isoform C.

VSP_018528

Natural variant

83

1

Q → E. Ref.3
Corresponds to variant rs2056844 [ dbSNP | Ensembl ].

VAR_026435

Natural variant

1511

1

S → P. Ref.2
Corresponds to variant rs2183573 [ dbSNP | Ensembl ].

VAR_026436

Natural variant

1699

1

L → P. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6
Corresponds to variant rs1041439 [ dbSNP | Ensembl ].

VAR_026437

Natural variant

2156

1

K → R.
Corresponds to variant rs2234548 [ dbSNP | Ensembl ].

VAR_057584

Experimental info

Sequence conflict

1560 – 1562

3

SSS → GTR in CAA10896. Ref.5

Sequence conflict

1840

1

M → V in AK002177. Ref.6

Sequence conflict

2134

1

E → G in AK002177. Ref.6

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

2320

Helix Strand Turn

Details...

Helix

1318 – 1330

13

Helix

1333 – 1338

6

Turn

1344 – 1346

3

Helix

1350 – 1353

4

Helix

1363 – 1368

6

Helix

1375 – 1392

18

Helix

1399 – 1422

24

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified November 30, 2010. Version 4. Checksum: 109714D79B9057E9	FASTA	2,320	262,936
	10 20 30 40 50 60 MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN 70 80 90 100 110 120 RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH 130 140 150 160 170 180 TVWKGSAFAA LHRGRPPEMP VNYGSPPNLV EIHRGKQLTG CSTFSTAFPG TMYQHIKMHR 190 200 210 220 230 240 RILGHLSAVY CVAFDRTGHR IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN 250 260 270 280 290 300 TMIAAGSCDK IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGSQRYMV STGADGTVCF 310 320 330 340 350 360 WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM YFLGFEAPEK 370 380 390 400 410 420 IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL EWRSILLDMA TRISGDLSSE 430 440 450 460 470 480 EERFMKPKVT MIAWNQNDSI VVTAVNDHVL KVWNSYTGQL LHNLMGHADE VFVLETHPFD 490 500 510 520 530 540 SRIMLSAGHD GSIFIWDITK GTKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL 550 560 570 580 590 600 LIFGFGCSKP YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH 610 620 630 640 650 660 PTKYQRLVPG RENSADEHLI PQLGYVATSD GEVIEQIISL QTNDNDERSP ESSILDGMIR 670 680 690 700 710 720 QLQQQQDQRM GADQDTIPRG LSNGEETPRR GFRRLSLDIQ SPPNIGLRRS GQVEGVRQMH 730 740 750 760 770 780 QNAPRSQIAT ERDLQAWKRR VVVPEVPLGI FRKLEDFRLE KGEEERNLYI IGRKRKTLQL 790 800 810 820 830 840 SHKSDSVVLV SQSRQRTCRR KYPNYGRRNR SWRELSSGNE SSSSVRHETS CDQSEGSGSS 850 860 870 880 890 900 EEDEWRSDRK SESYSESSSD SSSRYSDWTA DAGINLQPPL RTSCRRRITR FCSSSEDEIS 910 920 930 940 950 960 TENLSPPKRR RKRKKENKPK KENLRRMTPA ELANMEHLYE FHPPVWITDT TLRKSPFVPQ 970 980 990 1000 1010 1020 MGDEVIYFRQ GHEAYIEAVR RNNIYELNPN KEPWRKMDLR DQELVKIVGI RYEVGPPTLC 1030 1040 1050 1060 1070 1080 CLKLAFIDPA TGKLMDKSFS IRYHDMPDVI DFLVLRQFYD EARQRNWQSC DRFRSIIDDA 1090 1100 1110 1120 1130 1140 WWFGTVLSQE PYQPQYPDSH FQCYIVRWDN TEIEKLSPWD MEPIPDNVDP PEELGASISV 1150 1160 1170 1180 1190 1200 TTDELEKLLY KPQAGEWGQK SRDEECDRII