Reviewed, UniProtKB/Swiss-Prot Q9NSI6 (BRWD1_HUMAN)

Names and origin

Protein names

Recommended name:
    Bromodomain and WD repeat-containing protein 1
Alternative name(s):
    WD repeat-containing protein 9

Gene names

Name:	BRWD1
Synonyms:	C21orf107, WDR9

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be a transcriptional activator. May be involved in chromatin remodeling By similarity.
Subunit structure	Interacts with SMARCA4 By similarity.
Subcellular location	Cytoplasm. Nucleus By similarity.
Tissue specificity	Ubiquitously expressed. Ref.1
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.
Sequence similarities	Contains 2 bromo domains. Contains 8 WD repeats.
Sequence caution	The sequence CAA10896.1 differs from that shown. Reason: Frameshift at positions 1762 and 1770.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Bromodomain Repeat WD repeat
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9NSI6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9NSI6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2191-2320: EFVPRDREPN...GFRSWKENAQ → GKTFTANISK...NVLDFNGCTL

Isoform C (identifier: Q9NSI6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2191-2285: EFVPRDREPN...AKKKLLNVYK → DKTFSPVYL
     2286-2320: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2320	2320	Bromodomain and WD repeat-containing protein 1		PRO_0000050888
Regions
	Repeat	184 – 223	40	WD 1
	Repeat	226 – 265	40	WD 2
	Repeat	268 – 311	44	WD 3
	Repeat	322 – 365	44	WD 4
	Repeat	366 – 405	40	WD 5
	Repeat	424 – 463	40	WD 6
	Repeat	466 – 506	41	WD 7
	Repeat	514 – 553	40	WD 8
	Domain	1177 – 1247	71	Bromo 1
	Domain	1330 – 1400	71	Bromo 2
	Compositional bias	661 – 668	8	Poly-Gln
	Compositional bias	821 – 824	4	Poly-Ser
	Compositional bias	1539 – 1548	10	Poly-Ser
	Compositional bias	1687 – 1692	6	Poly-Glu
Amino acid modifications
	Modified residue	418	1	Phosphoserine Ref.7
	Modified residue	696	1	Phosphoserine Ref.8
	Modified residue	701	1	Phosphoserine Ref.8
	Modified residue	791	1	Phosphoserine Ref.7
	Modified residue	1275	1	Phosphothreonine Ref.8
	Modified residue	1289	1	Phosphoserine Ref.8
	Modified residue	1475	1	Phosphoserine
	Modified residue	1605	1	Phosphoserine Ref.8
	Modified residue	1607	1	Phosphoserine Ref.8
	Modified residue	1755	1	Phosphoserine By similarity
	Modified residue	1756	1	Phosphoserine By similarity
	Modified residue	1786	1	Phosphoserine Ref.8
	Modified residue	1788	1	Phosphoserine Ref.8
	Modified residue	1793	1	Phosphoserine Ref.8
	Modified residue	1904	1	Phosphoserine Ref.8
	Modified residue	1905	1	Phosphoserine Ref.8
	Modified residue	1907	1	Phosphoserine Ref.8
	Modified residue	1910	1	Phosphoserine Ref.8
	Modified residue	2018	1	Phosphoserine Ref.8
	Modified residue	2020	1	Phosphoserine Ref.8
	Modified residue	2052	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	2191 – 2320	130	EFVPR…KENAQ → GKTFTANISKTVRRQRQSKR PRLSVDDNDWEDLDYAKSKR VLRRSKIKTRNQGRRTVRYH DGDDDRSLENVLDFNGCTL in isoform B.		VSP_018526
	Alternative sequence	2191 – 2285	95	EFVPR…LNVYK → DKTFSPVYL in isoform C.		VSP_018527
