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Protein

Protein FAM207A

Gene

FAM207A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM207A
Gene namesi
Name:FAM207A
Synonyms:C21orf70
ORF Names:PRED56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160256.12
HGNCiHGNC:15811 FAM207A
neXtProtiNX_Q9NSI2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160256
PharmGKBiPA25865

Polymorphism and mutation databases

BioMutaiFAM207A
DMDMi17865450

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000795281 – 230Protein FAM207AAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphothreonineCombined sources1
Modified residuei203PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NSI2
MaxQBiQ9NSI2
PaxDbiQ9NSI2
PeptideAtlasiQ9NSI2
PRIDEiQ9NSI2
ProteomicsDBi82552
82553 [Q9NSI2-2]

PTM databases

iPTMnetiQ9NSI2
PhosphoSitePlusiQ9NSI2

Expressioni

Tissue specificityi

Not detected in any tested tissue.

Gene expression databases

BgeeiENSG00000160256
CleanExiHS_C21orf70
ExpressionAtlasiQ9NSI2 baseline and differential
GenevisibleiQ9NSI2 HS

Organism-specific databases

HPAiCAB034178
HPA036354

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-5457304,EBI-618309

Protein-protein interaction databases

BioGridi124511, 22 interactors
IntActiQ9NSI2, 10 interactors
MINTiQ9NSI2

Structurei

3D structure databases

ProteinModelPortaliQ9NSI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi133 – 136Poly-Arg4

Sequence similaritiesi

Belongs to the FAM207 family.Curated

Phylogenomic databases

eggNOGiENOG410IYMW Eukaryota
ENOG410XY31 LUCA
GeneTreeiENSGT00390000015709
HOGENOMiHOG000010293
HOVERGENiHBG051241
InParanoidiQ9NSI2
OMAiRERWLNK
OrthoDBiEOG091G1AV7
PhylomeDBiQ9NSI2
TreeFamiTF336348

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q9NSI2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKVRGLRAR VHQAAVRPKG EAAPGPAPPA PEATPPPASA AGKDWAFINT
60 70 80 90 100
NIFARTKIDP SALVQKLELD VRSVTSVRRG EAGSSARSVP SIRRGAEAKT
110 120 130 140 150
VLPKKEKMKL RREQWLQKIE AIKLAEQKHR EERRRRATVV VGDLHPLRDA
160 170 180 190 200
LPELLGLEAG SRRQARSRES NKPRPSELSR MSAAQRQQLL EEERTRFQEL
210 220 230
LASPAYRASP LVAIGQTLAR QMQLEDGGQL
Length:230
Mass (Da):25,456
Last modified:December 13, 2001 - v2
Checksum:iBC7D211C02EA0C89
GO
Isoform B (identifier: Q9NSI2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-95: Missing.

Show »
Length:215
Mass (Da):23,945
Checksum:i88C97E7CB9537DF6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021949212V → L. Corresponds to variant dbSNP:rs3737075Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00383181 – 95Missing in isoform B. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391113 mRNA Translation: AAL34504.1
AF391114 mRNA Translation: AAL34505.1
AL163301 Genomic DNA Translation: CAB90492.1 Sequence problems.
BC009341 mRNA Translation: AAH09341.1
CCDSiCCDS13718.1 [Q9NSI2-1]
CCDS82682.1 [Q9NSI2-2]
RefSeqiNP_001303912.1, NM_001316983.1
NP_001303913.1, NM_001316984.1 [Q9NSI2-2]
NP_001303914.1, NM_001316985.1
NP_001303915.1, NM_001316986.1
NP_001303917.1, NM_001316988.1
NP_478070.1, NM_058190.3 [Q9NSI2-1]
UniGeneiHs.410830

Genome annotation databases

EnsembliENST00000291634; ENSP00000291634; ENSG00000160256 [Q9NSI2-1]
ENST00000397826; ENSP00000380926; ENSG00000160256 [Q9NSI2-2]
GeneIDi85395
KEGGihsa:85395
UCSCiuc002zgl.4 human [Q9NSI2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF207A_HUMAN
AccessioniPrimary (citable) accession number: Q9NSI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: December 13, 2001
Last modified: June 20, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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