SGIDQLLNLD IAAAFAGPVD LCTYPKYCTV 1210 1220 1230 1240 1250 1260 VAYPTDLYTI RMRLVNRFYR RLSALVWEVR YIEHNARTFN EPESVIARSA KKITDQLLKF 1270 1280 1290 1300 1310 1320 IKNQHCTNIS ELSNTSENDE QNAEDLDDSD LPKTSSGRRR VHDGKKSIRA TNYVESNWKK 1330 1340 1350 1360 1370 1380 QCKELVNLIF QCEDSEPFRQ PVDLVEYPDY RDIIDTPMDF GTVRETLDAG NYDSPLEFCK 1390 1400 1410 1420 1430 1440 DIRLIFSNAK AYTPNKRSKI YSMTLRLSAL FEEKMKKISS DFKIGQKFNE KLRRSQRFKQ 1450 1460 1470 1480 1490 1500 RQNCKGDSQP NKSIRNLKPK RLKSQTKIIP ELVGSPTQST SSRTAYLGTH KTSAGISSGV 1510 1520 1530 1540 1550 1560 TSGDSSDSAE SSERRKRNRP ITNGSTLSES EVEDSLATSL SSSASSSSEE SKESSRARES 1570 1580 1590 1600 1610 1620 SSRSGLSRSS NLRVTRTRAA QRKTGPVSLA NGCGRKATRK RVYLSDSDNN SLETGEILKA 1630 1640 1650 1660 1670 1680 RAGNNRKVLR KCAAVAANKI KLMSDVEENS SSESVCSGRK LPHRNASAVA RKKLLHNSED 1690 1700 1710 1720 1730 1740 EQSLKSEIEE EELKDENQLL PVSSSHTAQS NVDESENRDS ESESDLRVAR KNWHANGYKS 1750 1760 1770 1780 1790 1800 HTPAPSKTKF LKIESSEEDS KSHDSDHACN RTAGPSTSVQ KLKAESISEE ADSEPGRSGG 1810 1820 1830 1840 1850 1860 RKYNTFHKNA SFFKKTKILS DSEDSESEEQ DREDGKCHKM EMNPISGNLN CDPIAMSQCS 1870 1880 1890 1900 1910 1920 SDHGCETDLD SDDDKIEKPN NFMKDSASQD NGLSRKISRK RVCSSDSDSS LQVVKKSSKA 1930 1940 1950 1960 1970 1980 RTGLLRITRR CAATAANKIK LMSDVEDVSL ENVHTRSKNG RKKPLHLACT TAKKKLSDCE 1990 2000 2010 2020 2030 2040 GSVHCEVPSE QYACEGKPPD PDSEGSTKVL SQALNGDSDS EDMLNSEHKH RHTNIHKIDA 2050 2060 2070 2080 2090 2100 PSKRKSSSVT SSGEDSKSHI PGSETDRTFS SESTLAQKAT AENNFEVELN YGLRRWNGRR 2110 2120 2130 2140 2150 2160 LRTYGKAPFS KTKVIHDSQE TAEKEVKRKR SHPELENVKI SETTGNSKFR PDTSSKSSDL 2170 2180 2190 2200 2210 2220 GSVTESDIDC TDNTKTKRRK TKGKAKVVRK EFVPRDREPN TKVRTCMHNQ KDAVQMPSET 2230 2240 2250 2260 2270 2280 LKAKMVPEKV PRRCATVAAN KIKIMSNLKE TISGPENVWI RKSSRKLPHR NASAAAKKKL 2290 2300 2310 2320 LNVYKEDDTT INSESEKELE DINRKMLFLR GFRSWKENAQ
	Isoform B [UniParc]. Checksum: EF2D6F3B745BB4EE	FASTA	2,269	257,238
	10 20 30 40 50 60 MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN 70 80 90 100 110 120 RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH 130 140 150 160 170 180 TVWKGSAFAA LHRGRPPEMP VNYGSPPNLV EIHRGKQLTG CSTFSTAFPG TMYQHIKMHR 190 200 210 220 230 240 RILGHLSAVY CVAFDRTGHR IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN 250 260 270 280 290 300 TMIAAGSCDK IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGSQRYMV STGADGTVCF 310 320 330 340 350 360 WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM YFLGFEAPEK 370 380 390 400 410 420 IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL EWRSILLDMA TRISGDLSSE 430 440 450 460 470 480 EERFMKPKVT MIAWNQNDSI VVTAVNDHVL KVWNSYTGQL LHNLMGHADE VFVLETHPFD 490 500 510 520 530 540 SRIMLSAGHD GSIFIWDITK GTKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL 550 560 570 580 590 600 LIFGFGCSKP YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH 610 620 630 640 650 660 PTKYQRLVPG RENSADEHLI PQLGYVATSD