	Alternative sequence	2286 – 2320	35	Missing in isoform C.		VSP_018528
	Natural variant	83	1	Q → E: dbSNP rs2056844. Ref.3		VAR_026435
	Natural variant	1511	1	S → P: dbSNP rs2183573. Ref.2		VAR_026436
	Natural variant	1699	1	P → L: dbSNP rs1041439. Ref.4 Ref.6		VAR_026437
	Natural variant	2156	1	K → R: dbSNP rs2234548.		VAR_057584
Experimental info
	Sequence conflict	1560 – 1562	3	SSS → GTR in CAA10896. Ref.5
	Sequence conflict	1840	1	M → V in AK002177. Ref.6
	Sequence conflict	2134	1	E → G in AK002177. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified May 16, 2006. Version 3. Checksum: 8DD714D1A3878254	FASTA	2,320	262,920
	10 20 30 40 50 60 MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN 70 80 90 100 110 120 RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH 130 140 150 160 170 180 TVWKGSAFAA LHRGRPPEMP VNYGSPPNLV EIHRGKQLTG CSTFSTAFPG TMYQHIKMHR 190 200 210 220 230 240 RILGHLSAVY CVAFDRTGHR IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN 250 260 270 280 290 300 TMIAAGSCDK IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGSQRYMV STGADGTVCF 310 320 330 340 350 360 WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM YFLGFEAPEK 370 380 390 400 410 420 IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL EWRSILLDMA TRISGDLSSE 430 440 450 460 470 480 EERFMKPKVT MIAWNQNDSI VVTAVNDHVL KVWNSYTGQL LHNLMGHADE VFVLETHPFD 490 500 510 520 530 540 SRIMLSAGHD GSIFIWDITK GTKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL 550 560 570 580 590 600 LIFGFGCSKP YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH 610 620 630 640 650 660 PTKYQRLVPG RENSADEHLI PQLGYVATSD GEVIEQIISL QTNDNDERSP ESSILDGMIR 670 680 690 700 710 720 QLQQQQDQRM GADQDTIPRG LSNGEETPRR GFRRLSLDIQ SPPNIGLRRS GQVEGVRQMH 730 740 750 760 770 780 QNAPRSQIAT ERDLQAWKRR VVVPEVPLGI FRKLEDFRLE KGEEERNLYI IGRKRKTLQL 790 800 810 820 830 840 SHKSDSVVLV SQSRQRTCRR KYPNYGRRNR SWRELSSGNE SSSSVRHETS CDQSEGSGSS 850 860 870 880 890 900 EEDEWRSDRK SESYSESSSD SSSRYSDWTA DAGINLQPPL RTSCRRRITR FCSSSEDEIS 910 920 930 940 950 960 TENLSPPKRR RKRKKENKPK KENLRRMTPA ELANMEHLYE FHPPVWITDT TLRKSPFVPQ 970 980 990 1000 1010 1020 MGDEVIYFRQ GHEAYIEAVR RNNIYELNPN KEPWRKMDLR DQELVKIVGI RYEVGPPTLC 1030 1040 1050 1060 1070 1080 CLKLAFIDPA TGKLMDKSFS IRYHDMPDVI DFLVLRQFYD EARQRNWQSC DRFRSIIDDA 1090 1100 1110 1120 1130 1140 WWFGTVLSQE PYQPQYPDSH FQCYIVRWDN TEIEKLSPWD MEPIPDNVDP PEELGASISV 1150 1160 1170 1180 1190 1200 TTDELEKLLY KPQAGEWGQK SRDEECDRII SGIDQLLNLD IAAAFAGPVD LCTYPKYCTV 1210 1220 1230 1240 1250 1260 VAYPTDLYTI RMRLVNRFYR RLSALVWEVR YIEHNARTFN EPESVIARSA KKITDQLLKF 1270 1280 1290 1300 1310 1320 IKNQHCTNIS ELSNTSENDE QNAEDLDDSD LPKTSSGRRR VHDGKKSIRA TNYVESNWKK 1330 1340 1350 1360 1370 1380 QCKELVNLIF QCEDSEPFRQ PVDLVEYPDY RDIIDTPMDF GTVRETLDAG NYDSPLEFCK 1390 1400 1410 1420 1430 1440 DIRLIFSNAK AYTPNKRSKI YSMTLRLSAL FEEKMKKISS DFKIGQKFNE KLRRSQRFKQ 1450 1460 1470 1480 1490 1500 RQNCKGDSQP NKSIRNLKPK RLKSQTKIIP ELVGSPTQST SSRTAYLGTH KTSAGISSGV 1510 1520 1530 1540 1550 