Reviewed, UniProtKB/Swiss-Prot Q9NSI2 (CU070_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C21orf70

Gene names

Name:	C21orf70
ORF Names:	PRED56

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity

Not detected in any tested tissue.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9NSI2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9NSI2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     81-95: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Uncharacterized protein C21orf70		PRO_0000079528
Regions
	Compositional bias	133 – 136	4	Poly-Arg
Amino acid modifications
	Modified residue	34	1	Phosphothreonine Ref.4 Ref.5 Ref.6
	Modified residue	203	1	Phosphoserine Ref.4 Ref.5
Natural variations
	Alternative sequence	81 – 95	15	Missing in isoform B.		VSP_003831
	Natural variant	212	1	V → L: dbSNP rs3737075.		VAR_021949

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified December 13, 2001. Version 2. Checksum: BC7D211C02EA0C89	FASTA	230	25,456
	10 20 30 40 50 60 MGKVRGLRAR VHQAAVRPKG EAAPGPAPPA PEATPPPASA AGKDWAFINT NIFARTKIDP 70 80 90 100 110 120 SALVQKLELD VRSVTSVRRG EAGSSARSVP SIRRGAEAKT VLPKKEKMKL RREQWLQKIE 130 140 150 160 170 180 AIKLAEQKHR EERRRRATVV VGDLHPLRDA LPELLGLEAG SRRQARSRES NKPRPSELSR 190 200 210 220 230 MSAAQRQQLL EEERTRFQEL LASPAYRASP LVAIGQTLAR QMQLEDGGQL
	Isoform B. Checksum: 88C97E7CB9537DF6	FASTA	215	23,945
	10 20 30 40 50 60 MGKVRGLRAR VHQAAVRPKG EAAPGPAPPA PEATPPPASA AGKDWAFINT NIFARTKIDP 70 80 90 100 110 120 SALVQKLELD VRSVTSVRRG AEAKTVLPKK EKMKLRREQW LQKIEAIKLA EQKHREERRR 130 140 150 160 170 180 RATVVVGDLH PLRDALPELL GLEAGSRRQA RSRESNKPRP SELSRMSAAQ RQQLLEEERT 190 200 210 RFQELLASPA YRASPLVAIG QTLARQMQLE DGGQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map." Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E. Genomics 78:46-54(2001) [PubMed: 11707072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS A AND B).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Brain.
[3]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-34 AND SER-203, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-34 AND SER-203, MASS SPECTROMETRY.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-34, MASS SPECTROMETRY.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-34, MASS SPECTROMETRY.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, MASS SPECTROMETRY. Tissue: T-cell.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF391113 mRNA. Translation: AAL34504.1. AF391114 mRNA. Translation: AAL34505.1. BC009341 mRNA. Translation: AAH09341.1. AL163301 Genomic DNA. Translation: CAB90492.1. Sequence problems.
IPI	IPI00027898. IPI00217294.
RefSeq	NP_478070.1.
UniGene	Hs.410830
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NSI2.
PTM databases
PhosphoSite	Q9NSI2.
Proteomic databases
PRIDE	Q9NSI2.
Genome annotation databases
Ensembl	ENST00000291634; ENSP00000291634; ENSG00000160256; Homo sapiens. [Genome view]
GeneID	85395.
KEGG	hsa:85395.
UCSC	uc002zgl.1. human. uc002zgm.1. human.
Organism-specific databases
CTD	85395.
GeneCards	GC13P018165. GC21P045184. GC21P045185.
HGNC	HGNC:15811. C21orf70.
PharmGKB	PA25865.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9NSI2.
HOVERGEN	Q9NSI2.
OMA	ERTRFQE
Gene expression databases
ArrayExpress	Q9NSI2.
Bgee	Q9NSI2.
CleanEx	HS_C21orf70.
Genevestigator	Q9NSI2.
GermOnline	ENSG00000160256. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	75952.

Entry information

Entry name

CU070_HUMAN

Accession

Primary (citable) accession number: Q9NSI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2001
Last sequence update:	December 13, 2001
Last modified:	November 24, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.