GEVIEQIISL QTNDNDERSP ESSILDGMIR 670 680 690 700 710 720 QLQQQQDQRM GADQDTIPRG LSNGEETPRR GFRRLSLDIQ SPPNIGLRRS GQVEGVRQMH 730 740 750 760 770 780 QNAPRSQIAT ERDLQAWKRR VVVPEVPLGI FRKLEDFRLE KGEEERNLYI IGRKRKTLQL 790 800 810 820 830 840 SHKSDSVVLV SQSRQRTCRR KYPNYGRRNR SWRELSSGNE SSSSVRHETS CDQSEGSGSS 850 860 870 880 890 900 EEDEWRSDRK SESYSESSSD SSSRYSDWTA DAGINLQPPL RTSCRRRITR FCSSSEDEIS 910 920 930 940 950 960 TENLSPPKRR RKRKKENKPK KENLRRMTPA ELANMEHLYE FHPPVWITDT TLRKSPFVPQ 970 980 990 1000 1010 1020 MGDEVIYFRQ GHEAYIEAVR RNNIYELNPN KEPWRKMDLR DQELVKIVGI RYEVGPPTLC 1030 1040 1050 1060 1070 1080 CLKLAFIDPA TGKLMDKSFS IRYHDMPDVI DFLVLRQFYD EARQRNWQSC DRFRSIIDDA 1090 1100 1110 1120 1130 1140 WWFGTVLSQE PYQPQYPDSH FQCYIVRWDN TEIEKLSPWD MEPIPDNVDP PEELGASISV 1150 1160 1170 1180 1190 1200 TTDELEKLLY KPQAGEWGQK SRDEECDRII SGIDQLLNLD IAAAFAGPVD LCTYPKYCTV 1210 1220 1230 1240 1250 1260 VAYPTDLYTI RMRLVNRFYR RLSALVWEVR YIEHNARTFN EPESVIARSA KKITDQLLKF 1270 1280 1290 1300 1310 1320 IKNQHCTNIS ELSNTSENDE QNAEDLDDSD LPKTSSGRRR VHDGKKSIRA TNYVESNWKK 1330 1340 1350 1360 1370 1380 QCKELVNLIF QCEDSEPFRQ PVDLVEYPDY RDIIDTPMDF GTVRETLDAG NYDSPLEFCK 1390 1400 1410 1420 1430 1440 DIRLIFSNAK AYTPNKRSKI YSMTLRLSAL FEEKMKKISS DFKIGQKFNE KLRRSQRFKQ 1450 1460 1470 1480 1490 1500 RQNCKGDSQP NKSIRNLKPK RLKSQTKIIP ELVGSPTQST SSRTAYLGTH KTSAGISSGV 1510 1520 1530 1540 1550 1560 TSGDSSDSAE SSERRKRNRP ITNGSTLSES EVEDSLATSL SSSASSSSEE SKESSRARES 1570 1580 1590 1600 1610 1620 SSRSGLSRSS NLRVTRTRAA QRKTGPVSLA NGCGRKATRK RVYLSDSDNN SLETGEILKA 1630 1640 1650 1660 1670 1680 RAGNNRKVLR KCAAVAANKI KLMSDVEENS SSESVCSGRK LPHRNASAVA RKKLLHNSED 1690 1700 1710 1720 1730 1740 EQSLKSEIEE EELKDENQLL PVSSSHTAQS NVDESENRDS ESESDLRVAR KNWHANGYKS 1750 1760 1770 1780 1790 1800 HTPAPSKTKF LKIESSEEDS KSHDSDHACN RTAGPSTSVQ KLKAESISEE ADSEPGRSGG 1810 1820 1830 1840 1850 1860 RKYNTFHKNA SFFKKTKILS DSEDSESEEQ DREDGKCHKM EMNPISGNLN CDPIAMSQCS 1870 1880 1890 1900 1910 1920 SDHGCETDLD SDDDKIEKPN NFMKDSASQD NGLSRKISRK RVCSSDSDSS LQVVKKSSKA 1930 1940 1950 1960 1970 1980 RTGLLRITRR CAATAANKIK LMSDVEDVSL ENVHTRSKNG RKKPLHLACT TAKKKLSDCE 1990 2000 2010 2020 2030 2040 GSVHCEVPSE QYACEGKPPD PDSEGSTKVL SQALNGDSDS EDMLNSEHKH RHTNIHKIDA 2050 2060 2070 2080 2090 2100 PSKRKSSSVT SSGEDSKSHI PGSETDRTFS SESTLAQKAT AENNFEVELN YGLRRWNGRR 2110 2120 2130 2140 2150 2160 LRTYGKAPFS KTKVIHDSQE TAEKEVKRKR SHPELENVKI SETTGNSKFR PDTSSKSSDL 2170 2180 2190 2200 2210 2220 GSVTESDIDC TDNTKTKRRK TKGKAKVVRK GKTFTANISK TVRRQRQSKR PRLSVDDNDW 2230 2240 2250 2260 EDLDYAKSKR VLRRSKIKTR NQGRRTVRYH DGDDDRSLEN VLDFNGCTL
	Isoform C [UniParc]. Checksum: D0B8757ED0AF6E32	FASTA	2,199	248,953