1560 TSGDSSDSAE SSERRKRNRP ITNGSTLSES EVEDSLATSL SSSASSSSEE SKESSRARES 1570 1580 1590 1600 1610 1620 SSRSGLSRSS NLRVTRTRAA QRKTGPVSLA NGCGRKATRK RVYLSDSDNN SLETGEILKA 1630 1640 1650 1660 1670 1680 RAGNNRKVLR KCAAVAANKI KLMSDVEENS SSESVCSGRK LPHRNASAVA RKKLLHNSED 1690 1700 1710 1720 1730 1740 EQSLKSEIEE EELKDENQPL PVSSSHTAQS NVDESENRDS ESESDLRVAR KNWHANGYKS 1750 1760 1770 1780 1790 1800 HTPAPSKTKF LKIESSEEDS KSHDSDHACN RTAGPSTSVQ KLKAESISEE ADSEPGRSGG 1810 1820 1830 1840 1850 1860 RKYNTFHKNA SFFKKTKILS DSEDSESEEQ DREDGKCHKM EMNPISGNLN CDPIAMSQCS 1870 1880 1890 1900 1910 1920 SDHGCETDLD SDDDKIEKPN NFMKDSASQD NGLSRKISRK RVCSSDSDSS LQVVKKSSKA 1930 1940 1950 1960 1970 1980 RTGLLRITRR CAATAANKIK LMSDVEDVSL ENVHTRSKNG RKKPLHLACT TAKKKLSDCE 1990 2000 2010 2020 2030 2040 GSVHCEVPSE QYACEGKPPD PDSEGSTKVL SQALNGDSDS EDMLNSEHKH RHTNIHKIDA 2050 2060 2070 2080 2090 2100 PSKRKSSSVT SSGEDSKSHI PGSETDRTFS SESTLAQKAT AENNFEVELN YGLRRWNGRR 2110 2120 2130 2140 2150 2160 LRTYGKAPFS KTKVIHDSQE TAEKEVKRKR SHPELENVKI SETTGNSKFR PDTSSKSSDL 2170 2180 2190 2200 2210 2220 GSVTESDIDC TDNTKTKRRK TKGKAKVVRK EFVPRDREPN TKVRTCMHNQ KDAVQMPSET 2230 2240 2250 2260 2270 2280 LKAKMVPEKV PRRCATVAAN KIKIMSNLKE TISGPENVWI RKSSRKLPHR NASAAAKKKL 2290 2300 2310 2320 LNVYKEDDTT INSESEKELE DINRKMLFLR GFRSWKENAQ
	Isoform B. Checksum: 276D6ABE68C231F2	FASTA	2,269	257,222
	10 20 30 40 50 60 MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN 70 80 90 100 110 120 RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH 130 140 150 160 170 180 TVWKGSAFAA LHRGRPPEMP VNYGSPPNLV EIHRGKQLTG CSTFSTAFPG TMYQHIKMHR 190 200 210 220 230 240 RILGHLSAVY CVAFDRTGHR IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN 250 260 270 280 290 300 TMIAAGSCDK IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGSQRYMV STGADGTVCF 310 320 330 340 350 360 WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM YFLGFEAPEK 370 380 390 400 410 420 IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL EWRSILLDMA TRISGDLSSE 430 440 450 460 470 480 EERFMKPKVT MIAWNQNDSI VVTAVNDHVL KVWNSYTGQL LHNLMGHADE VFVLETHPFD 490 500 510 520 530 540 SRIMLSAGHD GSIFIWDITK GTKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL 550 560 570 580 590 600 LIFGFGCSKP YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH 610 620 630 640 650 660 PTKYQRLVPG RENSADEHLI PQLGYVATSD GEVIEQIISL QTNDNDERSP ESSILDGMIR 670 680 690 700 710 720 QLQQQQDQRM GADQDTIPRG LSNGEETPRR GFRRLSLDIQ SPPNIGLRRS GQVEGVRQMH 730 740 750 760 770 780 QNAPRSQIAT ERDLQAWKRR VVVPEVPLGI FRKLEDFRLE KGEEERNLYI IGRKRKTLQL 790 800 810 820 830 840 SHKSDSVVLV SQSRQRTCRR KYPNYGRRNR SWRELSSGNE SSSSVRHETS CDQSEGSGSS 850 860 870 880 890 900 EEDEWRSDRK SESYSESSSD SSSRYSDWTA DAGINLQPPL RTSCRRRITR FCSSSEDEIS 910 920 930 940 950 960 TENLSPPKRR RKRKKENKPK KENLRRMTPA ELANMEHLYE FHPPVWITDT TLRKSPFVPQ 970 980 990 1000 1010 1020 MGDEVIYFRQ GHEAYIEAVR RNNIYELNPN KEPWRKMDLR DQELVKIVGI RYEVGPPTLC 1030 1040 1050 1060 1070 1080 CLKLAFIDPA TGKLMDKSFS IRYHDMPDVI DFLVLRQFYD EARQRNWQSC DRFRSIIDDA 1090 1100 1110 1120 1130 