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Protein

Protein FAM207A

Gene

FAM207A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM207A
Gene namesi
Name:FAM207A
Synonyms:C21orf70
ORF Names:PRED56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:15811. FAM207A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25865.

Polymorphism and mutation databases

BioMutaiFAM207A.
DMDMi17865450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Protein FAM207APRO_0000079528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341PhosphothreonineCombined sources
Modified residuei203 – 2031PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NSI2.
MaxQBiQ9NSI2.
PaxDbiQ9NSI2.
PRIDEiQ9NSI2.

PTM databases

iPTMnetiQ9NSI2.
PhosphoSiteiQ9NSI2.

Expressioni

Tissue specificityi

Not detected in any tested tissue.

Gene expression databases

BgeeiQ9NSI2.
CleanExiHS_C21orf70.
ExpressionAtlasiQ9NSI2. baseline and differential.
GenevisibleiQ9NSI2. HS.

Organism-specific databases

HPAiHPA036354.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-5457304,EBI-618309

Protein-protein interaction databases

BioGridi124511. 16 interactions.
IntActiQ9NSI2. 5 interactions.
MINTiMINT-4994119.
STRINGi9606.ENSP00000291634.

Structurei

3D structure databases

ProteinModelPortaliQ9NSI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi133 – 1364Poly-Arg

Sequence similaritiesi

Belongs to the FAM207 family.Curated

Phylogenomic databases

eggNOGiENOG410IYMW. Eukaryota.
ENOG410XY31. LUCA.
GeneTreeiENSGT00390000015709.
HOGENOMiHOG000010293.
HOVERGENiHBG051241.
InParanoidiQ9NSI2.
OMAiFSQMKQS.
OrthoDBiEOG7JX35Z.
PhylomeDBiQ9NSI2.
TreeFamiTF336348.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q9NSI2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKVRGLRAR VHQAAVRPKG EAAPGPAPPA PEATPPPASA AGKDWAFINT
60 70 80 90 100
NIFARTKIDP SALVQKLELD VRSVTSVRRG EAGSSARSVP SIRRGAEAKT
110 120 130 140 150
VLPKKEKMKL RREQWLQKIE AIKLAEQKHR EERRRRATVV VGDLHPLRDA
160 170 180 190 200
LPELLGLEAG SRRQARSRES NKPRPSELSR MSAAQRQQLL EEERTRFQEL
210 220 230
LASPAYRASP LVAIGQTLAR QMQLEDGGQL
Length:230
Mass (Da):25,456
Last modified:December 13, 2001 - v2
Checksum:iBC7D211C02EA0C89
GO
Isoform B (identifier: Q9NSI2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-95: Missing.

Show »
Length:215
Mass (Da):23,945
Checksum:i88C97E7CB9537DF6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti212 – 2121V → L.
Corresponds to variant rs3737075 [ dbSNP | Ensembl ].
VAR_021949

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei81 – 9515Missing in isoform B. 1 PublicationVSP_003831Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391113 mRNA. Translation: AAL34504.1.
AF391114 mRNA. Translation: AAL34505.1.
AL163301 Genomic DNA. Translation: CAB90492.1. Sequence problems.
BC009341 mRNA. Translation: AAH09341.1.
CCDSiCCDS13718.1. [Q9NSI2-1]
RefSeqiNP_001303912.1. NM_001316983.1.
NP_001303913.1. NM_001316984.1. [Q9NSI2-2]
NP_001303914.1. NM_001316985.1.
NP_001303915.1. NM_001316986.1.
NP_001303917.1. NM_001316988.1.
NP_478070.1. NM_058190.3. [Q9NSI2-1]
UniGeneiHs.410830.

Genome annotation databases

EnsembliENST00000291634; ENSP00000291634; ENSG00000160256. [Q9NSI2-1]
ENST00000397826; ENSP00000380926; ENSG00000160256. [Q9NSI2-2]
GeneIDi85395.
KEGGihsa:85395.
UCSCiuc002zgl.4. human. [Q9NSI2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391113 mRNA. Translation: AAL34504.1.
AF391114 mRNA. Translation: AAL34505.1.
AL163301 Genomic DNA. Translation: CAB90492.1. Sequence problems.
BC009341 mRNA. Translation: AAH09341.1.
CCDSiCCDS13718.1. [Q9NSI2-1]
RefSeqiNP_001303912.1. NM_001316983.1.
NP_001303913.1. NM_001316984.1. [Q9NSI2-2]
NP_001303914.1. NM_001316985.1.
NP_001303915.1. NM_001316986.1.
NP_001303917.1. NM_001316988.1.
NP_478070.1. NM_058190.3. [Q9NSI2-1]
UniGeneiHs.410830.

3D structure databases

ProteinModelPortaliQ9NSI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124511. 16 interactions.
IntActiQ9NSI2. 5 interactions.
MINTiMINT-4994119.
STRINGi9606.ENSP00000291634.

PTM databases

iPTMnetiQ9NSI2.
PhosphoSiteiQ9NSI2.

Polymorphism and mutation databases

BioMutaiFAM207A.
DMDMi17865450.

Proteomic databases

EPDiQ9NSI2.
MaxQBiQ9NSI2.
PaxDbiQ9NSI2.
PRIDEiQ9NSI2.

Protocols and materials databases

DNASUi85395.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291634; ENSP00000291634; ENSG00000160256. [Q9NSI2-1]
ENST00000397826; ENSP00000380926; ENSG00000160256. [Q9NSI2-2]
GeneIDi85395.
KEGGihsa:85395.
UCSCiuc002zgl.4. human. [Q9NSI2-1]

Organism-specific databases

CTDi85395.
GeneCardsiFAM207A.
H-InvDBHIX0016176.
HGNCiHGNC:15811. FAM207A.
HPAiHPA036354.
neXtProtiNX_Q9NSI2.
PharmGKBiPA25865.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYMW. Eukaryota.
ENOG410XY31. LUCA.
GeneTreeiENSGT00390000015709.
HOGENOMiHOG000010293.
HOVERGENiHBG051241.
InParanoidiQ9NSI2.
OMAiFSQMKQS.
OrthoDBiEOG7JX35Z.
PhylomeDBiQ9NSI2.
TreeFamiTF336348.

Miscellaneous databases

GenomeRNAii85395.
PROiQ9NSI2.

Gene expression databases

BgeeiQ9NSI2.
CleanExiHS_C21orf70.
ExpressionAtlasiQ9NSI2. baseline and differential.
GenevisibleiQ9NSI2. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
    Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
    Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Brain.
  4. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-34 AND SER-203, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF207A_HUMAN
AccessioniPrimary (citable) accession number: Q9NSI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: December 13, 2001
Last modified: June 8, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.