	10 20 30 40 50 60 MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN 70 80 90 100 110 120 RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH 130 140 150 160 170 180 TVWKGSAFAA LHRGRPPEMP VNYGSPPNLV EIHRGKQLTG CSTFSTAFPG TMYQHIKMHR 190 200 210 220 230 240 RILGHLSAVY CVAFDRTGHR IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN 250 260 270 280 290 300 TMIAAGSCDK IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGSQRYMV STGADGTVCF 310 320 330 340 350 360 WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM YFLGFEAPEK 370 380 390 400 410 420 IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL EWRSILLDMA TRISGDLSSE 430 440 450 460 470 480 EERFMKPKVT MIAWNQNDSI VVTAVNDHVL KVWNSYTGQL LHNLMGHADE VFVLETHPFD 490 500 510 520 530 540 SRIMLSAGHD GSIFIWDITK GTKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL 550 560 570 580 590 600 LIFGFGCSKP YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH 610 620 630 640 650 660 PTKYQRLVPG RENSADEHLI PQLGYVATSD GEVIEQIISL QTNDNDERSP ESSILDGMIR 670 680 690 700 710 720 QLQQQQDQRM GADQDTIPRG LSNGEETPRR GFRRLSLDIQ SPPNIGLRRS GQVEGVRQMH 730 740 750 760 770 780 QNAPRSQIAT ERDLQAWKRR VVVPEVPLGI FRKLEDFRLE KGEEERNLYI IGRKRKTLQL 790 800 810 820 830 840 SHKSDSVVLV SQSRQRTCRR KYPNYGRRNR SWRELSSGNE SSSSVRHETS CDQSEGSGSS 850 860 870 880 890 900 EEDEWRSDRK SESYSESSSD SSSRYSDWTA DAGINLQPPL RTSCRRRITR FCSSSEDEIS 910 920 930 940 950 960 TENLSPPKRR RKRKKENKPK KENLRRMTPA ELANMEHLYE FHPPVWITDT TLRKSPFVPQ 970 980 990 1000 1010 1020 MGDEVIYFRQ GHEAYIEAVR RNNIYELNPN KEPWRKMDLR DQELVKIVGI RYEVGPPTLC 1030 1040 1050 1060 1070 1080 CLKLAFIDPA TGKLMDKSFS IRYHDMPDVI DFLVLRQFYD EARQRNWQSC DRFRSIIDDA 1090 1100 1110 1120 1130 1140 WWFGTVLSQE PYQPQYPDSH FQCYIVRWDN TEIEKLSPWD MEPIPDNVDP PEELGASISV 1150 1160 1170 1180 1190 1200 TTDELEKLLY KPQAGEWGQK SRDEECDRII SGIDQLLNLD IAAAFAGPVD LCTYPKYCTV 1210 1220 1230 1240 1250 1260 VAYPTDLYTI RMRLVNRFYR RLSALVWEVR YIEHNARTFN EPESVIARSA KKITDQLLKF 1270 1280 1290 1300 1310 1320 IKNQHCTNIS ELSNTSENDE QNAEDLDDSD LPKTSSGRRR VHDGKKSIRA TNYVESNWKK 1330 1340 1350 1360 1370 1380 QCKELVNLIF QCEDSEPFRQ PVDLVEYPDY RDIIDTPMDF GTVRETLDAG NYDSPLEFCK 1390 1400 1410 1420 1430 1440 DIRLIFSNAK AYTPNKRSKI YSMTLRLSAL FEEKMKKISS DFKIGQKFNE KLRRSQRFKQ 1450 1460 1470 1480 1490 1500 RQNCKGDSQP NKSIRNLKPK RLKSQTKIIP ELVGSPTQST SSRTAYLGTH KTSAGISSGV 1510 1520 1530 1540 1550 1560 TSGDSSDSAE SSERRKRNRP ITNGSTLSES EVEDSLATSL SSSASSSSEE SKESSRARES 1570 1580 1590 1600 1610 1620 SSRSGLSRSS NLRVTRTRAA QRKTGPVSLA NGCGRKATRK RVYLSDSDNN SLETGEILKA 1630 1640 1650 1660 1670 1680 RAGNNRKVLR KCAAVAANKI KLMSDVEENS SSESVCSGRK LPHRNASAVA RKKLLHNSED 1690 1700 1710 1720 1730 1740 EQSLKSEIEE EELKDENQLL PVSSSHTAQS NVDESENRDS ESESDLRVAR KNWHANGYKS 1750 1760 1770 1780 1790 1800 HTPAPSKTKF LKIESSEEDS KSHDSDHACN RTAGPSTSVQ KLKAESISEE ADSEPGRSGG 1810 1820 1830 1840 1850 1860 RKYNTFHKNA SFFKKTKILS DSEDSESEEQ DREDGKCHKM EMNPISGNLN CDPIAMSQCS 1870 1880 1890 1900 1910 1920 SDHGCETDLD SDDDKIEKPN NFMKDSASQD NGLSRKISRK RVCSSDSDSS LQVVKKSSKA 1930 1940 1950 1960 1970 1980 RTGLLRITRR CAATAANKIK LMSDVEDVSL ENVHTRSKNG RKKPLHLACT TAKKKLSDCE 1990 2000 2010 2020 2030 2040 GSVHCEVPSE