1140 WWFGTVLSQE PYQPQYPDSH FQCYIVRWDN TEIEKLSPWD MEPIPDNVDP PEELGASISV 1150 1160 1170 1180 1190 1200 TTDELEKLLY KPQAGEWGQK SRDEECDRII SGIDQLLNLD IAAAFAGPVD LCTYPKYCTV 1210 1220 1230 1240 1250 1260 VAYPTDLYTI RMRLVNRFYR RLSALVWEVR YIEHNARTFN EPESVIARSA KKITDQLLKF 1270 1280 1290 1300 1310 1320 IKNQHCTNIS ELSNTSENDE QNAEDLDDSD LPKTSSGRRR VHDGKKSIRA TNYVESNWKK 1330 1340 1350 1360 1370 1380 QCKELVNLIF QCEDSEPFRQ PVDLVEYPDY RDIIDTPMDF GTVRETLDAG NYDSPLEFCK 1390 1400 1410 1420 1430 1440 DIRLIFSNAK AYTPNKRSKI YSMTLRLSAL FEEKMKKISS DFKIGQKFNE KLRRSQRFKQ 1450 1460 1470 1480 1490 1500 RQNCKGDSQP NKSIRNLKPK RLKSQTKIIP ELVGSPTQST SSRTAYLGTH KTSAGISSGV 1510 1520 1530 1540 1550 1560 TSGDSSDSAE SSERRKRNRP ITNGSTLSES EVEDSLATSL SSSASSSSEE SKESSRARES 1570 1580 1590 1600 1610 1620 SSRSGLSRSS NLRVTRTRAA QRKTGPVSLA NGCGRKATRK RVYLSDSDNN SLETGEILKA 1630 1640 1650 1660 1670 1680 RAGNNRKVLR KCAAVAANKI KLMSDVEENS SSESVCSGRK LPHRNASAVA RKKLLHNSED 1690 1700 1710 1720 1730 1740 EQSLKSEIEE EELKDENQPL PVSSSHTAQS NVDESENRDS ESESDLRVAR KNWHANGYKS 1750 1760 1770 1780 1790 1800 HTPAPSKTKF LKIESSEEDS KSHDSDHACN RTAGPSTSVQ KLKAESISEE ADSEPGRSGG 1810 1820 1830 1840 1850 1860 RKYNTFHKNA SFFKKTKILS DSEDSESEEQ DREDGKCHKM EMNPISGNLN CDPIAMSQCS 1870 1880 1890 1900 1910 1920 SDHGCETDLD SDDDKIEKPN NFMKDSASQD NGLSRKISRK RVCSSDSDSS LQVVKKSSKA 1930 1940 1950 1960 1970 1980 RTGLLRITRR CAATAANKIK LMSDVEDVSL ENVHTRSKNG RKKPLHLACT TAKKKLSDCE 1990 2000 2010 2020 2030 2040 GSVHCEVPSE QYACEGKPPD PDSEGSTKVL SQALNGDSDS EDMLNSEHKH RHTNIHKIDA 2050 2060 2070 2080 2090 2100 PSKRKSSSVT SSGEDSKSHI PGSETDRTFS SESTLAQKAT AENNFEVELN YGLRRWNGRR 2110 2120 2130 2140 2150 2160 LRTYGKAPFS KTKVIHDSQE TAEKEVKRKR SHPELENVKI SETTGNSKFR PDTSSKSSDL 2170 2180 2190 2200 2210 2220 GSVTESDIDC TDNTKTKRRK TKGKAKVVRK GKTFTANISK TVRRQRQSKR PRLSVDDNDW 2230 2240 2250 2260 EDLDYAKSKR VLRRSKIKTR NQGRRTVRYH DGDDDRSLEN VLDFNGCTL
	Isoform C. Checksum: A0B8757ED6977B67	FASTA	2,199	248,937
	10 20 30 40 50 60 MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN 70 80 90 100 110 120 RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH 130 140 150 160 170 180 TVWKGSAFAA LHRGRPPEMP VNYGSPPNLV EIHRGKQLTG CSTFSTAFPG TMYQHIKMHR 190 200 210 220 230 240 RILGHLSAVY CVAFDRTGHR IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN 250 260 270 280 290 300 TMIAAGSCDK IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGSQRYMV STGADGTVCF 310 320 330 340 350 360 WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM YFLGFEAPEK 370 380 390 400 410 420 IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL EWRSILLDMA TRISGDLSSE 430 440 450 460 470 480 EERFMKPKVT MIAWNQNDSI VVTAVNDHVL KVWNSYTGQL LHNLMGHADE VFVLETHPFD 490 500 510 520 530 540 SRIMLSAGHD GSIFIWDITK GTKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL 550 560 570 580 590 600 LIFGFGCSKP YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH 610 620 630 640 650 660 PTKYQRLVPG RENSADEHLI PQLGYVATSD GEVIEQIISL QTNDNDERSP ESSILDGMIR 670 680 690 700 710 720 QLQQQQDQRM GADQDTIPRG LSNGEETPRR GFRRLSLDIQ SPPNIGLRRS