QYACEGKPPD PDSEGSTKVL SQALNGDSDS EDMLNSEHKH RHTNIHKIDA 2050 2060 2070 2080 2090 2100 PSKRKSSSVT SSGEDSKSHI PGSETDRTFS SESTLAQKAT AENNFEVELN YGLRRWNGRR 2110 2120 2130 2140 2150 2160 LRTYGKAPFS KTKVIHDSQE TAEKEVKRKR SHPELENVKI SETTGNSKFR PDTSSKSSDL 2170 2180 2190 GSVTESDIDC TDNTKTKRRK TKGKAKVVRK DKTFSPVYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21." Ramos V.C., Vidal-Taboada J.M., Bergonon S., Egeo A., Fisher E.M.C., Scartezzini P., Oliva R. Biochim. Biophys. Acta 1577:377-383(2002) [PubMed: 12359327] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), TISSUE SPECIFICITY, VARIANT PRO-1699.
[2]	"Isolation and characterization of a new chromosome 21 gene, WDR9, with different alternatively spliced transcripts and different protein forms." Scott H.S., Barras C., Mittaz L., Michaud J., Guidi S., Scamuffa N., Antonarakis S. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), VARIANTS PRO-1511 AND PRO-1699.
[3]	"Isolation of WDR9 cDNA on human chromosome 21q22.3." Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C), VARIANTS GLU-83 AND PRO-1699. Tissue: Pancreas.
[4]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2." Vidal-Taboada J.M., Bergonon S., Sanchez M., Lopez-Acedo C., Groet J., Nizetic D., Egeo A., Scartezzini P., Katsanis N., Fisher E.M.C., Delabar J.-M., Oliva R. Biochem. Biophys. Res. Commun. 243:572-578(1998) [PubMed: 9480850] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1560-1779, VARIANT PRO-1699. Tissue: Fetal heart.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1645-2320 (ISOFORM B), VARIANT PRO-1699. Tissue: Placenta.
[7]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-418 AND SER-791, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-696; SER-701; THR-1275; SER-1289; SER-1605; SER-1607; SER-1786; SER-1788; SER-1793; SER-1904; SER-1905; SER-1907; SER-1910; SER-2018 AND SER-2020, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1475; SER-1605; SER-1607; SER-2018 AND SER-2020, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration." Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J. BMC Biol. 9:54-54(2011) [PubMed: 21834987] [Abstract] Cited for: FUNCTION.
[11]	"Crystal structure of the second bromodomain of human bromodomain and WD repeat-containing protein 1 isoform A (WDR9)." Structural genomics consortium (SGC) Submitted (FEB-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 1310-1430.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ238214 mRNA. Translation: CAC37033.2.
AJ292465 mRNA. Translation: CAC44371.1.
AJ292466 mRNA. Translation: CAC44372.1.
AB080586 mRNA. Translation: BAD74071.1.
AB080587 mRNA. Translation: BAD74072.1.
AF064861 Genomic DNA. No translation available.
AF129408 Genomic DNA. No translation available.
AL163279 Genomic DNA. Translation: CAB90452.1.
AJ222636 mRNA. Translation: CAA10896.1. Frameshift.
AK002177 mRNA. No translation available.