GQVEGVRQMH 730 740 750 760 770 780 QNAPRSQIAT ERDLQAWKRR VVVPEVPLGI FRKLEDFRLE KGEEERNLYI IGRKRKTLQL 790 800 810 820 830 840 SHKSDSVVLV SQSRQRTCRR KYPNYGRRNR SWRELSSGNE SSSSVRHETS CDQSEGSGSS 850 860 870 880 890 900 EEDEWRSDRK SESYSESSSD SSSRYSDWTA DAGINLQPPL RTSCRRRITR FCSSSEDEIS 910 920 930 940 950 960 TENLSPPKRR RKRKKENKPK KENLRRMTPA ELANMEHLYE FHPPVWITDT TLRKSPFVPQ 970 980 990 1000 1010 1020 MGDEVIYFRQ GHEAYIEAVR RNNIYELNPN KEPWRKMDLR DQELVKIVGI RYEVGPPTLC 1030 1040 1050 1060 1070 1080 CLKLAFIDPA TGKLMDKSFS IRYHDMPDVI DFLVLRQFYD EARQRNWQSC DRFRSIIDDA 1090 1100 1110 1120 1130 1140 WWFGTVLSQE PYQPQYPDSH FQCYIVRWDN TEIEKLSPWD MEPIPDNVDP PEELGASISV 1150 1160 1170 1180 1190 1200 TTDELEKLLY KPQAGEWGQK SRDEECDRII SGIDQLLNLD IAAAFAGPVD LCTYPKYCTV 1210 1220 1230 1240 1250 1260 VAYPTDLYTI RMRLVNRFYR RLSALVWEVR YIEHNARTFN EPESVIARSA KKITDQLLKF 1270 1280 1290 1300 1310 1320 IKNQHCTNIS ELSNTSENDE QNAEDLDDSD LPKTSSGRRR VHDGKKSIRA TNYVESNWKK 1330 1340 1350 1360 1370 1380 QCKELVNLIF QCEDSEPFRQ PVDLVEYPDY RDIIDTPMDF GTVRETLDAG NYDSPLEFCK 1390 1400 1410 1420 1430 1440 DIRLIFSNAK AYTPNKRSKI YSMTLRLSAL FEEKMKKISS DFKIGQKFNE KLRRSQRFKQ 1450 1460 1470 1480 1490 1500 RQNCKGDSQP NKSIRNLKPK RLKSQTKIIP ELVGSPTQST SSRTAYLGTH KTSAGISSGV 1510 1520 1530 1540 1550 1560 TSGDSSDSAE SSERRKRNRP ITNGSTLSES EVEDSLATSL SSSASSSSEE SKESSRARES 1570 1580 1590 1600 1610 1620 SSRSGLSRSS NLRVTRTRAA QRKTGPVSLA NGCGRKATRK RVYLSDSDNN SLETGEILKA 1630 1640 1650 1660 1670 1680 RAGNNRKVLR KCAAVAANKI KLMSDVEENS SSESVCSGRK LPHRNASAVA RKKLLHNSED 1690 1700 1710 1720 1730 1740 EQSLKSEIEE EELKDENQPL PVSSSHTAQS NVDESENRDS ESESDLRVAR KNWHANGYKS 1750 1760 1770 1780 1790 1800 HTPAPSKTKF LKIESSEEDS KSHDSDHACN RTAGPSTSVQ KLKAESISEE ADSEPGRSGG 1810 1820 1830 1840 1850 1860 RKYNTFHKNA SFFKKTKILS DSEDSESEEQ DREDGKCHKM EMNPISGNLN CDPIAMSQCS 1870 1880 1890 1900 1910 1920 SDHGCETDLD SDDDKIEKPN NFMKDSASQD NGLSRKISRK RVCSSDSDSS LQVVKKSSKA 1930 1940 1950 1960 1970 1980 RTGLLRITRR CAATAANKIK LMSDVEDVSL ENVHTRSKNG RKKPLHLACT TAKKKLSDCE 1990 2000 2010 2020 2030 2040 GSVHCEVPSE QYACEGKPPD PDSEGSTKVL SQALNGDSDS EDMLNSEHKH RHTNIHKIDA 2050 2060 2070 2080 2090 2100 PSKRKSSSVT SSGEDSKSHI PGSETDRTFS SESTLAQKAT AENNFEVELN YGLRRWNGRR 2110 2120 2130 2140 2150 2160 LRTYGKAPFS KTKVIHDSQE TAEKEVKRKR SHPELENVKI SETTGNSKFR PDTSSKSSDL 2170 2180 2190 GSVTESDIDC TDNTKTKRRK TKGKAKVVRK DKTFSPVYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21." Ramos V.C., Vidal-Taboada J.M., Bergonon S., Egeo A., Fisher E.M.C., Scartezzini P., Oliva R. Biochim. Biophys. Acta 1577:377-383(2002) [PubMed: 12359327] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), TISSUE SPECIFICITY.
[2]	"Isolation and characterization of a new chromosome 21 gene, WDR9, with different alternatively spliced transcripts and different protein forms." Scott H.S., Barras C., Mittaz L., Michaud J., Guidi S., Scamuffa N., Antonarakis S. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), VARIANT PRO-1511.
[3]	"Isolation of WDR9 cDNA on human chromosome 21q22.3." Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C), VARIANT GLU-83. Tissue: Pancreas.