IPI

IPI00250716.
IPI00289944.
IPI00746752.

RefSeq

NP_061836.2. NM_018963.4.
NP_387505.1. NM_033656.3.

UniGene

Hs.627139.
Hs.654740.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3Q2E	X-ray	1.74	A	1310-1430	[»]

ProteinModelPortal

Q9NSI6.

SMR

Q9NSI6. Positions 1317-1423.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9NSI6. 4 interactions.

STRING

Q9NSI6.

Polymorphism databases

DMDM

97535778.

Proteomic databases

PRIDE

Q9NSI6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000333229; ENSP00000330753; ENSG00000185658.

GeneID

54014.

KEGG

hsa:54014.

UCSC

uc002yxk.1. human.
uc002yxl.1. human.

Organism-specific databases

CTD

54014.

GeneCards

GC21M040556.

HGNC

HGNC:12760. BRWD1.

HPA

HPA030945.

neXtProt

NX_Q9NSI6.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG07767.

GeneTree

ENSGT00390000010788.

HOVERGEN

HBG080933.

InParanoid

Q9NSI6.

OMA

SIQFCNN.

OrthoDB

EOG470TGD.

PhylomeDB

Q9NSI6.

Gene expression databases

ArrayExpress

Q9NSI6.

Bgee

Q9NSI6.

CleanEx

HS_BRWD1.

Genevestigator

Q9NSI6.

GermOnline

ENSG00000185658. Homo sapiens.

Family and domain databases

InterPro

IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]

Gene3D

G3DSA:1.20.920.10. Bromodomain. 3 hits.
G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.

KO

K11798.

Pfam

PF00439. Bromodomain. 2 hits.
PF00400. WD40. 8 hits.
[Graphical view]

PRINTS

PR00503. BROMODOMAIN.

SMART

SM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view]

SUPFAM

SSF47370. Bromodomain. 2 hits.
SSF50978. WD40_like. 1 hit.

PROSITE

PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

56274.

Entry information

Entry name

BRWD1_HUMAN

Accession

Primary (citable) accession number: Q9NSI6
Secondary accession number(s): C9JK25 , O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 30, 2010
Last modified:	January 25, 2012
This is version 119 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.