[4]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-1699.
[5]	"High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2." Vidal-Taboada J.M., Bergonon S., Sanchez M., Lopez-Acedo C., Groet J., Nizetic D., Egeo A., Scartezzini P., Katsanis N., Fisher E.M.C., Delabar J.-M., Oliva R. Biochem. Biophys. Res. Commun. 243:572-578(1998) [PubMed: 9480850] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1560-1779. Tissue: Fetal heart.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1645-2320 (ISOFORM B), VARIANT LEU-1699. Tissue: Placenta.
[7]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-418 AND SER-791, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-696; SER-701; THR-1275; SER-1289; SER-1605; SER-1607; SER-1786; SER-1788; SER-1793; SER-1904; SER-1905; SER-1907; SER-1910; SER-2018 AND SER-2020, MASS SPECTROMETRY.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1475; SER-1605; SER-1607; SER-2018 AND SER-2020, MASS SPECTROMETRY. Tissue: T-cell.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ238214 mRNA. Translation: CAC37033.2. AJ292465 mRNA. Translation: CAC44371.1. AJ292466 mRNA. Translation: CAC44372.1. AB080586 mRNA. Translation: BAD74071.1. AB080587 mRNA. Translation: BAD74072.1. AL163279 Genomic DNA. Translation: CAB90452.1. AJ222636 mRNA. Translation: CAA10896.1. Frameshift. AK002177 mRNA. No translation available.
IPI	IPI00250716. IPI00289944. IPI00746752.
RefSeq	NP_061836.2. NP_387505.1.
UniGene	Hs.654740
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NSI6.
Proteomic databases
PRIDE	Q9NSI6.
Genome annotation databases
Ensembl	ENST00000333229; ENSP00000330753; ENSG00000185658; Homo sapiens. [Genome view]
GeneID	54014.
UCSC	uc002yxk.1. human. uc002yxl.1. human.
Organism-specific databases
CTD	54014.
GeneCards	GC21M039480.
H-InvDB	HIX0016115.
HGNC	HGNC:12760. BRWD1.
PharmGKB	PA134906879.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9NSI6.
InParanoid	Q9NSI6.
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000013602-MON.
Gene expression databases
ArrayExpress	Q9NSI6.
Bgee	Q9NSI6.
CleanEx	HS_BRWD1.
Genevestigator	Q9NSI6.
GermOnline	ENSG00000185658. Homo sapiens.
Family and domain databases
InterPro	IPR001487. Bromodomain. IPR018359. Bromodomain_CS. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:1.20.920.10. Bromodomain. 2 hits. G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
Pfam	PF00439. Bromodomain. 2 hits. PF00400. WD40. 6 hits. [Graphical view]
PRINTS	PR00503. BROMODOMAIN.
SMART	SM00297. BROMO. 2 hits. SM00320. WD40. 8 hits. [Graphical view]
PROSITE	PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 2 hits. PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	56274.

Entry information

Entry name

BRWD1_HUMAN

Accession

Primary (citable) accession number: Q9NSI6
Secondary accession number(s): O43721 , Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 16, 2006
Last modified:	December 15, 2009
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.